Binding of excreted and/or secreted products of adult hookworms to human NK cells in Necator americanus-infected individuals from Brazil
Autor(a) principal: | |
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Data de Publicação: | 2008 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/54365 |
Resumo: | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Biomarcadores de Diagnóstico e Monitoração. Belo Horizonte, MG, Brasil/Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Imunologia Celular e Molecular. Belo Horizonte, MG, Brasil/Universidade Federal de Ouro Preto. Escola de Farmácia. Departamento de Análises Clínicas. Ouro Preto, MG, Brasil |
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Carvalho, Andréa Teixeira deFujiwara, Ricardo ToshioStemmy, Erik J.Olive, DeniseDamsker, Jesse M.Loukas, AlexOliveira, Rodrigo CorrêaConstant, Stephanie L.Bethony, Jeffrey Michael2022-08-03T17:51:56Z2022-08-03T17:51:56Z2008CARVALHO, Andréa Teixeira de et al. Binding of excreted and/or secreted products of adult hookworms to human NK cells in Necator americanus-infected individuals from Brazil. Infect Immun., v. 76, n. 12, p. 5810-5816, 2008. doi: 10.1128/IAI.00419-080019-9567https://www.arca.fiocruz.br/handle/icict/5436510.1128/IAI.00419-08engAmerican Society For MicrobiologyBinding of excreted and/or secreted products of adult hookworms to human NK cells in Necator americanus-infected individuals from Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Biomarcadores de Diagnóstico e Monitoração. Belo Horizonte, MG, Brasil/Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Imunologia Celular e Molecular. Belo Horizonte, MG, Brasil/Universidade Federal de Ouro Preto. Escola de Farmácia. Departamento de Análises Clínicas. Ouro Preto, MG, BrasilFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Imunologia Celular e Molecular. Belo Horizonte, MG, Brasil/Department of Microbiology. Immunology and Tropical Medicine. The George Washington University Medical Center. Washington, DC, USADepartment of Microbiology. Immunology and Tropical Medicine. The George Washington University Medical Center. Washington, DC, USADepartment of Microbiology. Immunology and Tropical Medicine. The George Washington University Medical Center. Washington, DC, USADepartment of Microbiology. Immunology and Tropical Medicine. The George Washington University Medical Center. Washington, DC, USAQueensland Institute of Medical Research. Brisbane, Queensland, AustraliaFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Imunologia Celular e Molecular. Belo Horizonte, MG, BrasilDepartment of Microbiology. Immunology and Tropical Medicine. The George Washington University Medical Center. Washington, DC, USAFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Imunologia Celular e Molecular. Belo Horizonte, MG, Brasil/Department of Microbiology. Immunology and Tropical Medicine. The George Washington University Medical Center. Washington, DC, USAThe impact of the interaction between excreted and/or secreted (ES) Necator americanus products and NK cells from Necator-infected individuals was analyzed. We investigated the binding of ES products to NK cells, the expression of NK cell receptors (CD56, CD159a/NKG2A, CD314/NKG2D, CD335/NKp46, and KLRF1/NKp80), the frequency of gamma interferon (IFN-gamma)-producing NK cells after whole-blood in vitro stimulation, and the capacity of N. americanus ES products to induce NK cell chemotaxis. In contrast to those from noninfected individuals, NK cells from Necator-infected individuals demonstrated no binding with N. americanus ES products. This phenomenon was not due to alterations in NK cell receptor expression in infected subjects and could not be reproduced with NK cells from uninfected individuals by incubation with immunoregulatory cytokines (interleukin-10/transforming growth factor beta). Further, we found that a significantly greater percentage of NK cells from infected subjects than NK cells from uninfected individuals spontaneously produced IFN-gamma upon ex vivo culture. Our findings support a model whereby NK cells from Necator-infected individuals may interact with ES products, making these cells refractory to binding with exogenous ES products. During N. americanus infection, human NK cells are attracted to the site of infection by chemotactic ES products produced by adult Necator worms in the gut mucosa. Binding of ES products causes the NK cells to become activated and secrete IFN-gamma locally, thereby contributing to the adult hookworm's ability to evade host immune responses.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83082https://www.arca.fiocruz.br/bitstream/icict/54365/1/license.txt9193a7c197bc67acd023525e72a03240MD51ORIGINALBinding of excreted.pdfBinding of excreted.pdfapplication/pdf497780https://www.arca.fiocruz.br/bitstream/icict/54365/2/Binding%20of%20excreted.pdfd6b0f4fd7c65d5a0714fde6b0fcbf0b4MD52icict/543652022-08-03 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dc.title.pt_BR.fl_str_mv |
Binding of excreted and/or secreted products of adult hookworms to human NK cells in Necator americanus-infected individuals from Brazil |
title |
Binding of excreted and/or secreted products of adult hookworms to human NK cells in Necator americanus-infected individuals from Brazil |
spellingShingle |
Binding of excreted and/or secreted products of adult hookworms to human NK cells in Necator americanus-infected individuals from Brazil Carvalho, Andréa Teixeira de |
title_short |
Binding of excreted and/or secreted products of adult hookworms to human NK cells in Necator americanus-infected individuals from Brazil |
title_full |
Binding of excreted and/or secreted products of adult hookworms to human NK cells in Necator americanus-infected individuals from Brazil |
title_fullStr |
Binding of excreted and/or secreted products of adult hookworms to human NK cells in Necator americanus-infected individuals from Brazil |
title_full_unstemmed |
Binding of excreted and/or secreted products of adult hookworms to human NK cells in Necator americanus-infected individuals from Brazil |
title_sort |
Binding of excreted and/or secreted products of adult hookworms to human NK cells in Necator americanus-infected individuals from Brazil |
author |
Carvalho, Andréa Teixeira de |
author_facet |
Carvalho, Andréa Teixeira de Fujiwara, Ricardo Toshio Stemmy, Erik J. Olive, Denise Damsker, Jesse M. Loukas, Alex Oliveira, Rodrigo Corrêa Constant, Stephanie L. Bethony, Jeffrey Michael |
author_role |
author |
author2 |
Fujiwara, Ricardo Toshio Stemmy, Erik J. Olive, Denise Damsker, Jesse M. Loukas, Alex Oliveira, Rodrigo Corrêa Constant, Stephanie L. Bethony, Jeffrey Michael |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Carvalho, Andréa Teixeira de Fujiwara, Ricardo Toshio Stemmy, Erik J. Olive, Denise Damsker, Jesse M. Loukas, Alex Oliveira, Rodrigo Corrêa Constant, Stephanie L. Bethony, Jeffrey Michael |
description |
Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Biomarcadores de Diagnóstico e Monitoração. Belo Horizonte, MG, Brasil/Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Imunologia Celular e Molecular. Belo Horizonte, MG, Brasil/Universidade Federal de Ouro Preto. Escola de Farmácia. Departamento de Análises Clínicas. Ouro Preto, MG, Brasil |
publishDate |
2008 |
dc.date.issued.fl_str_mv |
2008 |
dc.date.accessioned.fl_str_mv |
2022-08-03T17:51:56Z |
dc.date.available.fl_str_mv |
2022-08-03T17:51:56Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
CARVALHO, Andréa Teixeira de et al. Binding of excreted and/or secreted products of adult hookworms to human NK cells in Necator americanus-infected individuals from Brazil. Infect Immun., v. 76, n. 12, p. 5810-5816, 2008. doi: 10.1128/IAI.00419-08 |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/54365 |
dc.identifier.issn.pt_BR.fl_str_mv |
0019-9567 |
dc.identifier.doi.none.fl_str_mv |
10.1128/IAI.00419-08 |
identifier_str_mv |
CARVALHO, Andréa Teixeira de et al. Binding of excreted and/or secreted products of adult hookworms to human NK cells in Necator americanus-infected individuals from Brazil. Infect Immun., v. 76, n. 12, p. 5810-5816, 2008. doi: 10.1128/IAI.00419-08 0019-9567 10.1128/IAI.00419-08 |
url |
https://www.arca.fiocruz.br/handle/icict/54365 |
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eng |
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eng |
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info:eu-repo/semantics/openAccess |
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openAccess |
dc.publisher.none.fl_str_mv |
American Society For Microbiology |
publisher.none.fl_str_mv |
American Society For Microbiology |
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