Thalidomide failed to inhibit angiogenesis and fibrosis in hepatic schistosomiasis of the mouse

Detalhes bibliográficos
Autor(a) principal: Lima,Camila Bião
Data de Publicação: 2007
Outros Autores: Iglesias,Karen Brasil, Andrade,Zilton A
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Memórias do Instituto Oswaldo Cruz
Texto Completo: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762007000700017
Resumo: The relationship between angiogenesis and fibrosis has been demonstrated in several pathological conditions, one of them being schistosomiasis. To observe whether suppression of angiogenesis would interfere with fibrosis, Thalidomide, an anti-angiogenesis drug, was administered during 30 consecutive days to mice with experimental schistosomiasis. Computerized morphometric measurements of fibrosis, and the counting of blood vessels from hepatic schistosomal lesions did not significantly differ when treated animals and their controls were compared at the end of the experiments. These rather unexpected results are presented under the understanding that they may be of interest during further studies on the anti-angiogenesis properties of thalidomide, and the relationship between angiogenesis and fibrosis.
id FIOCRUZ-4_fdfea66f19efdd77143c3e0a5af48888
oai_identifier_str oai:scielo:S0074-02762007000700017
network_acronym_str FIOCRUZ-4
network_name_str Memórias do Instituto Oswaldo Cruz
spelling Thalidomide failed to inhibit angiogenesis and fibrosis in hepatic schistosomiasis of the mouseThalidomideschistosomiasisangiogenesisfibrosisThe relationship between angiogenesis and fibrosis has been demonstrated in several pathological conditions, one of them being schistosomiasis. To observe whether suppression of angiogenesis would interfere with fibrosis, Thalidomide, an anti-angiogenesis drug, was administered during 30 consecutive days to mice with experimental schistosomiasis. Computerized morphometric measurements of fibrosis, and the counting of blood vessels from hepatic schistosomal lesions did not significantly differ when treated animals and their controls were compared at the end of the experiments. These rather unexpected results are presented under the understanding that they may be of interest during further studies on the anti-angiogenesis properties of thalidomide, and the relationship between angiogenesis and fibrosis.Instituto Oswaldo Cruz, Ministério da Saúde2007-11-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762007000700017Memórias do Instituto Oswaldo Cruz v.102 n.7 2007reponame:Memórias do Instituto Oswaldo Cruzinstname:Fundação Oswaldo Cruzinstacron:FIOCRUZ10.1590/S0074-02762007005000115info:eu-repo/semantics/openAccessLima,Camila BiãoIglesias,Karen BrasilAndrade,Zilton Aeng2020-04-25T17:50:13Zhttp://www.scielo.br/oai/scielo-oai.php0074-02761678-8060opendoar:null2020-04-26 02:15:23.603Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruztrue
dc.title.none.fl_str_mv Thalidomide failed to inhibit angiogenesis and fibrosis in hepatic schistosomiasis of the mouse
title Thalidomide failed to inhibit angiogenesis and fibrosis in hepatic schistosomiasis of the mouse
spellingShingle Thalidomide failed to inhibit angiogenesis and fibrosis in hepatic schistosomiasis of the mouse
Lima,Camila Bião
Thalidomide
schistosomiasis
angiogenesis
fibrosis
title_short Thalidomide failed to inhibit angiogenesis and fibrosis in hepatic schistosomiasis of the mouse
title_full Thalidomide failed to inhibit angiogenesis and fibrosis in hepatic schistosomiasis of the mouse
title_fullStr Thalidomide failed to inhibit angiogenesis and fibrosis in hepatic schistosomiasis of the mouse
title_full_unstemmed Thalidomide failed to inhibit angiogenesis and fibrosis in hepatic schistosomiasis of the mouse
title_sort Thalidomide failed to inhibit angiogenesis and fibrosis in hepatic schistosomiasis of the mouse
author Lima,Camila Bião
author_facet Lima,Camila Bião
Iglesias,Karen Brasil
Andrade,Zilton A
author_role author
author2 Iglesias,Karen Brasil
Andrade,Zilton A
author2_role author
author
dc.contributor.author.fl_str_mv Lima,Camila Bião
Iglesias,Karen Brasil
Andrade,Zilton A
dc.subject.por.fl_str_mv Thalidomide
schistosomiasis
angiogenesis
fibrosis
topic Thalidomide
schistosomiasis
angiogenesis
fibrosis
dc.description.none.fl_txt_mv The relationship between angiogenesis and fibrosis has been demonstrated in several pathological conditions, one of them being schistosomiasis. To observe whether suppression of angiogenesis would interfere with fibrosis, Thalidomide, an anti-angiogenesis drug, was administered during 30 consecutive days to mice with experimental schistosomiasis. Computerized morphometric measurements of fibrosis, and the counting of blood vessels from hepatic schistosomal lesions did not significantly differ when treated animals and their controls were compared at the end of the experiments. These rather unexpected results are presented under the understanding that they may be of interest during further studies on the anti-angiogenesis properties of thalidomide, and the relationship between angiogenesis and fibrosis.
description The relationship between angiogenesis and fibrosis has been demonstrated in several pathological conditions, one of them being schistosomiasis. To observe whether suppression of angiogenesis would interfere with fibrosis, Thalidomide, an anti-angiogenesis drug, was administered during 30 consecutive days to mice with experimental schistosomiasis. Computerized morphometric measurements of fibrosis, and the counting of blood vessels from hepatic schistosomal lesions did not significantly differ when treated animals and their controls were compared at the end of the experiments. These rather unexpected results are presented under the understanding that they may be of interest during further studies on the anti-angiogenesis properties of thalidomide, and the relationship between angiogenesis and fibrosis.
publishDate 2007
dc.date.none.fl_str_mv 2007-11-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762007000700017
url http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762007000700017
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0074-02762007005000115
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
dc.source.none.fl_str_mv Memórias do Instituto Oswaldo Cruz v.102 n.7 2007
reponame:Memórias do Instituto Oswaldo Cruz
instname:Fundação Oswaldo Cruz
instacron:FIOCRUZ
reponame_str Memórias do Instituto Oswaldo Cruz
collection Memórias do Instituto Oswaldo Cruz
instname_str Fundação Oswaldo Cruz
instacron_str FIOCRUZ
institution FIOCRUZ
repository.name.fl_str_mv Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruz
repository.mail.fl_str_mv
_version_ 1669937701850185728

Registros relacionados