Immune and inflammatory responses to Leishmania amazonensis isolated from different clinical forms of human leishmaniasis in CBA mice
Autor(a) principal: | |
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Data de Publicação: | 2011 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/1750 |
Resumo: | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil. |
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Souza, Valderes Lemos deVeras, Patrícia Sampaio TavaresBorges, Marcus WelbySilva, Tânia Maria CorreiaLeite, Bruna RFerraro, Rodrigo BFernandes, José Roberto MeyerBarral, Aldina Maria PradoCosta, Jackson Mauricio LopesFreitas, Luiz Antonio Rodrigues de2011-03-26T16:43:34Z2011-03-26T16:43:34Z2011SOUZA, V. L. et al. Immune and inflammatory responses to Leishmania amazonensis isolated from different clinical forms of human leishmaniasis in CBA mice. Memórias do Instituto Oswaldo Cruz, v.106, n.1, p.23-31, 2011.0074-0276https://www.arca.fiocruz.br/handle/icict/1750engACS PublicationsLeishmania amazonensisResposta inflamatóriaAtividade enzimaticaInflammatory responsesEnzymatic activityMiceLeishmanioseParasitosesCamundongos Endogâmicos CBAAnimaisImmune and inflammatory responses to Leishmania amazonensis isolated from different clinical forms of human leishmaniasis in CBA miceinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Instituto de Ciências da Saúde. Departamento de Biointeração. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.Universidade Federal do Rio de Janeiro. Departamento de Bioquímica Médica. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Departamento de Bioquímica Médica. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Departamento de Patologia e Medicina Legal. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / / Universidade Federal da Bahia. Faculdade de Medicina. Departamento de Patologia e Medicina Legal. Salvador, BA, Brasil.Leishmania amazonensis causes different diseases depending on the host and parasitic virulence factors. In this study, CBA mice were infected with L. amazonensis isolates from patients with localized (Ba125), diffuse cutaneous (Ba276) or visceral leishmaniasis (Ba109). Mice infected with Ba125 and Ba276 progressed rapidly and lesions displayed an infiltrate rich in parasitized macrophages and were necrotic and ulcerated. Ba109 induced smaller lesions and a mixed inflammatory infiltrate without necrosis or ulceration. Ba109 induced an insidious disease with lower parasite load in CBA mice, similar to human disease. Levels of IFN-γ, IL-4 and IL-10 did not differ among the groups. Because all groups were unable to control the infection, expression of IL-4 associated with low production of IFN-γ in the early phase of infection may account for susceptibility, but others factors may contribute to the differences observed in inflammatory responses and infection progression. Evaluation of some parasitic virulence factors revealed that Ba276 exhibits higher ecto-ADPase and 5'-nucleotidase activities compared to the Ba109 and Ba125 strains. Both Ba276 and Ba125 had higher arginase activity in comparison to Ba109. Finally, these data suggest that the differences in enzyme activities among parasites can account for differences in host inflammatory responses and infection progression.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://www.arca.fiocruz.br/bitstream/icict/1750/2/license.txt8a4605be74aa9ea9d79846c1fba20a33MD52TEXTMechanisms Involved in the Antinociceptive Effects of 7-Hydroxycoumarin.pdf.txtMechanisms Involved in the Antinociceptive Effects of 7-Hydroxycoumarin.pdf.txtExtracted texttext/plain36370https://www.arca.fiocruz.br/bitstream/icict/1750/5/Mechanisms%20Involved%20in%20the%20Antinociceptive%20Effects%20of%207-Hydroxycoumarin.pdf.txtc1a737970bd6795baaef264c5d37b6f2MD55ve_Valderes_Souza_etal_IGM_2011.pdf.txtve_Valderes_Souza_etal_IGM_2011.pdf.txtExtracted texttext/plain40747https://www.arca.fiocruz.br/bitstream/icict/1750/7/ve_Valderes_Souza_etal_IGM_2011.pdf.txtce2371323290af87ad8ce9008f4ca7a4MD57THUMBNAILMechanisms Involved in the Antinociceptive Effects of 7-Hydroxycoumarin.pdf.jpgMechanisms Involved in the Antinociceptive Effects of 7-Hydroxycoumarin.pdf.jpgGenerated Thumbnailimage/jpeg2440https://www.arca.fiocruz.br/bitstream/icict/1750/4/Mechanisms%20Involved%20in%20the%20Antinociceptive%20Effects%20of%207-Hydroxycoumarin.pdf.jpgad69d8894b2e19d19cb944157c599cd7MD54ORIGINALve_Valderes_Souza_etal_IGM_2011.pdfve_Valderes_Souza_etal_IGM_2011.pdfapplication/pdf1448897https://www.arca.fiocruz.br/bitstream/icict/1750/6/ve_Valderes_Souza_etal_IGM_2011.pdf3211b4b44fa58857f76fbcda28ada9b3MD56icict/17502023-03-15 14:33:57.038oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:57Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
dc.title.pt_BR.fl_str_mv |
Immune and inflammatory responses to Leishmania amazonensis isolated from different clinical forms of human leishmaniasis in CBA mice |
title |
Immune and inflammatory responses to Leishmania amazonensis isolated from different clinical forms of human leishmaniasis in CBA mice |
spellingShingle |
Immune and inflammatory responses to Leishmania amazonensis isolated from different clinical forms of human leishmaniasis in CBA mice Souza, Valderes Lemos de Leishmania amazonensis Resposta inflamatória Atividade enzimatica Inflammatory responses Enzymatic activity Mice Leishmaniose Parasitoses Camundongos Endogâmicos CBA Animais |
title_short |
Immune and inflammatory responses to Leishmania amazonensis isolated from different clinical forms of human leishmaniasis in CBA mice |
title_full |
Immune and inflammatory responses to Leishmania amazonensis isolated from different clinical forms of human leishmaniasis in CBA mice |
title_fullStr |
Immune and inflammatory responses to Leishmania amazonensis isolated from different clinical forms of human leishmaniasis in CBA mice |
title_full_unstemmed |
Immune and inflammatory responses to Leishmania amazonensis isolated from different clinical forms of human leishmaniasis in CBA mice |
title_sort |
Immune and inflammatory responses to Leishmania amazonensis isolated from different clinical forms of human leishmaniasis in CBA mice |
author |
Souza, Valderes Lemos de |
author_facet |
Souza, Valderes Lemos de Veras, Patrícia Sampaio Tavares Borges, Marcus Welby Silva, Tânia Maria Correia Leite, Bruna R Ferraro, Rodrigo B Fernandes, José Roberto Meyer Barral, Aldina Maria Prado Costa, Jackson Mauricio Lopes Freitas, Luiz Antonio Rodrigues de |
author_role |
author |
author2 |
Veras, Patrícia Sampaio Tavares Borges, Marcus Welby Silva, Tânia Maria Correia Leite, Bruna R Ferraro, Rodrigo B Fernandes, José Roberto Meyer Barral, Aldina Maria Prado Costa, Jackson Mauricio Lopes Freitas, Luiz Antonio Rodrigues de |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Souza, Valderes Lemos de Veras, Patrícia Sampaio Tavares Borges, Marcus Welby Silva, Tânia Maria Correia Leite, Bruna R Ferraro, Rodrigo B Fernandes, José Roberto Meyer Barral, Aldina Maria Prado Costa, Jackson Mauricio Lopes Freitas, Luiz Antonio Rodrigues de |
dc.subject.other.pt_BR.fl_str_mv |
Leishmania amazonensis Resposta inflamatória Atividade enzimatica |
topic |
Leishmania amazonensis Resposta inflamatória Atividade enzimatica Inflammatory responses Enzymatic activity Mice Leishmaniose Parasitoses Camundongos Endogâmicos CBA Animais |
dc.subject.en.pt_BR.fl_str_mv |
Inflammatory responses Enzymatic activity Mice |
dc.subject.decs.pt_BR.fl_str_mv |
Leishmaniose Parasitoses Camundongos Endogâmicos CBA Animais |
description |
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil. |
publishDate |
2011 |
dc.date.accessioned.fl_str_mv |
2011-03-26T16:43:34Z |
dc.date.available.fl_str_mv |
2011-03-26T16:43:34Z |
dc.date.issued.fl_str_mv |
2011 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
SOUZA, V. L. et al. Immune and inflammatory responses to Leishmania amazonensis isolated from different clinical forms of human leishmaniasis in CBA mice. Memórias do Instituto Oswaldo Cruz, v.106, n.1, p.23-31, 2011. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/1750 |
dc.identifier.issn.none.fl_str_mv |
0074-0276 |
identifier_str_mv |
SOUZA, V. L. et al. Immune and inflammatory responses to Leishmania amazonensis isolated from different clinical forms of human leishmaniasis in CBA mice. Memórias do Instituto Oswaldo Cruz, v.106, n.1, p.23-31, 2011. 0074-0276 |
url |
https://www.arca.fiocruz.br/handle/icict/1750 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
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info:eu-repo/semantics/openAccess |
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openAccess |
dc.publisher.none.fl_str_mv |
ACS Publications |
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ACS Publications |
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Repositório Institucional da FIOCRUZ (ARCA) |
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