Adenylyl cyclase type 9 gene polymorphisms are associated with asthma and allergy in Brazilian children

Detalhes bibliográficos
Autor(a) principal: Teixeira, Helena Maria Pitangueira
Data de Publicação: 2017
Outros Autores: Neves, Neuza Maria Alcantara, Barreto, Maurício Lima, Figueiredo, Camila Alexandrina Viana de, Costa, Ryan dos Santos
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/25665
Resumo: Barreto, Maurício Lima. “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.
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spelling Teixeira, Helena Maria PitangueiraNeves, Neuza Maria AlcantaraBarreto, Maurício LimaFigueiredo, Camila Alexandrina Viana deCosta, Ryan dos Santos2018-04-06T16:11:36Z2018-04-06T16:11:36Z2017TEIXEIRA, H. M. P. et al. Adenylyl cyclase type 9 gene polymorphisms are associated with asthma and allergy in Brazilian children. Molecular Immunology, v. 82, p. 137–145, 2017.0161-5890https://www.arca.fiocruz.br/handle/icict/2566510.1016/j.molimm.2017.01.001Barreto, Maurício Lima. “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.Universidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, BrasilUniversidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, BrasilUniversidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, BrasilUniversidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, BrasilUniversidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, BrasilAsthma is a chronic inflammatory disease of the respiratory tract. This heterogeneous disease is caused by the interaction of interindividual genetic variability and environmental factors. The gene adenylyl cyclase type 9 (ADCY9) encodes a protein called adenylyl cyclase (AC), responsible for producing the second messenger cyclic AMP (cAMP). cAMP is produced by T regulatory cells and is involved in the down-regulation of T effector cells. Failures in cAMP production may be related to an imbalance in the regulatory immune response, leading to immune-mediated diseases, such as allergic disorders. The aim of this study was to investigate how polymorphisms in the ADCY9 are associated with asthma and allergic markers. The study comprised 1309 subjects from the SCAALA (Social Changes Asthma and Allergy in Latin America) program. Genotyping was accomplished using the Illumina 2.5 Human Omni bead chip. Logistic regression was used to assess the association between allergy markers and ADCY9 variation in PLINK 1.07 software with adjustments for sex, age, helminth infection and ancestry markers. The ADCY9 candidate gene was associated with different phenotypes, such as asthma, specific IgE, skin prick test, and cytokine production. Among 133 markers analyzed, 29 SNPs where associated with asthma and allergic markers in silico analysis revealed the functional impact of the 6 SNPs on ADCY9 expression. It can be concluded that polymorphisms in the ADCY9 gene are significantly associated with asthma and/or allergy markers. We believe that such polymorphisms may lead to increased expression of adenylyl cyclase with a consequent increase in immunoregulatory activity. Therefore, these SNPs may offer an impact on the occurrence of these conditions in admixture population from countries such as Brazil.engElsevierAlergiaPolimorfismoAMPCélulas reguladoras TADCY9AsthmaAllergyPolymorphismcAMPT regulatory cellsADCY9AsthmaAdenylyl cyclase type 9 gene polymorphisms are associated with asthma and allergy in Brazilian childreninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/25665/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALTeixeira HM Adenylyl cyclase type 9 gene ....pdfTeixeira HM Adenylyl cyclase type 9 gene 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dc.title.pt_BR.fl_str_mv Adenylyl cyclase type 9 gene polymorphisms are associated with asthma and allergy in Brazilian children
title Adenylyl cyclase type 9 gene polymorphisms are associated with asthma and allergy in Brazilian children
spellingShingle Adenylyl cyclase type 9 gene polymorphisms are associated with asthma and allergy in Brazilian children
Teixeira, Helena Maria Pitangueira
Alergia
Polimorfismo
AMP
Células reguladoras T
ADCY9
Asthma
Allergy
Polymorphismc
AMP
T regulatory cells
ADCY9
Asthma
title_short Adenylyl cyclase type 9 gene polymorphisms are associated with asthma and allergy in Brazilian children
title_full Adenylyl cyclase type 9 gene polymorphisms are associated with asthma and allergy in Brazilian children
title_fullStr Adenylyl cyclase type 9 gene polymorphisms are associated with asthma and allergy in Brazilian children
title_full_unstemmed Adenylyl cyclase type 9 gene polymorphisms are associated with asthma and allergy in Brazilian children
title_sort Adenylyl cyclase type 9 gene polymorphisms are associated with asthma and allergy in Brazilian children
author Teixeira, Helena Maria Pitangueira
author_facet Teixeira, Helena Maria Pitangueira
Neves, Neuza Maria Alcantara
Barreto, Maurício Lima
Figueiredo, Camila Alexandrina Viana de
Costa, Ryan dos Santos
author_role author
author2 Neves, Neuza Maria Alcantara
Barreto, Maurício Lima
Figueiredo, Camila Alexandrina Viana de
Costa, Ryan dos Santos
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Teixeira, Helena Maria Pitangueira
Neves, Neuza Maria Alcantara
Barreto, Maurício Lima
Figueiredo, Camila Alexandrina Viana de
Costa, Ryan dos Santos
dc.subject.other.pt_BR.fl_str_mv Alergia
Polimorfismo
AMP
Células reguladoras T
ADCY9
Asthma
topic Alergia
Polimorfismo
AMP
Células reguladoras T
ADCY9
Asthma
Allergy
Polymorphismc
AMP
T regulatory cells
ADCY9
Asthma
dc.subject.en.pt_BR.fl_str_mv Allergy
Polymorphismc
AMP
T regulatory cells
ADCY9
Asthma
description Barreto, Maurício Lima. “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.
publishDate 2017
dc.date.issued.fl_str_mv 2017
dc.date.accessioned.fl_str_mv 2018-04-06T16:11:36Z
dc.date.available.fl_str_mv 2018-04-06T16:11:36Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv TEIXEIRA, H. M. P. et al. Adenylyl cyclase type 9 gene polymorphisms are associated with asthma and allergy in Brazilian children. Molecular Immunology, v. 82, p. 137–145, 2017.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/25665
dc.identifier.issn.pt_BR.fl_str_mv 0161-5890
dc.identifier.doi.none.fl_str_mv 10.1016/j.molimm.2017.01.001
identifier_str_mv TEIXEIRA, H. M. P. et al. Adenylyl cyclase type 9 gene polymorphisms are associated with asthma and allergy in Brazilian children. Molecular Immunology, v. 82, p. 137–145, 2017.
0161-5890
10.1016/j.molimm.2017.01.001
url https://www.arca.fiocruz.br/handle/icict/25665
dc.language.iso.fl_str_mv eng
language eng
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dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
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instacron_str FIOCRUZ
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