Emergence of Polyfunctional Cytotoxic CD4+ T Cells in Mycobacterium avium Immune Reconstitution Inflammatory Syndrome in Human Immunodeficiency Virus-Infected Patients

Detalhes bibliográficos
Autor(a) principal: Hsu, Denise C
Data de Publicação: 2018
Outros Autores: Breglio, Kimberly F, Pei, Luxin, Wong, Chun-Shu, Andrade, Bruno de Bezerril, Sheikh, Virginia, Smelkinson, Margery, Petrovas, Constantinos, Rupert, Adam, Santana, Leonardo Gil, Zelazny, Adrian, Holland, Steven M, Olivier, Kenneth, Barber, Daniel, Sereti, Irini
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/25926
Resumo: Andrade, Bruno de Bezerril. Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. 1Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, Maryland; 2Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, 3Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative, Fundação José Silveira, and 4Curso de Medicina, Faculdade de Tecnologia e Ciências, Salvador, Bahia, Brazil; 5Wellcome Centre for Infectious Disease Research in Africa, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, South Africa; 6Division of Infectious Diseases, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee; 7Biological Imaging Section, NIAID and 8Tissue Analysis Core Section, Vaccine Research Center, NIAID, NIH, Bethesda, Maryland; 9Functional Immunology Section, AIDS Monitoring Laboratory, SAIC-Frederick, National Cancer Institute, National Institutes of Health, Frederick, Maryland; and 10Department of Laboratory Medicine, 11Laboratory of Clinical Infectious Diseases, NIAID, 12Pulmonary Clinical Medicine Section, National Heart, Lung, and Blood Institute, and 13Laboratory of Parasitic Diseases, NIAID, NIH, Bethesda, Maryland
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spelling Hsu, Denise CBreglio, Kimberly FPei, LuxinWong, Chun-ShuAndrade, Bruno de BezerrilSheikh, VirginiaSmelkinson, MargeryPetrovas, ConstantinosRupert, AdamSantana, Leonardo GilZelazny, AdrianHolland, Steven MOlivier, KennethBarber, DanielSereti, Irini2018-04-18T13:17:51Z2018-04-18T13:17:51Z2018HSU, D. C. et al. Emergence of Polyfunctional Cytotoxic CD4+ T Cells in Mycobacterium avium Immune Reconstitution Inflammatory Syndrome in Human Immunodeficiency Virus-Infected Patients. Clinical Infectious Diseases, 2018.1058-4838https://www.arca.fiocruz.br/handle/icict/2592610.1093/cid/ciy016Andrade, Bruno de Bezerril. Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. 1Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, Maryland; 2Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, 3Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative, Fundação José Silveira, and 4Curso de Medicina, Faculdade de Tecnologia e Ciências, Salvador, Bahia, Brazil; 5Wellcome Centre for Infectious Disease Research in Africa, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, South Africa; 6Division of Infectious Diseases, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee; 7Biological Imaging Section, NIAID and 8Tissue Analysis Core Section, Vaccine Research Center, NIAID, NIH, Bethesda, Maryland; 9Functional Immunology Section, AIDS Monitoring Laboratory, SAIC-Frederick, National Cancer Institute, National Institutes of Health, Frederick, Maryland; and 10Department of Laboratory Medicine, 11Laboratory of Clinical Infectious Diseases, NIAID, 12Pulmonary Clinical Medicine Section, National Heart, Lung, and Blood Institute, and 13Laboratory of Parasitic Diseases, NIAID, NIH, Bethesda, MarylandIntramural Research Program of the NIAID at the NIH.Múltipla – ver em NotasImmune reconstitution inflammatory syndrome (IRIS) is an aberrant inflammatory response in individuals with advanced human immunodeficiency virus (HIV) infection, after antiretroviral therapy (ART) initiation. The pathogenesis of Mycobacterium avium complex (MAC)-associated IRIS has not been fully elucidated. Methods. We investigated monocyte and CD4+ T-cell responses in vitro, tumor necrosis factor (TNF) expression in tissues, and plasma cytokines and inflammatory markers, in 13 HIV-infected patients with MAC-IRIS and 14 HIV-uninfected patients with pulmonary MAC infection. Results. Prior to ART, HIV-infected compared with HIV-uninfected patients, had reduced TNF+ monocytes (P = .013), although similar cytokine (interferon gamma [IFN-γ], TNF, interleukin 2 [IL-2], and interleukin 17 [IL-17])–expressing CD4+ T cells. During IRIS, monocyte cytokine production was restored. IFN-γ+ (P = .027), TNF+ (P = .004), and polyfunctional CD4+ T cells (P = 0.03) also increased. These effectors were T-betlow, and some expressed markers of degranulation and cytotoxic potential. Blockade of cytotoxic T-lymphocyte associated protein 4 and lymphocyte activation gene-3 further increased CD4+ T-cell cytokine production. Tissue immunofluorescence showed higher proportions of CD4+ and CD68+ (monocyte/macrophage) cells expressed TNF during IRIS compared with HIV-uninfected patients. Plasma IFN-γ (P = .048), C-reactive protein (P = .008), and myeloperoxidase (P < .001) levels also increased, whereas interleukin 10 decreased (P = .008) during IRIS. Conclusions. Advanced HIV infection was associated with impaired MAC responses. Restoration of monocyte responses and expansion of polyfunctional MAC-specific T-betlow CD4+ T cells with cytotoxic potential after ART initiation may overwhelm existing regulatory and inhibitory mechanisms, leading to MAC-IRIS.engOxford University PressSíndrome inflamatória de reconstituição imuneÍRISComplexo Mycobacterium aviumMACHIVImmune reconstitution inflammatory syndromeIRISMycobacterium avium complexMACHIVEmergence of Polyfunctional Cytotoxic CD4+ T Cells in Mycobacterium avium Immune Reconstitution Inflammatory Syndrome in Human Immunodeficiency Virus-Infected Patientsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/25926/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALHsu D Emergence of Polyfunctional 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dc.title.pt_BR.fl_str_mv Emergence of Polyfunctional Cytotoxic CD4+ T Cells in Mycobacterium avium Immune Reconstitution Inflammatory Syndrome in Human Immunodeficiency Virus-Infected Patients
title Emergence of Polyfunctional Cytotoxic CD4+ T Cells in Mycobacterium avium Immune Reconstitution Inflammatory Syndrome in Human Immunodeficiency Virus-Infected Patients
spellingShingle Emergence of Polyfunctional Cytotoxic CD4+ T Cells in Mycobacterium avium Immune Reconstitution Inflammatory Syndrome in Human Immunodeficiency Virus-Infected Patients
Hsu, Denise C
Síndrome inflamatória de reconstituição imune
ÍRIS
Complexo Mycobacterium avium
MAC
HIV
Immune reconstitution inflammatory syndrome
IRIS
Mycobacterium avium complex
MAC
HIV
title_short Emergence of Polyfunctional Cytotoxic CD4+ T Cells in Mycobacterium avium Immune Reconstitution Inflammatory Syndrome in Human Immunodeficiency Virus-Infected Patients
title_full Emergence of Polyfunctional Cytotoxic CD4+ T Cells in Mycobacterium avium Immune Reconstitution Inflammatory Syndrome in Human Immunodeficiency Virus-Infected Patients
title_fullStr Emergence of Polyfunctional Cytotoxic CD4+ T Cells in Mycobacterium avium Immune Reconstitution Inflammatory Syndrome in Human Immunodeficiency Virus-Infected Patients
title_full_unstemmed Emergence of Polyfunctional Cytotoxic CD4+ T Cells in Mycobacterium avium Immune Reconstitution Inflammatory Syndrome in Human Immunodeficiency Virus-Infected Patients
title_sort Emergence of Polyfunctional Cytotoxic CD4+ T Cells in Mycobacterium avium Immune Reconstitution Inflammatory Syndrome in Human Immunodeficiency Virus-Infected Patients
author Hsu, Denise C
author_facet Hsu, Denise C
Breglio, Kimberly F
Pei, Luxin
Wong, Chun-Shu
Andrade, Bruno de Bezerril
Sheikh, Virginia
Smelkinson, Margery
Petrovas, Constantinos
Rupert, Adam
Santana, Leonardo Gil
Zelazny, Adrian
Holland, Steven M
Olivier, Kenneth
Barber, Daniel
Sereti, Irini
author_role author
author2 Breglio, Kimberly F
Pei, Luxin
Wong, Chun-Shu
Andrade, Bruno de Bezerril
Sheikh, Virginia
Smelkinson, Margery
Petrovas, Constantinos
Rupert, Adam
Santana, Leonardo Gil
Zelazny, Adrian
Holland, Steven M
Olivier, Kenneth
Barber, Daniel
Sereti, Irini
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Hsu, Denise C
Breglio, Kimberly F
Pei, Luxin
Wong, Chun-Shu
Andrade, Bruno de Bezerril
Sheikh, Virginia
Smelkinson, Margery
Petrovas, Constantinos
Rupert, Adam
Santana, Leonardo Gil
Zelazny, Adrian
Holland, Steven M
Olivier, Kenneth
Barber, Daniel
Sereti, Irini
dc.subject.other.pt_BR.fl_str_mv Síndrome inflamatória de reconstituição imune
ÍRIS
Complexo Mycobacterium avium
MAC
HIV
topic Síndrome inflamatória de reconstituição imune
ÍRIS
Complexo Mycobacterium avium
MAC
HIV
Immune reconstitution inflammatory syndrome
IRIS
Mycobacterium avium complex
MAC
HIV
dc.subject.en.pt_BR.fl_str_mv Immune reconstitution inflammatory syndrome
IRIS
Mycobacterium avium complex
MAC
HIV
description Andrade, Bruno de Bezerril. Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. 1Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, Maryland; 2Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, 3Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative, Fundação José Silveira, and 4Curso de Medicina, Faculdade de Tecnologia e Ciências, Salvador, Bahia, Brazil; 5Wellcome Centre for Infectious Disease Research in Africa, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, South Africa; 6Division of Infectious Diseases, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee; 7Biological Imaging Section, NIAID and 8Tissue Analysis Core Section, Vaccine Research Center, NIAID, NIH, Bethesda, Maryland; 9Functional Immunology Section, AIDS Monitoring Laboratory, SAIC-Frederick, National Cancer Institute, National Institutes of Health, Frederick, Maryland; and 10Department of Laboratory Medicine, 11Laboratory of Clinical Infectious Diseases, NIAID, 12Pulmonary Clinical Medicine Section, National Heart, Lung, and Blood Institute, and 13Laboratory of Parasitic Diseases, NIAID, NIH, Bethesda, Maryland
publishDate 2018
dc.date.accessioned.fl_str_mv 2018-04-18T13:17:51Z
dc.date.available.fl_str_mv 2018-04-18T13:17:51Z
dc.date.issued.fl_str_mv 2018
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.citation.fl_str_mv HSU, D. C. et al. Emergence of Polyfunctional Cytotoxic CD4+ T Cells in Mycobacterium avium Immune Reconstitution Inflammatory Syndrome in Human Immunodeficiency Virus-Infected Patients. Clinical Infectious Diseases, 2018.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/25926
dc.identifier.issn.pt_BR.fl_str_mv 1058-4838
dc.identifier.doi.none.fl_str_mv 10.1093/cid/ciy016
identifier_str_mv HSU, D. C. et al. Emergence of Polyfunctional Cytotoxic CD4+ T Cells in Mycobacterium avium Immune Reconstitution Inflammatory Syndrome in Human Immunodeficiency Virus-Infected Patients. Clinical Infectious Diseases, 2018.
1058-4838
10.1093/cid/ciy016
url https://www.arca.fiocruz.br/handle/icict/25926
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Oxford University Press
publisher.none.fl_str_mv Oxford University Press
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
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