Effect of partially purified fumonisins on cellular immune response in experimental murine paracoccidioidomycosis

Detalhes bibliográficos
Autor(a) principal: Sasaki, A. A.
Data de Publicação: 2013
Outros Autores: Hirooka, E. Y., Ono, E. Y. S., Kaminami, M. S., Pinge-Filho, Phileno, Khan, S. A., Kawamura, O., Ribeiro, A. B., Fujii, S., Itano, E. N.
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/15916
Resumo: CAPES, CNPq, Fundação Araucária, FAEP/UEL
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spelling Sasaki, A. A.Hirooka, E. Y.Ono, E. Y. S.Kaminami, M. S.Pinge-Filho, PhilenoKhan, S. A.Kawamura, O.Ribeiro, A. B.Fujii, S.Itano, E. N.2016-09-22T16:29:23Z2016-09-22T16:29:23Z2013SASAKI, A. A. et al. Effect of partially purified fumonisins on cellular immune response in experimental murine paracoccidioidomycosis. Afr. J. Biotechnol, v.12, n. 42, p. 6126-6132, 2013.1684-5315https://www.arca.fiocruz.br/handle/icict/15916CAPES, CNPq, Fundação Araucária, FAEP/UELUniversidade Estadual de Londrina. Departamento de Ciência Patológica. Londrina, PR, Brasil.Universidade Estadual de Londrina. Departamento de Ciência e Tecnologia de Alimentos. Londrina, PR, Brasil.Universidade Estadual de Londrina. Departamento de Bioquímica e Biotecnologia. Londrina, PR, Brasil.Universidade Estadual de Londrina. Departamento de Ciência Patológica. Londrina, PR, Brasil.Universidade Estadual de Londrina. Departamento de Ciência Patológica. Londrina, PR, Brasil. / Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brasil.Kagawa University. Department of Biochemistry and Food Science. Kagawa, Japan.Universidade Estadual de Londrina. Departamento de Ciência e Tecnologia de Alimentos. Londrina, PR, Brasil.Universidade Estadual de Londrina. Departamento de Ciência e Tecnologia de Alimentos. Londrina, PR, Brasil.Universidade Estadual de Londrina. Departamento de Ciência Patológica. Londrina, PR, Brasil.Universidade Estadual de Londrina. Departamento de Ciência Patológica. Londrina, PR, Brasil.Fumonisins are mycotoxins produced mainly by Fusarium verticillioides, which can modulate the immune response. Paracoccidioidomycosis (PCM), caused by the fungus Paracoccodioides brasiliensis (Pb), is one of the most important systemic mycoses in Latin America. The aim of this study was to evaluate the effect of the partially purified fumonisins on cellular immune response in mice infected with Pb. Four groups of male BALB/c mice were used. Groups PB and PB/FB were inoculated i.v. with 1 × 105 Pb yeast cells and, after 28 days, groups FB and PB/FB were inoculated (s.c.) with partially purified fumonisin B1 from F. verticillioides (5 × 2.25 mg FB1/kg body weight). After 7 days, cellular immune response was evaluated by delayed-type hypersensitivity (DTH) and lymphoproliferative assays (LA) using spleen cells. Nitric oxide (NO) production by spleen cells was also evaluated. The specific LA response to Pb antigen was higher in group PB than in FB and CTR groups (p< 0.05) but not significant with PB/FB. The DTH response was higher in infected than non infected groups (p<0.05) but also no significantly with PB and PB/FB groups. The lyphoproliferative response to ConA was decreased in FB or PB/FB in relation to CTR (p<0.05) but not with PB/FB and also a reduction of NO levels was observed in fumonisin treated in relation to control group FB1/kg (p<0.05). In conclusion, fumonisin B1 or other components of F. verticillioides extracts significantly suppress the unspecific cellular immune response and the NO production by splenocytes from P. brasiliensis infected or not infected BALB/c mice.porGeorge Nkem UdeEffect of partially purified fumonisins on cellular immune response in experimental murine paracoccidioidomycosisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFumonisinsParacoccodioides brasiliensislymphoproliferative assaynitric oxideImmunityParacoccidioidomycosisFumonisinasImunidade CelularParacoccidioidomicoseinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83074https://www.arca.fiocruz.br/bitstream/icict/15916/1/license.txt0271fb68963c017aa933c7aff60379f4MD51ORIGINALEffect of partially purified fumonisins.pdfEffect of partially purified fumonisins.pdfapplication/pdf311853https://www.arca.fiocruz.br/bitstream/icict/15916/2/Effect%20of%20partially%20purified%20fumonisins.pdf41cef9a214dda9ada664bf8000138f9dMD52TEXTEffect of partially purified fumonisins.pdf.txtEffect of partially purified fumonisins.pdf.txtExtracted texttext/plain30220https://www.arca.fiocruz.br/bitstream/icict/15916/3/Effect%20of%20partially%20purified%20fumonisins.pdf.txt9ba5bbbb405a207ac451de80f71c4e07MD53icict/159162018-04-04 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dc.title.pt_BR.fl_str_mv Effect of partially purified fumonisins on cellular immune response in experimental murine paracoccidioidomycosis
title Effect of partially purified fumonisins on cellular immune response in experimental murine paracoccidioidomycosis
spellingShingle Effect of partially purified fumonisins on cellular immune response in experimental murine paracoccidioidomycosis
Sasaki, A. A.
Fumonisins
Paracoccodioides brasiliensis
lymphoproliferative assay
nitric oxide
Immunity
Paracoccidioidomycosis
Fumonisinas
Imunidade Celular
Paracoccidioidomicose
title_short Effect of partially purified fumonisins on cellular immune response in experimental murine paracoccidioidomycosis
title_full Effect of partially purified fumonisins on cellular immune response in experimental murine paracoccidioidomycosis
title_fullStr Effect of partially purified fumonisins on cellular immune response in experimental murine paracoccidioidomycosis
title_full_unstemmed Effect of partially purified fumonisins on cellular immune response in experimental murine paracoccidioidomycosis
title_sort Effect of partially purified fumonisins on cellular immune response in experimental murine paracoccidioidomycosis
author Sasaki, A. A.
author_facet Sasaki, A. A.
Hirooka, E. Y.
Ono, E. Y. S.
Kaminami, M. S.
Pinge-Filho, Phileno
Khan, S. A.
Kawamura, O.
Ribeiro, A. B.
Fujii, S.
Itano, E. N.
author_role author
author2 Hirooka, E. Y.
Ono, E. Y. S.
Kaminami, M. S.
Pinge-Filho, Phileno
Khan, S. A.
Kawamura, O.
Ribeiro, A. B.
Fujii, S.
Itano, E. N.
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Sasaki, A. A.
Hirooka, E. Y.
Ono, E. Y. S.
Kaminami, M. S.
Pinge-Filho, Phileno
Khan, S. A.
Kawamura, O.
Ribeiro, A. B.
Fujii, S.
Itano, E. N.
dc.subject.en.pt_BR.fl_str_mv Fumonisins
Paracoccodioides brasiliensis
lymphoproliferative assay
nitric oxide
topic Fumonisins
Paracoccodioides brasiliensis
lymphoproliferative assay
nitric oxide
Immunity
Paracoccidioidomycosis
Fumonisinas
Imunidade Celular
Paracoccidioidomicose
dc.subject.en.En.fl_str_mv Immunity
Paracoccidioidomycosis
dc.subject.decs.pt_BR.fl_str_mv Fumonisinas
Imunidade Celular
Paracoccidioidomicose
description CAPES, CNPq, Fundação Araucária, FAEP/UEL
publishDate 2013
dc.date.issued.fl_str_mv 2013
dc.date.accessioned.fl_str_mv 2016-09-22T16:29:23Z
dc.date.available.fl_str_mv 2016-09-22T16:29:23Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SASAKI, A. A. et al. Effect of partially purified fumonisins on cellular immune response in experimental murine paracoccidioidomycosis. Afr. J. Biotechnol, v.12, n. 42, p. 6126-6132, 2013.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/15916
dc.identifier.issn.pt_BR.fl_str_mv 1684-5315
identifier_str_mv SASAKI, A. A. et al. Effect of partially purified fumonisins on cellular immune response in experimental murine paracoccidioidomycosis. Afr. J. Biotechnol, v.12, n. 42, p. 6126-6132, 2013.
1684-5315
url https://www.arca.fiocruz.br/handle/icict/15916
dc.language.iso.fl_str_mv por
language por
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv George Nkem Ude
publisher.none.fl_str_mv George Nkem Ude
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/15916/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/15916/2/Effect%20of%20partially%20purified%20fumonisins.pdf
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