Human immunodeficiency virus type 1: drug resistance in treated and untreated brazilian children

Detalhes bibliográficos
Autor(a) principal: Simonetti, S. R. R.
Data de Publicação: 2003
Outros Autores: Schatzmayr, H. G., Simonetti, J. P.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/44417
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Virologia. Núcleo de Retrovirus. Rio de Janeiro, RJ, Brasil.
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spelling Simonetti, S. R. R.Schatzmayr, H. G.Simonetti, J. P.2020-11-14T15:43:24Z2020-11-14T15:43:24Z2003SIMONETTI, S. R. R.; SCHATZMAYR, H. G.; SIMONETTI, J. P. Human immunodeficiency virus type 1: drug resistance in treated and untreated brazilian children. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 98, n, 6, p. 831-837, Sept. 2003.0074-0276https://www.arca.fiocruz.br/handle/icict/4441710.1590/S0074-027620030006000211678-8060engFundação Oswaldo Cruz. Instituto Oswaldo Cruz.Vírus da imunodeficiência humana tipo 1GenotipagemResistência a medicamentosCrianças brasileirasHuman immunodeficiency virus type 1 (HIV-1)GenotypingDrug resistanceBrazilian childrenHuman immunodeficiency virus type 1: drug resistance in treated and untreated brazilian childreninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Virologia. Núcleo de Retrovirus. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Virologia. Núcleo de Retrovirus. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Virologia. Núcleo de Retrovirus. Rio de Janeiro, RJ, Brasil.Twenty-two vertically human immunodeficiency virus type 1 (HIV-1) infected Brazilian children were studied for antiretroviral drug resistance. They were separated into 2 groups according to the administration of antiretroviral therapy into those who presented disease symptoms or without symptoms and no therapy. Viral genome sequencing reactions were loaded on an automated DNA sampler (TruGene, Visible Genetics) and compared to a database of wild type HIV-1. In the former group 8 of 12 children presented isolates with mutations conferring resistance to protease inhibitors (PIs), 7 presented isolates resistant to nucleoside reverse transcriptase inhibitors (NRTIs) and 2 presented isolates resistant to non-nucleoside reverse transcriptase inhibitors (NNRTIs). Ten children were included in the antiretroviral naïve group. Eight were susceptible to NRTIs and all of them were susceptible to PIs; one presented the V108I mutation, which confers low-level resistance to NNRTIs. The data report HIV mutant isolates both in treated and untreated infants. However, the frequency and the level of drug resistance were more frequent in the group receiving antiretroviral therapy, corroborating the concept of selective pressure acting on the emergence of resistant viral strains. 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dc.title.pt_BR.fl_str_mv Human immunodeficiency virus type 1: drug resistance in treated and untreated brazilian children
title Human immunodeficiency virus type 1: drug resistance in treated and untreated brazilian children
spellingShingle Human immunodeficiency virus type 1: drug resistance in treated and untreated brazilian children
Simonetti, S. R. R.
Vírus da imunodeficiência humana tipo 1
Genotipagem
Resistência a medicamentos
Crianças brasileiras
Human immunodeficiency virus type 1 (HIV-1)
Genotyping
Drug resistance
Brazilian children
title_short Human immunodeficiency virus type 1: drug resistance in treated and untreated brazilian children
title_full Human immunodeficiency virus type 1: drug resistance in treated and untreated brazilian children
title_fullStr Human immunodeficiency virus type 1: drug resistance in treated and untreated brazilian children
title_full_unstemmed Human immunodeficiency virus type 1: drug resistance in treated and untreated brazilian children
title_sort Human immunodeficiency virus type 1: drug resistance in treated and untreated brazilian children
author Simonetti, S. R. R.
author_facet Simonetti, S. R. R.
Schatzmayr, H. G.
Simonetti, J. P.
author_role author
author2 Schatzmayr, H. G.
Simonetti, J. P.
author2_role author
author
dc.contributor.author.fl_str_mv Simonetti, S. R. R.
Schatzmayr, H. G.
Simonetti, J. P.
dc.subject.other.pt_BR.fl_str_mv Vírus da imunodeficiência humana tipo 1
Genotipagem
Resistência a medicamentos
Crianças brasileiras
topic Vírus da imunodeficiência humana tipo 1
Genotipagem
Resistência a medicamentos
Crianças brasileiras
Human immunodeficiency virus type 1 (HIV-1)
Genotyping
Drug resistance
Brazilian children
dc.subject.en.pt_BR.fl_str_mv Human immunodeficiency virus type 1 (HIV-1)
Genotyping
Drug resistance
Brazilian children
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Virologia. Núcleo de Retrovirus. Rio de Janeiro, RJ, Brasil.
publishDate 2003
dc.date.issued.fl_str_mv 2003
dc.date.accessioned.fl_str_mv 2020-11-14T15:43:24Z
dc.date.available.fl_str_mv 2020-11-14T15:43:24Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv SIMONETTI, S. R. R.; SCHATZMAYR, H. G.; SIMONETTI, J. P. Human immunodeficiency virus type 1: drug resistance in treated and untreated brazilian children. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 98, n, 6, p. 831-837, Sept. 2003.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/44417
dc.identifier.issn.pt_BR.fl_str_mv 0074-0276
dc.identifier.doi.none.fl_str_mv 10.1590/S0074-02762003000600021
dc.identifier.eissn.none.fl_str_mv 1678-8060
identifier_str_mv SIMONETTI, S. R. R.; SCHATZMAYR, H. G.; SIMONETTI, J. P. Human immunodeficiency virus type 1: drug resistance in treated and untreated brazilian children. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 98, n, 6, p. 831-837, Sept. 2003.
0074-0276
10.1590/S0074-02762003000600021
1678-8060
url https://www.arca.fiocruz.br/handle/icict/44417
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto Oswaldo Cruz.
publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto Oswaldo Cruz.
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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instacron:FIOCRUZ
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instacron_str FIOCRUZ
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