Normal skin of HIV-infected individuals contains increased numbers of dermal CD8 T cells and normal numbers of Langerhans cells

Detalhes bibliográficos
Autor(a) principal: Galhardo, M. C. G.
Data de Publicação: 2004
Outros Autores: Alvarenga, F. F., Schueler, G., Perez, M., Morgado, M. G., Ferreira, H., Azevedo, L. M. S., Sampaio, E. P., Sarno, E. N.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/32911
Resumo: Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil.
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spelling Galhardo, M. C. G.Alvarenga, F. F.Schueler, G.Perez, M.Morgado, M. G.Ferreira, H.Azevedo, L. M. S.Sampaio, E. P.Sarno, E. N.2019-05-02T14:34:59Z2019-05-02T14:34:59Z2004GALHARDO, M. C. G. et al. Normal skin of HIV-infected individuals contains increased numbers of dermal CD8 T cells and normal numbers of Langerhans cells. Brazilian Journal of Medical and Biological Research, v. 37, p. 745-753, 2004.0100-879Xhttps://www.arca.fiocruz.br/handle/icict/3291110.1590/S0100-879X20040005000171414-431XengAssociação Brasileira de Divulgação CientíficaNormal skin of HIV-infected individuals contains increased numbers of dermal CD8 T cells and normal numbers of Langerhans cellsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil.Universidade Estadual do Rio de Janeiro. Departamento de Patologia. Rio de Janeiro, RJ, Brasil.Hospital Estadual Colônia Curupaiti. Serviço de Patologia. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Departamento de Medicina Preventiva. Núcleo de Estudos em Saúde Coletiva. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Serviço de Dermatologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.Dysregulation of the skin immune system (SIS) could explain the high prevalence of skin disorders in HIV+ individuals. The present study was carried out to determine whether alterations in the cell population of SIS and epidermal immunoactivation occur in the normal skin of HIV+ individuals. Forty-five biopsies were taken from the normal upper arm skin of 45 HIV+ patients and of 15 healthy controls. HIV+ individuals were divided into three categories according to their CD4 cell blood count (<200, 200-499 and > or = 500/microl). Hematoxylin-eosin was used to stain tissue sections for morphological analysis and immunohistochemistry was used for the evaluation of the frequency of macrophages, Langerhans cells, and CD lymphocyte subsets. In addition, semiquantitative analysis of LFA-1, ICAM-1 and HLA-DR was determined in epidermal cells. Macrophages, Langerhans cells, and CD lymphocyte subsets did not differ significantly between any of the patient categories and the control group. When all HIV+ individuals were compared as a group to the control group, a significant increase in dermal CD8+ T lymphocytes (P < 0.01) and lower CD4-CD8 ratios (P < 0.01) were observed in the HIV+ individuals. Epidermal ICAM-1 and HLA-DR expression was negative in both HIV+ and normal skin biopsies. No evidence of a depletion of the SIS population or of epidermal immunoactivation in normal skin from HIV+ individuals was demonstrable, suggesting that alterations in the central immune system are not necessarily reflected in the SIS of HIV-infected patients.HIVSkin immune systemCD8 T cellsCD4-CD8 ratioLangerhans cellsinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83104https://www.arca.fiocruz.br/bitstream/icict/32911/1/license.txt79178e5f2a0eb066867a274556814938MD51ORIGINALve_Galhardo_M_etal_INI_2004.pdfve_Galhardo_M_etal_INI_2004.pdfapplication/pdf1201091https://www.arca.fiocruz.br/bitstream/icict/32911/2/ve_Galhardo_M_etal_INI_2004.pdfe5c7ae43e24c5a5ac232d4cb8174ac82MD52TEXTve_Galhardo_M_etal_INI_2004.pdf.txtve_Galhardo_M_etal_INI_2004.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv Normal skin of HIV-infected individuals contains increased numbers of dermal CD8 T cells and normal numbers of Langerhans cells
title Normal skin of HIV-infected individuals contains increased numbers of dermal CD8 T cells and normal numbers of Langerhans cells
spellingShingle Normal skin of HIV-infected individuals contains increased numbers of dermal CD8 T cells and normal numbers of Langerhans cells
Galhardo, M. C. G.
HIV
Skin immune system
CD8 T cells
CD4-CD8 ratio
Langerhans cells
title_short Normal skin of HIV-infected individuals contains increased numbers of dermal CD8 T cells and normal numbers of Langerhans cells
title_full Normal skin of HIV-infected individuals contains increased numbers of dermal CD8 T cells and normal numbers of Langerhans cells
title_fullStr Normal skin of HIV-infected individuals contains increased numbers of dermal CD8 T cells and normal numbers of Langerhans cells
title_full_unstemmed Normal skin of HIV-infected individuals contains increased numbers of dermal CD8 T cells and normal numbers of Langerhans cells
title_sort Normal skin of HIV-infected individuals contains increased numbers of dermal CD8 T cells and normal numbers of Langerhans cells
author Galhardo, M. C. G.
author_facet Galhardo, M. C. G.
Alvarenga, F. F.
Schueler, G.
Perez, M.
Morgado, M. G.
Ferreira, H.
Azevedo, L. M. S.
Sampaio, E. P.
Sarno, E. N.
author_role author
author2 Alvarenga, F. F.
Schueler, G.
Perez, M.
Morgado, M. G.
Ferreira, H.
Azevedo, L. M. S.
Sampaio, E. P.
Sarno, E. N.
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Galhardo, M. C. G.
Alvarenga, F. F.
Schueler, G.
Perez, M.
Morgado, M. G.
Ferreira, H.
Azevedo, L. M. S.
Sampaio, E. P.
Sarno, E. N.
dc.subject.en.pt_BR.fl_str_mv HIV
Skin immune system
CD8 T cells
CD4-CD8 ratio
Langerhans cells
topic HIV
Skin immune system
CD8 T cells
CD4-CD8 ratio
Langerhans cells
description Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil.
publishDate 2004
dc.date.issued.fl_str_mv 2004
dc.date.accessioned.fl_str_mv 2019-05-02T14:34:59Z
dc.date.available.fl_str_mv 2019-05-02T14:34:59Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv GALHARDO, M. C. G. et al. Normal skin of HIV-infected individuals contains increased numbers of dermal CD8 T cells and normal numbers of Langerhans cells. Brazilian Journal of Medical and Biological Research, v. 37, p. 745-753, 2004.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/32911
dc.identifier.issn.pt_BR.fl_str_mv 0100-879X
dc.identifier.doi.none.fl_str_mv 10.1590/S0100-879X2004000500017
dc.identifier.eissn.none.fl_str_mv 1414-431X
identifier_str_mv GALHARDO, M. C. G. et al. Normal skin of HIV-infected individuals contains increased numbers of dermal CD8 T cells and normal numbers of Langerhans cells. Brazilian Journal of Medical and Biological Research, v. 37, p. 745-753, 2004.
0100-879X
10.1590/S0100-879X2004000500017
1414-431X
url https://www.arca.fiocruz.br/handle/icict/32911
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Associação Brasileira de Divulgação Científica
publisher.none.fl_str_mv Associação Brasileira de Divulgação Científica
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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