Early infection with Leishmania major restrains pathogenic response to Leishmania amazonensis and parasite growth.

Detalhes bibliográficos
Autor(a) principal: Lombana, Claudia Zuleida Gonzalez
Data de Publicação: 2008
Outros Autores: Santiago, Helton da Costa, Macedo, J. P., Rego, Virgínia Aparecida Seixas, Russo, Remo de Castro, Tafuri, Wagner Luiz, Afonso, Luís Carlos Crocco, Vieira, Leda Quercia
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFOP
dARK ID: ark:/61566/0013000005cbd
Texto Completo: http://www.repositorio.ufop.br/handle/123456789/4613
https://doi.org/10.1016/j.actatropica.2007.12.012
Resumo: Experimental models of infection with Leishmania spp. have provided knowledge of several immunological events involved in the resistance mechanism used by the host to restrain parasite growth. It is well accepted that concomitant immunity exists, and there is some evidence that it would play a major role in long-lasting acquired resistance to infection. In this paper, the resistance to Leishmania amazonensis infection in C57BL/6 mice infected with Leishmania major was investigated. C57BL/6 mice, which spontaneously heal lesions caused by infection with L. major, were infected with L. amazonensis at different times before and after L. major. We demonstrated that C57BL/6 mice previously infected with L. major restrain pathogenic responses induced by L. amazonensis infection and decrease parasite burdens by one order of magnitude. Coinfected mice showed production of IFN-_ in lesions similar to mice infected solely with L. major, but higher TNF-_ and nitric oxide synthase (iNOS) mRNA expression was observed. Surprisingly, the restrained pathogenic response was not related to IL-10 production, as evidenced by lower levels of both mRNA, protein expression in lesions from co-infected mice and in co-infections in IL-10−/− mice. Examination of the inflammatory infiltrate at the site of infection showed a reduced number of monocytes and lymphocytes in L. amazonensis lesions. Additionally, differential production of the CCL3/MIP-1_ and CCL5/RANTES was observed. We suggest that the control of lesion progression caused by L. amazonensis in C57BL/6 mice pre-infected with L. major is related to the induction of a down-regulatory environment at the site of infection with L. amazonensis.
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spelling Early infection with Leishmania major restrains pathogenic response to Leishmania amazonensis and parasite growth.Protozoan parasitesCutaneous leishmaniasisInfectionCellular recruitmentExperimental models of infection with Leishmania spp. have provided knowledge of several immunological events involved in the resistance mechanism used by the host to restrain parasite growth. It is well accepted that concomitant immunity exists, and there is some evidence that it would play a major role in long-lasting acquired resistance to infection. In this paper, the resistance to Leishmania amazonensis infection in C57BL/6 mice infected with Leishmania major was investigated. C57BL/6 mice, which spontaneously heal lesions caused by infection with L. major, were infected with L. amazonensis at different times before and after L. major. We demonstrated that C57BL/6 mice previously infected with L. major restrain pathogenic responses induced by L. amazonensis infection and decrease parasite burdens by one order of magnitude. Coinfected mice showed production of IFN-_ in lesions similar to mice infected solely with L. major, but higher TNF-_ and nitric oxide synthase (iNOS) mRNA expression was observed. Surprisingly, the restrained pathogenic response was not related to IL-10 production, as evidenced by lower levels of both mRNA, protein expression in lesions from co-infected mice and in co-infections in IL-10−/− mice. Examination of the inflammatory infiltrate at the site of infection showed a reduced number of monocytes and lymphocytes in L. amazonensis lesions. Additionally, differential production of the CCL3/MIP-1_ and CCL5/RANTES was observed. We suggest that the control of lesion progression caused by L. amazonensis in C57BL/6 mice pre-infected with L. major is related to the induction of a down-regulatory environment at the site of infection with L. amazonensis.2015-03-12T18:53:51Z2015-03-12T18:53:51Z2008info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfLOMBANA, C. Z. G. et al. Early infection with Leishmania major restrains pathogenic response to Leishmania amazonensis and parasite growth. Acta Tropica, v. 106, p. 27-38, 2008. Disponível em: <http://www.sciencedirect.com/science/article/pii/S0001706X08000041>. Acesso em: 08 nov. 2014.0001-706Xhttp://www.repositorio.ufop.br/handle/123456789/4613https://doi.org/10.1016/j.actatropica.2007.12.012ark:/61566/0013000005cbdO periódico Acta Tropica concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3525980735803.info:eu-repo/semantics/openAccessLombana, Claudia Zuleida GonzalezSantiago, Helton da CostaMacedo, J. P.Rego, Virgínia Aparecida SeixasRusso, Remo de CastroTafuri, Wagner LuizAfonso, Luís Carlos CroccoVieira, Leda Querciaengreponame:Repositório Institucional da UFOPinstname:Universidade Federal de Ouro Preto (UFOP)instacron:UFOP2024-11-10T16:35:54Zoai:repositorio.ufop.br:123456789/4613Repositório InstitucionalPUBhttp://www.repositorio.ufop.br/oai/requestrepositorio@ufop.edu.bropendoar:32332024-11-10T16:35:54Repositório Institucional da UFOP - Universidade Federal de Ouro Preto (UFOP)false
dc.title.none.fl_str_mv Early infection with Leishmania major restrains pathogenic response to Leishmania amazonensis and parasite growth.
title Early infection with Leishmania major restrains pathogenic response to Leishmania amazonensis and parasite growth.
spellingShingle Early infection with Leishmania major restrains pathogenic response to Leishmania amazonensis and parasite growth.
Lombana, Claudia Zuleida Gonzalez
Protozoan parasites
Cutaneous leishmaniasis
Infection
Cellular recruitment
title_short Early infection with Leishmania major restrains pathogenic response to Leishmania amazonensis and parasite growth.
title_full Early infection with Leishmania major restrains pathogenic response to Leishmania amazonensis and parasite growth.
title_fullStr Early infection with Leishmania major restrains pathogenic response to Leishmania amazonensis and parasite growth.
title_full_unstemmed Early infection with Leishmania major restrains pathogenic response to Leishmania amazonensis and parasite growth.
title_sort Early infection with Leishmania major restrains pathogenic response to Leishmania amazonensis and parasite growth.
author Lombana, Claudia Zuleida Gonzalez
author_facet Lombana, Claudia Zuleida Gonzalez
Santiago, Helton da Costa
Macedo, J. P.
Rego, Virgínia Aparecida Seixas
Russo, Remo de Castro
Tafuri, Wagner Luiz
Afonso, Luís Carlos Crocco
Vieira, Leda Quercia
author_role author
author2 Santiago, Helton da Costa
Macedo, J. P.
Rego, Virgínia Aparecida Seixas
Russo, Remo de Castro
Tafuri, Wagner Luiz
Afonso, Luís Carlos Crocco
Vieira, Leda Quercia
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Lombana, Claudia Zuleida Gonzalez
Santiago, Helton da Costa
Macedo, J. P.
Rego, Virgínia Aparecida Seixas
Russo, Remo de Castro
Tafuri, Wagner Luiz
Afonso, Luís Carlos Crocco
Vieira, Leda Quercia
dc.subject.por.fl_str_mv Protozoan parasites
Cutaneous leishmaniasis
Infection
Cellular recruitment
topic Protozoan parasites
Cutaneous leishmaniasis
Infection
Cellular recruitment
description Experimental models of infection with Leishmania spp. have provided knowledge of several immunological events involved in the resistance mechanism used by the host to restrain parasite growth. It is well accepted that concomitant immunity exists, and there is some evidence that it would play a major role in long-lasting acquired resistance to infection. In this paper, the resistance to Leishmania amazonensis infection in C57BL/6 mice infected with Leishmania major was investigated. C57BL/6 mice, which spontaneously heal lesions caused by infection with L. major, were infected with L. amazonensis at different times before and after L. major. We demonstrated that C57BL/6 mice previously infected with L. major restrain pathogenic responses induced by L. amazonensis infection and decrease parasite burdens by one order of magnitude. Coinfected mice showed production of IFN-_ in lesions similar to mice infected solely with L. major, but higher TNF-_ and nitric oxide synthase (iNOS) mRNA expression was observed. Surprisingly, the restrained pathogenic response was not related to IL-10 production, as evidenced by lower levels of both mRNA, protein expression in lesions from co-infected mice and in co-infections in IL-10−/− mice. Examination of the inflammatory infiltrate at the site of infection showed a reduced number of monocytes and lymphocytes in L. amazonensis lesions. Additionally, differential production of the CCL3/MIP-1_ and CCL5/RANTES was observed. We suggest that the control of lesion progression caused by L. amazonensis in C57BL/6 mice pre-infected with L. major is related to the induction of a down-regulatory environment at the site of infection with L. amazonensis.
publishDate 2008
dc.date.none.fl_str_mv 2008
2015-03-12T18:53:51Z
2015-03-12T18:53:51Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv LOMBANA, C. Z. G. et al. Early infection with Leishmania major restrains pathogenic response to Leishmania amazonensis and parasite growth. Acta Tropica, v. 106, p. 27-38, 2008. Disponível em: <http://www.sciencedirect.com/science/article/pii/S0001706X08000041>. Acesso em: 08 nov. 2014.
0001-706X
http://www.repositorio.ufop.br/handle/123456789/4613
https://doi.org/10.1016/j.actatropica.2007.12.012
dc.identifier.dark.fl_str_mv ark:/61566/0013000005cbd
identifier_str_mv LOMBANA, C. Z. G. et al. Early infection with Leishmania major restrains pathogenic response to Leishmania amazonensis and parasite growth. Acta Tropica, v. 106, p. 27-38, 2008. Disponível em: <http://www.sciencedirect.com/science/article/pii/S0001706X08000041>. Acesso em: 08 nov. 2014.
0001-706X
ark:/61566/0013000005cbd
url http://www.repositorio.ufop.br/handle/123456789/4613
https://doi.org/10.1016/j.actatropica.2007.12.012
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFOP
instname:Universidade Federal de Ouro Preto (UFOP)
instacron:UFOP
instname_str Universidade Federal de Ouro Preto (UFOP)
instacron_str UFOP
institution UFOP
reponame_str Repositório Institucional da UFOP
collection Repositório Institucional da UFOP
repository.name.fl_str_mv Repositório Institucional da UFOP - Universidade Federal de Ouro Preto (UFOP)
repository.mail.fl_str_mv repositorio@ufop.edu.br
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