Renal injury in DENV-4 fatal cases: viremia, immune response and cytokine profile
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2019 |
| Outros Autores: | , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/40933 |
Resumo: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil. |
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Nunes, Priscila Conrado GuerraRioja, Lilimar da SilveiraCoelho, Janice Mery Chicarino de OliveiraSalomão, Natália GedeãoRabelo, KíssilaJosé, Carollina CeiaRodrigues, Francisco das Chagas de CarvalhoAzeredo, Elzinandes Leal deOliveira, Carlos Alberto Basílio deOliveira, Rodrigo Basílio deNogueira, Rita Maria RibeiroSánchez-Arcila, Juan CamiloSantos, Flávia Barreto dosPaes, Marciano Viana2020-04-23T14:15:40Z2020-04-23T14:15:40Z2019NUNES, Priscila Conrado Guerra et al. Renal injury in DENV-4 fatal cases: viremia, immune response and cytokine profile. Pathogens, v. 8, n. 4, p. 1-11, 7 Nov. 2019.2076-0817https://www.arca.fiocruz.br/handle/icict/4093310.3390/pathogens80402232076-0817engMDPIDengue vírus tipo 4Caso fatalViremiaHistopatologiaCitocinasMediadores inflamatóriosDengue 4Fatal caseViremiaHistopathologyCytokinesInflammatory mediatorsRenal injury in DENV-4 fatal cases: viremia, immune response and cytokine profileinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil.Universidade do Estado do Rio de Janeiro. Centro Biomédico. Faculdade de Ciências Médicas. Departamento de Patologia e Laboratórios. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Anatomia Patológica. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ, Brasil.Universidade do Estado do Rio de Janeiro. Laboratório de Ultraestrutura e Biologia Tecidual. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Anatomia Patológica. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil.Universidade Federal do Estado do Rio de Janeiro. Anatomia Patológica. Rio de Janeiro, RJ, Brasil.Universidade Federal do Estado do Rio de Janeiro. Anatomia Patológica. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ, Brasil.University of California. School of Natural Sciences. CA, USA.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ, Brasil.Dengue virus (DENV) infections may result in asymptomatic cases or evolve into a severe disease, which involves multiple organ failure. Renal involvement in dengue can be potentially related to an increased mortality. Aiming to better understand the role of DENV in renal injury observed in human fatal cases, post-mortem investigations were performed in four DENV-4 renal autopsies during dengue epidemics in Brazil. Tissues were submitted to histopathology, immunohistochemistry, viral quantification, and characterization of cytokines and inflammatory mediators. Probably due the high viral load, several lesions were observed in the renal tissue, such as diffuse mononuclear infiltration around the glomerulus in the cortical region and in the medullary vessels, hyalinosis arteriolar, lymphocytic infiltrate, increased capsular fibrosis, proximal convoluted tubule (PCT) damage, edema, PCT debris formation, and thickening of the basal vessel membrane. These changes were associated with DENV-4 infection, as confirmed by the presence of DENV-specific NS3 protein, indicative of viral replication. The exacerbated presence of mononuclear cells at several renal tissue sites culminated in the secretion of proinflammatory cytokines and chemokines. Moreover, it can be suggested that the renal tissue injury observed here may have been due to the combination of both high viral load and exacerbated host immune response.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/40933/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALPriscilaNunes_FlaviaBarreto_etal_IOC_2019.pdfPriscilaNunes_FlaviaBarreto_etal_IOC_2019.pdfapplication/pdf2049258https://www.arca.fiocruz.br/bitstream/icict/40933/2/PriscilaNunes_FlaviaBarreto_etal_IOC_2019.pdf8d153261e35e09794d45c507bd8288d6MD52TEXTPriscilaNunes_FlaviaBarreto_etal_IOC_2019.pdf.txtPriscilaNunes_FlaviaBarreto_etal_IOC_2019.pdf.txtExtracted 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| dc.title.en.fl_str_mv |
Renal injury in DENV-4 fatal cases: viremia, immune response and cytokine profile |
| title |
Renal injury in DENV-4 fatal cases: viremia, immune response and cytokine profile |
| spellingShingle |
Renal injury in DENV-4 fatal cases: viremia, immune response and cytokine profile Nunes, Priscila Conrado Guerra Dengue vírus tipo 4 Caso fatal Viremia Histopatologia Citocinas Mediadores inflamatórios Dengue 4 Fatal case Viremia Histopathology Cytokines Inflammatory mediators |
| title_short |
Renal injury in DENV-4 fatal cases: viremia, immune response and cytokine profile |
| title_full |
Renal injury in DENV-4 fatal cases: viremia, immune response and cytokine profile |
| title_fullStr |
Renal injury in DENV-4 fatal cases: viremia, immune response and cytokine profile |
| title_full_unstemmed |
Renal injury in DENV-4 fatal cases: viremia, immune response and cytokine profile |
| title_sort |
Renal injury in DENV-4 fatal cases: viremia, immune response and cytokine profile |
| author |
Nunes, Priscila Conrado Guerra |
| author_facet |
Nunes, Priscila Conrado Guerra Rioja, Lilimar da Silveira Coelho, Janice Mery Chicarino de Oliveira Salomão, Natália Gedeão Rabelo, Kíssila José, Carollina Ceia Rodrigues, Francisco das Chagas de Carvalho Azeredo, Elzinandes Leal de Oliveira, Carlos Alberto Basílio de Oliveira, Rodrigo Basílio de Nogueira, Rita Maria Ribeiro Sánchez-Arcila, Juan Camilo Santos, Flávia Barreto dos Paes, Marciano Viana |
| author_role |
author |
| author2 |
Rioja, Lilimar da Silveira Coelho, Janice Mery Chicarino de Oliveira Salomão, Natália Gedeão Rabelo, Kíssila José, Carollina Ceia Rodrigues, Francisco das Chagas de Carvalho Azeredo, Elzinandes Leal de Oliveira, Carlos Alberto Basílio de Oliveira, Rodrigo Basílio de Nogueira, Rita Maria Ribeiro Sánchez-Arcila, Juan Camilo Santos, Flávia Barreto dos Paes, Marciano Viana |
| author2_role |
author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Nunes, Priscila Conrado Guerra Rioja, Lilimar da Silveira Coelho, Janice Mery Chicarino de Oliveira Salomão, Natália Gedeão Rabelo, Kíssila José, Carollina Ceia Rodrigues, Francisco das Chagas de Carvalho Azeredo, Elzinandes Leal de Oliveira, Carlos Alberto Basílio de Oliveira, Rodrigo Basílio de Nogueira, Rita Maria Ribeiro Sánchez-Arcila, Juan Camilo Santos, Flávia Barreto dos Paes, Marciano Viana |
| dc.subject.other.pt_BR.fl_str_mv |
Dengue vírus tipo 4 Caso fatal Viremia Histopatologia Citocinas Mediadores inflamatórios |
| topic |
Dengue vírus tipo 4 Caso fatal Viremia Histopatologia Citocinas Mediadores inflamatórios Dengue 4 Fatal case Viremia Histopathology Cytokines Inflammatory mediators |
| dc.subject.en.pt_BR.fl_str_mv |
Dengue 4 Fatal case Viremia Histopathology Cytokines Inflammatory mediators |
| description |
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil. |
| publishDate |
2019 |
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2019 |
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2020-04-23T14:15:40Z |
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2020-04-23T14:15:40Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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NUNES, Priscila Conrado Guerra et al. Renal injury in DENV-4 fatal cases: viremia, immune response and cytokine profile. Pathogens, v. 8, n. 4, p. 1-11, 7 Nov. 2019. |
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https://www.arca.fiocruz.br/handle/icict/40933 |
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2076-0817 |
| dc.identifier.doi.pt_BR.fl_str_mv |
10.3390/pathogens8040223 |
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2076-0817 |
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NUNES, Priscila Conrado Guerra et al. Renal injury in DENV-4 fatal cases: viremia, immune response and cytokine profile. Pathogens, v. 8, n. 4, p. 1-11, 7 Nov. 2019. 2076-0817 10.3390/pathogens8040223 |
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