CHROMOSOMAL ABERRATIONS IN LEUKOCYTE METAPHASES OF LEPROSY PATIENTS UNDER DAPSONE THERAPY
Autor(a) principal: | |
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Data de Publicação: | 1976 |
Outros Autores: | |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Hansenologia Internationalis (Online) |
Texto Completo: | https://periodicos.saude.sp.gov.br/hansenologia/article/view/35675 |
Resumo: | Chromosome analyses were made on leukocyte metaphases of 18 leprosy patients who were ingesting daily doses of 50 mg or 100 mg of DDS and of 40 healthy individuals used for control. These analyses have shown that the proportion of numerical chromosomal aberrations in the leukocyte metaphases of the leprosy patients did not differ significantly from that observed in the cells of the controls. In contrast, the frequency of cells with chromatid or chromosome breaks and gaps was significantly increased in the leukocytes of leprosy patients. Multiple regression analysis applied to the data recorded has shown that the increase of breaks and gaps in the chromosomes of leprosy patients can not be attributed to age, years under sulfonetherapy or to concentration of DDS in blood. |
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CHROMOSOMAL ABERRATIONS IN LEUKOCYTE METAPHASES OF LEPROSY PATIENTS UNDER DAPSONE THERAPY Aberrações cromossômicas em metáfases de leucócitos de pacientes de lepra sobterapia com dapsonaHanseniaseTerapêuticaDapsonaGenéticaAnálise cromossômicaAberrações cromossõmicasHanseniasisTherapyDapsoneGeneticsChromosome analysisChromosomal aberrationsChromosome analyses were made on leukocyte metaphases of 18 leprosy patients who were ingesting daily doses of 50 mg or 100 mg of DDS and of 40 healthy individuals used for control. These analyses have shown that the proportion of numerical chromosomal aberrations in the leukocyte metaphases of the leprosy patients did not differ significantly from that observed in the cells of the controls. In contrast, the frequency of cells with chromatid or chromosome breaks and gaps was significantly increased in the leukocytes of leprosy patients. Multiple regression analysis applied to the data recorded has shown that the increase of breaks and gaps in the chromosomes of leprosy patients can not be attributed to age, years under sulfonetherapy or to concentration of DDS in blood.As metáfases obtidas por cultura de leucócitos de 18 doentes de lepra, que ingeriam doses diárias de 50 mg a 100 mg de DDS, e de 40 indivíduos sadios tomados para controle foram submetidas a estudos cromossômicos. Nessas análises verificou-se que a proporção de aberrações numéricas dos cromossomos nas metáfases dos doentes de lepra não diferiu significativamente da observada nas células dos controles. Em oposição, a freqüência de metáfases com quebras e falhas cromatídicas e cromossômicas foi significativamente mais alta nos leucócitos dos doentes de lepra. A análise dos dados estudados por regressão múltipla permitiu constatar que o aumento das quebras e falhas cromossômicas nas metáfases dos doentes de lepra não pode ser atribuído à idade, aos anos sob sulfonoterapia, nem aos níveis sangüíneos de DDS.Instituto Lauro de Souza Lima da Secretaria de Estado da Saúde de São Paulo1976-06-30info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionAvaliado pelos paresapplication/pdfhttps://periodicos.saude.sp.gov.br/hansenologia/article/view/3567510.47878/hi.1976.v1.35675Hansenologia Internationalis: leprosy and other infectious diseases; Vol. 1 No. 1 (1976); 53-60Hansenologia Internationalis: hanseníase e outras doenças infecciosas; v. 1 n. 1 (1976); 53-601982-5161reponame:Hansenologia Internationalis (Online)instname:Instituto Lauro de Souza Lima (ILSL)instacron:ILSLporhttps://periodicos.saude.sp.gov.br/hansenologia/article/view/35675/34084BEIGUELMAN, B.PISANI, R. C. B.info:eu-repo/semantics/openAccess2021-05-20T20:40:54Zoai:ojs.periodicos.saude.sp.gov.br:article/35675Revistahttps://periodicos.saude.sp.gov.br/hansenologiaPRIhttps://periodicos.saude.sp.gov.br/hansenologia/oaihansen_int@ilsl.br || hansenologia.internationalis@gmail.com || periodicossp@saude.sp.gov.br1982-51610100-3283opendoar:2021-05-20T20:40:54Hansenologia Internationalis (Online) - Instituto Lauro de Souza Lima (ILSL)false |
dc.title.none.fl_str_mv |
CHROMOSOMAL ABERRATIONS IN LEUKOCYTE METAPHASES OF LEPROSY PATIENTS UNDER DAPSONE THERAPY Aberrações cromossômicas em metáfases de leucócitos de pacientes de lepra sobterapia com dapsona |
title |
CHROMOSOMAL ABERRATIONS IN LEUKOCYTE METAPHASES OF LEPROSY PATIENTS UNDER DAPSONE THERAPY |
spellingShingle |
CHROMOSOMAL ABERRATIONS IN LEUKOCYTE METAPHASES OF LEPROSY PATIENTS UNDER DAPSONE THERAPY BEIGUELMAN, B. Hanseniase Terapêutica Dapsona Genética Análise cromossômica Aberrações cromossõmicas Hanseniasis Therapy Dapsone Genetics Chromosome analysis Chromosomal aberrations |
title_short |
CHROMOSOMAL ABERRATIONS IN LEUKOCYTE METAPHASES OF LEPROSY PATIENTS UNDER DAPSONE THERAPY |
title_full |
CHROMOSOMAL ABERRATIONS IN LEUKOCYTE METAPHASES OF LEPROSY PATIENTS UNDER DAPSONE THERAPY |
title_fullStr |
CHROMOSOMAL ABERRATIONS IN LEUKOCYTE METAPHASES OF LEPROSY PATIENTS UNDER DAPSONE THERAPY |
title_full_unstemmed |
CHROMOSOMAL ABERRATIONS IN LEUKOCYTE METAPHASES OF LEPROSY PATIENTS UNDER DAPSONE THERAPY |
title_sort |
CHROMOSOMAL ABERRATIONS IN LEUKOCYTE METAPHASES OF LEPROSY PATIENTS UNDER DAPSONE THERAPY |
author |
BEIGUELMAN, B. |
author_facet |
BEIGUELMAN, B. PISANI, R. C. B. |
author_role |
author |
author2 |
PISANI, R. C. B. |
author2_role |
author |
dc.contributor.author.fl_str_mv |
BEIGUELMAN, B. PISANI, R. C. B. |
dc.subject.por.fl_str_mv |
Hanseniase Terapêutica Dapsona Genética Análise cromossômica Aberrações cromossõmicas Hanseniasis Therapy Dapsone Genetics Chromosome analysis Chromosomal aberrations |
topic |
Hanseniase Terapêutica Dapsona Genética Análise cromossômica Aberrações cromossõmicas Hanseniasis Therapy Dapsone Genetics Chromosome analysis Chromosomal aberrations |
description |
Chromosome analyses were made on leukocyte metaphases of 18 leprosy patients who were ingesting daily doses of 50 mg or 100 mg of DDS and of 40 healthy individuals used for control. These analyses have shown that the proportion of numerical chromosomal aberrations in the leukocyte metaphases of the leprosy patients did not differ significantly from that observed in the cells of the controls. In contrast, the frequency of cells with chromatid or chromosome breaks and gaps was significantly increased in the leukocytes of leprosy patients. Multiple regression analysis applied to the data recorded has shown that the increase of breaks and gaps in the chromosomes of leprosy patients can not be attributed to age, years under sulfonetherapy or to concentration of DDS in blood. |
publishDate |
1976 |
dc.date.none.fl_str_mv |
1976-06-30 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Avaliado pelos pares |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://periodicos.saude.sp.gov.br/hansenologia/article/view/35675 10.47878/hi.1976.v1.35675 |
url |
https://periodicos.saude.sp.gov.br/hansenologia/article/view/35675 |
identifier_str_mv |
10.47878/hi.1976.v1.35675 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://periodicos.saude.sp.gov.br/hansenologia/article/view/35675/34084 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Instituto Lauro de Souza Lima da Secretaria de Estado da Saúde de São Paulo |
publisher.none.fl_str_mv |
Instituto Lauro de Souza Lima da Secretaria de Estado da Saúde de São Paulo |
dc.source.none.fl_str_mv |
Hansenologia Internationalis: leprosy and other infectious diseases; Vol. 1 No. 1 (1976); 53-60 Hansenologia Internationalis: hanseníase e outras doenças infecciosas; v. 1 n. 1 (1976); 53-60 1982-5161 reponame:Hansenologia Internationalis (Online) instname:Instituto Lauro de Souza Lima (ILSL) instacron:ILSL |
instname_str |
Instituto Lauro de Souza Lima (ILSL) |
instacron_str |
ILSL |
institution |
ILSL |
reponame_str |
Hansenologia Internationalis (Online) |
collection |
Hansenologia Internationalis (Online) |
repository.name.fl_str_mv |
Hansenologia Internationalis (Online) - Instituto Lauro de Souza Lima (ILSL) |
repository.mail.fl_str_mv |
hansen_int@ilsl.br || hansenologia.internationalis@gmail.com || periodicossp@saude.sp.gov.br |
_version_ |
1796797580136415232 |