Potential immunomodulatory effects of plant lectins in Schistosoma mansoni infection
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2008 |
| Outros Autores: | , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/7406 |
Resumo: | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil |
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Reis, Eliana Almeida GomesAthanazio, Daniel AbensurCavada, Benildo SousaTeixeira, Edson HolandaPinto, Vicente de Paulo TeixeiraCarmo, Theomira Mauadie de AzevedoReis, AliceTrocolli, GrazielaCroda, Julio Henrique RosaHarn Junior, Donald ABarral Netto, ManoelReis, Mitermayer Galvão dos2014-03-13T18:51:28Z2014-03-13T18:51:28Z2008REIS, E. A. G. et al. Potential immunomodulatory effects of plant lectins in Schistosoma mansoni infection. Acta Tropica, v. 108, n. 2/3, p. 160-165, 2008.1873-6254https://www.arca.fiocruz.br/handle/icict/740610.1016/j.actatropica.2008.05.025engElsevier B.VPotential immunomodulatory effects of plant lectins in Schistosoma mansoni infectioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilUniversidade Federal do Ceará. Departamento de Bioquímica e Biologia Molecular. Fortaleza, CE, BrasilUniversidade Federal de Ceará. Faculdade de Medicina. Sobral, CE, BrasilUniversidade Federal de Ceará. Faculdade de Medicina. Sobral, CE, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilHarvard School of Public Health. Department of Immunology and Infectious Diseases. Boston, USAFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilLectins are sugar-binding glycoproteins that can stimulate, in a non-antigen-specific fashion, lymphocytes, leading to proliferation and cytokine production. Some lectins are utilized as in vitro mitogenic lymphocyte stimulators and their use as immunomodulators against infectious diseases has been evaluated experimentally. In the experimental murine model, the immune response to schistosomiasis is Th1-like during the initial stage of infection, with a shift towards a Th2-like response after oviposition. We report the response of schistosomiasis patients' (n=37) peripheral blood mononuclear cells (PBMC) to stimulation by lectins, including newly isolated lectins from Brazilian flora, and by Schistosomamansoni soluble egg antigens (SEA). Cytokine production upon lectin stimulation ex vivo was assessed in PBMC supernatants, collected at 24 and 72 h, by sandwich ELISA to IL-5, IL-10, TNF-alpha and IFN-gamma. In PBMC from infected patients all but one of the lectins induced a Th2-like cytokine response, characterized by elevated IL-5 production that was higher than that induced by SEA stimulation alone. Our results show that the Th2 environment present during schistosomiasis is not affected and that it may be further stimulated by the presence of lectins.LectinsSchistosoma mansoniCytokinesFatores Imunológicos/farmacologiaLectinas/farmacologiaLeucócitos Mononucleares/efeitos de drogasLeucócitos Mononucleares/imunologiaEsquistossomose mansoni/imunologiaAdolescenteAdultoAnimaisCélulas CultivadasCriançaCitocinas/secreçãoEnsaio de Imunoadsorção EnzimáticaFemininoHumanosMasculinoMeia-Idadeinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALReis E Potential Immunomodulatory....pdfReis E Potential Immunomodulatory....pdfapplication/pdf727632https://www.arca.fiocruz.br/bitstream/icict/7406/1/Reis%20E%20Potential%20Immunomodulatory....pdf4c436017589ebd87aa96d15e68b3d809MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/7406/2/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD52TEXTReis E Potential Immunomodulatory....pdf.txtReis E Potential Immunomodulatory....pdf.txtExtracted texttext/plain30318https://www.arca.fiocruz.br/bitstream/icict/7406/5/Reis%20E%20Potential%20Immunomodulatory....pdf.txt8c92a15672fa2c3ed9cb898b935f1cdeMD55THUMBNAILReis E Potential Immunomodulatory....pdf.jpgReis E Potential Immunomodulatory....pdf.jpgGenerated Thumbnailimage/jpeg2224https://www.arca.fiocruz.br/bitstream/icict/7406/4/Reis%20E%20Potential%20Immunomodulatory....pdf.jpg87cc7e521f9e7668240826d027c3c9dbMD54icict/74062023-03-15 14:33:14.237oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:14Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
Potential immunomodulatory effects of plant lectins in Schistosoma mansoni infection |
| title |
Potential immunomodulatory effects of plant lectins in Schistosoma mansoni infection |
| spellingShingle |
Potential immunomodulatory effects of plant lectins in Schistosoma mansoni infection Reis, Eliana Almeida Gomes Lectins Schistosoma mansoni Cytokines Fatores Imunológicos/farmacologia Lectinas/farmacologia Leucócitos Mononucleares/efeitos de drogas Leucócitos Mononucleares/imunologia Esquistossomose mansoni/imunologia Adolescente Adulto Animais Células Cultivadas Criança Citocinas/secreção Ensaio de Imunoadsorção Enzimática Feminino Humanos Masculino Meia-Idade |
| title_short |
Potential immunomodulatory effects of plant lectins in Schistosoma mansoni infection |
| title_full |
Potential immunomodulatory effects of plant lectins in Schistosoma mansoni infection |
| title_fullStr |
Potential immunomodulatory effects of plant lectins in Schistosoma mansoni infection |
| title_full_unstemmed |
Potential immunomodulatory effects of plant lectins in Schistosoma mansoni infection |
| title_sort |
Potential immunomodulatory effects of plant lectins in Schistosoma mansoni infection |
| author |
Reis, Eliana Almeida Gomes |
| author_facet |
Reis, Eliana Almeida Gomes Athanazio, Daniel Abensur Cavada, Benildo Sousa Teixeira, Edson Holanda Pinto, Vicente de Paulo Teixeira Carmo, Theomira Mauadie de Azevedo Reis, Alice Trocolli, Graziela Croda, Julio Henrique Rosa Harn Junior, Donald A Barral Netto, Manoel Reis, Mitermayer Galvão dos |
| author_role |
author |
| author2 |
Athanazio, Daniel Abensur Cavada, Benildo Sousa Teixeira, Edson Holanda Pinto, Vicente de Paulo Teixeira Carmo, Theomira Mauadie de Azevedo Reis, Alice Trocolli, Graziela Croda, Julio Henrique Rosa Harn Junior, Donald A Barral Netto, Manoel Reis, Mitermayer Galvão dos |
| author2_role |
author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Reis, Eliana Almeida Gomes Athanazio, Daniel Abensur Cavada, Benildo Sousa Teixeira, Edson Holanda Pinto, Vicente de Paulo Teixeira Carmo, Theomira Mauadie de Azevedo Reis, Alice Trocolli, Graziela Croda, Julio Henrique Rosa Harn Junior, Donald A Barral Netto, Manoel Reis, Mitermayer Galvão dos |
| dc.subject.en.pt_BR.fl_str_mv |
Lectins Schistosoma mansoni Cytokines |
| topic |
Lectins Schistosoma mansoni Cytokines Fatores Imunológicos/farmacologia Lectinas/farmacologia Leucócitos Mononucleares/efeitos de drogas Leucócitos Mononucleares/imunologia Esquistossomose mansoni/imunologia Adolescente Adulto Animais Células Cultivadas Criança Citocinas/secreção Ensaio de Imunoadsorção Enzimática Feminino Humanos Masculino Meia-Idade |
| dc.subject.decs.pt_BR.fl_str_mv |
Fatores Imunológicos/farmacologia Lectinas/farmacologia Leucócitos Mononucleares/efeitos de drogas Leucócitos Mononucleares/imunologia Esquistossomose mansoni/imunologia Adolescente Adulto Animais Células Cultivadas Criança Citocinas/secreção Ensaio de Imunoadsorção Enzimática Feminino Humanos Masculino Meia-Idade |
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Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil |
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2008 |
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2008 |
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2014-03-13T18:51:28Z |
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2014-03-13T18:51:28Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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REIS, E. A. G. et al. Potential immunomodulatory effects of plant lectins in Schistosoma mansoni infection. Acta Tropica, v. 108, n. 2/3, p. 160-165, 2008. |
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https://www.arca.fiocruz.br/handle/icict/7406 |
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1873-6254 |
| dc.identifier.doi.none.fl_str_mv |
10.1016/j.actatropica.2008.05.025 |
| identifier_str_mv |
REIS, E. A. G. et al. Potential immunomodulatory effects of plant lectins in Schistosoma mansoni infection. Acta Tropica, v. 108, n. 2/3, p. 160-165, 2008. 1873-6254 10.1016/j.actatropica.2008.05.025 |
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Elsevier B.V |
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Elsevier B.V |
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