Comparative efficacies of two antimony regimens to treat Leishmania braziliensis-induced cutaneous Leishmaniasis in rhesus macaques (Macaca mulatta)

Detalhes bibliográficos
Autor(a) principal: Grimaldi, G.
Data de Publicação: 2010
Outros Autores: Porrozzi, R., Friedrich, K., Teva, A., Marchevsky, R. S., Vieira, F., Miekeley, N., Paumgartten, F. J. R.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/19309
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Leishmaniose. Rio de Janeiro, RJ. Brasil.
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spelling Grimaldi, G.Porrozzi, R.Friedrich, K.Teva, A.Marchevsky, R. S.Vieira, F.Miekeley, N.Paumgartten, F. J. R.2017-06-06T12:36:55Z2017-06-06T12:36:55Z2010GRIMALDI JR., G. et al. Comparative Efficacies of Two Antimony Regimens To Treat Leishmania braziliensis-Induced Cutaneous Leishmaniasis in Rhesus Macaques (Macaca mulatta). Antimicrobial Agents and Chemotherapy, v.54, n.1, p.502-505, Jan.2010.0066-4804https://www.arca.fiocruz.br/handle/icict/1930910.1128/AAC.00858-091098-6596engAmerican Society for MicrobiologyLeishmaniose cutâneaMacaca mulattaEficáciaAntimônioCutaneous LeishmaniasisRhesus MacaquesAntimony RegimensEfficaciesN-methylglucomine antimoniateComparative efficacies of two antimony regimens to treat Leishmania braziliensis-induced cutaneous Leishmaniasis in rhesus macaques (Macaca mulatta)info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Leishmaniose. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Leishmaniose. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sérgio Arouca. Laboratório de Toxicologia Ambiental. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Leishmaniose. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto de Tecnologia de Imunobiológicos. Laboratório de Neurovirulência. Rio de Janeiro, RJ, Brasil.Pontifícia Universidade Católica do Rio de Janeiro. Departamento de Química. Rio de Janeiro, RJ, Brasil.Pontifícia Universidade Católica do Rio de Janeiro. Departamento de Química. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sérgio Arouca. Laboratório de Toxicologia Ambiental. Rio de Janeiro, RJ, Brasil.This study compared the efficacies of two N-methylglucomine antimoniate (MA) dose regimens for treating macaques with Leishmania braziliensis-induced chronic skin disease. Whereas all animals treated with the full dose (20 mg MA/kg/day) were cured, 50% of the monkeys receiving a low-dose regimen (5 mg MA/kg/day) relapsed. The antimony concentrations in macaque plasma and tissue samples were greater in the full-dose group than in that receiving a subtherapeutic MA regimen. Our data also suggest the presence of drug-induced hepatic pathology.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALgabriel_grimaldijr3_etal_IOC_2010.pdfgabriel_grimaldijr3_etal_IOC_2010.pdfapplication/pdf1324296https://www.arca.fiocruz.br/bitstream/icict/19309/2/gabriel_grimaldijr3_etal_IOC_2010.pdf0871ed867db708a7b4235b554c31e0f9MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/19309/1/license.txt5a560609d32a3863062d77ff32785d58MD51TEXTgabriel_grimaldijr3_etal_IOC_2010.pdf.txtgabriel_grimaldijr3_etal_IOC_2010.pdf.txtExtracted texttext/plain15124https://www.arca.fiocruz.br/bitstream/icict/19309/3/gabriel_grimaldijr3_etal_IOC_2010.pdf.txt2eab238a11a3c1ce8031e60760f73e3cMD53icict/193092022-06-24 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dc.title.pt_BR.fl_str_mv Comparative efficacies of two antimony regimens to treat Leishmania braziliensis-induced cutaneous Leishmaniasis in rhesus macaques (Macaca mulatta)
title Comparative efficacies of two antimony regimens to treat Leishmania braziliensis-induced cutaneous Leishmaniasis in rhesus macaques (Macaca mulatta)
spellingShingle Comparative efficacies of two antimony regimens to treat Leishmania braziliensis-induced cutaneous Leishmaniasis in rhesus macaques (Macaca mulatta)
Grimaldi, G.
Leishmaniose cutânea
Macaca mulatta
Eficácia
Antimônio
Cutaneous Leishmaniasis
Rhesus Macaques
Antimony Regimens
Efficacies
N-methylglucomine antimoniate
title_short Comparative efficacies of two antimony regimens to treat Leishmania braziliensis-induced cutaneous Leishmaniasis in rhesus macaques (Macaca mulatta)
title_full Comparative efficacies of two antimony regimens to treat Leishmania braziliensis-induced cutaneous Leishmaniasis in rhesus macaques (Macaca mulatta)
title_fullStr Comparative efficacies of two antimony regimens to treat Leishmania braziliensis-induced cutaneous Leishmaniasis in rhesus macaques (Macaca mulatta)
title_full_unstemmed Comparative efficacies of two antimony regimens to treat Leishmania braziliensis-induced cutaneous Leishmaniasis in rhesus macaques (Macaca mulatta)
title_sort Comparative efficacies of two antimony regimens to treat Leishmania braziliensis-induced cutaneous Leishmaniasis in rhesus macaques (Macaca mulatta)
author Grimaldi, G.
author_facet Grimaldi, G.
Porrozzi, R.
Friedrich, K.
Teva, A.
Marchevsky, R. S.
Vieira, F.
Miekeley, N.
Paumgartten, F. J. R.
author_role author
author2 Porrozzi, R.
Friedrich, K.
Teva, A.
Marchevsky, R. S.
Vieira, F.
Miekeley, N.
Paumgartten, F. J. R.
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Grimaldi, G.
Porrozzi, R.
Friedrich, K.
Teva, A.
Marchevsky, R. S.
Vieira, F.
Miekeley, N.
Paumgartten, F. J. R.
dc.subject.other.pt_BR.fl_str_mv Leishmaniose cutânea
Macaca mulatta
Eficácia
Antimônio
topic Leishmaniose cutânea
Macaca mulatta
Eficácia
Antimônio
Cutaneous Leishmaniasis
Rhesus Macaques
Antimony Regimens
Efficacies
N-methylglucomine antimoniate
dc.subject.en.pt_BR.fl_str_mv Cutaneous Leishmaniasis
Rhesus Macaques
Antimony Regimens
Efficacies
N-methylglucomine antimoniate
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Leishmaniose. Rio de Janeiro, RJ. Brasil.
publishDate 2010
dc.date.issued.fl_str_mv 2010
dc.date.accessioned.fl_str_mv 2017-06-06T12:36:55Z
dc.date.available.fl_str_mv 2017-06-06T12:36:55Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv GRIMALDI JR., G. et al. Comparative Efficacies of Two Antimony Regimens To Treat Leishmania braziliensis-Induced Cutaneous Leishmaniasis in Rhesus Macaques (Macaca mulatta). Antimicrobial Agents and Chemotherapy, v.54, n.1, p.502-505, Jan.2010.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/19309
dc.identifier.issn.pt_BR.fl_str_mv 0066-4804
dc.identifier.doi.none.fl_str_mv 10.1128/AAC.00858-09
dc.identifier.eissn.none.fl_str_mv 1098-6596
identifier_str_mv GRIMALDI JR., G. et al. Comparative Efficacies of Two Antimony Regimens To Treat Leishmania braziliensis-Induced Cutaneous Leishmaniasis in Rhesus Macaques (Macaca mulatta). Antimicrobial Agents and Chemotherapy, v.54, n.1, p.502-505, Jan.2010.
0066-4804
10.1128/AAC.00858-09
1098-6596
url https://www.arca.fiocruz.br/handle/icict/19309
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv American Society for Microbiology
publisher.none.fl_str_mv American Society for Microbiology
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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