Schistosoma mansoni antigens alter the cytokine response in vitro during cutaneous leishmaniasis

Detalhes bibliográficos
Autor(a) principal: Bafica, Aline Michelle Barbosa
Data de Publicação: 2011
Outros Autores: Cardoso, Luciana Santos, Oliveira, Sérgio Costa, Loukas, Alex, Varela, Giuseppe Tittoni, Oliveira, Ricardo Riccio, Bacellar, Olívia, Carvalho Filho, Edgar Marcelino, Araújo, Maria Ilma
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/27160
Resumo: Oliveira, Ricardo Riccio; Carvalho Filho, Edgar Marcelino de. “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.
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spelling Bafica, Aline Michelle BarbosaCardoso, Luciana SantosOliveira, Sérgio CostaLoukas, AlexVarela, Giuseppe TittoniOliveira, Ricardo RiccioBacellar, OlíviaCarvalho Filho, Edgar MarcelinoAraújo, Maria Ilma2018-06-28T13:16:05Z2018-06-28T13:16:05Z2011BAFICA, A. M. B. et al. Schistosoma mansoni antigens alter the cytokine response in vitro during cutaneous leishmaniasis. Memórias do Instituto Oswaldo Cruz, v. 106, n. 7, p. 856-863, 2011.0074-0276https://www.arca.fiocruz.br/handle/icict/27160Oliveira, Ricardo Riccio; Carvalho Filho, Edgar Marcelino de. “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.MCT/CNPq (479417/2008 3 universal) MIA, SCO and EMC are investigators supported by CNPq.Universidade Federal da Bahia. Hospital Universitário Prof. Edgard Santos. Serviço de Imunologia. Salvador, BA, BrasilUniversidade Federal da Bahia. Hospital Universitário Prof. Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Universidade do Estado da Bahia. Departamento de Ciências da Vida. Salvador, BA, BrasilUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, BrasilUniversity of Edinburgh. Center for Immunity, Infection and Evolution. Edinburgh, UKUniversidade Federal da Bahia. Hospital Universitário Prof. Edgard Santos. Serviço de Imunologia. Salvador, BA, BrasilUniversidade Federal da Bahia. Hospital Universitário Prof. Edgard Santos. Serviço de Imunologia. Salvador, BA, BrasilUniversidade Federal da Bahia. Hospital Universitário Prof. Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais. Salvador, BA, BrasilUniversidade Federal da Bahia. Hospital Universitário Prof. Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais. Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, BrasilUniversidade Federal da Bahia. Hospital Universitário Prof. Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais. Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, BrasilSchistosoma mansoni infection or associated products are able to down-modulate the type 1 CD4+ T cell inflammatory response characteristic of autoimmune diseases. In this study, we evaluated how S. mansoni antigens altered the immune response that was induced by the soluble Leishmania antigen (SLA) from cutaneous leishmaniasis (CL) patients. Cytokines were measured from the supernatants of peripheral blood mononuclear cell cultures stimulated with SLA. This was performed using the sandwich enzyme linked immunosorbent assay technique in the presence or absence of S. mansoni recombinant antigens Sm29, SmTSP-2 and PIII. The addition of S. mansoni antigens to the cultures resulted in the reduction of interferon gamma (IFN-γ) levels in 37-50% of patients. Although to a lesser extent, the antigens were also able to decrease the production of tumour necrosis factor-alpha (TNF-α). We compared patients that either had or did not have reduction in IFN-γ and TNF-α production in cultures stimulated with SLA in the presence of S. mansoni antigens. We found that there was no significant difference in the levels of interleukin (IL)-10 and IL-5 in response to S. mansoni antigens between the groups. The antigens used in this study down-modulated the in vitro proinflammatory response induced by SLA in a group of CL patients through a currently undefined mechanism.engInstituto Oswaldo CruzLeishmaniose cutâneaAntígenos de S. mansoniSm29SmTSP-2PIIICutaneous leishmaniasisS. mansoni antigensSm29SmTSP-2PIIISchistosoma mansoni antigens alter the cytokine response in vitro during cutaneous leishmaniasisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/27160/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALBafica AMB Schistosoma mansoni antigens alter ....pdfBafica AMB Schistosoma mansoni antigens alter 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dc.title.pt_BR.fl_str_mv Schistosoma mansoni antigens alter the cytokine response in vitro during cutaneous leishmaniasis
title Schistosoma mansoni antigens alter the cytokine response in vitro during cutaneous leishmaniasis
spellingShingle Schistosoma mansoni antigens alter the cytokine response in vitro during cutaneous leishmaniasis
Bafica, Aline Michelle Barbosa
Leishmaniose cutânea
Antígenos de S. mansoni
Sm29
SmTSP-2
PIII
Cutaneous leishmaniasis
S. mansoni antigens
Sm29
SmTSP-2
PIII
title_short Schistosoma mansoni antigens alter the cytokine response in vitro during cutaneous leishmaniasis
title_full Schistosoma mansoni antigens alter the cytokine response in vitro during cutaneous leishmaniasis
title_fullStr Schistosoma mansoni antigens alter the cytokine response in vitro during cutaneous leishmaniasis
title_full_unstemmed Schistosoma mansoni antigens alter the cytokine response in vitro during cutaneous leishmaniasis
title_sort Schistosoma mansoni antigens alter the cytokine response in vitro during cutaneous leishmaniasis
author Bafica, Aline Michelle Barbosa
author_facet Bafica, Aline Michelle Barbosa
Cardoso, Luciana Santos
Oliveira, Sérgio Costa
Loukas, Alex
Varela, Giuseppe Tittoni
Oliveira, Ricardo Riccio
Bacellar, Olívia
Carvalho Filho, Edgar Marcelino
Araújo, Maria Ilma
author_role author
author2 Cardoso, Luciana Santos
Oliveira, Sérgio Costa
Loukas, Alex
Varela, Giuseppe Tittoni
Oliveira, Ricardo Riccio
Bacellar, Olívia
Carvalho Filho, Edgar Marcelino
Araújo, Maria Ilma
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Bafica, Aline Michelle Barbosa
Cardoso, Luciana Santos
Oliveira, Sérgio Costa
Loukas, Alex
Varela, Giuseppe Tittoni
Oliveira, Ricardo Riccio
Bacellar, Olívia
Carvalho Filho, Edgar Marcelino
Araújo, Maria Ilma
dc.subject.other.pt_BR.fl_str_mv Leishmaniose cutânea
Antígenos de S. mansoni
Sm29
SmTSP-2
PIII
topic Leishmaniose cutânea
Antígenos de S. mansoni
Sm29
SmTSP-2
PIII
Cutaneous leishmaniasis
S. mansoni antigens
Sm29
SmTSP-2
PIII
dc.subject.en.pt_BR.fl_str_mv Cutaneous leishmaniasis
S. mansoni antigens
Sm29
SmTSP-2
PIII
description Oliveira, Ricardo Riccio; Carvalho Filho, Edgar Marcelino de. “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.
publishDate 2011
dc.date.issued.fl_str_mv 2011
dc.date.accessioned.fl_str_mv 2018-06-28T13:16:05Z
dc.date.available.fl_str_mv 2018-06-28T13:16:05Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv BAFICA, A. M. B. et al. Schistosoma mansoni antigens alter the cytokine response in vitro during cutaneous leishmaniasis. Memórias do Instituto Oswaldo Cruz, v. 106, n. 7, p. 856-863, 2011.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/27160
dc.identifier.issn.pt_BR.fl_str_mv 0074-0276
identifier_str_mv BAFICA, A. M. B. et al. Schistosoma mansoni antigens alter the cytokine response in vitro during cutaneous leishmaniasis. Memórias do Instituto Oswaldo Cruz, v. 106, n. 7, p. 856-863, 2011.
0074-0276
url https://www.arca.fiocruz.br/handle/icict/27160
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Instituto Oswaldo Cruz
publisher.none.fl_str_mv Instituto Oswaldo Cruz
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
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instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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