Experimental model of chronic osteomyelitis caused by Leishmania (L) amazonensis.
Autor(a) principal: | |
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Data de Publicação: | 2006 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/9212 |
Resumo: | Federal University of Maranhão. Nucleus of Tropical Pathology and Social Medicine. São Luís, MA, Brasil / University of São Paulo. Faculty of Medicine. Laboratory of Pathology of Infectious Diseases. Department of Pathology. São Paulo, SP, Brasil |
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Costa, Af Ali Uthant Moreira Lima daAbreu, Ana LuciaGomes, Claudia Maria de CastroSaldanha, Ana Cristina RodriguesBarral, Aldina Maria PradoCosta, Jackson Mauricio LopesCorbett, Carlos Eduardo Pereira2014-12-18T11:59:57Z2014-12-18T11:59:57Z2006COSTA, Af Ali U. M. et al. Experimental model of chronic osteomyelitis caused by Leishmania (L) amazonensis. Acta Tropica, v. 98, n. 2, p. 125-129, 2006.0001-706Xhttps://www.arca.fiocruz.br/handle/icict/9212engElsevierExperimental model of chronic osteomyelitis caused by Leishmania (L) amazonensis.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFederal University of Maranhão. Nucleus of Tropical Pathology and Social Medicine. São Luís, MA, Brasil / University of São Paulo. Faculty of Medicine. Laboratory of Pathology of Infectious Diseases. Department of Pathology. São Paulo, SP, BrasilState University of Maranhão. Faculty of Veterinary Medicine. Laboratory of Histology. São Luís, MA, BrasilUniversity of São Paulo. Faculty of Medicine. Laboratory of Pathology of Infectious Diseases. Department of Pathology. São Paulo, SP, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFederal University of Maranhão. Nucleus of Tropical Pathology and Social Medicine. São Luís, MA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilUniversity of São Paulo. Faculty of Medicine. Laboratory of Pathology of Infectious Diseases. Department of Pathology. São Paulo, SP, BrasilExperimental animal models have been used for the study of the physiopathogenesis of leishmaniasis, on some occasions with success, while in other situations such as bone alterations that accompany tegumentary leishmaniasis, especially in diffuse cutaneous form (DCL), the mechanisms are still unknown. In the present study, we determined these alterations in an animal model susceptible to Leishmania (L) amazonensis. Amastigotes of L. (L) amazonensis isolated from patients with diffuse cutaneous leishmaniasis (DCL) were inoculated into the hind paws of eight BALB/c mice, macroscopic and histopathological aspects were analyzed. After 90 and 120 days of evolution, histopathological analysis demonstrated a mononuclear cell infiltrate rich in plasma cells and intense parasitism of intra- and extra-medullary macrophages, with areas of bone necrosis and discrete involvement of cartilaginous tissue. The results show that the inflammatory process developed during L. (L) amazonensis infection might cause bone tissue destruction and secondarily affect the jointsOsteomyelitisPathologyDiffuse cutaneous leishmaniasisExperimental modelLeishmania/crescimento & desenvolvimentoLeishmaniose Tegumentar Difusa/patologiaOsteomielite/parasitologiaAnimaisModelos Animais de DoençasMembro Posterior/parasitologiaMembro Posterior/patologiaHistocitoquímicaHumanosLeishmaniose Tegumentar Difusa/imunologiaLeishmaniose Tegumentar Difusa/parasitologiaMacrófagos/imunologiaMacrófagos/parasitologiaMacrófagos/patologiaMasculinoCamundongosCamundongos Endogâmicos BALB COsteomielite/imunologiaOsteomielite/patologiainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/9212/1/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD51ORIGINALCosta AAUM Experimental model of chronic......pdfCosta AAUM Experimental model of chronic......pdfapplication/pdf462119https://www.arca.fiocruz.br/bitstream/icict/9212/2/Costa%20AAUM%20%20Experimental%20model%20of%20chronic......pdfb7c7bad86b32a1ed6caf914ff718b242MD52TEXTCosta AAUM Experimental model of chronic......pdf.txtCosta AAUM Experimental model of chronic......pdf.txtExtracted texttext/plain18103https://www.arca.fiocruz.br/bitstream/icict/9212/3/Costa%20AAUM%20%20Experimental%20model%20of%20chronic......pdf.txt3119ab96fe94589523589d30634d5adcMD53icict/92122023-03-15 14:33:02.951oai:www.arca.fiocruz.br:icict/9212TElDRU7Dh0EgREUgRElTVFJJQlVJw4fDg08gTsODTy1FWENMVVNJVkEKCkFvIGNvbmNvcmRhciBlIGFjZWl0YXIgZXN0YSBsaWNlbsOnYSB2b2PDqiAoYXV0b3Igb3UgZGV0ZW50b3IgZG9zIGRpcmVpdG9zIGF1dG9yYWlzKToKCmEpIERlY2xhcmEgcXVlIGNvbmhlY2UgYSBwb2zDrXRpY2EgZGUgY29weXJpZ2h0IGRhIGVkaXRvcmEgZG8gc2V1IGRvY3VtZW50by4KCmIpIERlY2xhcmEgcXVlIGNvbmhlY2UgZSBhY2VpdGEgYXMgRGlyZXRyaXplcyBwYXJhIG8gUmVwb3NpdMOzcmlvIEluc3RpdHVjaW9uYWwgZGEgRnVuZGHDp8OjbyBPc3dhbGRvIENydXogKEZJT0NSVVopLgoKYykgQ29uY2VkZSDDoCBGSU9DUlVaIG8gZGlyZWl0byBuw6NvLWV4Y2x1c2l2byBkZSBhcnF1aXZhciwgcmVwcm9kdXppciwgY29udmVydGVyIChjb21vIGRlZmluaWRvIGEgc2VndWlyKSwgY29tdW5pY2FyCiAKZS9vdSBkaXN0cmlidWlyIG5vIFJlcG9zaXTDs3JpbyBkYSBGSU9DUlVaLCBvIGRvY3VtZW50byBlbnRyZWd1ZSAoaW5jbHVpbmRvIG8gcmVzdW1vL2Fic3RyYWN0KSBlbSBmb3JtYXRvIGRpZ2l0YWwgb3UgCgpwb3IgcXVhbHF1ZXIgb3V0cm8gbWVpby4KCmQpIERlY2xhcmEgcXVlIGF1dG9yaXphIGEgRklPQ1JVWiBhIGFycXVpdmFyIG1haXMgZGUgdW1hIGPDs3BpYSBkZXN0ZSBkb2N1bWVudG8gZSBjb252ZXJ0w6otbG8sIHNlbSBhbHRlcmFyIG8gc2V1IGNvbnRlw7pkbywgCgpwYXJhIHF1YWxxdWVyIGZvcm1hdG8gZGUgYXJxdWl2bywgbWVpbyBvdSBzdXBvcnRlLCBwYXJhIGVmZWl0b3MgZGUgc2VndXJhbsOnYSwgcHJlc2VydmHDp8OjbyAoYmFja3VwKSBlIGFjZXNzby4KCmUpIERlY2xhcmEgcXVlIG8gZG9jdW1lbnRvIHN1Ym1ldGlkbyDDqSBvIHNldSB0cmFiYWxobyBvcmlnaW5hbCwgZSBxdWUgZGV0w6ltIG8gZGlyZWl0byBkZSBjb25jZWRlciBhIHRlcmNlaXJvcyBvcyBkaXJlaXRvcyAKCmNvbnRpZG9zIG5lc3RhIGxpY2Vuw6dhLiBEZWNsYXJhIHRhbWLDqW0gcXVlIGEgZW50cmVnYSBkbyBkb2N1bWVudG8gbsOjbyBpbmZyaW5nZSBvcyBkaXJlaXRvcyBkZSBxdWFscXVlciBvdXRyYSBwZXNzb2Egb3UgZW50aWRhZGUuCgpmKSBEZWNsYXJhIHF1ZSwgbm8gY2FzbyBkbyBkb2N1bWVudG8gc3VibWV0aWRvIGNvbnRlciBtYXRlcmlhbCBkbyBxdWFsIG7Do28gZGV0w6ltIG9zIGRpcmVpdG9zIGRlIGF1dG9yLCBvYnRldmUgYSBhdXRvcml6YcOnw6NvIAoKaXJyZXN0cml0YSBkbyByZXNwZWN0aXZvIGRldGVudG9yIGRlc3NlcyBkaXJlaXRvcywgcGFyYSBjZWRlciBhIEZJT0NSVVogb3MgZGlyZWl0b3MgcmVxdWVyaWRvcyBwb3IgZXN0YSBMaWNlbsOnYSBlIGF1dG9yaXphciBhIAoKdXRpbGl6w6EtbG9zIGxlZ2FsbWVudGUuIERlY2xhcmEgdGFtYsOpbSBxdWUgZXNzZSBtYXRlcmlhbCBjdWpvcyBkaXJlaXRvcyBzw6NvIGRlIHRlcmNlaXJvcyBlc3TDoSBjbGFyYW1lbnRlIGlkZW50aWZpY2FkbyBlIHJlY29uaGVjaWRvIAoKbm8gdGV4dG8gb3UgY29udGXDumRvIGRvIGRvY3VtZW50byBlbnRyZWd1ZS4KCmcpIFNFIE8gRE9DVU1FTlRPIEVOVFJFR1VFIMOJIEJBU0VBRE8gRU0gVFJBQkFMSE8gRklOQU5DSUFETyBPVSBBUE9JQURPIFBPUiBPVVRSQSBJTlNUSVRVScOHw4NPIFFVRSBOw4NPIEEgRklPQ1JVWiwgREVDTEFSQSBRVUUgQ1VNUFJJVSAKClFVQUlTUVVFUiBPQlJJR0HDh8OVRVMgRVhJR0lEQVMgUEVMTyBSRVNQRUNUSVZPIENPTlRSQVRPIE9VIEFDT1JETy4gQSBGSU9DUlVaIGlkZW50aWZpY2Fyw6EgY2xhcmFtZW50ZSBvKHMpIG5vbWUocykgZG8ocykgYXV0b3IoZXMpIGRvcyAKCmRpcmVpdG9zIGRvIGRvY3VtZW50byBlbnRyZWd1ZSBlIG7Do28gZmFyw6EgcXVhbHF1ZXIgYWx0ZXJhw6fDo28sIHBhcmEgYWzDqW0gZG8gcHJldmlzdG8gbmEgYWzDrW5lYSBjKS4KRepositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:02Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
dc.title.pt_BR.fl_str_mv |
Experimental model of chronic osteomyelitis caused by Leishmania (L) amazonensis. |
title |
Experimental model of chronic osteomyelitis caused by Leishmania (L) amazonensis. |
spellingShingle |
Experimental model of chronic osteomyelitis caused by Leishmania (L) amazonensis. Costa, Af Ali Uthant Moreira Lima da Osteomyelitis Pathology Diffuse cutaneous leishmaniasis Experimental model Leishmania/crescimento & desenvolvimento Leishmaniose Tegumentar Difusa/patologia Osteomielite/parasitologia Animais Modelos Animais de Doenças Membro Posterior/parasitologia Membro Posterior/patologia Histocitoquímica Humanos Leishmaniose Tegumentar Difusa/imunologia Leishmaniose Tegumentar Difusa/parasitologia Macrófagos/imunologia Macrófagos/parasitologia Macrófagos/patologia Masculino Camundongos Camundongos Endogâmicos BALB C Osteomielite/imunologia Osteomielite/patologia |
title_short |
Experimental model of chronic osteomyelitis caused by Leishmania (L) amazonensis. |
title_full |
Experimental model of chronic osteomyelitis caused by Leishmania (L) amazonensis. |
title_fullStr |
Experimental model of chronic osteomyelitis caused by Leishmania (L) amazonensis. |
title_full_unstemmed |
Experimental model of chronic osteomyelitis caused by Leishmania (L) amazonensis. |
title_sort |
Experimental model of chronic osteomyelitis caused by Leishmania (L) amazonensis. |
author |
Costa, Af Ali Uthant Moreira Lima da |
author_facet |
Costa, Af Ali Uthant Moreira Lima da Abreu, Ana Lucia Gomes, Claudia Maria de Castro Saldanha, Ana Cristina Rodrigues Barral, Aldina Maria Prado Costa, Jackson Mauricio Lopes Corbett, Carlos Eduardo Pereira |
author_role |
author |
author2 |
Abreu, Ana Lucia Gomes, Claudia Maria de Castro Saldanha, Ana Cristina Rodrigues Barral, Aldina Maria Prado Costa, Jackson Mauricio Lopes Corbett, Carlos Eduardo Pereira |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Costa, Af Ali Uthant Moreira Lima da Abreu, Ana Lucia Gomes, Claudia Maria de Castro Saldanha, Ana Cristina Rodrigues Barral, Aldina Maria Prado Costa, Jackson Mauricio Lopes Corbett, Carlos Eduardo Pereira |
dc.subject.en.pt_BR.fl_str_mv |
Osteomyelitis Pathology Diffuse cutaneous leishmaniasis Experimental model |
topic |
Osteomyelitis Pathology Diffuse cutaneous leishmaniasis Experimental model Leishmania/crescimento & desenvolvimento Leishmaniose Tegumentar Difusa/patologia Osteomielite/parasitologia Animais Modelos Animais de Doenças Membro Posterior/parasitologia Membro Posterior/patologia Histocitoquímica Humanos Leishmaniose Tegumentar Difusa/imunologia Leishmaniose Tegumentar Difusa/parasitologia Macrófagos/imunologia Macrófagos/parasitologia Macrófagos/patologia Masculino Camundongos Camundongos Endogâmicos BALB C Osteomielite/imunologia Osteomielite/patologia |
dc.subject.decs.pt_BR.fl_str_mv |
Leishmania/crescimento & desenvolvimento Leishmaniose Tegumentar Difusa/patologia Osteomielite/parasitologia Animais Modelos Animais de Doenças Membro Posterior/parasitologia Membro Posterior/patologia Histocitoquímica Humanos Leishmaniose Tegumentar Difusa/imunologia Leishmaniose Tegumentar Difusa/parasitologia Macrófagos/imunologia Macrófagos/parasitologia Macrófagos/patologia Masculino Camundongos Camundongos Endogâmicos BALB C Osteomielite/imunologia Osteomielite/patologia |
description |
Federal University of Maranhão. Nucleus of Tropical Pathology and Social Medicine. São Luís, MA, Brasil / University of São Paulo. Faculty of Medicine. Laboratory of Pathology of Infectious Diseases. Department of Pathology. São Paulo, SP, Brasil |
publishDate |
2006 |
dc.date.issued.fl_str_mv |
2006 |
dc.date.accessioned.fl_str_mv |
2014-12-18T11:59:57Z |
dc.date.available.fl_str_mv |
2014-12-18T11:59:57Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
COSTA, Af Ali U. M. et al. Experimental model of chronic osteomyelitis caused by Leishmania (L) amazonensis. Acta Tropica, v. 98, n. 2, p. 125-129, 2006. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/9212 |
dc.identifier.issn.none.fl_str_mv |
0001-706X |
identifier_str_mv |
COSTA, Af Ali U. M. et al. Experimental model of chronic osteomyelitis caused by Leishmania (L) amazonensis. Acta Tropica, v. 98, n. 2, p. 125-129, 2006. 0001-706X |
url |
https://www.arca.fiocruz.br/handle/icict/9212 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
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reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
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Fundação Oswaldo Cruz (FIOCRUZ) |
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FIOCRUZ |
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FIOCRUZ |
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Repositório Institucional da FIOCRUZ (ARCA) |
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Repositório Institucional da FIOCRUZ (ARCA) |
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