Evaluating seroprevalence to circumsporozoite protein to estimate exposure to three species of Plasmodium in the Brazilian Amazon.

Pereira, Virginia Araujo; Sánchez-Arcila, Juan Camilo; Vasconcelos, Mariana Pinheiro Alves; Ferreira, Amanda Ribeiro; Videira, Lorene de Souza; Teva, Antonio; Silva, Daiana Perce da; Marques, Maria Teresa Queiroz; Carvalho, Luzia Helena de; Banic, Dalma Maria; Pôrto, Luiz Cristóvão Sobrino; Ferreira, Joseli Oliveira

Evaluating seroprevalence to circumsporozoite protein to estimate exposure to three species of Plasmodium in the Brazilian Amazon.

Detalhes bibliográficos
Autor(a) principal:	Pereira, Virginia Araujo
Data de Publicação:	2018
Outros Autores:	Sánchez-Arcila, Juan Camilo, Vasconcelos, Mariana Pinheiro Alves, Ferreira, Amanda Ribeiro, Videira, Lorene de Souza, Teva, Antonio, Silva, Daiana Perce da, Marques, Maria Teresa Queiroz, Carvalho, Luzia Helena de, Banic, Dalma Maria, Pôrto, Luiz Cristóvão Sobrino, Ferreira, Joseli Oliveira
Tipo de documento:	Artigo
Idioma:	eng
Título da fonte:	Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo:	https://www.arca.fiocruz.br/handle/icict/28399
Resumo:	Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratorio de Imunoparasitologia. Rio de Janeiro, RJ, Brazil

Metadados do item

id	CRUZ_f010c2161be14b4e347828058e9e89a3
oai_identifier_str	oai:www.arca.fiocruz.br:icict/28399
network_acronym_str	CRUZ
network_name_str	Repositório Institucional da FIOCRUZ (ARCA)
repository_id_str	2135
spelling	Pereira, Virginia AraujoSánchez-Arcila, Juan CamiloVasconcelos, Mariana Pinheiro AlvesFerreira, Amanda RibeiroVideira, Lorene de SouzaTeva, AntonioSilva, Daiana Perce daMarques, Maria Teresa QueirozCarvalho, Luzia Helena deBanic, Dalma MariaPôrto, Luiz Cristóvão SobrinoFerreira, Joseli Oliveira2018-08-27T18:37:06Z2018-08-27T18:37:06Z2018PEREIRA, Virginia Araujo et al. Evaluating seroprevalence to circumsporozoite protein to estimate exposure to three species of Plasmodium in the Brazilian Amazon. Infect Dis Poverty, v. 7, n. 1, p.46, 20182049-9957https://www.arca.fiocruz.br/handle/icict/2839910.1186/s40249-018-0428-1engBioMed CentralProteína circunsporozóitaAntígeno leucocitário humanoAnticorpo IgGMalariaPorto VelhoRondôniaMarcador sorológicoCircumsporozoite proteinHuman leucocyte antigenIgG antibodyMalariaPorto VelhoRondôniaSerological markerEvaluating seroprevalence to circumsporozoite protein to estimate exposure to three species of Plasmodium in the Brazilian Amazon.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratorio de Imunoparasitologia. Rio de Janeiro, RJ, BrazilFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratorio de Imunoparasitologia. Rio de Janeiro, RJ, BrazilInstituto de Infectologia Emilio Ribas. São Paulo, SP, BrazilFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratorio de Imunoparasitologia. Rio de Janeiro, RJ, BrazilFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratorio de Imunoparasitologia. Rio de Janeiro, RJ, BrazilFundação Oswaldo Cruz. Escola Nacional de Saude Publica. Departamento de Ciencias Biologicas. Laboratorio de Imunodiagnostico. Rio de Janeiro, RJ, BrazilFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratorio de Imunologia Clinica. Rio de Janeiro, RJ, BrazilUniversidade Estadual do Rio de Janeiro. Laboratório de Histocompatibilidade e Criopreservação. Rio de Janeiro, RJ, BrazilFundação Oswaldo Cruz. Instituto René Rachou Biologia Molecular e Imunologia da Malária. Belo Horizonte, MG, BrazilFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratorio de Imunologia Clinica. Rio de Janeiro, RJ, BrazilUniversidade Estadual do Rio de Janeiro. Laboratório de Histocompatibilidade e Criopreservação. Rio de Janeiro, RJ, BrazilFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratorio de Imunoparasitologia. Rio de Janeiro, RJ, BrazilBACKGROUND: Brazil has seen a great decline in malaria and the country is moving towards elimination. However, for eventual elimination, the control program needs efficient tools in order to monitor malaria exposure and transmission. In this study, we aimed to evaluate whether seroprevalence to the circumsporozoite protein (CSP) is a good tool for monitoring the exposure to and/or evaluating the burden and distribution of Plasmodium species in the Brazilian Amazon. METHODS: Cross-sectional surveys were conducted in a rural area of Porto Velho, Rondônia state. Parasite infection was detected by microscopy and polymerase chain reaction. Antibodies to the sporozoite CSP repeats of Plasmodium vivax, P. falciparum, and P. malariae (PvCS, PfCS, and PmCS) were detected using the enzyme-linked immunosorbent assay technique. Human leukocyte antigen (HLA)-DRB1 and DQB1 genes were typed using Luminex® xMAP® technology. RESULTS: The prevalence of immunoglobulin G against P. vivax CSP peptide (62%) was higher than P. falciparum (49%) and P. malariae (46%) CSP peptide. Most of the studied individuals had antibodies to at least one of the three peptides (72%), 34% had antibodies to all three peptides and 28% were non-responders. Although the majority of the population was not infected at the time of the survey, 74.3% of parasite-negative individuals had antibodies to at least one of the CSPs. Importantly, among individuals carrying the haplotypes DRB104~DQB103, there was a significantly higher frequency of PfCS responders, and DRB116~DQB103 haplotype for PvCS and PfCS responders. In contrast, HLA-DRB101 and HLA-DQB105 allelic groups were associated with a lack of antibodies to P. vivax and P. falciparum CSP repeats, and the haplotype DRB101~DQB105 was also associated with non-responders, including non-responders to P. malariae. CONCLUSIONS: Our results show that in low transmission settings, naturally acquired antibody responses against the CSP repeats of P. vivax, P. falciparum, and P. malariae in a single cross-sectional study may not represent a valuable marker for monitoring recent malaria exposure, especially in an area with a high prevalence of P. vivax. Furthermore, HLA class II molecules play an important role in antibody response and require further study with a larger sample size. It will be of interest to consider HLA analysis when using serosurveillance to monitor malaria exposure among genetically diverse populations.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83082https://www.arca.fiocruz.br/bitstream/icict/28399/1/license.txt9193a7c197bc67acd023525e72a03240MD51ORIGINALEvaluating seroprevalence to circumsporozoite protein to estimate exposure to three species of Plasmodium in the Brazilian Amazon.pdfEvaluating seroprevalence to circumsporozoite protein to estimate exposure to three species of Plasmodium in the Brazilian Amazon.pdfapplication/pdf918934https://www.arca.fiocruz.br/bitstream/icict/28399/2/Evaluating%20seroprevalence%20to%20circumsporozoite%20protein%20to%20estimate%20exposure%20to%20three%20species%20of%20Plasmodium%20in%20the%20Brazilian%20Amazon.pdfd7618c4561d4cf1e8b8bee9c07afb76eMD52TEXTEvaluating seroprevalence to circumsporozoite protein to estimate exposure to three species of Plasmodium in the Brazilian Amazon.pdf.txtEvaluating seroprevalence to circumsporozoite protein to estimate exposure to three species of Plasmodium in the Brazilian Amazon.pdf.txtExtracted texttext/plain51272https://www.arca.fiocruz.br/bitstream/icict/28399/3/Evaluating%20seroprevalence%20to%20circumsporozoite%20protein%20to%20estimate%20exposure%20to%20three%20species%20of%20Plasmodium%20in%20the%20Brazilian%20Amazon.pdf.txt40875474070dd7ad4014636d5baca86eMD53icict/283992019-06-19 10:14:00.697oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352019-06-19T13:14Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv	Evaluating seroprevalence to circumsporozoite protein to estimate exposure to three species of Plasmodium in the Brazilian Amazon.
title	Evaluating seroprevalence to circumsporozoite protein to estimate exposure to three species of Plasmodium in the Brazilian Amazon.
spellingShingle	Evaluating seroprevalence to circumsporozoite protein to estimate exposure to three species of Plasmodium in the Brazilian Amazon. Pereira, Virginia Araujo Proteína circunsporozóita Antígeno leucocitário humano Anticorpo IgG Malaria Porto Velho Rondônia Marcador sorológico Circumsporozoite protein Human leucocyte antigen IgG antibody Malaria Porto Velho Rondônia Serological marker
title_short	Evaluating seroprevalence to circumsporozoite protein to estimate exposure to three species of Plasmodium in the Brazilian Amazon.
title_full	Evaluating seroprevalence to circumsporozoite protein to estimate exposure to three species of Plasmodium in the Brazilian Amazon.
title_fullStr	Evaluating seroprevalence to circumsporozoite protein to estimate exposure to three species of Plasmodium in the Brazilian Amazon.
title_full_unstemmed	Evaluating seroprevalence to circumsporozoite protein to estimate exposure to three species of Plasmodium in the Brazilian Amazon.
title_sort	Evaluating seroprevalence to circumsporozoite protein to estimate exposure to three species of Plasmodium in the Brazilian Amazon.
author	Pereira, Virginia Araujo
author_facet	Pereira, Virginia Araujo Sánchez-Arcila, Juan Camilo Vasconcelos, Mariana Pinheiro Alves Ferreira, Amanda Ribeiro Videira, Lorene de Souza Teva, Antonio Silva, Daiana Perce da Marques, Maria Teresa Queiroz Carvalho, Luzia Helena de Banic, Dalma Maria Pôrto, Luiz Cristóvão Sobrino Ferreira, Joseli Oliveira
author_role	author
author2	Sánchez-Arcila, Juan Camilo Vasconcelos, Mariana Pinheiro Alves Ferreira, Amanda Ribeiro Videira, Lorene de Souza Teva, Antonio Silva, Daiana Perce da Marques, Maria Teresa Queiroz Carvalho, Luzia Helena de Banic, Dalma Maria Pôrto, Luiz Cristóvão Sobrino Ferreira, Joseli Oliveira
author2_role	author author author author author author author author author author author
dc.contributor.author.fl_str_mv	Pereira, Virginia Araujo Sánchez-Arcila, Juan Camilo Vasconcelos, Mariana Pinheiro Alves Ferreira, Amanda Ribeiro Videira, Lorene de Souza Teva, Antonio Silva, Daiana Perce da Marques, Maria Teresa Queiroz Carvalho, Luzia Helena de Banic, Dalma Maria Pôrto, Luiz Cristóvão Sobrino Ferreira, Joseli Oliveira
dc.subject.other.pt_BR.fl_str_mv	Proteína circunsporozóita Antígeno leucocitário humano Anticorpo IgG Malaria Porto Velho Rondônia Marcador sorológico
topic	Proteína circunsporozóita Antígeno leucocitário humano Anticorpo IgG Malaria Porto Velho Rondônia Marcador sorológico Circumsporozoite protein Human leucocyte antigen IgG antibody Malaria Porto Velho Rondônia Serological marker
dc.subject.en.pt_BR.fl_str_mv	Circumsporozoite protein Human leucocyte antigen IgG antibody Malaria Porto Velho Rondônia Serological marker
description	Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratorio de Imunoparasitologia. Rio de Janeiro, RJ, Brazil
publishDate	2018
dc.date.accessioned.fl_str_mv	2018-08-27T18:37:06Z
dc.date.available.fl_str_mv	2018-08-27T18:37:06Z
dc.date.issued.fl_str_mv	2018
dc.type.status.fl_str_mv	info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv	info:eu-repo/semantics/article
format	article
status_str	publishedVersion
dc.identifier.citation.fl_str_mv	PEREIRA, Virginia Araujo et al. Evaluating seroprevalence to circumsporozoite protein to estimate exposure to three species of Plasmodium in the Brazilian Amazon. Infect Dis Poverty, v. 7, n. 1, p.46, 2018
dc.identifier.uri.fl_str_mv	https://www.arca.fiocruz.br/handle/icict/28399
dc.identifier.issn.pt_BR.fl_str_mv	2049-9957
dc.identifier.doi.none.fl_str_mv	10.1186/s40249-018-0428-1
identifier_str_mv	PEREIRA, Virginia Araujo et al. Evaluating seroprevalence to circumsporozoite protein to estimate exposure to three species of Plasmodium in the Brazilian Amazon. Infect Dis Poverty, v. 7, n. 1, p.46, 2018 2049-9957 10.1186/s40249-018-0428-1
url	https://www.arca.fiocruz.br/handle/icict/28399
dc.language.iso.fl_str_mv	eng
language	eng
dc.rights.driver.fl_str_mv	info:eu-repo/semantics/openAccess
eu_rights_str_mv	openAccess
dc.publisher.none.fl_str_mv	BioMed Central
publisher.none.fl_str_mv	BioMed Central
dc.source.none.fl_str_mv	reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ
instname_str	Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str	FIOCRUZ
institution	FIOCRUZ
reponame_str	Repositório Institucional da FIOCRUZ (ARCA)
collection	Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv	https://www.arca.fiocruz.br/bitstream/icict/28399/1/license.txt https://www.arca.fiocruz.br/bitstream/icict/28399/2/Evaluating%20seroprevalence%20to%20circumsporozoite%20protein%20to%20estimate%20exposure%20to%20three%20species%20of%20Plasmodium%20in%20the%20Brazilian%20Amazon.pdf https://www.arca.fiocruz.br/bitstream/icict/28399/3/Evaluating%20seroprevalence%20to%20circumsporozoite%20protein%20to%20estimate%20exposure%20to%20three%20species%20of%20Plasmodium%20in%20the%20Brazilian%20Amazon.pdf.txt
bitstream.checksum.fl_str_mv	9193a7c197bc67acd023525e72a03240 d7618c4561d4cf1e8b8bee9c07afb76e 40875474070dd7ad4014636d5baca86e
bitstream.checksumAlgorithm.fl_str_mv	MD5 MD5 MD5
repository.name.fl_str_mv	Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv	repositorio.arca@fiocruz.br
_version_	1798325085743874048

Evaluating seroprevalence to circumsporozoite protein to estimate exposure to three species of Plasmodium in the Brazilian Amazon.

Registros relacionados