Potential role of Hedgehog signaling pathway and myofibroblastic differentiation in central giant cell granuloma-A preliminary study

Detalhes bibliográficos
Autor(a) principal: Muniz, Vinicius Rio Verde Melo
Data de Publicação: 2019
Outros Autores: Nunes, Fábio Daumas, Xavier, Flávia Caló de Aquino, Cangussu, Maria Cristina Teixeira, Freitas, Rosean ade Almeida, Cury, Patrícia Ramos, Gurgel, Clarissa Araújo, Santos, Jean Nunes dos
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/36784
Resumo: Gurgel, Clarissa Araújo. Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento.
id CRUZ_ed8d1c8647b33ac15005f666bf75919a
oai_identifier_str oai:www.arca.fiocruz.br:icict/36784
network_acronym_str CRUZ
network_name_str Repositório Institucional da FIOCRUZ (ARCA)
repository_id_str 2135
spelling Muniz, Vinicius Rio Verde MeloNunes, Fábio DaumasXavier, Flávia Caló de AquinoCangussu, Maria Cristina TeixeiraFreitas, Rosean ade AlmeidaCury, Patrícia RamosGurgel, Clarissa AraújoSantos, Jean Nunes dos2019-10-31T16:32:30Z2019-10-31T16:32:30Z2019MUNIZ, Vinicius Rio Verde Melo et al. Potential role of Hedgehog signaling pathway and myofibroblastic differentiation in central giant cell granuloma-A preliminary study. Journal of Oral Pathology and Medicine, v. 48, p. 855–860, 2019.0904-2512https://www.arca.fiocruz.br/handle/icict/3678410.1111/jop.12949Gurgel, Clarissa Araújo. Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento.Conselho Nacional de Desenvolvimento Científico e Tecnológico” (CNPq); Coordenação de Aperfeiçoamento de Ensino Superior (CAPES).2020-01-06Federal University of Bahia. School of Dentistry. Dentistry and Health Postgraduation. Salvador, BA, Brazil.University of São Paulo. School of Dentistry. Laboratory of Oral and Maxillofacial Pathology. São Paulo, SP, Brazil.Federal University of Bahia. School of Dentistry. Laboratory of Oral and Maxillofacial Pathology. Salvador, BA, Brazil / Federal University of Bahia. School of Dentistry. Laboratory of Oral and Maxillofacial Pathology. Salvador, BA, Brazil.Federal University of Bahia. School of Dentistry. Dentistry and Health Postgraduation. Salvador, BA, Brazil.Federal University of Rio Grande do Norte. School of Dentistry. Laboratory of Oral and MaxillofacialFederal University of Bahia. School of Dentistry. Dentistry and Health Postgraduation. Salvador, BA, Brazil.Federal University of Bahia. School of Dentistry. Dentistry and Health Postgraduation. Salvador, BA, Brazil.Federal University of Bahia. School of Dentistry. Laboratory of Oral and Maxillofacial Pathology. Salvador, BA, Brazil / Federal University of Bahia. School of Dentistry. Laboratory of Oral and Maxillofacial Pathology. Salvador, BA, Brazil.This study investigated components of the Hedgehog (HH) signaling pathway (SHH, GLI1), cyclin D1, and smooth muscle actin (SMA) in central giant cell granulomas (CGCG). The relationship between these proteins and myofibroblasts was also studied. Material and methods: Twelve cases of non‐aggressive CGCG and 11 cases of aggressive CGCG were studied using immunohistochemistry for SHH, GLI1, Cyclin D1, and SMA. Results: Associations between all proteins in non‐aggressive and aggressive CGCG were not significant (P > .05). All cases of CGCG showed significantly higher expression of SMA compared with the other proteins (P < .01). A positive correlation (P = .04) was only observed between SHH and GLI1 for all cases of CGCG. Furthermore, a positive correlation between SHH and GLI1 in non‐aggressive CGCG (P = .04) and between GLI1 and cyclin D1 in aggressive CGCG (P = .03) were observed. There was also a negative correlation between the expression of SHH and SMA in non‐aggressive CGCG (P = .031). Conclusions: This study provided insights into the activation of the HH signaling pathway in CGCG. In addition, the activation of this pathway (SHH and GLI1) might play some role in the differentiation of stromal myofibroblasts, although these markers including Cyclin D1 and SMA do not indicate aggressiveness of the CGCG. Furthermore, this myofibroblastic differentiation process would occur at the expense of maturation of these lesions.engWileyCélula giganteGranulomaProteínas hedgehogImuno-histoquímicaGiant cellGranulomaHedgehog proteinsImmunohistochemistryPotential role of Hedgehog signaling pathway and myofibroblastic differentiation in central giant cell granuloma-A preliminary studyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/36784/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALMelo Muniz. V. R. V. Potential....pdfMelo Muniz. V. R. V. Potential....pdfapplication/pdf872341https://www.arca.fiocruz.br/bitstream/icict/36784/2/Melo%20Muniz.%20V.%20R.%20V.%20Potential....pdf657c8572224237db9ee02a36dd4af0ecMD52TEXTMelo Muniz. V. R. V. Potential....pdf.txtMelo Muniz. V. R. V. Potential....pdf.txtExtracted texttext/plain29732https://www.arca.fiocruz.br/bitstream/icict/36784/3/Melo%20Muniz.%20V.%20R.%20V.%20Potential....pdf.txt8f6ccd8c71bb0e5338636b3d9a216077MD53icict/367842023-03-15 14:34:21.373oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:34:21Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Potential role of Hedgehog signaling pathway and myofibroblastic differentiation in central giant cell granuloma-A preliminary study
title Potential role of Hedgehog signaling pathway and myofibroblastic differentiation in central giant cell granuloma-A preliminary study
spellingShingle Potential role of Hedgehog signaling pathway and myofibroblastic differentiation in central giant cell granuloma-A preliminary study
Muniz, Vinicius Rio Verde Melo
Célula gigante
Granuloma
Proteínas hedgehog
Imuno-histoquímica
Giant cell
Granuloma
Hedgehog proteins
Immunohistochemistry
title_short Potential role of Hedgehog signaling pathway and myofibroblastic differentiation in central giant cell granuloma-A preliminary study
title_full Potential role of Hedgehog signaling pathway and myofibroblastic differentiation in central giant cell granuloma-A preliminary study
title_fullStr Potential role of Hedgehog signaling pathway and myofibroblastic differentiation in central giant cell granuloma-A preliminary study
title_full_unstemmed Potential role of Hedgehog signaling pathway and myofibroblastic differentiation in central giant cell granuloma-A preliminary study
title_sort Potential role of Hedgehog signaling pathway and myofibroblastic differentiation in central giant cell granuloma-A preliminary study
author Muniz, Vinicius Rio Verde Melo
author_facet Muniz, Vinicius Rio Verde Melo
Nunes, Fábio Daumas
Xavier, Flávia Caló de Aquino
Cangussu, Maria Cristina Teixeira
Freitas, Rosean ade Almeida
Cury, Patrícia Ramos
Gurgel, Clarissa Araújo
Santos, Jean Nunes dos
author_role author
author2 Nunes, Fábio Daumas
Xavier, Flávia Caló de Aquino
Cangussu, Maria Cristina Teixeira
Freitas, Rosean ade Almeida
Cury, Patrícia Ramos
Gurgel, Clarissa Araújo
Santos, Jean Nunes dos
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Muniz, Vinicius Rio Verde Melo
Nunes, Fábio Daumas
Xavier, Flávia Caló de Aquino
Cangussu, Maria Cristina Teixeira
Freitas, Rosean ade Almeida
Cury, Patrícia Ramos
Gurgel, Clarissa Araújo
Santos, Jean Nunes dos
dc.subject.other.pt_BR.fl_str_mv Célula gigante
Granuloma
Proteínas hedgehog
Imuno-histoquímica
topic Célula gigante
Granuloma
Proteínas hedgehog
Imuno-histoquímica
Giant cell
Granuloma
Hedgehog proteins
Immunohistochemistry
dc.subject.en.pt_BR.fl_str_mv Giant cell
Granuloma
Hedgehog proteins
Immunohistochemistry
description Gurgel, Clarissa Araújo. Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento.
publishDate 2019
dc.date.accessioned.fl_str_mv 2019-10-31T16:32:30Z
dc.date.available.fl_str_mv 2019-10-31T16:32:30Z
dc.date.issued.fl_str_mv 2019
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv MUNIZ, Vinicius Rio Verde Melo et al. Potential role of Hedgehog signaling pathway and myofibroblastic differentiation in central giant cell granuloma-A preliminary study. Journal of Oral Pathology and Medicine, v. 48, p. 855–860, 2019.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/36784
dc.identifier.issn.pt_BR.fl_str_mv 0904-2512
dc.identifier.doi.none.fl_str_mv 10.1111/jop.12949
identifier_str_mv MUNIZ, Vinicius Rio Verde Melo et al. Potential role of Hedgehog signaling pathway and myofibroblastic differentiation in central giant cell granuloma-A preliminary study. Journal of Oral Pathology and Medicine, v. 48, p. 855–860, 2019.
0904-2512
10.1111/jop.12949
url https://www.arca.fiocruz.br/handle/icict/36784
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/36784/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/36784/2/Melo%20Muniz.%20V.%20R.%20V.%20Potential....pdf
https://www.arca.fiocruz.br/bitstream/icict/36784/3/Melo%20Muniz.%20V.%20R.%20V.%20Potential....pdf.txt
bitstream.checksum.fl_str_mv 5a560609d32a3863062d77ff32785d58
657c8572224237db9ee02a36dd4af0ec
8f6ccd8c71bb0e5338636b3d9a216077
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
_version_ 1813008970137206784

Registros relacionados