Clinical and immunologic predictors of Mycobacterium avium complex immune reconstitution inflammatory syndrome in a contemporary cohort of patients with HIV

Detalhes bibliográficos
Autor(a) principal: Breglio, Kimberly F.
Data de Publicação: 2020
Outros Autores: Vinhaes, Caian L., Arriaga Gutiérrez, María Belen, Nason, Martha, Roby, Gregg, Adelsberger, Joseph, Andrade, Bruno de Bezerril, Sheikh, Virginia, Sereti, Irini
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/44392
Resumo: Intramural Research program of the National Institute of Allergy and Infectious Diseases at the National Institutes of Health (NIH). This research was also made possible through the NIH Medical Research Scholars Program, a public-private partnership supported jointly by the NIH and generous contributions to the Foundation for the NIH from Pfizer Inc, The Doris Duke Charitable Foundation, The Alexandria Real Estate Equities, Inc. and Mr. and Mrs. Joel S. Marcus, and the Howard Hughes Medical Institute, as well as other private donors. The work of BBA is supported by the Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq; senior fellow) and by the Intramural Research Program of the Fundação Oswaldo Cruz, Brazil. CLV received a research fellowship from CNPq. MBA received a research fellowship from the Fundação de Amparo à Pesquisa do Estado da Bahia (FAPESB).
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spelling Breglio, Kimberly F.Vinhaes, Caian L.Arriaga Gutiérrez, María BelenNason, MarthaRoby, GreggAdelsberger, JosephAndrade, Bruno de BezerrilSheikh, VirginiaSereti, Irini2020-11-13T12:27:54Z2020-11-13T12:27:54Z2020BREGLIO, Kimberly F. et al. Clinical and immunologic predictors of Mycobacterium avium complex immune reconstitution inflammatory syndrome in a contemporary cohort of patients with HIV. Journal of Infectious Diseases, p. 1-26, 2020.0022-1899https://www.arca.fiocruz.br/handle/icict/4439210.1093/infdis/jiaa669Intramural Research program of the National Institute of Allergy and Infectious Diseases at the National Institutes of Health (NIH). This research was also made possible through the NIH Medical Research Scholars Program, a public-private partnership supported jointly by the NIH and generous contributions to the Foundation for the NIH from Pfizer Inc, The Doris Duke Charitable Foundation, The Alexandria Real Estate Equities, Inc. and Mr. and Mrs. Joel S. Marcus, and the Howard Hughes Medical Institute, as well as other private donors. The work of BBA is supported by the Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq; senior fellow) and by the Intramural Research Program of the Fundação Oswaldo Cruz, Brazil. CLV received a research fellowship from CNPq. MBA received a research fellowship from the Fundação de Amparo à Pesquisa do Estado da Bahia (FAPESB).National Institutes of Health. National Institute of Allergy and Infectious Diseases. Bethesda, MD, USA.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brazil / Faculdade de Tecnologia e Ciências. Curso de Medicina. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brazil / Universidade Federal da Bahia. Faculdade de Medicina, Salvador, BA, Brasil.National Institutes of Health. National Institute of Allergy and Infectious Diseases. Bethesda, MD, USA.National Institutes of Health. National Institute of Allergy and Infectious Diseases. Bethesda, MD, USA.Fredrick National Laboratory for Cancer Research. Leidos Biomedical Research Inc. Frederick, MD, USA.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brazil / Faculdade de Tecnologia e Ciências. Curso de Medicina. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina, Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil / Universidade Salvador. Laureate Universities. Curso de Medicina. Salvador, BA, Brasil.National Institutes of Health. National Institute of Allergy and Infectious Diseases. Bethesda, MD, USA.National Institutes of Health. National Institute of Allergy and Infectious Diseases. Bethesda, MD, USA.Background: Patients with HIV (PWH) can present with new or worsening symptoms associated with Mycobacterium avium complex (MAC) infection shortly after antiretroviral therapy (ART) initiation as MAC immune reconstitution inflammatory syndrome (MAC-IRIS). In this study, we assessed the utility of several laboratory tests as predictors of MAC-IRIS. Methods: PWH with clinical and histologic and/or microbiologic evidence of MAC-IRIS were identified and followed up to 96 weeks post-ART initiation within a prospective study of 206 ART-naïve patients with CD4 <100 cells/μL. Results: Fifteen (7.3%) patients presented with MAC-IRIS within a median interval of 26 days after ART initiation. Patients who developed MAC-IRIS had lower BMI, lower hemoglobin levels, a higher alkaline phosphatase and increased CD38 frequency and MFI on CD8+ T-cells, at the time of ART initiation compared to non-MAC IRIS patients. A decision tree inference model revealed that stratifying patients based on levels of alkaline phosphatase and D-dimer could predict the likelihood of MAC-IRIS. A binary logistic regression demonstrated that higher levels of alkaline phosphatase at baseline were associated with increased risk of MAC-IRIS development. Conclusions: High alkaline phosphatase levels and increased CD8+ T-cell activation with low CD4 counts at ART initiation should warrant suspicion for subsequent development of MAC-IRIS.engOxford University PressHIVMACMycobacteriumÍRISCRPDímeroFosfatase alcalinaHIVMACMycobacteriumIRISBiomarkerCRPD-dimerAlkaline phosphataseClinical and immunologic predictors of Mycobacterium avium complex immune reconstitution inflammatory syndrome in a contemporary cohort of patients with HIVinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83097https://www.arca.fiocruz.br/bitstream/icict/44392/1/license.txt36b51ef91c52b5338d9d29ba0cc807bcMD51ORIGINALBreglio, K. F. Clinical....pdfBreglio, K. F. 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dc.title.pt_BR.fl_str_mv Clinical and immunologic predictors of Mycobacterium avium complex immune reconstitution inflammatory syndrome in a contemporary cohort of patients with HIV
title Clinical and immunologic predictors of Mycobacterium avium complex immune reconstitution inflammatory syndrome in a contemporary cohort of patients with HIV
spellingShingle Clinical and immunologic predictors of Mycobacterium avium complex immune reconstitution inflammatory syndrome in a contemporary cohort of patients with HIV
Breglio, Kimberly F.
HIV
MAC
Mycobacterium
ÍRIS
CRP
Dímero
Fosfatase alcalina
HIV
MAC
Mycobacterium
IRIS
Biomarker
CRP
D-dimer
Alkaline phosphatase
title_short Clinical and immunologic predictors of Mycobacterium avium complex immune reconstitution inflammatory syndrome in a contemporary cohort of patients with HIV
title_full Clinical and immunologic predictors of Mycobacterium avium complex immune reconstitution inflammatory syndrome in a contemporary cohort of patients with HIV
title_fullStr Clinical and immunologic predictors of Mycobacterium avium complex immune reconstitution inflammatory syndrome in a contemporary cohort of patients with HIV
title_full_unstemmed Clinical and immunologic predictors of Mycobacterium avium complex immune reconstitution inflammatory syndrome in a contemporary cohort of patients with HIV
title_sort Clinical and immunologic predictors of Mycobacterium avium complex immune reconstitution inflammatory syndrome in a contemporary cohort of patients with HIV
author Breglio, Kimberly F.
author_facet Breglio, Kimberly F.
Vinhaes, Caian L.
Arriaga Gutiérrez, María Belen
Nason, Martha
Roby, Gregg
Adelsberger, Joseph
Andrade, Bruno de Bezerril
Sheikh, Virginia
Sereti, Irini
author_role author
author2 Vinhaes, Caian L.
Arriaga Gutiérrez, María Belen
Nason, Martha
Roby, Gregg
Adelsberger, Joseph
Andrade, Bruno de Bezerril
Sheikh, Virginia
Sereti, Irini
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Breglio, Kimberly F.
Vinhaes, Caian L.
Arriaga Gutiérrez, María Belen
Nason, Martha
Roby, Gregg
Adelsberger, Joseph
Andrade, Bruno de Bezerril
Sheikh, Virginia
Sereti, Irini
dc.subject.other.pt_BR.fl_str_mv HIV
MAC
Mycobacterium
ÍRIS
CRP
Dímero
Fosfatase alcalina
topic HIV
MAC
Mycobacterium
ÍRIS
CRP
Dímero
Fosfatase alcalina
HIV
MAC
Mycobacterium
IRIS
Biomarker
CRP
D-dimer
Alkaline phosphatase
dc.subject.en.pt_BR.fl_str_mv HIV
MAC
Mycobacterium
IRIS
Biomarker
CRP
D-dimer
Alkaline phosphatase
description Intramural Research program of the National Institute of Allergy and Infectious Diseases at the National Institutes of Health (NIH). This research was also made possible through the NIH Medical Research Scholars Program, a public-private partnership supported jointly by the NIH and generous contributions to the Foundation for the NIH from Pfizer Inc, The Doris Duke Charitable Foundation, The Alexandria Real Estate Equities, Inc. and Mr. and Mrs. Joel S. Marcus, and the Howard Hughes Medical Institute, as well as other private donors. The work of BBA is supported by the Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq; senior fellow) and by the Intramural Research Program of the Fundação Oswaldo Cruz, Brazil. CLV received a research fellowship from CNPq. MBA received a research fellowship from the Fundação de Amparo à Pesquisa do Estado da Bahia (FAPESB).
publishDate 2020
dc.date.accessioned.fl_str_mv 2020-11-13T12:27:54Z
dc.date.available.fl_str_mv 2020-11-13T12:27:54Z
dc.date.issued.fl_str_mv 2020
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv BREGLIO, Kimberly F. et al. Clinical and immunologic predictors of Mycobacterium avium complex immune reconstitution inflammatory syndrome in a contemporary cohort of patients with HIV. Journal of Infectious Diseases, p. 1-26, 2020.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/44392
dc.identifier.issn.pt_BR.fl_str_mv 0022-1899
dc.identifier.doi.pt_BR.fl_str_mv 10.1093/infdis/jiaa669
identifier_str_mv BREGLIO, Kimberly F. et al. Clinical and immunologic predictors of Mycobacterium avium complex immune reconstitution inflammatory syndrome in a contemporary cohort of patients with HIV. Journal of Infectious Diseases, p. 1-26, 2020.
0022-1899
10.1093/infdis/jiaa669
url https://www.arca.fiocruz.br/handle/icict/44392
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Oxford University Press
publisher.none.fl_str_mv Oxford University Press
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
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collection Repositório Institucional da FIOCRUZ (ARCA)
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