Defining the directionality and quality of influenza virus-specific CD8+ T cell cross-reactivity in individuals infected with hepatitis C virus

Detalhes bibliográficos
Autor(a) principal: Kasprowicz, Victoria
Data de Publicação: 2008
Outros Autores: Ward, Scott M., Turner, Alison, Grammatikos, Alexandros, Nolan, Brian E., Lewis-Ximenez, Lia, Sharp, Charles, Woodruff, Jenny, Fleming, Vicki M., Sims, Stuart, Walker, Bruce D., Sewell, Andrew K., Lauer, Georg M., Klenerman, Paul
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/31880
Resumo: Partners AIDS Research Center and Infectious Disease Division. Massachusetts General Hospital and Harvard Medical School. Charlestown, Massachusetts, USA.
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spelling Kasprowicz, VictoriaWard, Scott M.Turner, AlisonGrammatikos, AlexandrosNolan, Brian E.Lewis-Ximenez, LiaSharp, CharlesWoodruff, JennyFleming, Vicki M.Sims, StuartWalker, Bruce D.Sewell, Andrew K.Lauer, Georg M.Klenerman, Paul2019-02-26T14:51:06Z2019-02-26T14:51:06Z2008KASPROWICZ, Victoria; et al. Defining the directionality and quality of influenza virus–specific CD8+ T cell cross-reactivity in individuals infected with hepatitis C virus. Journal of Clinical Investigation, v.118, n.3, p.1143-1153, Mar. 2008.0021-9738https://www.arca.fiocruz.br/handle/icict/3188010.1172/JCI330821558-8238engAmerican Society for Clinical InvestigationVírus InfluenzaCD+8Células TIndivíduos infectadosVírus da hepatite CInfluenza virusCD+8 specificT cellsIndividuals infectedHepatitis C virusDefining the directionality and quality of influenza virus-specific CD8+ T cell cross-reactivity in individuals infected with hepatitis C virusinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlePartners AIDS Research Center and Infectious Disease Division. Massachusetts General Hospital and Harvard Medical School. Charlestown, Massachusetts, USA.Peter Medawar Building for Pathogen Research. Nuffield Department of Clinical Medicine. University of Oxford. Oxford, United Kingdom.Peter Medawar Building for Pathogen Research. Nuffield Department of Clinical Medicine. University of Oxford. Oxford, United Kingdom.Peter Medawar Building for Pathogen Research. Nuffield Department of Clinical Medicine. University of Oxford. Oxford, United Kingdom.Partners AIDS Research Center and Infectious Disease Division. Massachusetts General Hospital and Harvard Medical School. Charlestown, Massachusetts, USA.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Virologia. Rio de Janeiro, RJ. Brasil.Peter Medawar Building for Pathogen Research. Nuffield Department of Clinical Medicine. University of Oxford. Oxford, United Kingdom.Peter Medawar Building for Pathogen Research. Nuffield Department of Clinical Medicine. University of Oxford. Oxford, United Kingdom.Peter Medawar Building for Pathogen Research. Nuffield Department of Clinical Medicine. University of Oxford. Oxford, United Kingdom.Peter Medawar Building for Pathogen Research. Nuffield Department of Clinical Medicine. University of Oxford. Oxford, United Kingdom.Partners AIDS Research Center and Infectious Disease Division. Massachusetts General Hospital and Harvard Medical School. Charlestown, Massachusetts, USA.University of Cardiff. Department of Medical Biochemistry and Immunology. Cardiff, United Kingdom.Partners AIDS Research Center and Infectious Disease Division. Massachusetts General Hospital and Harvard Medical School. Charlestown, Massachusetts, USA.Peter Medawar Building for Pathogen Research. Nuffield Department of Clinical Medicine. University of Oxford. Oxford, United Kingdom.Cross-reactivity of murine and recently human CD8(+) T cells between different viral peptides, i.e., heterologous immunity, has been well characterized. However, the directionality and quality of these cross-reactions is critical in determining their biological importance. Herein we analyzed the response of human CD8(+) T cells that recognize both a hepatitis C virus peptide (HCV-NS3) and a peptide derived from the influenza neuraminidase protein (Flu-NA). To detect the cross-reactive CD8(+) T cells, we used peptide-MHC class I complexes (pMHCs) containing a new mutant form of MHC class I able to bind CD8 more strongly than normal MHC class I complexes. T cell responses against HCV-NS3 and Flu-NA peptide were undetectable in normal donors. In contrast, some responses against the Flu-NA peptide were identified in HCV(+) donors who showed strong HCV-NS3-specific reactivity. The Flu-NA peptide was a weak agonist for CD8(+) T cells in HCV(+) individuals on the basis of novel pMHCs and functional assays. These data support the idea of cross-reactivity between the 2 peptides, but indicate that reactivity toward the Flu-NA peptide is highly CD8-dependent and occurs predominantly after priming during HCV infection. Our findings indicate the utility of the novel pMHCs in dissecting cross-reactivity and suggest that cross-reactivity between HCV and influenza is relatively weak. Further studies are needed to relate affinity and functionality of cross-reactive T cells.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/31880/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALLialewis_ximenez_etal_IOC_2008.pdfLialewis_ximenez_etal_IOC_2008.pdfapplication/pdf1416233https://www.arca.fiocruz.br/bitstream/icict/31880/2/Lialewis_ximenez_etal_IOC_2008.pdf15ba340cdad2d7b2a88c2386da840dbaMD52TEXTLialewis_ximenez_etal_IOC_2008.pdf.txtLialewis_ximenez_etal_IOC_2008.pdf.txtExtracted texttext/plain60524https://www.arca.fiocruz.br/bitstream/icict/31880/3/Lialewis_ximenez_etal_IOC_2008.pdf.txtcbdca2a49cfae0c898b7d506f28b1366MD53icict/318802019-02-27 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dc.title.pt_BR.fl_str_mv Defining the directionality and quality of influenza virus-specific CD8+ T cell cross-reactivity in individuals infected with hepatitis C virus
title Defining the directionality and quality of influenza virus-specific CD8+ T cell cross-reactivity in individuals infected with hepatitis C virus
spellingShingle Defining the directionality and quality of influenza virus-specific CD8+ T cell cross-reactivity in individuals infected with hepatitis C virus
Kasprowicz, Victoria
Vírus Influenza
CD+8
Células T
Indivíduos infectados
Vírus da hepatite C
Influenza virus
CD+8 specific
T cells
Individuals infected
Hepatitis C virus
title_short Defining the directionality and quality of influenza virus-specific CD8+ T cell cross-reactivity in individuals infected with hepatitis C virus
title_full Defining the directionality and quality of influenza virus-specific CD8+ T cell cross-reactivity in individuals infected with hepatitis C virus
title_fullStr Defining the directionality and quality of influenza virus-specific CD8+ T cell cross-reactivity in individuals infected with hepatitis C virus
title_full_unstemmed Defining the directionality and quality of influenza virus-specific CD8+ T cell cross-reactivity in individuals infected with hepatitis C virus
title_sort Defining the directionality and quality of influenza virus-specific CD8+ T cell cross-reactivity in individuals infected with hepatitis C virus
author Kasprowicz, Victoria
author_facet Kasprowicz, Victoria
Ward, Scott M.
Turner, Alison
Grammatikos, Alexandros
Nolan, Brian E.
Lewis-Ximenez, Lia
Sharp, Charles
Woodruff, Jenny
Fleming, Vicki M.
Sims, Stuart
Walker, Bruce D.
Sewell, Andrew K.
Lauer, Georg M.
Klenerman, Paul
author_role author
author2 Ward, Scott M.
Turner, Alison
Grammatikos, Alexandros
Nolan, Brian E.
Lewis-Ximenez, Lia
Sharp, Charles
Woodruff, Jenny
Fleming, Vicki M.
Sims, Stuart
Walker, Bruce D.
Sewell, Andrew K.
Lauer, Georg M.
Klenerman, Paul
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Kasprowicz, Victoria
Ward, Scott M.
Turner, Alison
Grammatikos, Alexandros
Nolan, Brian E.
Lewis-Ximenez, Lia
Sharp, Charles
Woodruff, Jenny
Fleming, Vicki M.
Sims, Stuart
Walker, Bruce D.
Sewell, Andrew K.
Lauer, Georg M.
Klenerman, Paul
dc.subject.other.pt_BR.fl_str_mv Vírus Influenza
CD+8
Células T
Indivíduos infectados
Vírus da hepatite C
topic Vírus Influenza
CD+8
Células T
Indivíduos infectados
Vírus da hepatite C
Influenza virus
CD+8 specific
T cells
Individuals infected
Hepatitis C virus
dc.subject.en.pt_BR.fl_str_mv Influenza virus
CD+8 specific
T cells
Individuals infected
Hepatitis C virus
description Partners AIDS Research Center and Infectious Disease Division. Massachusetts General Hospital and Harvard Medical School. Charlestown, Massachusetts, USA.
publishDate 2008
dc.date.issued.fl_str_mv 2008
dc.date.accessioned.fl_str_mv 2019-02-26T14:51:06Z
dc.date.available.fl_str_mv 2019-02-26T14:51:06Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv KASPROWICZ, Victoria; et al. Defining the directionality and quality of influenza virus–specific CD8+ T cell cross-reactivity in individuals infected with hepatitis C virus. Journal of Clinical Investigation, v.118, n.3, p.1143-1153, Mar. 2008.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/31880
dc.identifier.issn.pt_BR.fl_str_mv 0021-9738
dc.identifier.doi.none.fl_str_mv 10.1172/JCI33082
dc.identifier.eissn.none.fl_str_mv 1558-8238
identifier_str_mv KASPROWICZ, Victoria; et al. Defining the directionality and quality of influenza virus–specific CD8+ T cell cross-reactivity in individuals infected with hepatitis C virus. Journal of Clinical Investigation, v.118, n.3, p.1143-1153, Mar. 2008.
0021-9738
10.1172/JCI33082
1558-8238
url https://www.arca.fiocruz.br/handle/icict/31880
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv American Society for Clinical Investigation
publisher.none.fl_str_mv American Society for Clinical Investigation
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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