Experimental model of chronic osteomyelitis caused by Leishmania (L) amazonensis.

Detalhes bibliográficos
Autor(a) principal: Costa, Af Ali Uthant Moreira Lima da
Data de Publicação: 2006
Outros Autores: Abreu, Ana Lucia, Gomes, Claudia Maria de Castro, Saldanha, Ana Cristina Rodrigues, Barral, Aldina Maria Prado, Costa, Jackson Mauricio Lopes, Corbett, Carlos Eduardo Pereira
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/9212
Resumo: Federal University of Maranhão. Nucleus of Tropical Pathology and Social Medicine. São Luís, MA, Brasil / University of São Paulo. Faculty of Medicine. Laboratory of Pathology of Infectious Diseases. Department of Pathology. São Paulo, SP, Brasil
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spelling Costa, Af Ali Uthant Moreira Lima daAbreu, Ana LuciaGomes, Claudia Maria de CastroSaldanha, Ana Cristina RodriguesBarral, Aldina Maria PradoCosta, Jackson Mauricio LopesCorbett, Carlos Eduardo Pereira2014-12-18T11:59:57Z2014-12-18T11:59:57Z2006COSTA, Af Ali U. M. et al. Experimental model of chronic osteomyelitis caused by Leishmania (L) amazonensis. Acta Tropica, v. 98, n. 2, p. 125-129, 2006.0001-706Xhttps://www.arca.fiocruz.br/handle/icict/9212engElsevierExperimental model of chronic osteomyelitis caused by Leishmania (L) amazonensis.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFederal University of Maranhão. Nucleus of Tropical Pathology and Social Medicine. São Luís, MA, Brasil / University of São Paulo. Faculty of Medicine. Laboratory of Pathology of Infectious Diseases. Department of Pathology. São Paulo, SP, BrasilState University of Maranhão. Faculty of Veterinary Medicine. Laboratory of Histology. São Luís, MA, BrasilUniversity of São Paulo. Faculty of Medicine. Laboratory of Pathology of Infectious Diseases. Department of Pathology. São Paulo, SP, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFederal University of Maranhão. Nucleus of Tropical Pathology and Social Medicine. São Luís, MA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilUniversity of São Paulo. Faculty of Medicine. Laboratory of Pathology of Infectious Diseases. Department of Pathology. São Paulo, SP, BrasilExperimental animal models have been used for the study of the physiopathogenesis of leishmaniasis, on some occasions with success, while in other situations such as bone alterations that accompany tegumentary leishmaniasis, especially in diffuse cutaneous form (DCL), the mechanisms are still unknown. In the present study, we determined these alterations in an animal model susceptible to Leishmania (L) amazonensis. Amastigotes of L. (L) amazonensis isolated from patients with diffuse cutaneous leishmaniasis (DCL) were inoculated into the hind paws of eight BALB/c mice, macroscopic and histopathological aspects were analyzed. After 90 and 120 days of evolution, histopathological analysis demonstrated a mononuclear cell infiltrate rich in plasma cells and intense parasitism of intra- and extra-medullary macrophages, with areas of bone necrosis and discrete involvement of cartilaginous tissue. The results show that the inflammatory process developed during L. (L) amazonensis infection might cause bone tissue destruction and secondarily affect the jointsOsteomyelitisPathologyDiffuse cutaneous leishmaniasisExperimental modelLeishmania/crescimento & desenvolvimentoLeishmaniose Tegumentar Difusa/patologiaOsteomielite/parasitologiaAnimaisModelos Animais de DoençasMembro Posterior/parasitologiaMembro Posterior/patologiaHistocitoquímicaHumanosLeishmaniose Tegumentar Difusa/imunologiaLeishmaniose Tegumentar Difusa/parasitologiaMacrófagos/imunologiaMacrófagos/parasitologiaMacrófagos/patologiaMasculinoCamundongosCamundongos Endogâmicos BALB COsteomielite/imunologiaOsteomielite/patologiainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/9212/1/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD51ORIGINALCosta AAUM Experimental model of chronic......pdfCosta AAUM Experimental model of chronic......pdfapplication/pdf462119https://www.arca.fiocruz.br/bitstream/icict/9212/2/Costa%20AAUM%20%20Experimental%20model%20of%20chronic......pdfb7c7bad86b32a1ed6caf914ff718b242MD52TEXTCosta AAUM Experimental model of chronic......pdf.txtCosta AAUM Experimental model of chronic......pdf.txtExtracted texttext/plain18103https://www.arca.fiocruz.br/bitstream/icict/9212/3/Costa%20AAUM%20%20Experimental%20model%20of%20chronic......pdf.txt3119ab96fe94589523589d30634d5adcMD53icict/92122023-03-15 14:33:02.951oai:www.arca.fiocruz.br:icict/9212TElDRU7Dh0EgREUgRElTVFJJQlVJw4fDg08gTsODTy1FWENMVVNJVkEKCkFvIGNvbmNvcmRhciBlIGFjZWl0YXIgZXN0YSBsaWNlbsOnYSB2b2PDqiAoYXV0b3Igb3UgZGV0ZW50b3IgZG9zIGRpcmVpdG9zIGF1dG9yYWlzKToKCmEpIERlY2xhcmEgcXVlIGNvbmhlY2UgYSBwb2zDrXRpY2EgZGUgY29weXJpZ2h0IGRhIGVkaXRvcmEgZG8gc2V1IGRvY3VtZW50by4KCmIpIERlY2xhcmEgcXVlIGNvbmhlY2UgZSBhY2VpdGEgYXMgRGlyZXRyaXplcyBwYXJhIG8gUmVwb3NpdMOzcmlvIEluc3RpdHVjaW9uYWwgZGEgRnVuZGHDp8OjbyBPc3dhbGRvIENydXogKEZJT0NSVVopLgoKYykgQ29uY2VkZSDDoCBGSU9DUlVaIG8gZGlyZWl0byBuw6NvLWV4Y2x1c2l2byBkZSBhcnF1aXZhciwgcmVwcm9kdXppciwgY29udmVydGVyIChjb21vIGRlZmluaWRvIGEgc2VndWlyKSwgY29tdW5pY2FyCiAKZS9vdSBkaXN0cmlidWlyIG5vIFJlcG9zaXTDs3JpbyBkYSBGSU9DUlVaLCBvIGRvY3VtZW50byBlbnRyZWd1ZSAoaW5jbHVpbmRvIG8gcmVzdW1vL2Fic3RyYWN0KSBlbSBmb3JtYXRvIGRpZ2l0YWwgb3UgCgpwb3IgcXVhbHF1ZXIgb3V0cm8gbWVpby4KCmQpIERlY2xhcmEgcXVlIGF1dG9yaXphIGEgRklPQ1JVWiBhIGFycXVpdmFyIG1haXMgZGUgdW1hIGPDs3BpYSBkZXN0ZSBkb2N1bWVudG8gZSBjb252ZXJ0w6otbG8sIHNlbSBhbHRlcmFyIG8gc2V1IGNvbnRlw7pkbywgCgpwYXJhIHF1YWxxdWVyIGZvcm1hdG8gZGUgYXJxdWl2bywgbWVpbyBvdSBzdXBvcnRlLCBwYXJhIGVmZWl0b3MgZGUgc2VndXJhbsOnYSwgcHJlc2VydmHDp8OjbyAoYmFja3VwKSBlIGFjZXNzby4KCmUpIERlY2xhcmEgcXVlIG8gZG9jdW1lbnRvIHN1Ym1ldGlkbyDDqSBvIHNldSB0cmFiYWxobyBvcmlnaW5hbCwgZSBxdWUgZGV0w6ltIG8gZGlyZWl0byBkZSBjb25jZWRlciBhIHRlcmNlaXJvcyBvcyBkaXJlaXRvcyAKCmNvbnRpZG9zIG5lc3RhIGxpY2Vuw6dhLiBEZWNsYXJhIHRhbWLDqW0gcXVlIGEgZW50cmVnYSBkbyBkb2N1bWVudG8gbsOjbyBpbmZyaW5nZSBvcyBkaXJlaXRvcyBkZSBxdWFscXVlciBvdXRyYSBwZXNzb2Egb3UgZW50aWRhZGUuCgpmKSBEZWNsYXJhIHF1ZSwgbm8gY2FzbyBkbyBkb2N1bWVudG8gc3VibWV0aWRvIGNvbnRlciBtYXRlcmlhbCBkbyBxdWFsIG7Do28gZGV0w6ltIG9zIGRpcmVpdG9zIGRlIGF1dG9yLCBvYnRldmUgYSBhdXRvcml6YcOnw6NvIAoKaXJyZXN0cml0YSBkbyByZXNwZWN0aXZvIGRldGVudG9yIGRlc3NlcyBkaXJlaXRvcywgcGFyYSBjZWRlciBhIEZJT0NSVVogb3MgZGlyZWl0b3MgcmVxdWVyaWRvcyBwb3IgZXN0YSBMaWNlbsOnYSBlIGF1dG9yaXphciBhIAoKdXRpbGl6w6EtbG9zIGxlZ2FsbWVudGUuIERlY2xhcmEgdGFtYsOpbSBxdWUgZXNzZSBtYXRlcmlhbCBjdWpvcyBkaXJlaXRvcyBzw6NvIGRlIHRlcmNlaXJvcyBlc3TDoSBjbGFyYW1lbnRlIGlkZW50aWZpY2FkbyBlIHJlY29uaGVjaWRvIAoKbm8gdGV4dG8gb3UgY29udGXDumRvIGRvIGRvY3VtZW50byBlbnRyZWd1ZS4KCmcpIFNFIE8gRE9DVU1FTlRPIEVOVFJFR1VFIMOJIEJBU0VBRE8gRU0gVFJBQkFMSE8gRklOQU5DSUFETyBPVSBBUE9JQURPIFBPUiBPVVRSQSBJTlNUSVRVScOHw4NPIFFVRSBOw4NPIEEgRklPQ1JVWiwgREVDTEFSQSBRVUUgQ1VNUFJJVSAKClFVQUlTUVVFUiBPQlJJR0HDh8OVRVMgRVhJR0lEQVMgUEVMTyBSRVNQRUNUSVZPIENPTlRSQVRPIE9VIEFDT1JETy4gQSBGSU9DUlVaIGlkZW50aWZpY2Fyw6EgY2xhcmFtZW50ZSBvKHMpIG5vbWUocykgZG8ocykgYXV0b3IoZXMpIGRvcyAKCmRpcmVpdG9zIGRvIGRvY3VtZW50byBlbnRyZWd1ZSBlIG7Do28gZmFyw6EgcXVhbHF1ZXIgYWx0ZXJhw6fDo28sIHBhcmEgYWzDqW0gZG8gcHJldmlzdG8gbmEgYWzDrW5lYSBjKS4KRepositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:02Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Experimental model of chronic osteomyelitis caused by Leishmania (L) amazonensis.
title Experimental model of chronic osteomyelitis caused by Leishmania (L) amazonensis.
spellingShingle Experimental model of chronic osteomyelitis caused by Leishmania (L) amazonensis.
Costa, Af Ali Uthant Moreira Lima da
Osteomyelitis
Pathology
Diffuse cutaneous leishmaniasis
Experimental model
Leishmania/crescimento & desenvolvimento
Leishmaniose Tegumentar Difusa/patologia
Osteomielite/parasitologia
Animais
Modelos Animais de Doenças
Membro Posterior/parasitologia
Membro Posterior/patologia
Histocitoquímica
Humanos
Leishmaniose Tegumentar Difusa/imunologia
Leishmaniose Tegumentar Difusa/parasitologia
Macrófagos/imunologia
Macrófagos/parasitologia
Macrófagos/patologia
Masculino
Camundongos
Camundongos Endogâmicos BALB C
Osteomielite/imunologia
Osteomielite/patologia
title_short Experimental model of chronic osteomyelitis caused by Leishmania (L) amazonensis.
title_full Experimental model of chronic osteomyelitis caused by Leishmania (L) amazonensis.
title_fullStr Experimental model of chronic osteomyelitis caused by Leishmania (L) amazonensis.
title_full_unstemmed Experimental model of chronic osteomyelitis caused by Leishmania (L) amazonensis.
title_sort Experimental model of chronic osteomyelitis caused by Leishmania (L) amazonensis.
author Costa, Af Ali Uthant Moreira Lima da
author_facet Costa, Af Ali Uthant Moreira Lima da
Abreu, Ana Lucia
Gomes, Claudia Maria de Castro
Saldanha, Ana Cristina Rodrigues
Barral, Aldina Maria Prado
Costa, Jackson Mauricio Lopes
Corbett, Carlos Eduardo Pereira
author_role author
author2 Abreu, Ana Lucia
Gomes, Claudia Maria de Castro
Saldanha, Ana Cristina Rodrigues
Barral, Aldina Maria Prado
Costa, Jackson Mauricio Lopes
Corbett, Carlos Eduardo Pereira
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Costa, Af Ali Uthant Moreira Lima da
Abreu, Ana Lucia
Gomes, Claudia Maria de Castro
Saldanha, Ana Cristina Rodrigues
Barral, Aldina Maria Prado
Costa, Jackson Mauricio Lopes
Corbett, Carlos Eduardo Pereira
dc.subject.en.pt_BR.fl_str_mv Osteomyelitis
Pathology
Diffuse cutaneous leishmaniasis
Experimental model
topic Osteomyelitis
Pathology
Diffuse cutaneous leishmaniasis
Experimental model
Leishmania/crescimento & desenvolvimento
Leishmaniose Tegumentar Difusa/patologia
Osteomielite/parasitologia
Animais
Modelos Animais de Doenças
Membro Posterior/parasitologia
Membro Posterior/patologia
Histocitoquímica
Humanos
Leishmaniose Tegumentar Difusa/imunologia
Leishmaniose Tegumentar Difusa/parasitologia
Macrófagos/imunologia
Macrófagos/parasitologia
Macrófagos/patologia
Masculino
Camundongos
Camundongos Endogâmicos BALB C
Osteomielite/imunologia
Osteomielite/patologia
dc.subject.decs.pt_BR.fl_str_mv Leishmania/crescimento & desenvolvimento
Leishmaniose Tegumentar Difusa/patologia
Osteomielite/parasitologia
Animais
Modelos Animais de Doenças
Membro Posterior/parasitologia
Membro Posterior/patologia
Histocitoquímica
Humanos
Leishmaniose Tegumentar Difusa/imunologia
Leishmaniose Tegumentar Difusa/parasitologia
Macrófagos/imunologia
Macrófagos/parasitologia
Macrófagos/patologia
Masculino
Camundongos
Camundongos Endogâmicos BALB C
Osteomielite/imunologia
Osteomielite/patologia
description Federal University of Maranhão. Nucleus of Tropical Pathology and Social Medicine. São Luís, MA, Brasil / University of São Paulo. Faculty of Medicine. Laboratory of Pathology of Infectious Diseases. Department of Pathology. São Paulo, SP, Brasil
publishDate 2006
dc.date.issued.fl_str_mv 2006
dc.date.accessioned.fl_str_mv 2014-12-18T11:59:57Z
dc.date.available.fl_str_mv 2014-12-18T11:59:57Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv COSTA, Af Ali U. M. et al. Experimental model of chronic osteomyelitis caused by Leishmania (L) amazonensis. Acta Tropica, v. 98, n. 2, p. 125-129, 2006.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/9212
dc.identifier.issn.none.fl_str_mv 0001-706X
identifier_str_mv COSTA, Af Ali U. M. et al. Experimental model of chronic osteomyelitis caused by Leishmania (L) amazonensis. Acta Tropica, v. 98, n. 2, p. 125-129, 2006.
0001-706X
url https://www.arca.fiocruz.br/handle/icict/9212
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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