Review of the current treatments for leishmaniases
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/20439 |
Resumo: | Laboratorio de Investigação Médica (LIM-38) do Hospital das Clínicas da Faculdade de Medicina, USP and Conselho Nacional de Pesquisa. |
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Lindoso, José Angelo LaulettaCosta, Jackson Maurício LopesQueiroz, Igor ThiagoGoto, Hiro2017-07-28T13:02:12Z2017-07-28T13:02:12Z2012LINDOSO, J. A. L. et al. Review of the current treatments for leishmaniases. Research and Reports in Tropical Medicine, v. 3, p. 69–77, 2012.1179-7282https://www.arca.fiocruz.br/handle/icict/20439Laboratorio de Investigação Médica (LIM-38) do Hospital das Clínicas da Faculdade de Medicina, USP and Conselho Nacional de Pesquisa.Instituto de Infectologia Emilio Ribas-SES. São Paulo, SP, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilUniversidade de São Paulo. Faculdade de Medicina. Departamento de Doenças Infecciosas. São Paulo, SP, BrasilUniversidade de São Paulo. Faculdade de Medicina. Instituto de Medicina Tropical de São Paulo. São Paulo, SP, BrasilAbstract: Leishmaniases are vector-borne zoonotic diseases that are prevalent in tropical and subtropical areas in the world, with two million new cases occurring yearly. Visceral and tegumentary forms of leishmaniasis are known. The latter form may present as localized cutaneous or mucosal forms, disseminated, diffuse forms, or leishmaniasis recidiva cutis. Visceral leishmaniasis is caused by parasites of the species Leishmania (Leishmania) donovani and L. (L.) infantum, and tegumentary leishmaniasis is caused by 15 other species, with distinct distributions in the Old and New World. The varied clinical manifestations, the multitude of Leishmania species, and the increasing incidence of HIV coinfection make the diagnosis and treatment of leishmaniases complex. Since there are no solid data relating clinical manifestations, treatment outcomes and Leishmania species the decision regarding the best therapeutic option is almost entirely based on clinical manifestations. Because most of the literature is focused on leishmaniasis in the Old World, in this review we present data on the treatment of New World leishmaniasis in more detail. Ranked therapeutic options, clinical trials, and also observations, even with a restricted number of subjects, on treatment outcome of visceral and different forms of tegumentary leishmaniasis, are presented. Treatment for leishmaniasis in HIV-coinfected patients is addressed as well. Some of these data strongly suggest that the differences in the outcome of the treatment are related to the Leishmania species. Therefore, although it is not possible at most points of care to identify the species causing the infection – a process that requires a well equipped laboratory – the infecting species should be identified whenever possible. More recent approaches, such as the use of immunomodulators and immunotherapy, and the lines for development of new candidate drugs are mentionedengDove Medical PressTegumentarVisceralTerapiaHIVLeishmaniaTegumentaryVisceralTherapyHIVLeishmaniaReview of the current treatments for leishmaniasesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/20439/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALLindoso JAL Review-of-the-current-treatments-for-leish.pdfLindoso JAL Review-of-the-current-treatments-for-leish.pdfapplication/pdf211384https://www.arca.fiocruz.br/bitstream/icict/20439/2/Lindoso%20JAL%20Review-of-the-current-treatments-for-leish.pdf61778a967ff340e48f91656f3031ca1dMD52TEXTLindoso JAL 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dc.title.pt_BR.fl_str_mv |
Review of the current treatments for leishmaniases |
title |
Review of the current treatments for leishmaniases |
spellingShingle |
Review of the current treatments for leishmaniases Lindoso, José Angelo Lauletta Tegumentar Visceral Terapia HIV Leishmania Tegumentary Visceral Therapy HIV Leishmania |
title_short |
Review of the current treatments for leishmaniases |
title_full |
Review of the current treatments for leishmaniases |
title_fullStr |
Review of the current treatments for leishmaniases |
title_full_unstemmed |
Review of the current treatments for leishmaniases |
title_sort |
Review of the current treatments for leishmaniases |
author |
Lindoso, José Angelo Lauletta |
author_facet |
Lindoso, José Angelo Lauletta Costa, Jackson Maurício Lopes Queiroz, Igor Thiago Goto, Hiro |
author_role |
author |
author2 |
Costa, Jackson Maurício Lopes Queiroz, Igor Thiago Goto, Hiro |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Lindoso, José Angelo Lauletta Costa, Jackson Maurício Lopes Queiroz, Igor Thiago Goto, Hiro |
dc.subject.other.pt_BR.fl_str_mv |
Tegumentar Visceral Terapia HIV Leishmania |
topic |
Tegumentar Visceral Terapia HIV Leishmania Tegumentary Visceral Therapy HIV Leishmania |
dc.subject.en.pt_BR.fl_str_mv |
Tegumentary Visceral Therapy HIV Leishmania |
description |
Laboratorio de Investigação Médica (LIM-38) do Hospital das Clínicas da Faculdade de Medicina, USP and Conselho Nacional de Pesquisa. |
publishDate |
2012 |
dc.date.issued.fl_str_mv |
2012 |
dc.date.accessioned.fl_str_mv |
2017-07-28T13:02:12Z |
dc.date.available.fl_str_mv |
2017-07-28T13:02:12Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
LINDOSO, J. A. L. et al. Review of the current treatments for leishmaniases. Research and Reports in Tropical Medicine, v. 3, p. 69–77, 2012. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/20439 |
dc.identifier.issn.pt_BR.fl_str_mv |
1179-7282 |
identifier_str_mv |
LINDOSO, J. A. L. et al. Review of the current treatments for leishmaniases. Research and Reports in Tropical Medicine, v. 3, p. 69–77, 2012. 1179-7282 |
url |
https://www.arca.fiocruz.br/handle/icict/20439 |
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eng |
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eng |
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openAccess |
dc.publisher.none.fl_str_mv |
Dove Medical Press |
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Dove Medical Press |
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