Image-guided percutaneous intralesional administration of mesenchymal stromal cells in subjects with chronic complete spinal cord injury: a pilot study
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2017 |
| Outros Autores: | , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/20638 |
Resumo: | Brazilian Development Bank (BNDES). |
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Larocca, Ticiana FerreiraMacêdo, Carolina ThéSouza, Bruno Solano de FreitasSouza, Yuri M AndradeVillarreal, Cristiane FloraMatos, André CostaSilva, Daniela NascimentoSilva, Kátia Nunes daSouza, Clarissa Lima E Moura dePaixão, Daniela da SilvaBezerra, Milena da RochaAlves, Rodrigo LealSoares, Milena Botelho PereiraSantos, Ricardo Ribeiro dos2017-08-16T13:45:57Z2017-08-16T13:45:57Z2017LAROCCA, T. F. et al. Image-guided percutaneous intralesional administration of mesenchymal stromal cells in subjects with chronic complete spinal cord injury: a pilot study. Cytotherapy, jul. 2017.1465-3249https://www.arca.fiocruz.br/handle/icict/2063810.1016/j.jcyt.2017.06.006Brazilian Development Bank (BNDES).Hospital São Rafael. Center for Biotechnology and Cell Therapy. Salvador, BA, Brazil / Hospital São Rafael. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, BrasilHospital São Rafael. Center for Biotechnology and Cell Therapy. Salvador, BA, Brazil / Hospital São Rafael. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, BrasilHospital São Rafael. Center for Biotechnology and Cell Therapy. Salvador, BA, Brazil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / National Institute of Science andTechnology for Regenerative Medicine. Rio de Janeiro, RJ, BrazilHospital São Rafael. Salvador, BA, BrasilHospital São Rafael. Center for Biotechnology and Cell Therapy. Salvador, BA, Brazil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / University of Bahia. Faculty of Pharmacy. Salvador, BA, BrazilHospital São Rafael. Salvador, BA, BrasilHospital São Rafael. Center for Biotechnology and Cell Therapy. Salvador, BA, Brazil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, BrasilHospital São Rafael. Center for Biotechnology and Cell Therapy. Salvador, BA, Brazil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, BrasilHospital São Rafael. Center for Biotechnology and Cell Therapy. Salvador, BA, Brazil / Hospital São Rafael. Salvador, BA, BrasilHospital São Rafael. Center for Biotechnology and Cell Therapy. Salvador, BA, BrazilHospital São Rafael. Center for Biotechnology and Cell Therapy. Salvador, BA, BrazilHospital São Rafael. Salvador, BA, BrasilHospital São Rafael. Center for Biotechnology and Cell Therapy. Salvador, BA, Brazil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / National Institute of Science andTechnology for Regenerative Medicine. Rio de Janeiro, RJ, BrazilHospital São Rafael. Center for Biotechnology and Cell Therapy. Salvador, BA, Brazil / National Institute of Science andTechnology for Regenerative Medicine. Rio de Janeiro, RJ, BrazilThe potential of cell therapies to improve neurological function in subjects with spinal cord injury (SCI) is currently under investigation. In this context, the choice of cell type, dose, route and administration regimen are key factors. Mesenchymal stromal cells (MSCs) can be easily obtained, expanded and are suitable for autologous transplantation. Here we conducted a pilot study that evaluated safety, feasibility and potential efficacy of intralesional MSCs transplantation performed through image-guided percutaneous injection, in subjects with chronic complete SCI. Methods. Five subjects with chronic traumatic SCI (>6 months), at thoracic level, classified as American Spinal Cord Injury Association impairment scale (AIS) grade A, complete injury, were included. Somatosensory evoked potentials (SSEP), spinal magnetic resonance imaging (MRI) and urodynamics were assessed before and after treatment. Autologous MSCs were injected directly into the lesion site through percutaneous injection guided by computerized tomography (CT). Results. Tomography-guided percutaneous cell transplantation was a safe procedure without adverse effects. All subjects displayed improvements in spinal cord independence measure (SCIM) scores and functional independence measure (FIM), mainly due to improvements in bowel movements and regularity. Three subjects showed improved sensitivity to tactile stimulation.Two subjects improved AIS grade to B, incomplete injury, although this was sustained in only one of them during the study follow-up. Conclusion. Autologous bone marrow MSC transplantation, performed through CT-guided percutaneous injection, was shown to be safe and feasible. Further studies are required to demonstrate efficacy of this therapeutic scheme.engElsevierTerapia celularEstudo clínicocélulas estomatais mesenquimais,Lesão da medula espinhalCell therapyClinical studyMesenchymal stromal cellsSpinal cord injuryImage-guided percutaneous intralesional administration of mesenchymal stromal cells in subjects with chronic complete spinal cord injury: a pilot studyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/20638/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALLarocca TF Image-guided....pdfLarocca TF Image-guided....pdfapplication/pdf387218https://www.arca.fiocruz.br/bitstream/icict/20638/2/Larocca%20TF%20Image-guided....pdf3e5d59f868cf7e153f1aa904be8b2251MD52TEXTLarocca TF 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| dc.title.pt_BR.fl_str_mv |
Image-guided percutaneous intralesional administration of mesenchymal stromal cells in subjects with chronic complete spinal cord injury: a pilot study |
| title |
Image-guided percutaneous intralesional administration of mesenchymal stromal cells in subjects with chronic complete spinal cord injury: a pilot study |
| spellingShingle |
Image-guided percutaneous intralesional administration of mesenchymal stromal cells in subjects with chronic complete spinal cord injury: a pilot study Larocca, Ticiana Ferreira Terapia celular Estudo clínico células estomatais mesenquimais, Lesão da medula espinhal Cell therapy Clinical study Mesenchymal stromal cells Spinal cord injury |
| title_short |
Image-guided percutaneous intralesional administration of mesenchymal stromal cells in subjects with chronic complete spinal cord injury: a pilot study |
| title_full |
Image-guided percutaneous intralesional administration of mesenchymal stromal cells in subjects with chronic complete spinal cord injury: a pilot study |
| title_fullStr |
Image-guided percutaneous intralesional administration of mesenchymal stromal cells in subjects with chronic complete spinal cord injury: a pilot study |
| title_full_unstemmed |
Image-guided percutaneous intralesional administration of mesenchymal stromal cells in subjects with chronic complete spinal cord injury: a pilot study |
| title_sort |
Image-guided percutaneous intralesional administration of mesenchymal stromal cells in subjects with chronic complete spinal cord injury: a pilot study |
| author |
Larocca, Ticiana Ferreira |
| author_facet |
Larocca, Ticiana Ferreira Macêdo, Carolina Thé Souza, Bruno Solano de Freitas Souza, Yuri M Andrade Villarreal, Cristiane Flora Matos, André Costa Silva, Daniela Nascimento Silva, Kátia Nunes da Souza, Clarissa Lima E Moura de Paixão, Daniela da Silva Bezerra, Milena da Rocha Alves, Rodrigo Leal Soares, Milena Botelho Pereira Santos, Ricardo Ribeiro dos |
| author_role |
author |
| author2 |
Macêdo, Carolina Thé Souza, Bruno Solano de Freitas Souza, Yuri M Andrade Villarreal, Cristiane Flora Matos, André Costa Silva, Daniela Nascimento Silva, Kátia Nunes da Souza, Clarissa Lima E Moura de Paixão, Daniela da Silva Bezerra, Milena da Rocha Alves, Rodrigo Leal Soares, Milena Botelho Pereira Santos, Ricardo Ribeiro dos |
| author2_role |
author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Larocca, Ticiana Ferreira Macêdo, Carolina Thé Souza, Bruno Solano de Freitas Souza, Yuri M Andrade Villarreal, Cristiane Flora Matos, André Costa Silva, Daniela Nascimento Silva, Kátia Nunes da Souza, Clarissa Lima E Moura de Paixão, Daniela da Silva Bezerra, Milena da Rocha Alves, Rodrigo Leal Soares, Milena Botelho Pereira Santos, Ricardo Ribeiro dos |
| dc.subject.other.pt_BR.fl_str_mv |
Terapia celular Estudo clínico células estomatais mesenquimais, Lesão da medula espinhal |
| topic |
Terapia celular Estudo clínico células estomatais mesenquimais, Lesão da medula espinhal Cell therapy Clinical study Mesenchymal stromal cells Spinal cord injury |
| dc.subject.en.pt_BR.fl_str_mv |
Cell therapy Clinical study Mesenchymal stromal cells Spinal cord injury |
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Brazilian Development Bank (BNDES). |
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2017 |
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2017-08-16T13:45:57Z |
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2017-08-16T13:45:57Z |
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2017 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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LAROCCA, T. F. et al. Image-guided percutaneous intralesional administration of mesenchymal stromal cells in subjects with chronic complete spinal cord injury: a pilot study. Cytotherapy, jul. 2017. |
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https://www.arca.fiocruz.br/handle/icict/20638 |
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1465-3249 |
| dc.identifier.doi.none.fl_str_mv |
10.1016/j.jcyt.2017.06.006 |
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LAROCCA, T. F. et al. Image-guided percutaneous intralesional administration of mesenchymal stromal cells in subjects with chronic complete spinal cord injury: a pilot study. Cytotherapy, jul. 2017. 1465-3249 10.1016/j.jcyt.2017.06.006 |
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Elsevier |
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