A Stillborn Multiple Organs' Investigation from a Maternal DENV-4 Infection: Histopathological and Inflammatory Mediators Characterization

Detalhes bibliográficos
Autor(a) principal: Nunes, Priscila
Data de Publicação: 2019
Outros Autores: Nogueira, Rita, Coelho, Janice, Rodrigues, Francisco, Salomão, Natália, José, Carollina, Carvalho, Jorge de, Rabelo, Kíssila, Azeredo, Elzinandes de, Oliveira, Rodrigo Basílio de, Oliveira, Carlos Basílio de, Santos, Flávia dos, Paes, Marciano
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/32922
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ. Brasil.
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spelling Nunes, PriscilaNogueira, RitaCoelho, JaniceRodrigues, FranciscoSalomão, NatáliaJosé, CarollinaCarvalho, Jorge deRabelo, KíssilaAzeredo, Elzinandes deOliveira, Rodrigo Basílio deOliveira, Carlos Basílio deSantos, Flávia dosPaes, Marciano2019-05-02T17:25:14Z2019-05-02T17:25:14Z2019NUNES, Priscila et al. Stillborn Multiple Organs’ Investigation from a Maternal DENV-4 Infection: Histopathological and Inflammatory Mediators Characterization. Viruses, v. 11, n. 319, 14p, 2019.1999-4915https://www.arca.fiocruz.br/handle/icict/3292210.3390/v110403191999-4915engMDPIDengue 4GravidezMorte FetalCitocinasMediadores inflamatóriosPregnancyDengue 4Fetal deathCytokinesInflammatory mediatorsA Stillborn Multiple Organs' Investigation from a Maternal DENV-4 Infection: Histopathological and Inflammatory Mediators Characterizationinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia. Laboratório de Anatomia Patológica. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia. Laboratório de Anatomia Patológica. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ. Brasil.Universidade do Estado do Rio de Janeiro. Laboratório de Ultraestrutura e Biologia Tecidual. Rio de Janeiro, RJ, Brasil.Universidade do Estado do Rio de Janeiro. Laboratório de Ultraestrutura e Biologia Tecidual. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ. Brasil.Universidade Federal do Estado do Rio de Janeiro. Anatomia Patológica. Rio de Janeiro, RJ, Brasil.Universidade Federal do Estado do Rio de Janeiro. Anatomia Patológica. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ. Brasil.Dengue virus (DENV) is an emerging virus involved in outbreaks in Brazil. The association between the virus and vertical transmission, with disorders in the placenta, has raised a worldwide concern. On the 29th gestational week, a pregnant woman presented severe complications due to a DENV infection leading to maternal and fetus death. Postmortem analysis of fetal organs demonstrated the presence of DENV using reverse transcriptase polymerase chain reaction (RT-PCR) in the fetal brain and DENV non-structural protein 3 (NS3) staining in placenta and several peripheral fetal tissues, such as the brain, liver, lungs, and spleen. Histological analysis of the placenta and fetal organs revealed different types of tissue abnormalities, which included inflammation, hemorrhage, edema, and necrosis in placenta and tissue disorganization in the fetus, such as spongiform parenchyma, microglial inflammation, steatosis, hyalinose arteriolar, inflammatory cells in the alveolar septa, and disorganization of the lymphoid follicle. Increased cellularity (macrophage, Hofbauer cells and TCD8+ lymphocytes) and up-regulation of inflammatory mediators such as IFN-γ, TNF-α, RANTES/CCL5, MCP1/CCL2, and VEGF/R2 were detected in the liver, lung, spleen, brain, and placenta, supporting placental and fetus peripheral tissues inflammation. Maternal infection leading to the production of those vascular mediators may alter the vascular permeability, facilitating the virus entry and tissue and barrier dysfunction.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/32922/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALPriscilaNunes_FlaviaSantos_etal_IOC_2019.pdfPriscilaNunes_FlaviaSantos_etal_IOC_2019.pdfapplication/pdf10215272https://www.arca.fiocruz.br/bitstream/icict/32922/2/PriscilaNunes_FlaviaSantos_etal_IOC_2019.pdf24406932e8083ca4fef8c818205090ceMD52TEXTPriscilaNunes_FlaviaSantos_etal_IOC_2019.pdf.txtPriscilaNunes_FlaviaSantos_etal_IOC_2019.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv A Stillborn Multiple Organs' Investigation from a Maternal DENV-4 Infection: Histopathological and Inflammatory Mediators Characterization
title A Stillborn Multiple Organs' Investigation from a Maternal DENV-4 Infection: Histopathological and Inflammatory Mediators Characterization
spellingShingle A Stillborn Multiple Organs' Investigation from a Maternal DENV-4 Infection: Histopathological and Inflammatory Mediators Characterization
Nunes, Priscila
Dengue 4
Gravidez
Morte Fetal
Citocinas
Mediadores inflamatórios
Pregnancy
Dengue 4
Fetal death
Cytokines
Inflammatory mediators
title_short A Stillborn Multiple Organs' Investigation from a Maternal DENV-4 Infection: Histopathological and Inflammatory Mediators Characterization
title_full A Stillborn Multiple Organs' Investigation from a Maternal DENV-4 Infection: Histopathological and Inflammatory Mediators Characterization
title_fullStr A Stillborn Multiple Organs' Investigation from a Maternal DENV-4 Infection: Histopathological and Inflammatory Mediators Characterization
title_full_unstemmed A Stillborn Multiple Organs' Investigation from a Maternal DENV-4 Infection: Histopathological and Inflammatory Mediators Characterization
title_sort A Stillborn Multiple Organs' Investigation from a Maternal DENV-4 Infection: Histopathological and Inflammatory Mediators Characterization
author Nunes, Priscila
author_facet Nunes, Priscila
Nogueira, Rita
Coelho, Janice
Rodrigues, Francisco
Salomão, Natália
José, Carollina
Carvalho, Jorge de
Rabelo, Kíssila
Azeredo, Elzinandes de
Oliveira, Rodrigo Basílio de
Oliveira, Carlos Basílio de
Santos, Flávia dos
Paes, Marciano
author_role author
author2 Nogueira, Rita
Coelho, Janice
Rodrigues, Francisco
Salomão, Natália
José, Carollina
Carvalho, Jorge de
Rabelo, Kíssila
Azeredo, Elzinandes de
Oliveira, Rodrigo Basílio de
Oliveira, Carlos Basílio de
Santos, Flávia dos
Paes, Marciano
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Nunes, Priscila
Nogueira, Rita
Coelho, Janice
Rodrigues, Francisco
Salomão, Natália
José, Carollina
Carvalho, Jorge de
Rabelo, Kíssila
Azeredo, Elzinandes de
Oliveira, Rodrigo Basílio de
Oliveira, Carlos Basílio de
Santos, Flávia dos
Paes, Marciano
dc.subject.other.pt_BR.fl_str_mv Dengue 4
Gravidez
Morte Fetal
Citocinas
Mediadores inflamatórios
topic Dengue 4
Gravidez
Morte Fetal
Citocinas
Mediadores inflamatórios
Pregnancy
Dengue 4
Fetal death
Cytokines
Inflammatory mediators
dc.subject.en.pt_BR.fl_str_mv Pregnancy
Dengue 4
Fetal death
Cytokines
Inflammatory mediators
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ. Brasil.
publishDate 2019
dc.date.accessioned.fl_str_mv 2019-05-02T17:25:14Z
dc.date.available.fl_str_mv 2019-05-02T17:25:14Z
dc.date.issued.fl_str_mv 2019
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv NUNES, Priscila et al. Stillborn Multiple Organs’ Investigation from a Maternal DENV-4 Infection: Histopathological and Inflammatory Mediators Characterization. Viruses, v. 11, n. 319, 14p, 2019.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/32922
dc.identifier.issn.pt_BR.fl_str_mv 1999-4915
dc.identifier.doi.none.fl_str_mv 10.3390/v11040319
dc.identifier.eissn.none.fl_str_mv 1999-4915
identifier_str_mv NUNES, Priscila et al. Stillborn Multiple Organs’ Investigation from a Maternal DENV-4 Infection: Histopathological and Inflammatory Mediators Characterization. Viruses, v. 11, n. 319, 14p, 2019.
1999-4915
10.3390/v11040319
url https://www.arca.fiocruz.br/handle/icict/32922
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/32922/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/32922/2/PriscilaNunes_FlaviaSantos_etal_IOC_2019.pdf
https://www.arca.fiocruz.br/bitstream/icict/32922/3/PriscilaNunes_FlaviaSantos_etal_IOC_2019.pdf.txt
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