IL-17 Mediates Immunopathology in the Absence of IL-10 Following Leishmania major Infection

Detalhes bibliográficos
Autor(a) principal: Lombana, Claudia Gonzalez
Data de Publicação: 2013
Outros Autores: Gimblet, Ciara, Bacellar, Maria Olívia Amado Ramos, Oliveira, Walker W., Passos, Sara, Carvalho, Lucas Pedreira de, Goldschmidt, Michael, Carvalho Filho, Edgar Marcelino de, Scott, Phillip
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://repositorio.ufba.br/ri/handle/ri/16684
Resumo: p. 1-14
id UFBA-2_913ffa8e6cfcb0f864db217df7c3281a
oai_identifier_str oai:repositorio.ufba.br:ri/16684
network_acronym_str UFBA-2
network_name_str Repositório Institucional da UFBA
repository_id_str 1932
spelling Lombana, Claudia GonzalezGimblet, CiaraBacellar, Maria Olívia Amado RamosOliveira, Walker W.Passos, SaraCarvalho, Lucas Pedreira deGoldschmidt, MichaelCarvalho Filho, Edgar Marcelino deScott, PhillipLombana, Claudia GonzalezGimblet, CiaraBacellar, Maria Olívia Amado RamosOliveira, Walker W.Passos, SaraCarvalho, Lucas Pedreira deGoldschmidt, MichaelCarvalho Filho, Edgar Marcelino deScott, Phillip2014-12-01T11:51:48Z2014-12-01T11:51:48Z20131932-6203http://repositorio.ufba.br/ri/handle/ri/16684v. 9, n. 3p. 1-14Leishmaniasis, resulting from infection with the protozoan parasite Leishmania, consists of a wide spectrum of clinical manifestations, from healing cutaneous lesions to fatal visceral infections. A particularly severe form of cutaneous leishmaniasis, termed mucosal leishmaniasis, exhibits decreased IL-10 levels and an exaggerated inflammatory response that perpetuates the disease. Using a mouse model of leishmaniasis, we investigated what cytokines contribute to increased pathology when IL-10-mediated regulation is absent. Leishmania major infected C57BL/6 mice lacking IL-10 regulation developed larger lesions than controls, but fewer parasites. Both IFN-γ and IL-17 levels were substantially elevated in mice lacking the capacity to respond to IL-10. IFN-γ promoted an increased infiltration of monocytes, while IL-17 contributed to an increase in neutrophils. Surprisingly, however, we found that IFN-γ did not contribute to increased pathology, but instead regulated the IL-17 response. Thus, blocking IFN-γ led to a significant increase in IL-17, neutrophils and disease. Similarly, the production of IL-17 by cells from leishmaniasis patients was also regulated by IL-10 and IFN-γ. Additional studies found that the IL-1 receptor was required for both the IL-17 response and increased pathology. Therefore, we propose that regulating IL-17, possibly by downregulating IL-1β, may be a useful approach for controlling immunopathology in leishmaniasis.Submitted by Edileide Reis (leyde-landy@hotmail.com) on 2014-12-01T11:23:49Z No. of bitstreams: 1 Claudia Gonzalez Lombana.pdf: 1907722 bytes, checksum: cc9acc0548f3518beac68821242128f2 (MD5)Approved for entry into archive by Flávia Ferreira (flaviaccf@yahoo.com.br) on 2014-12-01T11:51:48Z (GMT) No. of bitstreams: 1 Claudia Gonzalez Lombana.pdf: 1907722 bytes, checksum: cc9acc0548f3518beac68821242128f2 (MD5)Made available in DSpace on 2014-12-01T11:51:48Z (GMT). No. of bitstreams: 1 Claudia Gonzalez Lombana.pdf: 1907722 bytes, checksum: cc9acc0548f3518beac68821242128f2 (MD5) Previous issue date: 2013http://dx.doi.org/10.1371/journal.ppat.1003243reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBALeishmaniasisInterleukin-17Interleukin-10Leishmaniasis cutaneousIL-17 Mediates Immunopathology in the Absence of IL-10 Following Leishmania major InfectionPLoS ONEinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleBrasilinfo:eu-repo/semantics/openAccessengORIGINALClaudia Gonzalez Lombana.pdfClaudia Gonzalez Lombana.pdfapplication/pdf1907722https://repositorio.ufba.br/bitstream/ri/16684/1/Claudia%20Gonzalez%20Lombana.pdfcc9acc0548f3518beac68821242128f2MD51LICENSElicense.txtlicense.txttext/plain1345https://repositorio.ufba.br/bitstream/ri/16684/2/license.txtff6eaa8b858ea317fded99f125f5fcd0MD52TEXTClaudia Gonzalez Lombana.pdf.txtClaudia Gonzalez Lombana.pdf.txtExtracted texttext/plain71580https://repositorio.ufba.br/bitstream/ri/16684/3/Claudia%20Gonzalez%20Lombana.pdf.txt3f47a2fa71d2b7364d7f732c692276c3MD53ri/166842022-07-05 14:05:18.535oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:05:18Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv IL-17 Mediates Immunopathology in the Absence of IL-10 Following Leishmania major Infection
dc.title.alternative.pt_BR.fl_str_mv PLoS ONE
title IL-17 Mediates Immunopathology in the Absence of IL-10 Following Leishmania major Infection
spellingShingle IL-17 Mediates Immunopathology in the Absence of IL-10 Following Leishmania major Infection
Lombana, Claudia Gonzalez
Leishmaniasis
Interleukin-17
Interleukin-10
Leishmaniasis cutaneous
title_short IL-17 Mediates Immunopathology in the Absence of IL-10 Following Leishmania major Infection
title_full IL-17 Mediates Immunopathology in the Absence of IL-10 Following Leishmania major Infection
title_fullStr IL-17 Mediates Immunopathology in the Absence of IL-10 Following Leishmania major Infection
title_full_unstemmed IL-17 Mediates Immunopathology in the Absence of IL-10 Following Leishmania major Infection
title_sort IL-17 Mediates Immunopathology in the Absence of IL-10 Following Leishmania major Infection
author Lombana, Claudia Gonzalez
author_facet Lombana, Claudia Gonzalez
Gimblet, Ciara
Bacellar, Maria Olívia Amado Ramos
Oliveira, Walker W.
Passos, Sara
Carvalho, Lucas Pedreira de
Goldschmidt, Michael
Carvalho Filho, Edgar Marcelino de
Scott, Phillip
author_role author
author2 Gimblet, Ciara
Bacellar, Maria Olívia Amado Ramos
Oliveira, Walker W.
Passos, Sara
Carvalho, Lucas Pedreira de
Goldschmidt, Michael
Carvalho Filho, Edgar Marcelino de
Scott, Phillip
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Lombana, Claudia Gonzalez
Gimblet, Ciara
Bacellar, Maria Olívia Amado Ramos
Oliveira, Walker W.
Passos, Sara
Carvalho, Lucas Pedreira de
Goldschmidt, Michael
Carvalho Filho, Edgar Marcelino de
Scott, Phillip
Lombana, Claudia Gonzalez
Gimblet, Ciara
Bacellar, Maria Olívia Amado Ramos
Oliveira, Walker W.
Passos, Sara
Carvalho, Lucas Pedreira de
Goldschmidt, Michael
Carvalho Filho, Edgar Marcelino de
Scott, Phillip
dc.subject.por.fl_str_mv Leishmaniasis
Interleukin-17
Interleukin-10
Leishmaniasis cutaneous
topic Leishmaniasis
Interleukin-17
Interleukin-10
Leishmaniasis cutaneous
description p. 1-14
publishDate 2013
dc.date.issued.fl_str_mv 2013
dc.date.accessioned.fl_str_mv 2014-12-01T11:51:48Z
dc.date.available.fl_str_mv 2014-12-01T11:51:48Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://repositorio.ufba.br/ri/handle/ri/16684
dc.identifier.issn.none.fl_str_mv 1932-6203
dc.identifier.number.pt_BR.fl_str_mv v. 9, n. 3
identifier_str_mv 1932-6203
v. 9, n. 3
url http://repositorio.ufba.br/ri/handle/ri/16684
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.country.fl_str_mv Brasil
dc.source.pt_BR.fl_str_mv http://dx.doi.org/10.1371/journal.ppat.1003243
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
instname:Universidade Federal da Bahia (UFBA)
instacron:UFBA
instname_str Universidade Federal da Bahia (UFBA)
instacron_str UFBA
institution UFBA
reponame_str Repositório Institucional da UFBA
collection Repositório Institucional da UFBA
bitstream.url.fl_str_mv https://repositorio.ufba.br/bitstream/ri/16684/1/Claudia%20Gonzalez%20Lombana.pdf
https://repositorio.ufba.br/bitstream/ri/16684/2/license.txt
https://repositorio.ufba.br/bitstream/ri/16684/3/Claudia%20Gonzalez%20Lombana.pdf.txt
bitstream.checksum.fl_str_mv cc9acc0548f3518beac68821242128f2
ff6eaa8b858ea317fded99f125f5fcd0
3f47a2fa71d2b7364d7f732c692276c3
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
repository.name.fl_str_mv Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)
repository.mail.fl_str_mv
_version_ 1808459490485338112

Registros relacionados