Extracellular matrix alterations in experimental Leishmania amazonensis infection in susceptible and resistant mice

Detalhes bibliográficos
Autor(a) principal: Almeida, Mariana Silva
Data de Publicação: 2012
Outros Autores: Carvalho, Luiz O. P., Silva, Ana L. Abreu, Souza, Celeste S. F., Hardoim, Daiana J., Calabrese, Kátia S.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/18336
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunomodulação e Protozoologia. Rio de Janeiro, RJ, Brasil.
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spelling Almeida, Mariana SilvaCarvalho, Luiz O. P.Silva, Ana L. AbreuSouza, Celeste S. F.Hardoim, Daiana J.Calabrese, Kátia S.2017-04-09T17:53:02Z2017-04-09T17:53:02Z2012ALMEIDA, Mariana Silva; et al. Extracellular matrix alterations in experimental Leishmania amazonensis infection in susceptible and resistant mice. Veterinary Research, v.43, n.10, 9p, 2012.0928-4249https://www.arca.fiocruz.br/handle/icict/1833610.1186/1297-9716-43-101297-9716engBioMed CentralLeishmanioseLaminina Fibronectinas Alterações da matriz extracelularInfecçãoLeishmania amazonensisfibronectinlamininoxytalan fibresExtracellular matrix alterationsinfectionExtracellular matrix alterations in experimental Leishmania amazonensis infection in susceptible and resistant miceinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunomodulação e Protozoologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunomodulação e Protozoologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunomodulação e Protozoologia. Rio de Janeiro, RJ, Brasil / Universidade Estadual do Maranhão. Departamento de Patologia. São Luis, MA, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunomodulação e Protozoologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunomodulação e Protozoologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunomodulação e Protozoologia. Rio de Janeiro, RJ, Brasil.Leishmania is inoculated, by the bite of an infected sandfly, into the skin of the host, where the promastigotes are phagocyted by dermal macrophages. The dermal region comprises cells and abundant extracellular matrix. Studies show that matrix metalloproteinases play an important role in host defense responses against pathogens in mammals and that their activities lead to the production of antimicrobial peptides. The aim of this study is to evaluate the changes in the distribution of fibronectin and laminin as well as in the elastic system fibres during the course of infection caused by Leishmania amazonensis in mice with distinct genetic backgrounds of susceptibility to this parasite. The results showed that BALB/c presented an enhancement of fibronectin during the course of infection when compared to their control group while the infected or non-infected C3H.He showed a decrease of this protein at end of the experiment. Laminin, on the other hand, remained unaltered in both strains. Also in both BALB/c and C3H.He mice the elastic and elaunin fibres remained unchanged while the oxytalan fibres decreased along the experiment. Ninety days after the infection C3H.He mice had recovered their capacity to produce oxytalan fibres.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/18336/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALceleste_souza_etal_IOC_2012.pdfceleste_souza_etal_IOC_2012.pdfapplication/pdf4071688https://www.arca.fiocruz.br/bitstream/icict/18336/2/celeste_souza_etal_IOC_2012.pdfbe9a7b5c819ca7994ef54d3f4bad9150MD52TEXTceleste_souza_etal_IOC_2012.pdf.txtceleste_souza_etal_IOC_2012.pdf.txtExtracted texttext/plain31832https://www.arca.fiocruz.br/bitstream/icict/18336/3/celeste_souza_etal_IOC_2012.pdf.txt2be108916192b466b30f23885d0bf9a3MD53icict/183362018-08-15 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dc.title.pt_BR.fl_str_mv Extracellular matrix alterations in experimental Leishmania amazonensis infection in susceptible and resistant mice
title Extracellular matrix alterations in experimental Leishmania amazonensis infection in susceptible and resistant mice
spellingShingle Extracellular matrix alterations in experimental Leishmania amazonensis infection in susceptible and resistant mice
Almeida, Mariana Silva
Leishmaniose
Laminina 
Fibronectinas 
Alterações da matriz extracelular
Infecção
Leishmania amazonensis
fibronectin
laminin
oxytalan fibres
Extracellular matrix alterations
infection
title_short Extracellular matrix alterations in experimental Leishmania amazonensis infection in susceptible and resistant mice
title_full Extracellular matrix alterations in experimental Leishmania amazonensis infection in susceptible and resistant mice
title_fullStr Extracellular matrix alterations in experimental Leishmania amazonensis infection in susceptible and resistant mice
title_full_unstemmed Extracellular matrix alterations in experimental Leishmania amazonensis infection in susceptible and resistant mice
title_sort Extracellular matrix alterations in experimental Leishmania amazonensis infection in susceptible and resistant mice
author Almeida, Mariana Silva
author_facet Almeida, Mariana Silva
Carvalho, Luiz O. P.
Silva, Ana L. Abreu
Souza, Celeste S. F.
Hardoim, Daiana J.
Calabrese, Kátia S.
author_role author
author2 Carvalho, Luiz O. P.
Silva, Ana L. Abreu
Souza, Celeste S. F.
Hardoim, Daiana J.
Calabrese, Kátia S.
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Almeida, Mariana Silva
Carvalho, Luiz O. P.
Silva, Ana L. Abreu
Souza, Celeste S. F.
Hardoim, Daiana J.
Calabrese, Kátia S.
dc.subject.other.pt_BR.fl_str_mv Leishmaniose
Laminina 
Fibronectinas 
Alterações da matriz extracelular
Infecção
topic Leishmaniose
Laminina 
Fibronectinas 
Alterações da matriz extracelular
Infecção
Leishmania amazonensis
fibronectin
laminin
oxytalan fibres
Extracellular matrix alterations
infection
dc.subject.en.pt_BR.fl_str_mv Leishmania amazonensis
fibronectin
laminin
oxytalan fibres
Extracellular matrix alterations
infection
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunomodulação e Protozoologia. Rio de Janeiro, RJ, Brasil.
publishDate 2012
dc.date.issued.fl_str_mv 2012
dc.date.accessioned.fl_str_mv 2017-04-09T17:53:02Z
dc.date.available.fl_str_mv 2017-04-09T17:53:02Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv ALMEIDA, Mariana Silva; et al. Extracellular matrix alterations in experimental Leishmania amazonensis infection in susceptible and resistant mice. Veterinary Research, v.43, n.10, 9p, 2012.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/18336
dc.identifier.issn.pt_BR.fl_str_mv 0928-4249
dc.identifier.doi.none.fl_str_mv 10.1186/1297-9716-43-10
dc.identifier.eissn.none.fl_str_mv 1297-9716
identifier_str_mv ALMEIDA, Mariana Silva; et al. Extracellular matrix alterations in experimental Leishmania amazonensis infection in susceptible and resistant mice. Veterinary Research, v.43, n.10, 9p, 2012.
0928-4249
10.1186/1297-9716-43-10
1297-9716
url https://www.arca.fiocruz.br/handle/icict/18336
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv BioMed Central
publisher.none.fl_str_mv BioMed Central
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/18336/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/18336/2/celeste_souza_etal_IOC_2012.pdf
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