Image-guided percutaneous intralesional administration of mesenchymal stromal cells in subjects with chronic complete spinal cord injury: a pilot study

Detalhes bibliográficos
Autor(a) principal: Larocca, Ticiana Ferreira
Data de Publicação: 2017
Outros Autores: Macêdo, Carolina Thé, Souza, Bruno Solano de Freitas, Souza, Yuri M Andrade, Villarreal, Cristiane Flora, Matos, André Costa, Silva, Daniela Nascimento, Silva, Kátia Nunes da, Souza, Clarissa Lima E Moura de, Paixão, Daniela da Silva, Bezerra, Milena da Rocha, Alves, Rodrigo Leal, Soares, Milena Botelho Pereira, Santos, Ricardo Ribeiro dos
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/20638
Resumo: Brazilian Development Bank (BNDES).
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spelling Larocca, Ticiana FerreiraMacêdo, Carolina ThéSouza, Bruno Solano de FreitasSouza, Yuri M AndradeVillarreal, Cristiane FloraMatos, André CostaSilva, Daniela NascimentoSilva, Kátia Nunes daSouza, Clarissa Lima E Moura dePaixão, Daniela da SilvaBezerra, Milena da RochaAlves, Rodrigo LealSoares, Milena Botelho PereiraSantos, Ricardo Ribeiro dos2017-08-16T13:45:57Z2017-08-16T13:45:57Z2017LAROCCA, T. F. et al. Image-guided percutaneous intralesional administration of mesenchymal stromal cells in subjects with chronic complete spinal cord injury: a pilot study. Cytotherapy, jul. 2017.1465-3249https://www.arca.fiocruz.br/handle/icict/2063810.1016/j.jcyt.2017.06.006Brazilian Development Bank (BNDES).Hospital São Rafael. Center for Biotechnology and Cell Therapy. Salvador, BA, Brazil / Hospital São Rafael. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, BrasilHospital São Rafael. Center for Biotechnology and Cell Therapy. Salvador, BA, Brazil / Hospital São Rafael. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, BrasilHospital São Rafael. Center for Biotechnology and Cell Therapy. Salvador, BA, Brazil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / National Institute of Science andTechnology for Regenerative Medicine. Rio de Janeiro, RJ, BrazilHospital São Rafael. Salvador, BA, BrasilHospital São Rafael. Center for Biotechnology and Cell Therapy. Salvador, BA, Brazil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / University of Bahia. Faculty of Pharmacy. Salvador, BA, BrazilHospital São Rafael. Salvador, BA, BrasilHospital São Rafael. Center for Biotechnology and Cell Therapy. Salvador, BA, Brazil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, BrasilHospital São Rafael. Center for Biotechnology and Cell Therapy. Salvador, BA, Brazil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, BrasilHospital São Rafael. Center for Biotechnology and Cell Therapy. Salvador, BA, Brazil / Hospital São Rafael. Salvador, BA, BrasilHospital São Rafael. Center for Biotechnology and Cell Therapy. Salvador, BA, BrazilHospital São Rafael. Center for Biotechnology and Cell Therapy. Salvador, BA, BrazilHospital São Rafael. Salvador, BA, BrasilHospital São Rafael. Center for Biotechnology and Cell Therapy. Salvador, BA, Brazil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / National Institute of Science andTechnology for Regenerative Medicine. Rio de Janeiro, RJ, BrazilHospital São Rafael. Center for Biotechnology and Cell Therapy. Salvador, BA, Brazil / National Institute of Science andTechnology for Regenerative Medicine. Rio de Janeiro, RJ, BrazilThe potential of cell therapies to improve neurological function in subjects with spinal cord injury (SCI) is currently under investigation. In this context, the choice of cell type, dose, route and administration regimen are key factors. Mesenchymal stromal cells (MSCs) can be easily obtained, expanded and are suitable for autologous transplantation. Here we conducted a pilot study that evaluated safety, feasibility and potential efficacy of intralesional MSCs transplantation performed through image-guided percutaneous injection, in subjects with chronic complete SCI. Methods. Five subjects with chronic traumatic SCI (>6 months), at thoracic level, classified as American Spinal Cord Injury Association impairment scale (AIS) grade A, complete injury, were included. Somatosensory evoked potentials (SSEP), spinal magnetic resonance imaging (MRI) and urodynamics were assessed before and after treatment. Autologous MSCs were injected directly into the lesion site through percutaneous injection guided by computerized tomography (CT). Results. Tomography-guided percutaneous cell transplantation was a safe procedure without adverse effects. All subjects displayed improvements in spinal cord independence measure (SCIM) scores and functional independence measure (FIM), mainly due to improvements in bowel movements and regularity. Three subjects showed improved sensitivity to tactile stimulation.Two subjects improved AIS grade to B, incomplete injury, although this was sustained in only one of them during the study follow-up. Conclusion. Autologous bone marrow MSC transplantation, performed through CT-guided percutaneous injection, was shown to be safe and feasible. Further studies are required to demonstrate efficacy of this therapeutic scheme.engElsevierTerapia celularEstudo clínicocélulas estomatais mesenquimais,Lesão da medula espinhalCell therapyClinical studyMesenchymal stromal cellsSpinal cord injuryImage-guided percutaneous intralesional administration of mesenchymal stromal cells in subjects with chronic complete spinal cord injury: a pilot studyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/20638/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALLarocca TF Image-guided....pdfLarocca TF Image-guided....pdfapplication/pdf387218https://www.arca.fiocruz.br/bitstream/icict/20638/2/Larocca%20TF%20Image-guided....pdf3e5d59f868cf7e153f1aa904be8b2251MD52TEXTLarocca TF 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dc.title.pt_BR.fl_str_mv Image-guided percutaneous intralesional administration of mesenchymal stromal cells in subjects with chronic complete spinal cord injury: a pilot study
title Image-guided percutaneous intralesional administration of mesenchymal stromal cells in subjects with chronic complete spinal cord injury: a pilot study
spellingShingle Image-guided percutaneous intralesional administration of mesenchymal stromal cells in subjects with chronic complete spinal cord injury: a pilot study
Larocca, Ticiana Ferreira
Terapia celular
Estudo clínico
células estomatais mesenquimais,
Lesão da medula espinhal
Cell therapy
Clinical study
Mesenchymal stromal cells
Spinal cord injury
title_short Image-guided percutaneous intralesional administration of mesenchymal stromal cells in subjects with chronic complete spinal cord injury: a pilot study
title_full Image-guided percutaneous intralesional administration of mesenchymal stromal cells in subjects with chronic complete spinal cord injury: a pilot study
title_fullStr Image-guided percutaneous intralesional administration of mesenchymal stromal cells in subjects with chronic complete spinal cord injury: a pilot study
title_full_unstemmed Image-guided percutaneous intralesional administration of mesenchymal stromal cells in subjects with chronic complete spinal cord injury: a pilot study
title_sort Image-guided percutaneous intralesional administration of mesenchymal stromal cells in subjects with chronic complete spinal cord injury: a pilot study
author Larocca, Ticiana Ferreira
author_facet Larocca, Ticiana Ferreira
Macêdo, Carolina Thé
Souza, Bruno Solano de Freitas
Souza, Yuri M Andrade
Villarreal, Cristiane Flora
Matos, André Costa
Silva, Daniela Nascimento
Silva, Kátia Nunes da
Souza, Clarissa Lima E Moura de
Paixão, Daniela da Silva
Bezerra, Milena da Rocha
Alves, Rodrigo Leal
Soares, Milena Botelho Pereira
Santos, Ricardo Ribeiro dos
author_role author
author2 Macêdo, Carolina Thé
Souza, Bruno Solano de Freitas
Souza, Yuri M Andrade
Villarreal, Cristiane Flora
Matos, André Costa
Silva, Daniela Nascimento
Silva, Kátia Nunes da
Souza, Clarissa Lima E Moura de
Paixão, Daniela da Silva
Bezerra, Milena da Rocha
Alves, Rodrigo Leal
Soares, Milena Botelho Pereira
Santos, Ricardo Ribeiro dos
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Larocca, Ticiana Ferreira
Macêdo, Carolina Thé
Souza, Bruno Solano de Freitas
Souza, Yuri M Andrade
Villarreal, Cristiane Flora
Matos, André Costa
Silva, Daniela Nascimento
Silva, Kátia Nunes da
Souza, Clarissa Lima E Moura de
Paixão, Daniela da Silva
Bezerra, Milena da Rocha
Alves, Rodrigo Leal
Soares, Milena Botelho Pereira
Santos, Ricardo Ribeiro dos
dc.subject.other.pt_BR.fl_str_mv Terapia celular
Estudo clínico
células estomatais mesenquimais,
Lesão da medula espinhal
topic Terapia celular
Estudo clínico
células estomatais mesenquimais,
Lesão da medula espinhal
Cell therapy
Clinical study
Mesenchymal stromal cells
Spinal cord injury
dc.subject.en.pt_BR.fl_str_mv Cell therapy
Clinical study
Mesenchymal stromal cells
Spinal cord injury
description Brazilian Development Bank (BNDES).
publishDate 2017
dc.date.accessioned.fl_str_mv 2017-08-16T13:45:57Z
dc.date.available.fl_str_mv 2017-08-16T13:45:57Z
dc.date.issued.fl_str_mv 2017
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv LAROCCA, T. F. et al. Image-guided percutaneous intralesional administration of mesenchymal stromal cells in subjects with chronic complete spinal cord injury: a pilot study. Cytotherapy, jul. 2017.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/20638
dc.identifier.issn.pt_BR.fl_str_mv 1465-3249
dc.identifier.doi.none.fl_str_mv 10.1016/j.jcyt.2017.06.006
identifier_str_mv LAROCCA, T. F. et al. Image-guided percutaneous intralesional administration of mesenchymal stromal cells in subjects with chronic complete spinal cord injury: a pilot study. Cytotherapy, jul. 2017.
1465-3249
10.1016/j.jcyt.2017.06.006
url https://www.arca.fiocruz.br/handle/icict/20638
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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