Trypanosoma cruzi down-regulates mechanosensitive proteins in cardiomyocytes

Detalhes bibliográficos
Autor(a) principal: Melo, Tatiana G.
Data de Publicação: 2019
Outros Autores: Adesse, Daniel, Meirelles, Maria de Nazareth, Pereira, Mirian Claudia S.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/37459
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Ultraestrutura Celular. Rio de Janeiro, RJ, Brasil.
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spelling Melo, Tatiana G.Adesse, DanielMeirelles, Maria de NazarethPereira, Mirian Claudia S.2019-11-28T14:38:13Z2019-11-28T14:38:13Z2019MELO, Tatiana G. et al. Trypanosoma cruzi down-regulates mechanosensitive proteins in cardiomyocytes. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 114, p. 1-9, 2019.0074-0276https://www.arca.fiocruz.br/handle/icict/3745910.1590/0074-027601805931678-8060engFundação Oswaldo Cruz. Instituto Oswaldo Cruz.Trypanosoma cruziCardiomiócitoAdesão focalTalinaTrypanosoma cruziCardiomyocyteFocal adhesionTalinPaxilinMechanotransductionMecanotransduçãoTalinaTrypanosoma cruzi down-regulates mechanosensitive proteins in cardiomyocytesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Ultraestrutura Celular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Estrutural. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Ultraestrutura Celular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Ultraestrutura Celular. Rio de Janeiro, RJ, Brasil.Cardiac physiology depends on coupling and electrical and mechanical coordination through the intercalated disc. Focal adhesions offer mechanical support and signal transduction events during heart contraction-relaxation processes. Talin links integrins to the actin cytoskeleton and serves as a scaffold for the recruitment of other proteins, such as paxillin in focal adhesion formation and regulation. Chagasic cardiomyopathy is caused by infection by Trypanosoma cruzi and is a debilitating condition comprising extensive fibrosis, inflammation, cardiac hypertrophy and electrical alterations that culminate in heart failure.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/37459/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALDanielAdesse_MirianCPereira_etal_IOC_2019.pdfDanielAdesse_MirianCPereira_etal_IOC_2019.pdfapplication/pdf12985927https://www.arca.fiocruz.br/bitstream/icict/37459/2/DanielAdesse_MirianCPereira_etal_IOC_2019.pdfa2a1054330d0181da5d8c32fab131abdMD52TEXTDanielAdesse_MirianCPereira_etal_IOC_2019.pdf.txtDanielAdesse_MirianCPereira_etal_IOC_2019.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv Trypanosoma cruzi down-regulates mechanosensitive proteins in cardiomyocytes
title Trypanosoma cruzi down-regulates mechanosensitive proteins in cardiomyocytes
spellingShingle Trypanosoma cruzi down-regulates mechanosensitive proteins in cardiomyocytes
Melo, Tatiana G.
Trypanosoma cruzi
Cardiomiócito
Adesão focal
Talina
Trypanosoma cruzi
Cardiomyocyte
Focal adhesion
Talin
Paxilin
Mechanotransduction
Mecanotransdução
Talina
title_short Trypanosoma cruzi down-regulates mechanosensitive proteins in cardiomyocytes
title_full Trypanosoma cruzi down-regulates mechanosensitive proteins in cardiomyocytes
title_fullStr Trypanosoma cruzi down-regulates mechanosensitive proteins in cardiomyocytes
title_full_unstemmed Trypanosoma cruzi down-regulates mechanosensitive proteins in cardiomyocytes
title_sort Trypanosoma cruzi down-regulates mechanosensitive proteins in cardiomyocytes
author Melo, Tatiana G.
author_facet Melo, Tatiana G.
Adesse, Daniel
Meirelles, Maria de Nazareth
Pereira, Mirian Claudia S.
author_role author
author2 Adesse, Daniel
Meirelles, Maria de Nazareth
Pereira, Mirian Claudia S.
author2_role author
author
author
dc.contributor.author.fl_str_mv Melo, Tatiana G.
Adesse, Daniel
Meirelles, Maria de Nazareth
Pereira, Mirian Claudia S.
dc.subject.other.pt_BR.fl_str_mv Trypanosoma cruzi
Cardiomiócito
Adesão focal
Talina
topic Trypanosoma cruzi
Cardiomiócito
Adesão focal
Talina
Trypanosoma cruzi
Cardiomyocyte
Focal adhesion
Talin
Paxilin
Mechanotransduction
Mecanotransdução
Talina
dc.subject.en.pt_BR.fl_str_mv Trypanosoma cruzi
Cardiomyocyte
Focal adhesion
Talin
Paxilin
Mechanotransduction
dc.subject.decs.pt_BR.fl_str_mv Mecanotransdução
Talina
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Ultraestrutura Celular. Rio de Janeiro, RJ, Brasil.
publishDate 2019
dc.date.accessioned.fl_str_mv 2019-11-28T14:38:13Z
dc.date.available.fl_str_mv 2019-11-28T14:38:13Z
dc.date.issued.fl_str_mv 2019
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv MELO, Tatiana G. et al. Trypanosoma cruzi down-regulates mechanosensitive proteins in cardiomyocytes. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 114, p. 1-9, 2019.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/37459
dc.identifier.issn.pt_BR.fl_str_mv 0074-0276
dc.identifier.doi.none.fl_str_mv 10.1590/0074-02760180593
dc.identifier.eissn.none.fl_str_mv 1678-8060
identifier_str_mv MELO, Tatiana G. et al. Trypanosoma cruzi down-regulates mechanosensitive proteins in cardiomyocytes. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 114, p. 1-9, 2019.
0074-0276
10.1590/0074-02760180593
1678-8060
url https://www.arca.fiocruz.br/handle/icict/37459
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto Oswaldo Cruz.
publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto Oswaldo Cruz.
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
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