Modulation and function of Pumilio proteins in cancer

Detalhes bibliográficos
Autor(a) principal: Silva, Isabelle Leticia Zaboroski
Data de Publicação: 2022
Outros Autores: Kohata, Arissa Andreina, Shigunov, Patrícia
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/52453
Resumo: Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Biologia Básica de Células Tronco. Curitiba, PR, Brasil.
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spelling Silva, Isabelle Leticia ZaboroskiKohata, Arissa AndreinaShigunov, Patrícia2022-04-28T19:23:48Z2022-04-28T19:23:48Z2022SILVA, Isabelle Leticia Zaboroski; KOHATA, Arissa Andreina; SHIGUNOV, Patrícia. Modulation and function of Pumilio proteins in cancer. Seminars in Cancer Biology, p. 1–12, 2022.https://www.arca.fiocruz.br/handle/icict/52453engAcademic PressCancerNeoplasiasProteínas de Ligação a RNAProliferaçãoCarcinogênesePumilio proteinsNeoplasmsRNA-Binding ProteinsCarcinogenesisNeoplasiasProteínas de Unión al ARNModulation and function of Pumilio proteins in cancerinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Biologia Básica de Células Tronco. Curitiba, PR, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Biologia Básica de Células Tronco. Curitiba, PR, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Biologia Básica de Células Tronco. Curitiba, PR, Brasil.Post-transcriptional regulation is involved in tumorigenesis, and in this control, RNA-binding proteins are the main protagonists. Pumilio proteins are highly conserved RNA-binding proteins that regulate many aspects of RNA processing. The dysregulation of Pumilio expression is associated with different types of cancer. This review summarizes the roles of Pumilio 1 and Pumilio 2 in cancer and discusses the factors that account for their distinct biological functions. Pumilio levels seem to be related to tumor progression and poor prognoses in some kinds of tumors, such as lung, pancreatic, prostate, and cervical cancers. Pumilio 1 is associated with cancer proliferation, migration, and invasion, and so is Pumilio 2, although there are contradictory reports regarding the latter. Furthermore, the circular RNA, circPUM1, has been described as a miRNAs sponge, regulating miRNA involved in the cell cycle. The expression and function of Pumilio proteins depend on the fine adjustment of a set of modulators, including miRNAs, lncRNAs, and circRNAs; this demonstrates that Pumilio plays an important role in tumorigenesis through a variety of regulatory axes.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83084https://www.arca.fiocruz.br/bitstream/icict/52453/1/license.txt783568c2893d2e25a99990b126be1772MD51ORIGINAL1-s2.0-S1044579X22000669Pre-print.pdf1-s2.0-S1044579X22000669Pre-print.pdfapplication/pdf7413470https://www.arca.fiocruz.br/bitstream/icict/52453/2/1-s2.0-S1044579X22000669Pre-print.pdf7606f962519b5c15c69d42f13bf51c83MD52icict/524532022-04-28 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dc.title.pt_BR.fl_str_mv Modulation and function of Pumilio proteins in cancer
title Modulation and function of Pumilio proteins in cancer
spellingShingle Modulation and function of Pumilio proteins in cancer
Silva, Isabelle Leticia Zaboroski
Cancer
Neoplasias
Proteínas de Ligação a RNA
Proliferação
Carcinogênese
Pumilio proteins
Neoplasms
RNA-Binding Proteins
Carcinogenesis
Neoplasias
Proteínas de Unión al ARN
title_short Modulation and function of Pumilio proteins in cancer
title_full Modulation and function of Pumilio proteins in cancer
title_fullStr Modulation and function of Pumilio proteins in cancer
title_full_unstemmed Modulation and function of Pumilio proteins in cancer
title_sort Modulation and function of Pumilio proteins in cancer
author Silva, Isabelle Leticia Zaboroski
author_facet Silva, Isabelle Leticia Zaboroski
Kohata, Arissa Andreina
Shigunov, Patrícia
author_role author
author2 Kohata, Arissa Andreina
Shigunov, Patrícia
author2_role author
author
dc.contributor.author.fl_str_mv Silva, Isabelle Leticia Zaboroski
Kohata, Arissa Andreina
Shigunov, Patrícia
dc.subject.other.pt_BR.fl_str_mv Cancer
Neoplasias
Proteínas de Ligação a RNA
Proliferação
Carcinogênese
topic Cancer
Neoplasias
Proteínas de Ligação a RNA
Proliferação
Carcinogênese
Pumilio proteins
Neoplasms
RNA-Binding Proteins
Carcinogenesis
Neoplasias
Proteínas de Unión al ARN
dc.subject.en.pt_BR.fl_str_mv Pumilio proteins
Neoplasms
RNA-Binding Proteins
Carcinogenesis
dc.subject.es.pt_BR.fl_str_mv Neoplasias
Proteínas de Unión al ARN
description Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Biologia Básica de Células Tronco. Curitiba, PR, Brasil.
publishDate 2022
dc.date.accessioned.fl_str_mv 2022-04-28T19:23:48Z
dc.date.available.fl_str_mv 2022-04-28T19:23:48Z
dc.date.issued.fl_str_mv 2022
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SILVA, Isabelle Leticia Zaboroski; KOHATA, Arissa Andreina; SHIGUNOV, Patrícia. Modulation and function of Pumilio proteins in cancer. Seminars in Cancer Biology, p. 1–12, 2022.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/52453
identifier_str_mv SILVA, Isabelle Leticia Zaboroski; KOHATA, Arissa Andreina; SHIGUNOV, Patrícia. Modulation and function of Pumilio proteins in cancer. Seminars in Cancer Biology, p. 1–12, 2022.
url https://www.arca.fiocruz.br/handle/icict/52453
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Academic Press
publisher.none.fl_str_mv Academic Press
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/52453/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/52453/2/1-s2.0-S1044579X22000669Pre-print.pdf
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MD5
repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
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