Cytokine Profiling in Chagas Disease: Towards Understanding the Association with Infecting Trypanosoma cruzi Discrete Typing Units (A BENEFIT TRIAL Sub-Study).

Detalhes bibliográficos
Autor(a) principal: Poveda, Cristina
Data de Publicação: 2014
Outros Autores: Fresno, Manuel, Girones, Nuria, Martins Filho, Olindo Assis, Ramirez, Juan David, Santi-Rocca, Julien, Marin Neto, José Antonio, Morillo, Carlos A., Rosas, Fernando, Guhl, Felipe
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
DOI: 10.1371/journal.pone.0091154
Texto Completo: https://www.arca.fiocruz.br/handle/icict/9433
Resumo: Universidad de los Andes. Facultad de Ciencias. Centro de investigaciones en Microbiologıa y Parasitologıa Tropical. Bogota, Colombia
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spelling Poveda, CristinaFresno, ManuelGirones, NuriaMartins Filho, Olindo AssisRamirez, Juan DavidSanti-Rocca, JulienMarin Neto, José AntonioMorillo, Carlos A.Rosas, FernandoGuhl, Felipe2015-02-04T17:46:33Z2015-02-04T17:46:33Z2014POVEDA, Cristina et al. Cytokine Profiling in Chagas Disease: Towards Understanding the Association with Infecting Trypanosoma cruzi Discrete Typing Units (A BENEFIT TRIAL Sub-Study). PLoS ONE, v. 9, n. 3, p. e91154, 2014.1553-7366https://www.arca.fiocruz.br/handle/icict/943310.1371/journal.pone.0091154engPublic Library of ScienceCytokine Profiling in Chagas Disease: Towards Understanding the Association with Infecting Trypanosoma cruzi Discrete Typing Units (A BENEFIT TRIAL Sub-Study).info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidad de los Andes. Facultad de Ciencias. Centro de investigaciones en Microbiologıa y Parasitologıa Tropical. Bogota, ColombiaUniversidad Autonoma de Madrid. Consejo Superior de Investigaciones Cientıficas. Centro de Biologıa Molecular Severo Ochoa. Cantoblanco, Madrid, SpainUniversidad Autonoma de Madrid. Consejo Superior de Investigaciones Cientıficas. Centro de Biologıa Molecular Severo Ochoa. Cantoblanco, Madrid, SpainFundação Oswaldo Cruz. Centro de Pesquisa René Rachou. Laboratório de Biomarcadores de Diagnóstico e Monitoração. Belo Horizonte, MG, BrazilUniversidad de los Andes. Facultad de Ciencias. Centro de investigaciones en Microbiologıa y Parasitologıa Tropical. Bogota, ColombiaUniversidad Autonoma de Madrid. Consejo Superior de Investigaciones Cientıficas. Centro de Biologıa Molecular Severo Ochoa. Madrid, SpainUniversidade de São Paulo. Faculdade de Medicina. Departamento de Medicina Interna. Divisão de Cardiologia. Sao Paulo, SP, BrazilMcMaster University. Department of Medicine. Cardiology Division. Hamilton, Ontario, CanadaClınica Abood Shaio.Electrofisiologıa. Bogota, ColombiaUniversidad de los Andes. Facultad de Ciencias. Centro de investigaciones en Microbiologıa y Parasitologıa Tropical. Bogota, ColombiaBackground: Chagas disease caused by the protozoan Trypanosoma cruzi is an important public health problem in Latin America. The immunological mechanisms involved in Chagas disease pathogenesis remain incompletely elucidated. The aim of this study was to explore cytokine profiles and their possible association to the infecting DTU and the pathogenesis of Chagas disease. Methods: 109 sero-positive T. cruzi patients and 21 negative controls from Bolivia and Colombia, were included. Flow cytometry assays for 13 cytokines were conducted on human sera. Patients were divided into two groups: in one we compared the quantification of cytokines between patients with and without chronic cardiomyopathy; in second group we compared the levels of cytokines and the genetic variability of T. cruzi. Results: Significant difference in anti-inflammatory and pro-inflammatory cytokines profiles was observed between the two groups cardiac and non-cardiac. Moreover, serum levels of IFN-c, IL-12, IL-22 and IL-10 presented an association with the genetic variability of T.cruzi, with significant differences in TcI and mixed infections TcI/TcII. Conclusion: Expression of anti-inflammatory and pro-inflammatory cytokines may play a relevant role in determining the clinical presentation of chronic patients with Chagas disease and suggests the occurrence of specific immune responses, probably associated to different T. cruzi DTUs.Trypanosoma cruziChagas diseaseinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/9433/1/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD51ORIGINAL2014_040.pdf2014_040.pdfapplication/pdf1730665https://www.arca.fiocruz.br/bitstream/icict/9433/2/2014_040.pdfd30ffc680bdd9870a34563560437708cMD52TEXT2014_040.pdf.txt2014_040.pdf.txtExtracted texttext/plain41488https://www.arca.fiocruz.br/bitstream/icict/9433/3/2014_040.pdf.txt3efbfc2e946ba0cc35906d52b131aba2MD53icict/94332019-06-19 10:07:34.148oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352019-06-19T13:07:34Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Cytokine Profiling in Chagas Disease: Towards Understanding the Association with Infecting Trypanosoma cruzi Discrete Typing Units (A BENEFIT TRIAL Sub-Study).
title Cytokine Profiling in Chagas Disease: Towards Understanding the Association with Infecting Trypanosoma cruzi Discrete Typing Units (A BENEFIT TRIAL Sub-Study).
spellingShingle Cytokine Profiling in Chagas Disease: Towards Understanding the Association with Infecting Trypanosoma cruzi Discrete Typing Units (A BENEFIT TRIAL Sub-Study).
Poveda, Cristina
Trypanosoma cruzi
Chagas disease
title_short Cytokine Profiling in Chagas Disease: Towards Understanding the Association with Infecting Trypanosoma cruzi Discrete Typing Units (A BENEFIT TRIAL Sub-Study).
title_full Cytokine Profiling in Chagas Disease: Towards Understanding the Association with Infecting Trypanosoma cruzi Discrete Typing Units (A BENEFIT TRIAL Sub-Study).
title_fullStr Cytokine Profiling in Chagas Disease: Towards Understanding the Association with Infecting Trypanosoma cruzi Discrete Typing Units (A BENEFIT TRIAL Sub-Study).
title_full_unstemmed Cytokine Profiling in Chagas Disease: Towards Understanding the Association with Infecting Trypanosoma cruzi Discrete Typing Units (A BENEFIT TRIAL Sub-Study).
title_sort Cytokine Profiling in Chagas Disease: Towards Understanding the Association with Infecting Trypanosoma cruzi Discrete Typing Units (A BENEFIT TRIAL Sub-Study).
author Poveda, Cristina
author_facet Poveda, Cristina
Fresno, Manuel
Girones, Nuria
Martins Filho, Olindo Assis
Ramirez, Juan David
Santi-Rocca, Julien
Marin Neto, José Antonio
Morillo, Carlos A.
Rosas, Fernando
Guhl, Felipe
author_role author
author2 Fresno, Manuel
Girones, Nuria
Martins Filho, Olindo Assis
Ramirez, Juan David
Santi-Rocca, Julien
Marin Neto, José Antonio
Morillo, Carlos A.
Rosas, Fernando
Guhl, Felipe
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Poveda, Cristina
Fresno, Manuel
Girones, Nuria
Martins Filho, Olindo Assis
Ramirez, Juan David
Santi-Rocca, Julien
Marin Neto, José Antonio
Morillo, Carlos A.
Rosas, Fernando
Guhl, Felipe
dc.subject.en.pt_BR.fl_str_mv Trypanosoma cruzi
Chagas disease
topic Trypanosoma cruzi
Chagas disease
description Universidad de los Andes. Facultad de Ciencias. Centro de investigaciones en Microbiologıa y Parasitologıa Tropical. Bogota, Colombia
publishDate 2014
dc.date.issued.fl_str_mv 2014
dc.date.accessioned.fl_str_mv 2015-02-04T17:46:33Z
dc.date.available.fl_str_mv 2015-02-04T17:46:33Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.citation.fl_str_mv POVEDA, Cristina et al. Cytokine Profiling in Chagas Disease: Towards Understanding the Association with Infecting Trypanosoma cruzi Discrete Typing Units (A BENEFIT TRIAL Sub-Study). PLoS ONE, v. 9, n. 3, p. e91154, 2014.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/9433
dc.identifier.issn.none.fl_str_mv 1553-7366
dc.identifier.doi.none.fl_str_mv 10.1371/journal.pone.0091154
identifier_str_mv POVEDA, Cristina et al. Cytokine Profiling in Chagas Disease: Towards Understanding the Association with Infecting Trypanosoma cruzi Discrete Typing Units (A BENEFIT TRIAL Sub-Study). PLoS ONE, v. 9, n. 3, p. e91154, 2014.
1553-7366
10.1371/journal.pone.0091154
url https://www.arca.fiocruz.br/handle/icict/9433
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