Trypanosoma cruzi down-regulates mechanosensitive proteins in cardiomyocytes
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/37459 |
Resumo: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Ultraestrutura Celular. Rio de Janeiro, RJ, Brasil. |
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Melo, Tatiana G.Adesse, DanielMeirelles, Maria de NazarethPereira, Mirian Claudia S.2019-11-28T14:38:13Z2019-11-28T14:38:13Z2019MELO, Tatiana G. et al. Trypanosoma cruzi down-regulates mechanosensitive proteins in cardiomyocytes. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 114, p. 1-9, 2019.0074-0276https://www.arca.fiocruz.br/handle/icict/3745910.1590/0074-027601805931678-8060engFundação Oswaldo Cruz. Instituto Oswaldo Cruz.Trypanosoma cruziCardiomiócitoAdesão focalTalinaTrypanosoma cruziCardiomyocyteFocal adhesionTalinPaxilinMechanotransductionMecanotransduçãoTalinaTrypanosoma cruzi down-regulates mechanosensitive proteins in cardiomyocytesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Ultraestrutura Celular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Estrutural. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Ultraestrutura Celular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Ultraestrutura Celular. Rio de Janeiro, RJ, Brasil.Cardiac physiology depends on coupling and electrical and mechanical coordination through the intercalated disc. Focal adhesions offer mechanical support and signal transduction events during heart contraction-relaxation processes. Talin links integrins to the actin cytoskeleton and serves as a scaffold for the recruitment of other proteins, such as paxillin in focal adhesion formation and regulation. Chagasic cardiomyopathy is caused by infection by Trypanosoma cruzi and is a debilitating condition comprising extensive fibrosis, inflammation, cardiac hypertrophy and electrical alterations that culminate in heart failure.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/37459/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALDanielAdesse_MirianCPereira_etal_IOC_2019.pdfDanielAdesse_MirianCPereira_etal_IOC_2019.pdfapplication/pdf12985927https://www.arca.fiocruz.br/bitstream/icict/37459/2/DanielAdesse_MirianCPereira_etal_IOC_2019.pdfa2a1054330d0181da5d8c32fab131abdMD52TEXTDanielAdesse_MirianCPereira_etal_IOC_2019.pdf.txtDanielAdesse_MirianCPereira_etal_IOC_2019.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv |
Trypanosoma cruzi down-regulates mechanosensitive proteins in cardiomyocytes |
title |
Trypanosoma cruzi down-regulates mechanosensitive proteins in cardiomyocytes |
spellingShingle |
Trypanosoma cruzi down-regulates mechanosensitive proteins in cardiomyocytes Melo, Tatiana G. Trypanosoma cruzi Cardiomiócito Adesão focal Talina Trypanosoma cruzi Cardiomyocyte Focal adhesion Talin Paxilin Mechanotransduction Mecanotransdução Talina |
title_short |
Trypanosoma cruzi down-regulates mechanosensitive proteins in cardiomyocytes |
title_full |
Trypanosoma cruzi down-regulates mechanosensitive proteins in cardiomyocytes |
title_fullStr |
Trypanosoma cruzi down-regulates mechanosensitive proteins in cardiomyocytes |
title_full_unstemmed |
Trypanosoma cruzi down-regulates mechanosensitive proteins in cardiomyocytes |
title_sort |
Trypanosoma cruzi down-regulates mechanosensitive proteins in cardiomyocytes |
author |
Melo, Tatiana G. |
author_facet |
Melo, Tatiana G. Adesse, Daniel Meirelles, Maria de Nazareth Pereira, Mirian Claudia S. |
author_role |
author |
author2 |
Adesse, Daniel Meirelles, Maria de Nazareth Pereira, Mirian Claudia S. |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Melo, Tatiana G. Adesse, Daniel Meirelles, Maria de Nazareth Pereira, Mirian Claudia S. |
dc.subject.other.pt_BR.fl_str_mv |
Trypanosoma cruzi Cardiomiócito Adesão focal Talina |
topic |
Trypanosoma cruzi Cardiomiócito Adesão focal Talina Trypanosoma cruzi Cardiomyocyte Focal adhesion Talin Paxilin Mechanotransduction Mecanotransdução Talina |
dc.subject.en.pt_BR.fl_str_mv |
Trypanosoma cruzi Cardiomyocyte Focal adhesion Talin Paxilin Mechanotransduction |
dc.subject.decs.pt_BR.fl_str_mv |
Mecanotransdução Talina |
description |
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Ultraestrutura Celular. Rio de Janeiro, RJ, Brasil. |
publishDate |
2019 |
dc.date.accessioned.fl_str_mv |
2019-11-28T14:38:13Z |
dc.date.available.fl_str_mv |
2019-11-28T14:38:13Z |
dc.date.issued.fl_str_mv |
2019 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
MELO, Tatiana G. et al. Trypanosoma cruzi down-regulates mechanosensitive proteins in cardiomyocytes. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 114, p. 1-9, 2019. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/37459 |
dc.identifier.issn.pt_BR.fl_str_mv |
0074-0276 |
dc.identifier.doi.none.fl_str_mv |
10.1590/0074-02760180593 |
dc.identifier.eissn.none.fl_str_mv |
1678-8060 |
identifier_str_mv |
MELO, Tatiana G. et al. Trypanosoma cruzi down-regulates mechanosensitive proteins in cardiomyocytes. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 114, p. 1-9, 2019. 0074-0276 10.1590/0074-02760180593 1678-8060 |
url |
https://www.arca.fiocruz.br/handle/icict/37459 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. |
publisher.none.fl_str_mv |
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. |
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