Evaluating seroprevalence to circumsporozoite protein to estimate exposure to three species of Plasmodium in the Brazilian Amazon.
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/28399 |
Resumo: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratorio de Imunoparasitologia. Rio de Janeiro, RJ, Brazil |
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Pereira, Virginia AraujoSánchez-Arcila, Juan CamiloVasconcelos, Mariana Pinheiro AlvesFerreira, Amanda RibeiroVideira, Lorene de SouzaTeva, AntonioSilva, Daiana Perce daMarques, Maria Teresa QueirozCarvalho, Luzia Helena deBanic, Dalma MariaPôrto, Luiz Cristóvão SobrinoFerreira, Joseli Oliveira2018-08-27T18:37:06Z2018-08-27T18:37:06Z2018PEREIRA, Virginia Araujo et al. Evaluating seroprevalence to circumsporozoite protein to estimate exposure to three species of Plasmodium in the Brazilian Amazon. Infect Dis Poverty, v. 7, n. 1, p.46, 20182049-9957https://www.arca.fiocruz.br/handle/icict/2839910.1186/s40249-018-0428-1engBioMed CentralProteína circunsporozóitaAntígeno leucocitário humanoAnticorpo IgGMalariaPorto VelhoRondôniaMarcador sorológicoCircumsporozoite proteinHuman leucocyte antigenIgG antibodyMalariaPorto VelhoRondôniaSerological markerEvaluating seroprevalence to circumsporozoite protein to estimate exposure to three species of Plasmodium in the Brazilian Amazon.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratorio de Imunoparasitologia. Rio de Janeiro, RJ, BrazilFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratorio de Imunoparasitologia. Rio de Janeiro, RJ, BrazilInstituto de Infectologia Emilio Ribas. São Paulo, SP, BrazilFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratorio de Imunoparasitologia. Rio de Janeiro, RJ, BrazilFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratorio de Imunoparasitologia. Rio de Janeiro, RJ, BrazilFundação Oswaldo Cruz. Escola Nacional de Saude Publica. Departamento de Ciencias Biologicas. Laboratorio de Imunodiagnostico. Rio de Janeiro, RJ, BrazilFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratorio de Imunologia Clinica. Rio de Janeiro, RJ, BrazilUniversidade Estadual do Rio de Janeiro. Laboratório de Histocompatibilidade e Criopreservação. Rio de Janeiro, RJ, BrazilFundação Oswaldo Cruz. Instituto René Rachou Biologia Molecular e Imunologia da Malária. Belo Horizonte, MG, BrazilFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratorio de Imunologia Clinica. Rio de Janeiro, RJ, BrazilUniversidade Estadual do Rio de Janeiro. Laboratório de Histocompatibilidade e Criopreservação. Rio de Janeiro, RJ, BrazilFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratorio de Imunoparasitologia. Rio de Janeiro, RJ, BrazilBACKGROUND: Brazil has seen a great decline in malaria and the country is moving towards elimination. However, for eventual elimination, the control program needs efficient tools in order to monitor malaria exposure and transmission. In this study, we aimed to evaluate whether seroprevalence to the circumsporozoite protein (CSP) is a good tool for monitoring the exposure to and/or evaluating the burden and distribution of Plasmodium species in the Brazilian Amazon. METHODS: Cross-sectional surveys were conducted in a rural area of Porto Velho, Rondônia state. Parasite infection was detected by microscopy and polymerase chain reaction. Antibodies to the sporozoite CSP repeats of Plasmodium vivax, P. falciparum, and P. malariae (PvCS, PfCS, and PmCS) were detected using the enzyme-linked immunosorbent assay technique. Human leukocyte antigen (HLA)-DRB1 and DQB1 genes were typed using Luminex® xMAP® technology. RESULTS: The prevalence of immunoglobulin G against P. vivax CSP peptide (62%) was higher than P. falciparum (49%) and P. malariae (46%) CSP peptide. Most of the studied individuals had antibodies to at least one of the three peptides (72%), 34% had antibodies to all three peptides and 28% were non-responders. Although the majority of the population was not infected at the time of the survey, 74.3% of parasite-negative individuals had antibodies to at least one of the CSPs. Importantly, among individuals carrying the haplotypes DRB1*04~DQB1*03, there was a significantly higher frequency of PfCS responders, and DRB1*16~DQB1*03 haplotype for PvCS and PfCS responders. In contrast, HLA-DRB1*01 and HLA-DQB1*05 allelic groups were associated with a lack of antibodies to P. vivax and P. falciparum CSP repeats, and the haplotype DRB1*01~DQB1*05 was also associated with non-responders, including non-responders to P. malariae. CONCLUSIONS: Our results show that in low transmission settings, naturally acquired antibody responses against the CSP repeats of P. vivax, P. falciparum, and P. malariae in a single cross-sectional study may not represent a valuable marker for monitoring recent malaria exposure, especially in an area with a high prevalence of P. vivax. Furthermore, HLA class II molecules play an important role in antibody response and require further study with a larger sample size. It will be of interest to consider HLA analysis when using serosurveillance to monitor malaria exposure among genetically diverse populations.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83082https://www.arca.fiocruz.br/bitstream/icict/28399/1/license.txt9193a7c197bc67acd023525e72a03240MD51ORIGINALEvaluating seroprevalence to circumsporozoite protein to estimate exposure to three species of Plasmodium in the Brazilian Amazon.pdfEvaluating seroprevalence to circumsporozoite protein to estimate exposure to three species of Plasmodium in the Brazilian Amazon.pdfapplication/pdf918934https://www.arca.fiocruz.br/bitstream/icict/28399/2/Evaluating%20seroprevalence%20to%20circumsporozoite%20protein%20to%20estimate%20exposure%20to%20three%20species%20of%20Plasmodium%20in%20the%20Brazilian%20Amazon.pdfd7618c4561d4cf1e8b8bee9c07afb76eMD52TEXTEvaluating seroprevalence to circumsporozoite protein to estimate exposure to three species of Plasmodium in the Brazilian Amazon.pdf.txtEvaluating seroprevalence to circumsporozoite protein to estimate exposure to three species of Plasmodium in the Brazilian Amazon.pdf.txtExtracted texttext/plain51272https://www.arca.fiocruz.br/bitstream/icict/28399/3/Evaluating%20seroprevalence%20to%20circumsporozoite%20protein%20to%20estimate%20exposure%20to%20three%20species%20of%20Plasmodium%20in%20the%20Brazilian%20Amazon.pdf.txt40875474070dd7ad4014636d5baca86eMD53icict/283992019-06-19 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dc.title.pt_BR.fl_str_mv |
Evaluating seroprevalence to circumsporozoite protein to estimate exposure to three species of Plasmodium in the Brazilian Amazon. |
title |
Evaluating seroprevalence to circumsporozoite protein to estimate exposure to three species of Plasmodium in the Brazilian Amazon. |
spellingShingle |
Evaluating seroprevalence to circumsporozoite protein to estimate exposure to three species of Plasmodium in the Brazilian Amazon. Pereira, Virginia Araujo Proteína circunsporozóita Antígeno leucocitário humano Anticorpo IgG Malaria Porto Velho Rondônia Marcador sorológico Circumsporozoite protein Human leucocyte antigen IgG antibody Malaria Porto Velho Rondônia Serological marker |
title_short |
Evaluating seroprevalence to circumsporozoite protein to estimate exposure to three species of Plasmodium in the Brazilian Amazon. |
title_full |
Evaluating seroprevalence to circumsporozoite protein to estimate exposure to three species of Plasmodium in the Brazilian Amazon. |
title_fullStr |
Evaluating seroprevalence to circumsporozoite protein to estimate exposure to three species of Plasmodium in the Brazilian Amazon. |
title_full_unstemmed |
Evaluating seroprevalence to circumsporozoite protein to estimate exposure to three species of Plasmodium in the Brazilian Amazon. |
title_sort |
Evaluating seroprevalence to circumsporozoite protein to estimate exposure to three species of Plasmodium in the Brazilian Amazon. |
author |
Pereira, Virginia Araujo |
author_facet |
Pereira, Virginia Araujo Sánchez-Arcila, Juan Camilo Vasconcelos, Mariana Pinheiro Alves Ferreira, Amanda Ribeiro Videira, Lorene de Souza Teva, Antonio Silva, Daiana Perce da Marques, Maria Teresa Queiroz Carvalho, Luzia Helena de Banic, Dalma Maria Pôrto, Luiz Cristóvão Sobrino Ferreira, Joseli Oliveira |
author_role |
author |
author2 |
Sánchez-Arcila, Juan Camilo Vasconcelos, Mariana Pinheiro Alves Ferreira, Amanda Ribeiro Videira, Lorene de Souza Teva, Antonio Silva, Daiana Perce da Marques, Maria Teresa Queiroz Carvalho, Luzia Helena de Banic, Dalma Maria Pôrto, Luiz Cristóvão Sobrino Ferreira, Joseli Oliveira |
author2_role |
author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Pereira, Virginia Araujo Sánchez-Arcila, Juan Camilo Vasconcelos, Mariana Pinheiro Alves Ferreira, Amanda Ribeiro Videira, Lorene de Souza Teva, Antonio Silva, Daiana Perce da Marques, Maria Teresa Queiroz Carvalho, Luzia Helena de Banic, Dalma Maria Pôrto, Luiz Cristóvão Sobrino Ferreira, Joseli Oliveira |
dc.subject.other.pt_BR.fl_str_mv |
Proteína circunsporozóita Antígeno leucocitário humano Anticorpo IgG Malaria Porto Velho Rondônia Marcador sorológico |
topic |
Proteína circunsporozóita Antígeno leucocitário humano Anticorpo IgG Malaria Porto Velho Rondônia Marcador sorológico Circumsporozoite protein Human leucocyte antigen IgG antibody Malaria Porto Velho Rondônia Serological marker |
dc.subject.en.pt_BR.fl_str_mv |
Circumsporozoite protein Human leucocyte antigen IgG antibody Malaria Porto Velho Rondônia Serological marker |
description |
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratorio de Imunoparasitologia. Rio de Janeiro, RJ, Brazil |
publishDate |
2018 |
dc.date.accessioned.fl_str_mv |
2018-08-27T18:37:06Z |
dc.date.available.fl_str_mv |
2018-08-27T18:37:06Z |
dc.date.issued.fl_str_mv |
2018 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
PEREIRA, Virginia Araujo et al. Evaluating seroprevalence to circumsporozoite protein to estimate exposure to three species of Plasmodium in the Brazilian Amazon. Infect Dis Poverty, v. 7, n. 1, p.46, 2018 |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/28399 |
dc.identifier.issn.pt_BR.fl_str_mv |
2049-9957 |
dc.identifier.doi.none.fl_str_mv |
10.1186/s40249-018-0428-1 |
identifier_str_mv |
PEREIRA, Virginia Araujo et al. Evaluating seroprevalence to circumsporozoite protein to estimate exposure to three species of Plasmodium in the Brazilian Amazon. Infect Dis Poverty, v. 7, n. 1, p.46, 2018 2049-9957 10.1186/s40249-018-0428-1 |
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https://www.arca.fiocruz.br/handle/icict/28399 |
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eng |
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eng |
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info:eu-repo/semantics/openAccess |
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openAccess |
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BioMed Central |
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BioMed Central |
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