Evaluating seroprevalence to circumsporozoite protein to estimate exposure to three species of Plasmodium in the Brazilian Amazon.

Detalhes bibliográficos
Autor(a) principal: Pereira, Virginia Araujo
Data de Publicação: 2018
Outros Autores: Sánchez-Arcila, Juan Camilo, Vasconcelos, Mariana Pinheiro Alves, Ferreira, Amanda Ribeiro, Videira, Lorene de Souza, Teva, Antonio, Silva, Daiana Perce da, Marques, Maria Teresa Queiroz, Carvalho, Luzia Helena de, Banic, Dalma Maria, Pôrto, Luiz Cristóvão Sobrino, Ferreira, Joseli Oliveira
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/28399
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratorio de Imunoparasitologia. Rio de Janeiro, RJ, Brazil
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spelling Pereira, Virginia AraujoSánchez-Arcila, Juan CamiloVasconcelos, Mariana Pinheiro AlvesFerreira, Amanda RibeiroVideira, Lorene de SouzaTeva, AntonioSilva, Daiana Perce daMarques, Maria Teresa QueirozCarvalho, Luzia Helena deBanic, Dalma MariaPôrto, Luiz Cristóvão SobrinoFerreira, Joseli Oliveira2018-08-27T18:37:06Z2018-08-27T18:37:06Z2018PEREIRA, Virginia Araujo et al. Evaluating seroprevalence to circumsporozoite protein to estimate exposure to three species of Plasmodium in the Brazilian Amazon. Infect Dis Poverty, v. 7, n. 1, p.46, 20182049-9957https://www.arca.fiocruz.br/handle/icict/2839910.1186/s40249-018-0428-1engBioMed CentralProteína circunsporozóitaAntígeno leucocitário humanoAnticorpo IgGMalariaPorto VelhoRondôniaMarcador sorológicoCircumsporozoite proteinHuman leucocyte antigenIgG antibodyMalariaPorto VelhoRondôniaSerological markerEvaluating seroprevalence to circumsporozoite protein to estimate exposure to three species of Plasmodium in the Brazilian Amazon.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratorio de Imunoparasitologia. Rio de Janeiro, RJ, BrazilFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratorio de Imunoparasitologia. Rio de Janeiro, RJ, BrazilInstituto de Infectologia Emilio Ribas. São Paulo, SP, BrazilFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratorio de Imunoparasitologia. Rio de Janeiro, RJ, BrazilFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratorio de Imunoparasitologia. Rio de Janeiro, RJ, BrazilFundação Oswaldo Cruz. Escola Nacional de Saude Publica. Departamento de Ciencias Biologicas. Laboratorio de Imunodiagnostico. Rio de Janeiro, RJ, BrazilFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratorio de Imunologia Clinica. Rio de Janeiro, RJ, BrazilUniversidade Estadual do Rio de Janeiro. Laboratório de Histocompatibilidade e Criopreservação. Rio de Janeiro, RJ, BrazilFundação Oswaldo Cruz. Instituto René Rachou Biologia Molecular e Imunologia da Malária. Belo Horizonte, MG, BrazilFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratorio de Imunologia Clinica. Rio de Janeiro, RJ, BrazilUniversidade Estadual do Rio de Janeiro. Laboratório de Histocompatibilidade e Criopreservação. Rio de Janeiro, RJ, BrazilFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratorio de Imunoparasitologia. Rio de Janeiro, RJ, BrazilBACKGROUND: Brazil has seen a great decline in malaria and the country is moving towards elimination. However, for eventual elimination, the control program needs efficient tools in order to monitor malaria exposure and transmission. In this study, we aimed to evaluate whether seroprevalence to the circumsporozoite protein (CSP) is a good tool for monitoring the exposure to and/or evaluating the burden and distribution of Plasmodium species in the Brazilian Amazon. METHODS: Cross-sectional surveys were conducted in a rural area of Porto Velho, Rondônia state. Parasite infection was detected by microscopy and polymerase chain reaction. Antibodies to the sporozoite CSP repeats of Plasmodium vivax, P. falciparum, and P. malariae (PvCS, PfCS, and PmCS) were detected using the enzyme-linked immunosorbent assay technique. Human leukocyte antigen (HLA)-DRB1 and DQB1 genes were typed using Luminex® xMAP® technology. RESULTS: The prevalence of immunoglobulin G against P. vivax CSP peptide (62%) was higher than P. falciparum (49%) and P. malariae (46%) CSP peptide. Most of the studied individuals had antibodies to at least one of the three peptides (72%), 34% had antibodies to all three peptides and 28% were non-responders. Although the majority of the population was not infected at the time of the survey, 74.3% of parasite-negative individuals had antibodies to at least one of the CSPs. Importantly, among individuals carrying the haplotypes DRB1*04~DQB1*03, there was a significantly higher frequency of PfCS responders, and DRB1*16~DQB1*03 haplotype for PvCS and PfCS responders. In contrast, HLA-DRB1*01 and HLA-DQB1*05 allelic groups were associated with a lack of antibodies to P. vivax and P. falciparum CSP repeats, and the haplotype DRB1*01~DQB1*05 was also associated with non-responders, including non-responders to P. malariae. CONCLUSIONS: Our results show that in low transmission settings, naturally acquired antibody responses against the CSP repeats of P. vivax, P. falciparum, and P. malariae in a single cross-sectional study may not represent a valuable marker for monitoring recent malaria exposure, especially in an area with a high prevalence of P. vivax. Furthermore, HLA class II molecules play an important role in antibody response and require further study with a larger sample size. It will be of interest to consider HLA analysis when using serosurveillance to monitor malaria exposure among genetically diverse populations.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83082https://www.arca.fiocruz.br/bitstream/icict/28399/1/license.txt9193a7c197bc67acd023525e72a03240MD51ORIGINALEvaluating seroprevalence to circumsporozoite protein to estimate exposure to three species of Plasmodium in the Brazilian Amazon.pdfEvaluating seroprevalence to circumsporozoite protein to estimate exposure to three species of Plasmodium in the Brazilian Amazon.pdfapplication/pdf918934https://www.arca.fiocruz.br/bitstream/icict/28399/2/Evaluating%20seroprevalence%20to%20circumsporozoite%20protein%20to%20estimate%20exposure%20to%20three%20species%20of%20Plasmodium%20in%20the%20Brazilian%20Amazon.pdfd7618c4561d4cf1e8b8bee9c07afb76eMD52TEXTEvaluating seroprevalence to circumsporozoite protein to estimate exposure to three species of Plasmodium in the Brazilian Amazon.pdf.txtEvaluating seroprevalence to circumsporozoite protein to estimate exposure to three species of Plasmodium in the Brazilian Amazon.pdf.txtExtracted texttext/plain51272https://www.arca.fiocruz.br/bitstream/icict/28399/3/Evaluating%20seroprevalence%20to%20circumsporozoite%20protein%20to%20estimate%20exposure%20to%20three%20species%20of%20Plasmodium%20in%20the%20Brazilian%20Amazon.pdf.txt40875474070dd7ad4014636d5baca86eMD53icict/283992019-06-19 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dc.title.pt_BR.fl_str_mv Evaluating seroprevalence to circumsporozoite protein to estimate exposure to three species of Plasmodium in the Brazilian Amazon.
title Evaluating seroprevalence to circumsporozoite protein to estimate exposure to three species of Plasmodium in the Brazilian Amazon.
spellingShingle Evaluating seroprevalence to circumsporozoite protein to estimate exposure to three species of Plasmodium in the Brazilian Amazon.
Pereira, Virginia Araujo
Proteína circunsporozóita
Antígeno leucocitário humano
Anticorpo IgG
Malaria
Porto Velho
Rondônia
Marcador sorológico
Circumsporozoite protein
Human leucocyte antigen
IgG antibody
Malaria
Porto Velho
Rondônia
Serological marker
title_short Evaluating seroprevalence to circumsporozoite protein to estimate exposure to three species of Plasmodium in the Brazilian Amazon.
title_full Evaluating seroprevalence to circumsporozoite protein to estimate exposure to three species of Plasmodium in the Brazilian Amazon.
title_fullStr Evaluating seroprevalence to circumsporozoite protein to estimate exposure to three species of Plasmodium in the Brazilian Amazon.
title_full_unstemmed Evaluating seroprevalence to circumsporozoite protein to estimate exposure to three species of Plasmodium in the Brazilian Amazon.
title_sort Evaluating seroprevalence to circumsporozoite protein to estimate exposure to three species of Plasmodium in the Brazilian Amazon.
author Pereira, Virginia Araujo
author_facet Pereira, Virginia Araujo
Sánchez-Arcila, Juan Camilo
Vasconcelos, Mariana Pinheiro Alves
Ferreira, Amanda Ribeiro
Videira, Lorene de Souza
Teva, Antonio
Silva, Daiana Perce da
Marques, Maria Teresa Queiroz
Carvalho, Luzia Helena de
Banic, Dalma Maria
Pôrto, Luiz Cristóvão Sobrino
Ferreira, Joseli Oliveira
author_role author
author2 Sánchez-Arcila, Juan Camilo
Vasconcelos, Mariana Pinheiro Alves
Ferreira, Amanda Ribeiro
Videira, Lorene de Souza
Teva, Antonio
Silva, Daiana Perce da
Marques, Maria Teresa Queiroz
Carvalho, Luzia Helena de
Banic, Dalma Maria
Pôrto, Luiz Cristóvão Sobrino
Ferreira, Joseli Oliveira
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Pereira, Virginia Araujo
Sánchez-Arcila, Juan Camilo
Vasconcelos, Mariana Pinheiro Alves
Ferreira, Amanda Ribeiro
Videira, Lorene de Souza
Teva, Antonio
Silva, Daiana Perce da
Marques, Maria Teresa Queiroz
Carvalho, Luzia Helena de
Banic, Dalma Maria
Pôrto, Luiz Cristóvão Sobrino
Ferreira, Joseli Oliveira
dc.subject.other.pt_BR.fl_str_mv Proteína circunsporozóita
Antígeno leucocitário humano
Anticorpo IgG
Malaria
Porto Velho
Rondônia
Marcador sorológico
topic Proteína circunsporozóita
Antígeno leucocitário humano
Anticorpo IgG
Malaria
Porto Velho
Rondônia
Marcador sorológico
Circumsporozoite protein
Human leucocyte antigen
IgG antibody
Malaria
Porto Velho
Rondônia
Serological marker
dc.subject.en.pt_BR.fl_str_mv Circumsporozoite protein
Human leucocyte antigen
IgG antibody
Malaria
Porto Velho
Rondônia
Serological marker
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratorio de Imunoparasitologia. Rio de Janeiro, RJ, Brazil
publishDate 2018
dc.date.accessioned.fl_str_mv 2018-08-27T18:37:06Z
dc.date.available.fl_str_mv 2018-08-27T18:37:06Z
dc.date.issued.fl_str_mv 2018
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv PEREIRA, Virginia Araujo et al. Evaluating seroprevalence to circumsporozoite protein to estimate exposure to three species of Plasmodium in the Brazilian Amazon. Infect Dis Poverty, v. 7, n. 1, p.46, 2018
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/28399
dc.identifier.issn.pt_BR.fl_str_mv 2049-9957
dc.identifier.doi.none.fl_str_mv 10.1186/s40249-018-0428-1
identifier_str_mv PEREIRA, Virginia Araujo et al. Evaluating seroprevalence to circumsporozoite protein to estimate exposure to three species of Plasmodium in the Brazilian Amazon. Infect Dis Poverty, v. 7, n. 1, p.46, 2018
2049-9957
10.1186/s40249-018-0428-1
url https://www.arca.fiocruz.br/handle/icict/28399
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv BioMed Central
publisher.none.fl_str_mv BioMed Central
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