Hyperplasia of elastic tissue in hepatic schistosomal fibrosis
Autor(a) principal: | |
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Data de Publicação: | 1991 |
Outros Autores: | |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/5710 |
Resumo: | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil |
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Andrade, Zilton de AraújoFreitas, Luiz Antonio Rodrigues de2012-10-22T19:46:01Z2012-10-22T19:46:01Z1991ANDRADE, Z. A.; FREITAS, L. A. Hyperplasia of elastic tissue in hepatic schistosomal fibrosis. Memórias do Instituto Oswaldo Cruz, v. 86, n. 4, p. 447-56, oct.-dec. 1991.0074-0276https://www.arca.fiocruz.br/handle/icict/5710engHyperplasia of elastic tissue in hepatic schistosomal fibrosisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilElastic tissue hyperplasia, revealed by means of histological, immunocytochemical and ultra-structural methods, appeared as a prominent change in surgical liver biopsies taken from 61 patients with schistosomal periportal and septal fibrosis. Such hyperplasia was absent in experimental murine schistosomiasis, including mice with "pipe-stem" fibrosis. Displaced connective tissue cells in periportal areas, such as smooth muscle cells, more frequently observed in human material, could be the site of excessive elastin synthesis, and could explain the differences observed in human and experimental materials. Elastic tissue, sometimes represented by its microfibrillar components, also appeared to be more condensed in areas of matrix (collagen) degradation, suggesting a participation of this tissue in the remodelling of the extracellular matrix. By its rectratile properties elastic tissue hyperplasia in hepatic schistosomiasis can cause vascular narrowing and thus play a role in the pathogenesis of portal hypertension.Elastic tissueElastinSchistosomiasisPeriportal fibrosisLiverTecido Elástico/patologiaCirrose Hepática/patologiaHepatopatias Parasitárias/patologiaEsquistossomose mansoni/patologiaAdolescenteAdultoFemininoHumanosHiperplasia/patologiaFígado/ultraestruturaMasculinoMeia-Idadeinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALAndrade ZA Hyperplasia of elastic tissue ....pdfAndrade ZA Hyperplasia of elastic tissue ....pdfapplication/pdf836289https://www.arca.fiocruz.br/bitstream/icict/5710/1/Andrade%20ZA%20Hyperplasia%20of%20elastic%20tissue%20....pdfb8a763239dd7676ebe033d7a51d75b9fMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-82008https://www.arca.fiocruz.br/bitstream/icict/5710/2/license.txt06db3f0df647fd9ddff657403bbe0ee2MD52TEXTAndrade ZA Hyperplasia of elastic tissue ....pdf.txtAndrade ZA Hyperplasia of elastic tissue ....pdf.txtExtracted texttext/plain10https://www.arca.fiocruz.br/bitstream/icict/5710/5/Andrade%20ZA%20Hyperplasia%20of%20elastic%20tissue%20....pdf.txt2c6eb67c8897d916ae47524b1a844d3fMD55THUMBNAILAndrade ZA Hyperplasia of elastic tissue ....pdf.jpgAndrade ZA Hyperplasia of elastic tissue ....pdf.jpgGenerated Thumbnailimage/jpeg2289https://www.arca.fiocruz.br/bitstream/icict/5710/4/Andrade%20ZA%20Hyperplasia%20of%20elastic%20tissue%20....pdf.jpge568b4d2eaa1fea375989d3fa5a4629dMD54icict/57102023-03-15 14:33:15.137oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:15Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
dc.title.pt_BR.fl_str_mv |
Hyperplasia of elastic tissue in hepatic schistosomal fibrosis |
title |
Hyperplasia of elastic tissue in hepatic schistosomal fibrosis |
spellingShingle |
Hyperplasia of elastic tissue in hepatic schistosomal fibrosis Andrade, Zilton de Araújo Elastic tissue Elastin Schistosomiasis Periportal fibrosis Liver Tecido Elástico/patologia Cirrose Hepática/patologia Hepatopatias Parasitárias/patologia Esquistossomose mansoni/patologia Adolescente Adulto Feminino Humanos Hiperplasia/patologia Fígado/ultraestrutura Masculino Meia-Idade |
title_short |
Hyperplasia of elastic tissue in hepatic schistosomal fibrosis |
title_full |
Hyperplasia of elastic tissue in hepatic schistosomal fibrosis |
title_fullStr |
Hyperplasia of elastic tissue in hepatic schistosomal fibrosis |
title_full_unstemmed |
Hyperplasia of elastic tissue in hepatic schistosomal fibrosis |
title_sort |
Hyperplasia of elastic tissue in hepatic schistosomal fibrosis |
author |
Andrade, Zilton de Araújo |
author_facet |
Andrade, Zilton de Araújo Freitas, Luiz Antonio Rodrigues de |
author_role |
author |
author2 |
Freitas, Luiz Antonio Rodrigues de |
author2_role |
author |
dc.contributor.author.fl_str_mv |
Andrade, Zilton de Araújo Freitas, Luiz Antonio Rodrigues de |
dc.subject.en.pt_BR.fl_str_mv |
Elastic tissue Elastin Schistosomiasis Periportal fibrosis Liver |
topic |
Elastic tissue Elastin Schistosomiasis Periportal fibrosis Liver Tecido Elástico/patologia Cirrose Hepática/patologia Hepatopatias Parasitárias/patologia Esquistossomose mansoni/patologia Adolescente Adulto Feminino Humanos Hiperplasia/patologia Fígado/ultraestrutura Masculino Meia-Idade |
dc.subject.decs.pt_BR.fl_str_mv |
Tecido Elástico/patologia Cirrose Hepática/patologia Hepatopatias Parasitárias/patologia Esquistossomose mansoni/patologia Adolescente Adulto Feminino Humanos Hiperplasia/patologia Fígado/ultraestrutura Masculino Meia-Idade |
description |
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil |
publishDate |
1991 |
dc.date.issued.fl_str_mv |
1991 |
dc.date.accessioned.fl_str_mv |
2012-10-22T19:46:01Z |
dc.date.available.fl_str_mv |
2012-10-22T19:46:01Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
ANDRADE, Z. A.; FREITAS, L. A. Hyperplasia of elastic tissue in hepatic schistosomal fibrosis. Memórias do Instituto Oswaldo Cruz, v. 86, n. 4, p. 447-56, oct.-dec. 1991. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/5710 |
dc.identifier.issn.none.fl_str_mv |
0074-0276 |
identifier_str_mv |
ANDRADE, Z. A.; FREITAS, L. A. Hyperplasia of elastic tissue in hepatic schistosomal fibrosis. Memórias do Instituto Oswaldo Cruz, v. 86, n. 4, p. 447-56, oct.-dec. 1991. 0074-0276 |
url |
https://www.arca.fiocruz.br/handle/icict/5710 |
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eng |
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eng |
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info:eu-repo/semantics/openAccess |
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openAccess |
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