Hairless mice as an experimental model of infection with Leishmania amazonensis

Detalhes bibliográficos
Autor(a) principal: Araujo, Vanessa Carneiro Pereira
Data de Publicação: 2015
Outros Autores: Fukutani, Kiyoshi Ferreira, Oshiro, Elisa Teruya, Rodrigues, Patrik Oening, Rizk, Yasmin Silva, Carollo, Carlos Alexandre, Arruda, Carla Cardozo Pinto
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/14689
Resumo: Universidade Federal de Mato Grosso do Sul. Laboratório de Parasitologia Humana. Centro de Ciências Biológicas e da Saúde. Campo Grande, MG, Brasil
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spelling Araujo, Vanessa Carneiro PereiraFukutani, Kiyoshi FerreiraOshiro, Elisa TeruyaRodrigues, Patrik OeningRizk, Yasmin SilvaCarollo, Carlos AlexandreArruda, Carla Cardozo Pinto2016-06-29T16:52:20Z2016-07-07T11:39:46Z2016-06-29T16:52:20Z2016-07-07T11:39:46Z2015ARAUJO, V. C. P. et al. Hairless mice as an experimental model of infection with Leishmania amazonensis. Experimental Parasitology, v. 157, p. 138-144, 2015.0014-4894https://www.arca.fiocruz.br/handle/icict/14689engElsevierHairless mice as an experimental model of infection with Leishmania amazonensisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal de Mato Grosso do Sul. Laboratório de Parasitologia Humana. Centro de Ciências Biológicas e da Saúde. Campo Grande, MG, BrasilFundação Gonçalo Moniz, Centro de Pesquisas Gonçalo Moniz. Laborat orio de Imunoparasitologia. Salvador, BA, BrasilUniversidade Federal de Mato Grosso do Sul. Laboratório de Parasitologia Humana. Centro de Ciências Biológicas e da Saúde. Campo Grande, MG, BrasilUniversidade Federal de Mato Grosso do Sul. Laborat ório de Tecnologia Farmacêutica. Centro de Ciências Biológicas e da Saúde. Campo Grande, MG, BrasilUniversidade Federal de Mato Grosso do Sul. Laboratório de Parasitologia Humana. Centro de Ciências Biológicas e da Saúde. Campo Grande, MG, BrasilUniversidade Federal de do Sul. Laboratório de Produtos Naturais e Espectrometria de Massas e LaPNEM. Centro de Ciências Biológicas e da Saúde. Campo Grande, MG, BrasilUniversidade Federal de Mato Grosso do Sul. Laboratório de Parasitologia Humana. Centro de Ciências Biológicas e da Saúde. Campo Grande, MG, BrasilHRS/J Hairless mice have been investigated as an experimental model in cutaneous leishmaniasis induced by Leishmania (Leishmania) amazonensis. The animals were inoculated with 106 promastigotes into the right hind footpad and the course of infection was followed up for 30, 60 and 90 days. BALB/c mice were infected and used as control. Hairless mice were susceptible to L. (L.) amazonensis infection and a progressive increase in number of parasites and footpad thickness was detected over time. Signals of dissemination and visceralization were confirmed by the presence of parasite in the draining lymph node of lesion and spleen, at different times post infection. IL-10 gene expression evaluated by RT-PCR was significantly higher in Hairless mice at 60 days post infection, corroborating the pattern of susceptibility. These results point this inbred strain as a promising susceptible model for the study of experimental infection induced by L. (L.) amazonensis. This model would allow the use of other infectionCutaneous leishmaniasisExperimental infectionHRS/J mouseinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZTEXTAraujo VCP Hairless mice as an....pdf.txtAraujo VCP Hairless mice as an....pdf.txtExtracted texttext/plain40116https://www.arca.fiocruz.br/bitstream/icict/14689/4/Araujo%20VCP%20Hairless%20mice%20as%20an....pdf.txt8dd1701db3717ea86b09044018100c60MD54ORIGINALAraujo VCP Hairless mice as an....pdfapplication/pdf1756100https://www.arca.fiocruz.br/bitstream/icict/14689/2/Araujo%20VCP%20Hairless%20mice%20as%20an....pdf5278f0058e7b1523c51580a101b00ffbMD52LICENSElicense.txttext/plain2991https://www.arca.fiocruz.br/bitstream/icict/14689/3/license.txt5a560609d32a3863062d77ff32785d58MD53icict/146892023-03-15 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dc.title.pt_BR.fl_str_mv Hairless mice as an experimental model of infection with Leishmania amazonensis
title Hairless mice as an experimental model of infection with Leishmania amazonensis
spellingShingle Hairless mice as an experimental model of infection with Leishmania amazonensis
Araujo, Vanessa Carneiro Pereira
Cutaneous leishmaniasis
Experimental infection
HRS/J mouse
title_short Hairless mice as an experimental model of infection with Leishmania amazonensis
title_full Hairless mice as an experimental model of infection with Leishmania amazonensis
title_fullStr Hairless mice as an experimental model of infection with Leishmania amazonensis
title_full_unstemmed Hairless mice as an experimental model of infection with Leishmania amazonensis
title_sort Hairless mice as an experimental model of infection with Leishmania amazonensis
author Araujo, Vanessa Carneiro Pereira
author_facet Araujo, Vanessa Carneiro Pereira
Fukutani, Kiyoshi Ferreira
Oshiro, Elisa Teruya
Rodrigues, Patrik Oening
Rizk, Yasmin Silva
Carollo, Carlos Alexandre
Arruda, Carla Cardozo Pinto
author_role author
author2 Fukutani, Kiyoshi Ferreira
Oshiro, Elisa Teruya
Rodrigues, Patrik Oening
Rizk, Yasmin Silva
Carollo, Carlos Alexandre
Arruda, Carla Cardozo Pinto
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Araujo, Vanessa Carneiro Pereira
Fukutani, Kiyoshi Ferreira
Oshiro, Elisa Teruya
Rodrigues, Patrik Oening
Rizk, Yasmin Silva
Carollo, Carlos Alexandre
Arruda, Carla Cardozo Pinto
dc.subject.en.pt_BR.fl_str_mv Cutaneous leishmaniasis
Experimental infection
HRS/J mouse
topic Cutaneous leishmaniasis
Experimental infection
HRS/J mouse
description Universidade Federal de Mato Grosso do Sul. Laboratório de Parasitologia Humana. Centro de Ciências Biológicas e da Saúde. Campo Grande, MG, Brasil
publishDate 2015
dc.date.issued.fl_str_mv 2015
dc.date.accessioned.fl_str_mv 2016-06-29T16:52:20Z
2016-07-07T11:39:46Z
dc.date.available.fl_str_mv 2016-06-29T16:52:20Z
2016-07-07T11:39:46Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv ARAUJO, V. C. P. et al. Hairless mice as an experimental model of infection with Leishmania amazonensis. Experimental Parasitology, v. 157, p. 138-144, 2015.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/14689
dc.identifier.issn.pt_BR.fl_str_mv 0014-4894
identifier_str_mv ARAUJO, V. C. P. et al. Hairless mice as an experimental model of infection with Leishmania amazonensis. Experimental Parasitology, v. 157, p. 138-144, 2015.
0014-4894
url https://www.arca.fiocruz.br/handle/icict/14689
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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