Evaluation of the Expression of CCR5 and CX3CR1 Receptors and Correlation with the Functionality of T Cells in Women infected with ZIKV during Pregnancy
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/46076 |
Resumo: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil. |
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Macedo, Débora FamiliarPaiva, Iury AmancioSilva, Jessica Badolato Corrêa daCarvalho, Fabiana Rabe deDias, Helver GonçalvesCorrêa, Alex PauvolidSantos, Caroline Fernandes dosGandini, MarianaSilva, Andréa AliceCavalcanti, Silvia Maria BaetaOliveira, Solange Artimos deVianna, Renata Artimos de OliveiraAzeredo, Elzinandes Leal deGrifoni, AlbaSette, AlessandroWeiskopf, DanielaCardoso, Claudete Aparecida AraújoPinto, Luzia Maria de Oliveira2021-02-12T20:01:09Z2021-02-12T20:01:09Z2021MACEDO, Débora Familiar et al. Evaluation of the Expression of CCR5 and CX3CR1 Receptors and Correlation with the Functionality of T Cells in Women infected with ZIKV during Pregnancy. Viruses, v. 12, n. 191, p. 1-18, Jan. 2021.1999-4915https://www.arca.fiocruz.br/handle/icict/4607610.3390/v13020191engMDPIZika virusGravidezCélulas TResposta inflamatóriaAtividade citotóxicaReceptores de quimiocinaZIKVPregnancyT cellsInflammatory responseCytotoxic activityChemokine receptorsEvaluation of the Expression of CCR5 and CX3CR1 Receptors and Correlation with the Functionality of T Cells in Women infected with ZIKV during Pregnancyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil.Universidade Federal Fluminense. Escolal de Medicina. Laboratório Multiusuário para Pesquisa em Nefrologia e Ciência Médica. Niterói, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil.Department of Veterinary Integrative Biosciences. Texas A&M University, Texas, TX, USA / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Vírus Respiratório e do Sarampo. Laboratório Nacional de Referência e Regional Laboratório de Referência nas Américas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Microbiologia Celular. Rio de Janeiro, RJ, Brasil.Universidade Federal Fluminense. Escolal de Medicina. Laboratório Multiusuário para Pesquisa em Nefrologia e Ciência Médica. Niterói, RJ, Brasil.Universidade Federal Fluminense. Instituto Biomédico. Departamento de Microbiologia e Parasitologia. Laboratório de Diagnóstico Virológico. Niterói, RJ, Brasil.Universidade Federal Fluminense. Escola de Medicina. Departamento Materno-Infantil. Niterói, RJ, Brasil.Universidade Federal Fluminense. Escola de Medicina. Departamento Materno-Infantil. Niterói, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil.Center for Infectious Disease and Vaccine Research. La Jolla Institute for Immunology. La Jolla, CA, USA.Center for Infectious Disease and Vaccine Research. La Jolla Institute for Immunology. La Jolla, CA, USA / Department of Medicine, Division of Infectious Diseases and Global Public Health, University of California. CA, USA.Center for Infectious Disease and Vaccine Research. La Jolla Institute for Immunology. La Jolla, CA, USA.Universidade Federal Fluminense. Escolal de Medicina. Laboratório Multiusuário para Pesquisa em Nefrologia e Ciência Médica. Niterói, RJ, Brasil / Universidade Federal Fluminense. Escola de Medicina. Departamento Materno-Infantil. Niterói, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil.There have been reports of neurological abnormalities associated with the Zika virus (ZIKV), such as congenital Zika syndrome (CZS) in children born to mothers infected during pregnancy. We investigated how the immune response to ZIKV during pregnancy is primed and conduct a thorough evaluation of the inflammatory and cytotoxic profiles as well as the expression of CCR5 and CX3CR1. We compared the reactivity of T cells to ZIKV peptides in convalescent mothers infected during pregnancy. The child’s clinical outcome (i.e., born with or without CZS) was taken to be the variable. The cells were stimulated in vitro with ZIKV peptides and evaluated using the ELISPOT and flow cytometry assays. After in vitro stimulation with ZIKV peptides, we observed a tendency toward a higher Interferon gamma (IFN- )-producing T cell responses in mothers who had asymptomatic children and a higher CD107a expression in T cells in mothers who had children with CZS.We found a higher frequency of T cells expressing CD107a+ and co-expressing CX3CR1+CCR5+, which is much clearer in the T cells of mothers who had CZS children. We suggest that this differential profile influenced the clinical outcome of babies. These data need to be further investigated, including the evaluation of other ZIKV peptides and markers and functional assays.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/46076/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALFamiliar-Macedo_Débora_etal_IOC_2021.pdfFamiliar-Macedo_Débora_etal_IOC_2021.pdfapplication/pdf1532526https://www.arca.fiocruz.br/bitstream/icict/46076/2/Familiar-Macedo_D%c3%a9bora_etal_IOC_2021.pdf415fb4a7cc1d341c2baad3ffadd560bbMD52TEXTFamiliar-Macedo_Débora_etal_IOC_2021.pdf.txtFamiliar-Macedo_Débora_etal_IOC_2021.pdf.txtExtracted texttext/plain75840https://www.arca.fiocruz.br/bitstream/icict/46076/3/Familiar-Macedo_D%c3%a9bora_etal_IOC_2021.pdf.txt84718e91bebc4627122e25090541a5a3MD53icict/460762021-02-13 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dc.title.pt_BR.fl_str_mv |
Evaluation of the Expression of CCR5 and CX3CR1 Receptors and Correlation with the Functionality of T Cells in Women infected with ZIKV during Pregnancy |
title |
Evaluation of the Expression of CCR5 and CX3CR1 Receptors and Correlation with the Functionality of T Cells in Women infected with ZIKV during Pregnancy |
spellingShingle |
Evaluation of the Expression of CCR5 and CX3CR1 Receptors and Correlation with the Functionality of T Cells in Women infected with ZIKV during Pregnancy Macedo, Débora Familiar Zika virus Gravidez Células T Resposta inflamatória Atividade citotóxica Receptores de quimiocina ZIKV Pregnancy T cells Inflammatory response Cytotoxic activity Chemokine receptors |
title_short |
Evaluation of the Expression of CCR5 and CX3CR1 Receptors and Correlation with the Functionality of T Cells in Women infected with ZIKV during Pregnancy |
title_full |
Evaluation of the Expression of CCR5 and CX3CR1 Receptors and Correlation with the Functionality of T Cells in Women infected with ZIKV during Pregnancy |
title_fullStr |
Evaluation of the Expression of CCR5 and CX3CR1 Receptors and Correlation with the Functionality of T Cells in Women infected with ZIKV during Pregnancy |
title_full_unstemmed |
Evaluation of the Expression of CCR5 and CX3CR1 Receptors and Correlation with the Functionality of T Cells in Women infected with ZIKV during Pregnancy |
title_sort |
Evaluation of the Expression of CCR5 and CX3CR1 Receptors and Correlation with the Functionality of T Cells in Women infected with ZIKV during Pregnancy |
author |
Macedo, Débora Familiar |
author_facet |
Macedo, Débora Familiar Paiva, Iury Amancio Silva, Jessica Badolato Corrêa da Carvalho, Fabiana Rabe de Dias, Helver Gonçalves Corrêa, Alex Pauvolid Santos, Caroline Fernandes dos Gandini, Mariana Silva, Andréa Alice Cavalcanti, Silvia Maria Baeta Oliveira, Solange Artimos de Vianna, Renata Artimos de Oliveira Azeredo, Elzinandes Leal de Grifoni, Alba Sette, Alessandro Weiskopf, Daniela Cardoso, Claudete Aparecida Araújo Pinto, Luzia Maria de Oliveira |
author_role |
author |
author2 |
Paiva, Iury Amancio Silva, Jessica Badolato Corrêa da Carvalho, Fabiana Rabe de Dias, Helver Gonçalves Corrêa, Alex Pauvolid Santos, Caroline Fernandes dos Gandini, Mariana Silva, Andréa Alice Cavalcanti, Silvia Maria Baeta Oliveira, Solange Artimos de Vianna, Renata Artimos de Oliveira Azeredo, Elzinandes Leal de Grifoni, Alba Sette, Alessandro Weiskopf, Daniela Cardoso, Claudete Aparecida Araújo Pinto, Luzia Maria de Oliveira |
author2_role |
author author author author author author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Macedo, Débora Familiar Paiva, Iury Amancio Silva, Jessica Badolato Corrêa da Carvalho, Fabiana Rabe de Dias, Helver Gonçalves Corrêa, Alex Pauvolid Santos, Caroline Fernandes dos Gandini, Mariana Silva, Andréa Alice Cavalcanti, Silvia Maria Baeta Oliveira, Solange Artimos de Vianna, Renata Artimos de Oliveira Azeredo, Elzinandes Leal de Grifoni, Alba Sette, Alessandro Weiskopf, Daniela Cardoso, Claudete Aparecida Araújo Pinto, Luzia Maria de Oliveira |
dc.subject.other.pt_BR.fl_str_mv |
Zika virus Gravidez Células T Resposta inflamatória Atividade citotóxica Receptores de quimiocina |
topic |
Zika virus Gravidez Células T Resposta inflamatória Atividade citotóxica Receptores de quimiocina ZIKV Pregnancy T cells Inflammatory response Cytotoxic activity Chemokine receptors |
dc.subject.en.pt_BR.fl_str_mv |
ZIKV Pregnancy T cells Inflammatory response Cytotoxic activity Chemokine receptors |
description |
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil. |
publishDate |
2021 |
dc.date.accessioned.fl_str_mv |
2021-02-12T20:01:09Z |
dc.date.available.fl_str_mv |
2021-02-12T20:01:09Z |
dc.date.issued.fl_str_mv |
2021 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
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article |
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publishedVersion |
dc.identifier.citation.fl_str_mv |
MACEDO, Débora Familiar et al. Evaluation of the Expression of CCR5 and CX3CR1 Receptors and Correlation with the Functionality of T Cells in Women infected with ZIKV during Pregnancy. Viruses, v. 12, n. 191, p. 1-18, Jan. 2021. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/46076 |
dc.identifier.issn.pt_BR.fl_str_mv |
1999-4915 |
dc.identifier.doi.none.fl_str_mv |
10.3390/v13020191 |
identifier_str_mv |
MACEDO, Débora Familiar et al. Evaluation of the Expression of CCR5 and CX3CR1 Receptors and Correlation with the Functionality of T Cells in Women infected with ZIKV during Pregnancy. Viruses, v. 12, n. 191, p. 1-18, Jan. 2021. 1999-4915 10.3390/v13020191 |
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https://www.arca.fiocruz.br/handle/icict/46076 |
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eng |
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eng |
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MDPI |
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MDPI |
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