Early infection with Leishmania major restrains pathogenic response to Leishmania amazonensis and parasite growth.
Autor(a) principal: | |
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Data de Publicação: | 2008 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFOP |
dARK ID: | ark:/61566/0013000005cbd |
Texto Completo: | http://www.repositorio.ufop.br/handle/123456789/4613 https://doi.org/10.1016/j.actatropica.2007.12.012 |
Resumo: | Experimental models of infection with Leishmania spp. have provided knowledge of several immunological events involved in the resistance mechanism used by the host to restrain parasite growth. It is well accepted that concomitant immunity exists, and there is some evidence that it would play a major role in long-lasting acquired resistance to infection. In this paper, the resistance to Leishmania amazonensis infection in C57BL/6 mice infected with Leishmania major was investigated. C57BL/6 mice, which spontaneously heal lesions caused by infection with L. major, were infected with L. amazonensis at different times before and after L. major. We demonstrated that C57BL/6 mice previously infected with L. major restrain pathogenic responses induced by L. amazonensis infection and decrease parasite burdens by one order of magnitude. Coinfected mice showed production of IFN-_ in lesions similar to mice infected solely with L. major, but higher TNF-_ and nitric oxide synthase (iNOS) mRNA expression was observed. Surprisingly, the restrained pathogenic response was not related to IL-10 production, as evidenced by lower levels of both mRNA, protein expression in lesions from co-infected mice and in co-infections in IL-10−/− mice. Examination of the inflammatory infiltrate at the site of infection showed a reduced number of monocytes and lymphocytes in L. amazonensis lesions. Additionally, differential production of the CCL3/MIP-1_ and CCL5/RANTES was observed. We suggest that the control of lesion progression caused by L. amazonensis in C57BL/6 mice pre-infected with L. major is related to the induction of a down-regulatory environment at the site of infection with L. amazonensis. |
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Early infection with Leishmania major restrains pathogenic response to Leishmania amazonensis and parasite growth.Protozoan parasitesCutaneous leishmaniasisInfectionCellular recruitmentExperimental models of infection with Leishmania spp. have provided knowledge of several immunological events involved in the resistance mechanism used by the host to restrain parasite growth. It is well accepted that concomitant immunity exists, and there is some evidence that it would play a major role in long-lasting acquired resistance to infection. In this paper, the resistance to Leishmania amazonensis infection in C57BL/6 mice infected with Leishmania major was investigated. C57BL/6 mice, which spontaneously heal lesions caused by infection with L. major, were infected with L. amazonensis at different times before and after L. major. We demonstrated that C57BL/6 mice previously infected with L. major restrain pathogenic responses induced by L. amazonensis infection and decrease parasite burdens by one order of magnitude. Coinfected mice showed production of IFN-_ in lesions similar to mice infected solely with L. major, but higher TNF-_ and nitric oxide synthase (iNOS) mRNA expression was observed. Surprisingly, the restrained pathogenic response was not related to IL-10 production, as evidenced by lower levels of both mRNA, protein expression in lesions from co-infected mice and in co-infections in IL-10−/− mice. Examination of the inflammatory infiltrate at the site of infection showed a reduced number of monocytes and lymphocytes in L. amazonensis lesions. Additionally, differential production of the CCL3/MIP-1_ and CCL5/RANTES was observed. We suggest that the control of lesion progression caused by L. amazonensis in C57BL/6 mice pre-infected with L. major is related to the induction of a down-regulatory environment at the site of infection with L. amazonensis.2015-03-12T18:53:51Z2015-03-12T18:53:51Z2008info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfLOMBANA, C. Z. G. et al. Early infection with Leishmania major restrains pathogenic response to Leishmania amazonensis and parasite growth. Acta Tropica, v. 106, p. 27-38, 2008. Disponível em: <http://www.sciencedirect.com/science/article/pii/S0001706X08000041>. Acesso em: 08 nov. 2014.0001-706Xhttp://www.repositorio.ufop.br/handle/123456789/4613https://doi.org/10.1016/j.actatropica.2007.12.012ark:/61566/0013000005cbdO periódico Acta Tropica concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3525980735803.info:eu-repo/semantics/openAccessLombana, Claudia Zuleida GonzalezSantiago, Helton da CostaMacedo, J. P.Rego, Virgínia Aparecida SeixasRusso, Remo de CastroTafuri, Wagner LuizAfonso, Luís Carlos CroccoVieira, Leda Querciaengreponame:Repositório Institucional da UFOPinstname:Universidade Federal de Ouro Preto (UFOP)instacron:UFOP2024-11-10T16:35:54Zoai:repositorio.ufop.br:123456789/4613Repositório InstitucionalPUBhttp://www.repositorio.ufop.br/oai/requestrepositorio@ufop.edu.bropendoar:32332024-11-10T16:35:54Repositório Institucional da UFOP - Universidade Federal de Ouro Preto (UFOP)false |
dc.title.none.fl_str_mv |
Early infection with Leishmania major restrains pathogenic response to Leishmania amazonensis and parasite growth. |
title |
Early infection with Leishmania major restrains pathogenic response to Leishmania amazonensis and parasite growth. |
spellingShingle |
Early infection with Leishmania major restrains pathogenic response to Leishmania amazonensis and parasite growth. Lombana, Claudia Zuleida Gonzalez Protozoan parasites Cutaneous leishmaniasis Infection Cellular recruitment |
title_short |
Early infection with Leishmania major restrains pathogenic response to Leishmania amazonensis and parasite growth. |
title_full |
Early infection with Leishmania major restrains pathogenic response to Leishmania amazonensis and parasite growth. |
title_fullStr |
Early infection with Leishmania major restrains pathogenic response to Leishmania amazonensis and parasite growth. |
title_full_unstemmed |
Early infection with Leishmania major restrains pathogenic response to Leishmania amazonensis and parasite growth. |
title_sort |
Early infection with Leishmania major restrains pathogenic response to Leishmania amazonensis and parasite growth. |
author |
Lombana, Claudia Zuleida Gonzalez |
author_facet |
Lombana, Claudia Zuleida Gonzalez Santiago, Helton da Costa Macedo, J. P. Rego, Virgínia Aparecida Seixas Russo, Remo de Castro Tafuri, Wagner Luiz Afonso, Luís Carlos Crocco Vieira, Leda Quercia |
author_role |
author |
author2 |
Santiago, Helton da Costa Macedo, J. P. Rego, Virgínia Aparecida Seixas Russo, Remo de Castro Tafuri, Wagner Luiz Afonso, Luís Carlos Crocco Vieira, Leda Quercia |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Lombana, Claudia Zuleida Gonzalez Santiago, Helton da Costa Macedo, J. P. Rego, Virgínia Aparecida Seixas Russo, Remo de Castro Tafuri, Wagner Luiz Afonso, Luís Carlos Crocco Vieira, Leda Quercia |
dc.subject.por.fl_str_mv |
Protozoan parasites Cutaneous leishmaniasis Infection Cellular recruitment |
topic |
Protozoan parasites Cutaneous leishmaniasis Infection Cellular recruitment |
description |
Experimental models of infection with Leishmania spp. have provided knowledge of several immunological events involved in the resistance mechanism used by the host to restrain parasite growth. It is well accepted that concomitant immunity exists, and there is some evidence that it would play a major role in long-lasting acquired resistance to infection. In this paper, the resistance to Leishmania amazonensis infection in C57BL/6 mice infected with Leishmania major was investigated. C57BL/6 mice, which spontaneously heal lesions caused by infection with L. major, were infected with L. amazonensis at different times before and after L. major. We demonstrated that C57BL/6 mice previously infected with L. major restrain pathogenic responses induced by L. amazonensis infection and decrease parasite burdens by one order of magnitude. Coinfected mice showed production of IFN-_ in lesions similar to mice infected solely with L. major, but higher TNF-_ and nitric oxide synthase (iNOS) mRNA expression was observed. Surprisingly, the restrained pathogenic response was not related to IL-10 production, as evidenced by lower levels of both mRNA, protein expression in lesions from co-infected mice and in co-infections in IL-10−/− mice. Examination of the inflammatory infiltrate at the site of infection showed a reduced number of monocytes and lymphocytes in L. amazonensis lesions. Additionally, differential production of the CCL3/MIP-1_ and CCL5/RANTES was observed. We suggest that the control of lesion progression caused by L. amazonensis in C57BL/6 mice pre-infected with L. major is related to the induction of a down-regulatory environment at the site of infection with L. amazonensis. |
publishDate |
2008 |
dc.date.none.fl_str_mv |
2008 2015-03-12T18:53:51Z 2015-03-12T18:53:51Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
LOMBANA, C. Z. G. et al. Early infection with Leishmania major restrains pathogenic response to Leishmania amazonensis and parasite growth. Acta Tropica, v. 106, p. 27-38, 2008. Disponível em: <http://www.sciencedirect.com/science/article/pii/S0001706X08000041>. Acesso em: 08 nov. 2014. 0001-706X http://www.repositorio.ufop.br/handle/123456789/4613 https://doi.org/10.1016/j.actatropica.2007.12.012 |
dc.identifier.dark.fl_str_mv |
ark:/61566/0013000005cbd |
identifier_str_mv |
LOMBANA, C. Z. G. et al. Early infection with Leishmania major restrains pathogenic response to Leishmania amazonensis and parasite growth. Acta Tropica, v. 106, p. 27-38, 2008. Disponível em: <http://www.sciencedirect.com/science/article/pii/S0001706X08000041>. Acesso em: 08 nov. 2014. 0001-706X ark:/61566/0013000005cbd |
url |
http://www.repositorio.ufop.br/handle/123456789/4613 https://doi.org/10.1016/j.actatropica.2007.12.012 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UFOP instname:Universidade Federal de Ouro Preto (UFOP) instacron:UFOP |
instname_str |
Universidade Federal de Ouro Preto (UFOP) |
instacron_str |
UFOP |
institution |
UFOP |
reponame_str |
Repositório Institucional da UFOP |
collection |
Repositório Institucional da UFOP |
repository.name.fl_str_mv |
Repositório Institucional da UFOP - Universidade Federal de Ouro Preto (UFOP) |
repository.mail.fl_str_mv |
repositorio@ufop.edu.br |
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1817705761289011200 |