Cellular Analysis of Cutaneous Leishmaniasis Lymphadenopathy: Insights into the Early Phases of Human Disease

Detalhes bibliográficos
Autor(a) principal: Bomfim, Maria da Glória
Data de Publicação: 2007
Outros Autores: Andrade, Bruno de Bezerril, Santos, Silvane, Andrade, Jorge Clarêncio de Souza, Barral Netto, Manoel, Barral, Aldina Maria Prado
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/14794
Resumo: Universidade Federal da Bahia. Salvador, BA, Brasil / Instituto do Milênio. Instituto de Investigação em Imunologia. Salvador, BA, Brasil
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spelling Bomfim, Maria da GlóriaAndrade, Bruno de BezerrilSantos, SilvaneAndrade, Jorge Clarêncio de SouzaBarral Netto, ManoelBarral, Aldina Maria Prado2016-07-06T14:31:03Z2016-07-07T19:04:20Z2016-07-06T14:31:03Z2016-07-07T19:04:20Z2007BOMFIM, M. G. et al. Cellular Analysis of Cutaneous Leishmaniasis Lymphadenopathy: Insights into the Early Phases of Human Disease. American Journal of Tropical Medicine and Hygiene, v. 77, n. 5, p. 854–859, 2007.0002-9637https://www.arca.fiocruz.br/handle/icict/14794engAmerican Society of Tropical Medicine and HygieneCellular Analysis of Cutaneous Leishmaniasis Lymphadenopathy: Insights into the Early Phases of Human Diseaseinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal da Bahia. Salvador, BA, Brasil / Instituto do Milênio. Instituto de Investigação em Imunologia. Salvador, BA, BrasilFundação Gonçalo Moniz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilUniversidade Federal da Bahia. Salvador, BA, Brasil / Instituto do Milênio. Instituto de Investigação em Imunologia. Salvador, BA, BrasilFundação Gonçalo Moniz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Gonçalo Moniz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Gonçalo Moniz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilLymphadenopathy is an early clinical sign in cutaneous leishmaniasis (CL), caused by Viannia parasites, and may help to understand the initial host response to these species of Leishmania. We report on characteristics of cells obtained from lymph nodes from cutaneous leishmaniasis patients with lymphadenopathy without ulceration (early phase, N 21) or lymphadenopathy and ulceration (late phase, N 29). Early-phase patients exhibited a higher proportion of neutrophils, eosinophils, and CD8+ T cells. Conversely, CD19+ B lymphocytes and plasma cells were more frequently observed in late-phase patients. The signal for IL-10 was significantly higher in late-phase patients; signals for IFN- or IL-4 were similar in both groups. These data reinforce observations of an initial mixed Th1–Th2 profile as well as the early role of the CD8 T cell in cutaneous leishmaniasis. Additionally, there is a chronologic relationship between ulcer development and B-cell increase. IL-10 also increases at a late stage and may be important in limiting tissue damage.LeishmaniaIL10 protein,Interleukin-10Plasma CellsCutaneous LeishmaniasisLymphadenopathyAnimalsinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZTEXTBomfim G Cellular analysis....pdf.txtBomfim G Cellular analysis....pdf.txtExtracted texttext/plain30409https://www.arca.fiocruz.br/bitstream/icict/14794/4/Bomfim%20G%20Cellular%20analysis....pdf.txt5317db40a00c096bafa0df6797360ce8MD54ORIGINALBomfim G Cellular analysis....pdfapplication/pdf160243https://www.arca.fiocruz.br/bitstream/icict/14794/2/Bomfim%20G%20Cellular%20analysis....pdf7473c415ca2c57947a0d2f0c249d9e2dMD52LICENSElicense.txttext/plain2991https://www.arca.fiocruz.br/bitstream/icict/14794/3/license.txt5a560609d32a3863062d77ff32785d58MD53icict/147942023-03-15 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dc.title.pt_BR.fl_str_mv Cellular Analysis of Cutaneous Leishmaniasis Lymphadenopathy: Insights into the Early Phases of Human Disease
title Cellular Analysis of Cutaneous Leishmaniasis Lymphadenopathy: Insights into the Early Phases of Human Disease
spellingShingle Cellular Analysis of Cutaneous Leishmaniasis Lymphadenopathy: Insights into the Early Phases of Human Disease
Bomfim, Maria da Glória
Leishmania
IL10 protein,
Interleukin-10
Plasma Cells
Cutaneous Leishmaniasis
Lymphadenopathy
Animals
title_short Cellular Analysis of Cutaneous Leishmaniasis Lymphadenopathy: Insights into the Early Phases of Human Disease
title_full Cellular Analysis of Cutaneous Leishmaniasis Lymphadenopathy: Insights into the Early Phases of Human Disease
title_fullStr Cellular Analysis of Cutaneous Leishmaniasis Lymphadenopathy: Insights into the Early Phases of Human Disease
title_full_unstemmed Cellular Analysis of Cutaneous Leishmaniasis Lymphadenopathy: Insights into the Early Phases of Human Disease
title_sort Cellular Analysis of Cutaneous Leishmaniasis Lymphadenopathy: Insights into the Early Phases of Human Disease
author Bomfim, Maria da Glória
author_facet Bomfim, Maria da Glória
Andrade, Bruno de Bezerril
Santos, Silvane
Andrade, Jorge Clarêncio de Souza
Barral Netto, Manoel
Barral, Aldina Maria Prado
author_role author
author2 Andrade, Bruno de Bezerril
Santos, Silvane
Andrade, Jorge Clarêncio de Souza
Barral Netto, Manoel
Barral, Aldina Maria Prado
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Bomfim, Maria da Glória
Andrade, Bruno de Bezerril
Santos, Silvane
Andrade, Jorge Clarêncio de Souza
Barral Netto, Manoel
Barral, Aldina Maria Prado
dc.subject.en.pt_BR.fl_str_mv Leishmania
IL10 protein,
Interleukin-10
Plasma Cells
Cutaneous Leishmaniasis
Lymphadenopathy
Animals
topic Leishmania
IL10 protein,
Interleukin-10
Plasma Cells
Cutaneous Leishmaniasis
Lymphadenopathy
Animals
description Universidade Federal da Bahia. Salvador, BA, Brasil / Instituto do Milênio. Instituto de Investigação em Imunologia. Salvador, BA, Brasil
publishDate 2007
dc.date.issued.fl_str_mv 2007
dc.date.accessioned.fl_str_mv 2016-07-06T14:31:03Z
2016-07-07T19:04:20Z
dc.date.available.fl_str_mv 2016-07-06T14:31:03Z
2016-07-07T19:04:20Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv BOMFIM, M. G. et al. Cellular Analysis of Cutaneous Leishmaniasis Lymphadenopathy: Insights into the Early Phases of Human Disease. American Journal of Tropical Medicine and Hygiene, v. 77, n. 5, p. 854–859, 2007.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/14794
dc.identifier.issn.pt_BR.fl_str_mv 0002-9637
identifier_str_mv BOMFIM, M. G. et al. Cellular Analysis of Cutaneous Leishmaniasis Lymphadenopathy: Insights into the Early Phases of Human Disease. American Journal of Tropical Medicine and Hygiene, v. 77, n. 5, p. 854–859, 2007.
0002-9637
url https://www.arca.fiocruz.br/handle/icict/14794
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv American Society of Tropical Medicine and Hygiene
publisher.none.fl_str_mv American Society of Tropical Medicine and Hygiene
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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