Review of the current treatments for leishmaniases

Detalhes bibliográficos
Autor(a) principal: Lindoso, José Angelo Lauletta
Data de Publicação: 2012
Outros Autores: Costa, Jackson Maurício Lopes, Queiroz, Igor Thiago, Goto, Hiro
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/20439
Resumo: Laboratorio de Investigação Médica (LIM-38) do Hospital das Clínicas da Faculdade de Medicina, USP and Conselho Nacional de Pesquisa.
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spelling Lindoso, José Angelo LaulettaCosta, Jackson Maurício LopesQueiroz, Igor ThiagoGoto, Hiro2017-07-28T13:02:12Z2017-07-28T13:02:12Z2012LINDOSO, J. A. L. et al. Review of the current treatments for leishmaniases. Research and Reports in Tropical Medicine, v. 3, p. 69–77, 2012.1179-7282https://www.arca.fiocruz.br/handle/icict/20439Laboratorio de Investigação Médica (LIM-38) do Hospital das Clínicas da Faculdade de Medicina, USP and Conselho Nacional de Pesquisa.Instituto de Infectologia Emilio Ribas-SES. São Paulo, SP, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilUniversidade de São Paulo. Faculdade de Medicina. Departamento de Doenças Infecciosas. São Paulo, SP, BrasilUniversidade de São Paulo. Faculdade de Medicina. Instituto de Medicina Tropical de São Paulo. São Paulo, SP, BrasilAbstract: Leishmaniases are vector-borne zoonotic diseases that are prevalent in tropical and subtropical areas in the world, with two million new cases occurring yearly. Visceral and tegumentary forms of leishmaniasis are known. The latter form may present as localized cutaneous or mucosal forms, disseminated, diffuse forms, or leishmaniasis recidiva cutis. Visceral leishmaniasis is caused by parasites of the species Leishmania (Leishmania) donovani and L. (L.) infantum, and tegumentary leishmaniasis is caused by 15 other species, with distinct distributions in the Old and New World. The varied clinical manifestations, the multitude of Leishmania species, and the increasing incidence of HIV coinfection make the diagnosis and treatment of leishmaniases complex. Since there are no solid data relating clinical manifestations, treatment outcomes and Leishmania species the decision regarding the best therapeutic option is almost entirely based on clinical manifestations. Because most of the literature is focused on leishmaniasis in the Old World, in this review we present data on the treatment of New World leishmaniasis in more detail. Ranked therapeutic options, clinical trials, and also observations, even with a restricted number of subjects, on treatment outcome of visceral and different forms of tegumentary leishmaniasis, are presented. Treatment for leishmaniasis in HIV-coinfected patients is addressed as well. Some of these data strongly suggest that the differences in the outcome of the treatment are related to the Leishmania species. Therefore, although it is not possible at most points of care to identify the species causing the infection – a process that requires a well equipped laboratory – the infecting species should be identified whenever possible. More recent approaches, such as the use of immunomodulators and immunotherapy, and the lines for development of new candidate drugs are mentionedengDove Medical PressTegumentarVisceralTerapiaHIVLeishmaniaTegumentaryVisceralTherapyHIVLeishmaniaReview of the current treatments for leishmaniasesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/20439/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALLindoso JAL Review-of-the-current-treatments-for-leish.pdfLindoso JAL Review-of-the-current-treatments-for-leish.pdfapplication/pdf211384https://www.arca.fiocruz.br/bitstream/icict/20439/2/Lindoso%20JAL%20Review-of-the-current-treatments-for-leish.pdf61778a967ff340e48f91656f3031ca1dMD52TEXTLindoso JAL 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dc.title.pt_BR.fl_str_mv Review of the current treatments for leishmaniases
title Review of the current treatments for leishmaniases
spellingShingle Review of the current treatments for leishmaniases
Lindoso, José Angelo Lauletta
Tegumentar
Visceral
Terapia
HIV
Leishmania
Tegumentary
Visceral
Therapy
HIV
Leishmania
title_short Review of the current treatments for leishmaniases
title_full Review of the current treatments for leishmaniases
title_fullStr Review of the current treatments for leishmaniases
title_full_unstemmed Review of the current treatments for leishmaniases
title_sort Review of the current treatments for leishmaniases
author Lindoso, José Angelo Lauletta
author_facet Lindoso, José Angelo Lauletta
Costa, Jackson Maurício Lopes
Queiroz, Igor Thiago
Goto, Hiro
author_role author
author2 Costa, Jackson Maurício Lopes
Queiroz, Igor Thiago
Goto, Hiro
author2_role author
author
author
dc.contributor.author.fl_str_mv Lindoso, José Angelo Lauletta
Costa, Jackson Maurício Lopes
Queiroz, Igor Thiago
Goto, Hiro
dc.subject.other.pt_BR.fl_str_mv Tegumentar
Visceral
Terapia
HIV
Leishmania
topic Tegumentar
Visceral
Terapia
HIV
Leishmania
Tegumentary
Visceral
Therapy
HIV
Leishmania
dc.subject.en.pt_BR.fl_str_mv Tegumentary
Visceral
Therapy
HIV
Leishmania
description Laboratorio de Investigação Médica (LIM-38) do Hospital das Clínicas da Faculdade de Medicina, USP and Conselho Nacional de Pesquisa.
publishDate 2012
dc.date.issued.fl_str_mv 2012
dc.date.accessioned.fl_str_mv 2017-07-28T13:02:12Z
dc.date.available.fl_str_mv 2017-07-28T13:02:12Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv LINDOSO, J. A. L. et al. Review of the current treatments for leishmaniases. Research and Reports in Tropical Medicine, v. 3, p. 69–77, 2012.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/20439
dc.identifier.issn.pt_BR.fl_str_mv 1179-7282
identifier_str_mv LINDOSO, J. A. L. et al. Review of the current treatments for leishmaniases. Research and Reports in Tropical Medicine, v. 3, p. 69–77, 2012.
1179-7282
url https://www.arca.fiocruz.br/handle/icict/20439
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Dove Medical Press
publisher.none.fl_str_mv Dove Medical Press
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
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instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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