Involvement of the capsular GalXM-induced IL-17 cytokine in the control of Cryptococcus neoformans infection

Detalhes bibliográficos
Autor(a) principal: Freitas, Isabel Ferreira LaRocque de
Data de Publicação: 2018
Outros Autores: Rocha, Juliana Dutra B., Nunes, Marise Pinheiro, Oliveira, Priscila Angelica V., Nascimento, Danielle de Oliveira, Lima, Leonardo Freire de, Takiya, Christina Maeda, Morrot, Alexandre, Ricardo, Debora Decote, Previato, Jose Osvaldo, Previato, Lucia Mendonça, Lima, Celio Geraldo Freire de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/31228
Resumo: Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil.
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spelling Freitas, Isabel Ferreira LaRocque deRocha, Juliana Dutra B.Nunes, Marise PinheiroOliveira, Priscila Angelica V.Nascimento, Danielle de OliveiraLima, Leonardo Freire deTakiya, Christina MaedaMorrot, AlexandreRicardo, Debora DecotePreviato, Jose OsvaldoPreviato, Lucia MendonçaLima, Celio Geraldo Freire de2019-01-22T15:42:06Z2019-01-22T15:42:06Z2018FREITAS, Isabel Fereira LaRocque de; et al. Involvement of the capsular GalXMinduced IL-17 cytokine in the control of Cryptococcus neoformans infection. Scientific Reports, v.8, 16378, 16p, Nov. 2018.2045-2322https://www.arca.fiocruz.br/handle/icict/3122810.1038/s41598-018-34649-4engNature ResearchCryptococcus neoformanscitocina IL-17 capsuladaInfecçãoGalXMinducedControleCryptococcus neoformansInfectionIL-17 cytokineControlecapsular GalXMinducedInvolvement of the capsular GalXM-induced IL-17 cytokine in the control of Cryptococcus neoformans infectioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ. Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ. Brasil / Universidade Federal do Rio de Janeiro. Faculdade de Medicina. Rio de Janeiro, RJ, Brasil.Universidade Federal Rural do Rio de Janeiro. Instituto de Veterinária. Seropédica, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil.Cryptococcus neoformans is an opportunistic fungus that can cause lethal brain infections in immunosuppressed individuals. Infection usually occurs via the inhalation of a spore or desiccated yeast which can then disseminate from the lung to the brain and other tissues. Dissemination and disease is largely influence by the production of copious amounts of cryptococcal polysaccharides, both which are secreted to the extracellular environment or assembled into a thick capsule surrounding the cell body. There are two important polysaccharides: glucuronoxylomannan (GXM) and galactoxylomannan, also called as glucuronoxylomanogalactan (GXMGal or GalXM). Although GXM is more abundant, GalXM has a more potent modulatory effect. In the present study, we show that GalXM is a potent activator of murine dendritic cells, and when co-cultured with T cells, induces a Th17 cytokine response. We also demonstrated that treating mice with GalXM prior to infection with C. neoformans protects from infection, and this phenomenon is dependent on IL-6 and IL-17. These findings help us understand the immune biology of capsular polysaccharides in fungal pathogenesis.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/31228/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALmarisep_nunes_etal_IOC_2018.pdfmarisep_nunes_etal_IOC_2018.pdfapplication/pdf1948055https://www.arca.fiocruz.br/bitstream/icict/31228/2/marisep_nunes_etal_IOC_2018.pdfaa4c6dd74bde818694451ae1b63ffc83MD52TEXTmarisep_nunes_etal_IOC_2018.pdf.txtmarisep_nunes_etal_IOC_2018.pdf.txtExtracted texttext/plain76925https://www.arca.fiocruz.br/bitstream/icict/31228/3/marisep_nunes_etal_IOC_2018.pdf.txt06b778e7ca9e20baff7e2d133f1269f5MD53icict/312282022-06-24 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dc.title.pt_BR.fl_str_mv Involvement of the capsular GalXM-induced IL-17 cytokine in the control of Cryptococcus neoformans infection
title Involvement of the capsular GalXM-induced IL-17 cytokine in the control of Cryptococcus neoformans infection
spellingShingle Involvement of the capsular GalXM-induced IL-17 cytokine in the control of Cryptococcus neoformans infection
Freitas, Isabel Ferreira LaRocque de
Cryptococcus neoformans
citocina IL-17 capsulada
Infecção
GalXMinduced
Controle
Cryptococcus neoformans
Infection
IL-17 cytokine
Controle
capsular GalXMinduced
title_short Involvement of the capsular GalXM-induced IL-17 cytokine in the control of Cryptococcus neoformans infection
title_full Involvement of the capsular GalXM-induced IL-17 cytokine in the control of Cryptococcus neoformans infection
title_fullStr Involvement of the capsular GalXM-induced IL-17 cytokine in the control of Cryptococcus neoformans infection
title_full_unstemmed Involvement of the capsular GalXM-induced IL-17 cytokine in the control of Cryptococcus neoformans infection
title_sort Involvement of the capsular GalXM-induced IL-17 cytokine in the control of Cryptococcus neoformans infection
author Freitas, Isabel Ferreira LaRocque de
author_facet Freitas, Isabel Ferreira LaRocque de
Rocha, Juliana Dutra B.
Nunes, Marise Pinheiro
Oliveira, Priscila Angelica V.
Nascimento, Danielle de Oliveira
Lima, Leonardo Freire de
Takiya, Christina Maeda
Morrot, Alexandre
Ricardo, Debora Decote
Previato, Jose Osvaldo
Previato, Lucia Mendonça
Lima, Celio Geraldo Freire de
author_role author
author2 Rocha, Juliana Dutra B.
Nunes, Marise Pinheiro
Oliveira, Priscila Angelica V.
Nascimento, Danielle de Oliveira
Lima, Leonardo Freire de
Takiya, Christina Maeda
Morrot, Alexandre
Ricardo, Debora Decote
Previato, Jose Osvaldo
Previato, Lucia Mendonça
Lima, Celio Geraldo Freire de
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Freitas, Isabel Ferreira LaRocque de
Rocha, Juliana Dutra B.
Nunes, Marise Pinheiro
Oliveira, Priscila Angelica V.
Nascimento, Danielle de Oliveira
Lima, Leonardo Freire de
Takiya, Christina Maeda
Morrot, Alexandre
Ricardo, Debora Decote
Previato, Jose Osvaldo
Previato, Lucia Mendonça
Lima, Celio Geraldo Freire de
dc.subject.other.pt_BR.fl_str_mv Cryptococcus neoformans
citocina IL-17 capsulada
Infecção
GalXMinduced
Controle
topic Cryptococcus neoformans
citocina IL-17 capsulada
Infecção
GalXMinduced
Controle
Cryptococcus neoformans
Infection
IL-17 cytokine
Controle
capsular GalXMinduced
dc.subject.en.pt_BR.fl_str_mv Cryptococcus neoformans
Infection
IL-17 cytokine
Controle
capsular GalXMinduced
description Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil.
publishDate 2018
dc.date.issued.fl_str_mv 2018
dc.date.accessioned.fl_str_mv 2019-01-22T15:42:06Z
dc.date.available.fl_str_mv 2019-01-22T15:42:06Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv FREITAS, Isabel Fereira LaRocque de; et al. Involvement of the capsular GalXMinduced IL-17 cytokine in the control of Cryptococcus neoformans infection. Scientific Reports, v.8, 16378, 16p, Nov. 2018.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/31228
dc.identifier.issn.pt_BR.fl_str_mv 2045-2322
dc.identifier.doi.none.fl_str_mv 10.1038/s41598-018-34649-4
identifier_str_mv FREITAS, Isabel Fereira LaRocque de; et al. Involvement of the capsular GalXMinduced IL-17 cytokine in the control of Cryptococcus neoformans infection. Scientific Reports, v.8, 16378, 16p, Nov. 2018.
2045-2322
10.1038/s41598-018-34649-4
url https://www.arca.fiocruz.br/handle/icict/31228
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Nature Research
publisher.none.fl_str_mv Nature Research
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
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