Biological behavior of Leishmania amazonensis isolated from humans with cutaneous, mucosal, or visceral leishmaniasis in BALB/C mice

Detalhes bibliográficos
Autor(a) principal: Almeida, Roque Pacheco de
Data de Publicação: 1996
Outros Autores: Barral Netto, Manoel, Jesus, Amélia Maria Ribeiro de, Freitas, Luiz Antonio Rodrigues de, Carvalho Filho, Edgar Marcelino, Barral, Aldina Maria Prado
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/7612
Resumo: Hospital Universitario Professor Edgard Santos. Universidade Federal daBahia. Serviço de Imunologia. Salvador, BA, Brasil
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spelling Almeida, Roque Pacheco deBarral Netto, ManoelJesus, Amélia Maria Ribeiro deFreitas, Luiz Antonio Rodrigues deCarvalho Filho, Edgar MarcelinoBarral, Aldina Maria Prado2014-05-13T13:56:28Z2014-05-13T13:56:28Z1996ALMEIDA, R. P. et al. Biological behavior of Leishmania amazonensis isolated from humans with cutaneous, mucosal, or visceral leishmaniasis in BALB/C mice. American Journal of Tropical Medicine and Hygiene, v. 54, n. 2, p. 178-184, 1996.0002-9637https://www.arca.fiocruz.br/handle/icict/7612engAmerican Society of Tropical Medicine and HygieneBiological behavior of Leishmania amazonensis isolated from humans with cutaneous, mucosal, or visceral leishmaniasis in BALB/C miceinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleHospital Universitario Professor Edgard Santos. Universidade Federal daBahia. Serviço de Imunologia. Salvador, BA, BrasilHospital Universitario Professor Edgard Santos. Universidade Federal daBahia. Serviço de Imunologia. Salvador, BA, BrasilHospital Universitario Professor Edgard Santos. Universidade Federal daBahia. Serviço de Imunologia. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilHospital Universitario Professor Edgard Santos. Universidade Federal daBahia. Serviço de Imunologia. Salvador, BA, BrasilHospital Universitario Professor Edgard Santos. Universidade Federal daBahia. Serviço de Imunologia. Salvador, BA, BrasilLeishmania amazonensis causes a wide spectrum of disease in humans. In this study, we evaluated BALB/c mice infected with five strains of L. amazonensis isolated from patients with either cutaneous, mucosal, or visceral leishmaniasis. Mice infected with cutaneous and mucosal isolates developed ulcerating footpad lesions with parasite-loaded macrophages and extensive tissue destruction. Skin métastases,early dissemination of parasites to the spleen, and high anü-Leishmaniaantibody levels were also noted. Mice infected with L. amazonensis strains isolated from patients with visceral disease had a controlled infection, with small footpad lesions with mononuclear cell infiltration, few infected macrophages, and granuloma formation. They had no skin métastases,delayed dissemination of the parasite to the spleen, lower levels of IgG and higher levels of IgG2a against L. amazonensis. These findings demonstrate an unexpected resistance of BALB/c mice to the infection with L. amazonensis isolated from patients with visceral leishmaniasis. This resistance seems to be due to differences in these parasites that may be related to the altered course of the disease in humans and in isogenic BALB/c mice.Leishmania/patogenicidadeLeishmaniose Cutânea/parasitologiaLeishmaniose Mucocutânea/parasitologiaLeishmaniose Visceral/parasitologiaAnimaisAnticorpos Antiprotozoários/sangueFemininoHumanosImunoglobulina G/sangueLeishmania/imunologiaMasculinoCamundongosCamundongos Endogâmicos BALB Cinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALAlmeida R Biological behavior....pdfAlmeida R Biological behavior....pdfapplication/pdf791231https://www.arca.fiocruz.br/bitstream/icict/7612/1/Almeida%20R%20Biological%20behavior....pdf71f2bb4f14d53bf6ec92782cee92125cMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/7612/2/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD52TEXTAlmeida R Biological behavior....pdf.txtAlmeida R Biological behavior....pdf.txtExtracted texttext/plain33267https://www.arca.fiocruz.br/bitstream/icict/7612/5/Almeida%20R%20Biological%20behavior....pdf.txt775e44e9b89c60c6a12eba606e5703aeMD55THUMBNAILAlmeida R Biological behavior....pdf.jpgAlmeida R Biological behavior....pdf.jpgGenerated Thumbnailimage/jpeg2574https://www.arca.fiocruz.br/bitstream/icict/7612/4/Almeida%20R%20Biological%20behavior....pdf.jpg12edd3606e1ffa195d4dfcc16bb7799cMD54icict/76122023-03-15 14:32:56.335oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:32:56Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Biological behavior of Leishmania amazonensis isolated from humans with cutaneous, mucosal, or visceral leishmaniasis in BALB/C mice
title Biological behavior of Leishmania amazonensis isolated from humans with cutaneous, mucosal, or visceral leishmaniasis in BALB/C mice
spellingShingle Biological behavior of Leishmania amazonensis isolated from humans with cutaneous, mucosal, or visceral leishmaniasis in BALB/C mice
Almeida, Roque Pacheco de
Leishmania/patogenicidade
Leishmaniose Cutânea/parasitologia
Leishmaniose Mucocutânea/parasitologia
Leishmaniose Visceral/parasitologia
Animais
Anticorpos Antiprotozoários/sangue
Feminino
Humanos
Imunoglobulina G/sangue
Leishmania/imunologia
Masculino
Camundongos
Camundongos Endogâmicos BALB C
title_short Biological behavior of Leishmania amazonensis isolated from humans with cutaneous, mucosal, or visceral leishmaniasis in BALB/C mice
title_full Biological behavior of Leishmania amazonensis isolated from humans with cutaneous, mucosal, or visceral leishmaniasis in BALB/C mice
title_fullStr Biological behavior of Leishmania amazonensis isolated from humans with cutaneous, mucosal, or visceral leishmaniasis in BALB/C mice
title_full_unstemmed Biological behavior of Leishmania amazonensis isolated from humans with cutaneous, mucosal, or visceral leishmaniasis in BALB/C mice
title_sort Biological behavior of Leishmania amazonensis isolated from humans with cutaneous, mucosal, or visceral leishmaniasis in BALB/C mice
author Almeida, Roque Pacheco de
author_facet Almeida, Roque Pacheco de
Barral Netto, Manoel
Jesus, Amélia Maria Ribeiro de
Freitas, Luiz Antonio Rodrigues de
Carvalho Filho, Edgar Marcelino
Barral, Aldina Maria Prado
author_role author
author2 Barral Netto, Manoel
Jesus, Amélia Maria Ribeiro de
Freitas, Luiz Antonio Rodrigues de
Carvalho Filho, Edgar Marcelino
Barral, Aldina Maria Prado
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Almeida, Roque Pacheco de
Barral Netto, Manoel
Jesus, Amélia Maria Ribeiro de
Freitas, Luiz Antonio Rodrigues de
Carvalho Filho, Edgar Marcelino
Barral, Aldina Maria Prado
dc.subject.decs.pt_BR.fl_str_mv Leishmania/patogenicidade
Leishmaniose Cutânea/parasitologia
Leishmaniose Mucocutânea/parasitologia
Leishmaniose Visceral/parasitologia
Animais
Anticorpos Antiprotozoários/sangue
Feminino
Humanos
Imunoglobulina G/sangue
Leishmania/imunologia
Masculino
Camundongos
Camundongos Endogâmicos BALB C
topic Leishmania/patogenicidade
Leishmaniose Cutânea/parasitologia
Leishmaniose Mucocutânea/parasitologia
Leishmaniose Visceral/parasitologia
Animais
Anticorpos Antiprotozoários/sangue
Feminino
Humanos
Imunoglobulina G/sangue
Leishmania/imunologia
Masculino
Camundongos
Camundongos Endogâmicos BALB C
description Hospital Universitario Professor Edgard Santos. Universidade Federal daBahia. Serviço de Imunologia. Salvador, BA, Brasil
publishDate 1996
dc.date.issued.fl_str_mv 1996
dc.date.accessioned.fl_str_mv 2014-05-13T13:56:28Z
dc.date.available.fl_str_mv 2014-05-13T13:56:28Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv ALMEIDA, R. P. et al. Biological behavior of Leishmania amazonensis isolated from humans with cutaneous, mucosal, or visceral leishmaniasis in BALB/C mice. American Journal of Tropical Medicine and Hygiene, v. 54, n. 2, p. 178-184, 1996.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/7612
dc.identifier.issn.none.fl_str_mv 0002-9637
identifier_str_mv ALMEIDA, R. P. et al. Biological behavior of Leishmania amazonensis isolated from humans with cutaneous, mucosal, or visceral leishmaniasis in BALB/C mice. American Journal of Tropical Medicine and Hygiene, v. 54, n. 2, p. 178-184, 1996.
0002-9637
url https://www.arca.fiocruz.br/handle/icict/7612
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv American Society of Tropical Medicine and Hygiene
publisher.none.fl_str_mv American Society of Tropical Medicine and Hygiene
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
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instname_str Fundação Oswaldo Cruz (FIOCRUZ)
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reponame_str Repositório Institucional da FIOCRUZ (ARCA)
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