Biological behavior of Leishmania amazonensis isolated from humans with cutaneous, mucosal, or visceral leishmaniasis in BALB/C mice
Autor(a) principal: | |
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Data de Publicação: | 1996 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/7612 |
Resumo: | Hospital Universitario Professor Edgard Santos. Universidade Federal daBahia. Serviço de Imunologia. Salvador, BA, Brasil |
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Almeida, Roque Pacheco deBarral Netto, ManoelJesus, Amélia Maria Ribeiro deFreitas, Luiz Antonio Rodrigues deCarvalho Filho, Edgar MarcelinoBarral, Aldina Maria Prado2014-05-13T13:56:28Z2014-05-13T13:56:28Z1996ALMEIDA, R. P. et al. Biological behavior of Leishmania amazonensis isolated from humans with cutaneous, mucosal, or visceral leishmaniasis in BALB/C mice. American Journal of Tropical Medicine and Hygiene, v. 54, n. 2, p. 178-184, 1996.0002-9637https://www.arca.fiocruz.br/handle/icict/7612engAmerican Society of Tropical Medicine and HygieneBiological behavior of Leishmania amazonensis isolated from humans with cutaneous, mucosal, or visceral leishmaniasis in BALB/C miceinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleHospital Universitario Professor Edgard Santos. Universidade Federal daBahia. Serviço de Imunologia. Salvador, BA, BrasilHospital Universitario Professor Edgard Santos. Universidade Federal daBahia. Serviço de Imunologia. Salvador, BA, BrasilHospital Universitario Professor Edgard Santos. Universidade Federal daBahia. Serviço de Imunologia. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilHospital Universitario Professor Edgard Santos. Universidade Federal daBahia. Serviço de Imunologia. Salvador, BA, BrasilHospital Universitario Professor Edgard Santos. Universidade Federal daBahia. Serviço de Imunologia. Salvador, BA, BrasilLeishmania amazonensis causes a wide spectrum of disease in humans. In this study, we evaluated BALB/c mice infected with five strains of L. amazonensis isolated from patients with either cutaneous, mucosal, or visceral leishmaniasis. Mice infected with cutaneous and mucosal isolates developed ulcerating footpad lesions with parasite-loaded macrophages and extensive tissue destruction. Skin métastases,early dissemination of parasites to the spleen, and high anü-Leishmaniaantibody levels were also noted. Mice infected with L. amazonensis strains isolated from patients with visceral disease had a controlled infection, with small footpad lesions with mononuclear cell infiltration, few infected macrophages, and granuloma formation. They had no skin métastases,delayed dissemination of the parasite to the spleen, lower levels of IgG and higher levels of IgG2a against L. amazonensis. These findings demonstrate an unexpected resistance of BALB/c mice to the infection with L. amazonensis isolated from patients with visceral leishmaniasis. This resistance seems to be due to differences in these parasites that may be related to the altered course of the disease in humans and in isogenic BALB/c mice.Leishmania/patogenicidadeLeishmaniose Cutânea/parasitologiaLeishmaniose Mucocutânea/parasitologiaLeishmaniose Visceral/parasitologiaAnimaisAnticorpos Antiprotozoários/sangueFemininoHumanosImunoglobulina G/sangueLeishmania/imunologiaMasculinoCamundongosCamundongos Endogâmicos BALB Cinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALAlmeida R Biological behavior....pdfAlmeida R Biological behavior....pdfapplication/pdf791231https://www.arca.fiocruz.br/bitstream/icict/7612/1/Almeida%20R%20Biological%20behavior....pdf71f2bb4f14d53bf6ec92782cee92125cMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/7612/2/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD52TEXTAlmeida R Biological behavior....pdf.txtAlmeida R Biological behavior....pdf.txtExtracted texttext/plain33267https://www.arca.fiocruz.br/bitstream/icict/7612/5/Almeida%20R%20Biological%20behavior....pdf.txt775e44e9b89c60c6a12eba606e5703aeMD55THUMBNAILAlmeida R Biological behavior....pdf.jpgAlmeida R Biological behavior....pdf.jpgGenerated Thumbnailimage/jpeg2574https://www.arca.fiocruz.br/bitstream/icict/7612/4/Almeida%20R%20Biological%20behavior....pdf.jpg12edd3606e1ffa195d4dfcc16bb7799cMD54icict/76122023-03-15 14:32:56.335oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:32:56Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
dc.title.pt_BR.fl_str_mv |
Biological behavior of Leishmania amazonensis isolated from humans with cutaneous, mucosal, or visceral leishmaniasis in BALB/C mice |
title |
Biological behavior of Leishmania amazonensis isolated from humans with cutaneous, mucosal, or visceral leishmaniasis in BALB/C mice |
spellingShingle |
Biological behavior of Leishmania amazonensis isolated from humans with cutaneous, mucosal, or visceral leishmaniasis in BALB/C mice Almeida, Roque Pacheco de Leishmania/patogenicidade Leishmaniose Cutânea/parasitologia Leishmaniose Mucocutânea/parasitologia Leishmaniose Visceral/parasitologia Animais Anticorpos Antiprotozoários/sangue Feminino Humanos Imunoglobulina G/sangue Leishmania/imunologia Masculino Camundongos Camundongos Endogâmicos BALB C |
title_short |
Biological behavior of Leishmania amazonensis isolated from humans with cutaneous, mucosal, or visceral leishmaniasis in BALB/C mice |
title_full |
Biological behavior of Leishmania amazonensis isolated from humans with cutaneous, mucosal, or visceral leishmaniasis in BALB/C mice |
title_fullStr |
Biological behavior of Leishmania amazonensis isolated from humans with cutaneous, mucosal, or visceral leishmaniasis in BALB/C mice |
title_full_unstemmed |
Biological behavior of Leishmania amazonensis isolated from humans with cutaneous, mucosal, or visceral leishmaniasis in BALB/C mice |
title_sort |
Biological behavior of Leishmania amazonensis isolated from humans with cutaneous, mucosal, or visceral leishmaniasis in BALB/C mice |
author |
Almeida, Roque Pacheco de |
author_facet |
Almeida, Roque Pacheco de Barral Netto, Manoel Jesus, Amélia Maria Ribeiro de Freitas, Luiz Antonio Rodrigues de Carvalho Filho, Edgar Marcelino Barral, Aldina Maria Prado |
author_role |
author |
author2 |
Barral Netto, Manoel Jesus, Amélia Maria Ribeiro de Freitas, Luiz Antonio Rodrigues de Carvalho Filho, Edgar Marcelino Barral, Aldina Maria Prado |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Almeida, Roque Pacheco de Barral Netto, Manoel Jesus, Amélia Maria Ribeiro de Freitas, Luiz Antonio Rodrigues de Carvalho Filho, Edgar Marcelino Barral, Aldina Maria Prado |
dc.subject.decs.pt_BR.fl_str_mv |
Leishmania/patogenicidade Leishmaniose Cutânea/parasitologia Leishmaniose Mucocutânea/parasitologia Leishmaniose Visceral/parasitologia Animais Anticorpos Antiprotozoários/sangue Feminino Humanos Imunoglobulina G/sangue Leishmania/imunologia Masculino Camundongos Camundongos Endogâmicos BALB C |
topic |
Leishmania/patogenicidade Leishmaniose Cutânea/parasitologia Leishmaniose Mucocutânea/parasitologia Leishmaniose Visceral/parasitologia Animais Anticorpos Antiprotozoários/sangue Feminino Humanos Imunoglobulina G/sangue Leishmania/imunologia Masculino Camundongos Camundongos Endogâmicos BALB C |
description |
Hospital Universitario Professor Edgard Santos. Universidade Federal daBahia. Serviço de Imunologia. Salvador, BA, Brasil |
publishDate |
1996 |
dc.date.issued.fl_str_mv |
1996 |
dc.date.accessioned.fl_str_mv |
2014-05-13T13:56:28Z |
dc.date.available.fl_str_mv |
2014-05-13T13:56:28Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
ALMEIDA, R. P. et al. Biological behavior of Leishmania amazonensis isolated from humans with cutaneous, mucosal, or visceral leishmaniasis in BALB/C mice. American Journal of Tropical Medicine and Hygiene, v. 54, n. 2, p. 178-184, 1996. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/7612 |
dc.identifier.issn.none.fl_str_mv |
0002-9637 |
identifier_str_mv |
ALMEIDA, R. P. et al. Biological behavior of Leishmania amazonensis isolated from humans with cutaneous, mucosal, or visceral leishmaniasis in BALB/C mice. American Journal of Tropical Medicine and Hygiene, v. 54, n. 2, p. 178-184, 1996. 0002-9637 |
url |
https://www.arca.fiocruz.br/handle/icict/7612 |
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eng |
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eng |
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info:eu-repo/semantics/openAccess |
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openAccess |
dc.publisher.none.fl_str_mv |
American Society of Tropical Medicine and Hygiene |
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American Society of Tropical Medicine and Hygiene |
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reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
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