Interleukin-2 production during murine infection by Leishmania mexicana amazonensis.

Detalhes bibliográficos
Autor(a) principal: Barral Netto, Manoel
Data de Publicação: 1986
Outros Autores: Roters, Silene B., Barral, Aldina Maria Prado
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/7466
Resumo: Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil
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spelling Barral Netto, ManoelRoters, Silene B.Barral, Aldina Maria Prado2014-03-28T13:20:17Z2014-03-28T13:20:17Z1986BARRAL-NETTO, M.; ROTERS, S. B.; BARRAL, A. Interleukin-2 production during murine infection by Leishmania mexicana amazonensis. Memórias do Instituto Oswaldo Cruz, v. 81, n. 1, p. 43-47, 1986.0074-0276https://www.arca.fiocruz.br/handle/icict/7466engFiocruzInterleukin-2 production during murine infection by Leishmania mexicana amazonensis.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, BrasilUniversidade Federal da Bahia. Hospital Prof. Edgar Santos. Laboratório de Imunologia. Salvador, BA, BrasilHighly susceptible BALB/c mice, resistant C57B1/6 and their F1 progeny (BDF1) were infected subcutaneously in the foot pad with Leishmania mexicana amazonensis. At various times after infection, spleen or draining popliteal lymph node cells were assayed for their capacity to generate Interleukin-2 (I1-2) by Concanavalin A (ConA) stimulation. In both BALB/c and C57B1/6 strains there was a transient increase in their capacity to produce I1-2, from the 3rd to the 10th week post-infection. Return to pre-infection levels occurred between 13th to 16th week post-infection in all three strains. BALB/c mice always produced higher titers of I1-2 than C57B1/6, but such differences were statistically significant only at 3 and 10 weeks post-infection. BDF1 mice had titers similar to those observed in BALB/c mice. I1-2 production by ConA-stimulated lymph node cells was lower as compared to the spleen, but with a similar pattern among the three mice strains. Our data show that susceptibility to infection by L. mexicana amazonensis is not associated with deficient ConA-stimulated I1-2 production.Cutaneous leishmaniasisInterleukin-2Leishmania (immunology)Murine leishmaniasisLymphokinesConcanavalina A/farmacologiaInterleucina-2/biossínteseLeishmaniose/imunologiaBaço/imunologiaAnimaisLeishmania mexicana/imunologiaCamundongosCamundongos Endogâmicos BALB CCamundongos Endogâmicos C57BLinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALBarral-Netto Interleukin-2 Production....pdfBarral-Netto Interleukin-2 Production....pdfapplication/pdf224550https://www.arca.fiocruz.br/bitstream/icict/7466/1/Barral-Netto%20Interleukin-2%20Production....pdf03bc87e16a024eb97b93b59a1123fb90MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/7466/2/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD52TEXTBarral-Netto Interleukin-2 Production....pdf.txtBarral-Netto Interleukin-2 Production....pdf.txtExtracted texttext/plain5https://www.arca.fiocruz.br/bitstream/icict/7466/5/Barral-Netto%20Interleukin-2%20Production....pdf.txtcc9067c2ee470dc248b14b194209a34eMD55THUMBNAILBarral-Netto Interleukin-2 Production....pdf.jpgBarral-Netto Interleukin-2 Production....pdf.jpgGenerated Thumbnailimage/jpeg2523https://www.arca.fiocruz.br/bitstream/icict/7466/4/Barral-Netto%20Interleukin-2%20Production....pdf.jpgf8d7317fed798ad0ebce1d6ef4b772abMD54icict/74662023-03-15 14:33:10.518oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:10Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Interleukin-2 production during murine infection by Leishmania mexicana amazonensis.
title Interleukin-2 production during murine infection by Leishmania mexicana amazonensis.
spellingShingle Interleukin-2 production during murine infection by Leishmania mexicana amazonensis.
Barral Netto, Manoel
Cutaneous leishmaniasis
Interleukin-2
Leishmania (immunology)
Murine leishmaniasis
Lymphokines
Concanavalina A/farmacologia
Interleucina-2/biossíntese
Leishmaniose/imunologia
Baço/imunologia
Animais
Leishmania mexicana/imunologia
Camundongos
Camundongos Endogâmicos BALB C
Camundongos Endogâmicos C57BL
title_short Interleukin-2 production during murine infection by Leishmania mexicana amazonensis.
title_full Interleukin-2 production during murine infection by Leishmania mexicana amazonensis.
title_fullStr Interleukin-2 production during murine infection by Leishmania mexicana amazonensis.
title_full_unstemmed Interleukin-2 production during murine infection by Leishmania mexicana amazonensis.
title_sort Interleukin-2 production during murine infection by Leishmania mexicana amazonensis.
author Barral Netto, Manoel
author_facet Barral Netto, Manoel
Roters, Silene B.
Barral, Aldina Maria Prado
author_role author
author2 Roters, Silene B.
Barral, Aldina Maria Prado
author2_role author
author
dc.contributor.author.fl_str_mv Barral Netto, Manoel
Roters, Silene B.
Barral, Aldina Maria Prado
dc.subject.en.pt_BR.fl_str_mv Cutaneous leishmaniasis
Interleukin-2
Leishmania (immunology)
Murine leishmaniasis
Lymphokines
topic Cutaneous leishmaniasis
Interleukin-2
Leishmania (immunology)
Murine leishmaniasis
Lymphokines
Concanavalina A/farmacologia
Interleucina-2/biossíntese
Leishmaniose/imunologia
Baço/imunologia
Animais
Leishmania mexicana/imunologia
Camundongos
Camundongos Endogâmicos BALB C
Camundongos Endogâmicos C57BL
dc.subject.decs.pt_BR.fl_str_mv Concanavalina A/farmacologia
Interleucina-2/biossíntese
Leishmaniose/imunologia
Baço/imunologia
Animais
Leishmania mexicana/imunologia
Camundongos
Camundongos Endogâmicos BALB C
Camundongos Endogâmicos C57BL
description Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil
publishDate 1986
dc.date.issued.fl_str_mv 1986
dc.date.accessioned.fl_str_mv 2014-03-28T13:20:17Z
dc.date.available.fl_str_mv 2014-03-28T13:20:17Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.citation.fl_str_mv BARRAL-NETTO, M.; ROTERS, S. B.; BARRAL, A. Interleukin-2 production during murine infection by Leishmania mexicana amazonensis. Memórias do Instituto Oswaldo Cruz, v. 81, n. 1, p. 43-47, 1986.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/7466
dc.identifier.issn.none.fl_str_mv 0074-0276
identifier_str_mv BARRAL-NETTO, M.; ROTERS, S. B.; BARRAL, A. Interleukin-2 production during murine infection by Leishmania mexicana amazonensis. Memórias do Instituto Oswaldo Cruz, v. 81, n. 1, p. 43-47, 1986.
0074-0276
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