Schistosoma mansoni antigens alter the cytokine response in vitro during cutaneous leishmaniasis
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2011 |
| Outros Autores: | , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFBA |
| Texto Completo: | http://www.repositorio.ufba.br/ri/handle/ri/5453 |
Resumo: | p. 856-863. |
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Bafica, Aline Michelle BarbosaCardoso, Luciana SantosOliveira, Sérgio CostaLoukas, AlexVarela, Giuseppe TittoniOliveira, Ricardo RiccioBacellar, Maria Olívia Amado RamosCarvalho Filho, Edgar Marcelino deAraujo, Maria Ilma Andrade SantosBafica, Aline Michelle BarbosaCardoso, Luciana SantosOliveira, Sérgio CostaLoukas, AlexVarela, Giuseppe TittoniOliveira, Ricardo RiccioBacellar, Maria Olívia Amado RamosCarvalho Filho, Edgar Marcelino deAraujo, Maria Ilma Andrade Santos2012-02-25T16:34:45Z2012-02-25T16:34:45Z20111678-8060http://www.repositorio.ufba.br/ri/handle/ri/5453106(7)p. 856-863.Schistosoma mansoni infection or associated products are able to down-modulate the type 1 CD4+ T cell inflammatory response characteristic of autoimmune diseases. In this study, we evaluated how S. mansoni antigens altered the immune response that was induced by the soluble Leishmania antigen (SLA) from cutaneous leishmaniasis (CL) patients. Cytokines were measured from the supernatants of peripheral blood mononuclear cell cultures stimulated with SLA. This was performed using the sandwich enzyme linked immunosorbent assay technique in the presence or absence of S. mansoni recombinant antigens Sm29, SmTSP-2 and PIII. The addition of S. mansoni antigens to the cultures resulted in the reduction of interferon gamma (IFN-γ) levels in 37-50% of patients. Although to a lesser extent, the antigens were also able to decrease the production of tumour necrosis factor-alpha (TNF-α). We compared patients that either had or did not have reduction in IFN-γ and TNF-α production in cultures stimulated with SLA in the presence of S. mansoni antigens. We found that there was no significant difference in the levels of interleukin (IL)-10 and IL-5 in response to S. mansoni antigens between the groups. The antigens used in this study down-modulated the in vitro proinflammatory response induced by SLA in a group of CL patients through a currently undefined mechanism.Submitted by Ana Valéria de Jesus Moura (anavaleria_131@hotmail.com) on 2012-02-25T16:34:44Z No. of bitstreams: 1 Schistosoma mansoni antigens alter the cytokine response in vitro during cutaneous leishmaniasis.pdf: 620811 bytes, checksum: 59f42a968b34ba4faefcf7a37f0ac0b9 (MD5)Made available in DSpace on 2012-02-25T16:34:45Z (GMT). No. of bitstreams: 1 Schistosoma mansoni antigens alter the cytokine response in vitro during cutaneous leishmaniasis.pdf: 620811 bytes, checksum: 59f42a968b34ba4faefcf7a37f0ac0b9 (MD5) Previous issue date: 2011cutaneous leishmaniasisS. mansoni antigensSm29SmTSP-2PIIISchistosoma mansoni antigens alter the cytokine response in vitro during cutaneous leishmaniasisMemórias do Instituto Oswaldo Cruzinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleengreponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAinfo:eu-repo/semantics/openAccessORIGINALSchistosoma mansoni antigens alter the cytokine response in vitro during cutaneous leishmaniasis.pdfSchistosoma mansoni antigens alter the cytokine response in vitro during cutaneous leishmaniasis.pdfapplication/pdf620811https://repositorio.ufba.br/bitstream/ri/5453/1/Schistosoma%20mansoni%20antigens%20alter%20the%20cytokine%20response%20in%20vitro%20during%20cutaneous%20leishmaniasis.pdf59f42a968b34ba4faefcf7a37f0ac0b9MD51LICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/5453/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52TEXTSchistosoma mansoni antigens alter the cytokine response in vitro during cutaneous leishmaniasis.pdf.txtSchistosoma mansoni antigens alter the cytokine response in vitro during cutaneous leishmaniasis.pdf.txtExtracted texttext/plain39837https://repositorio.ufba.br/bitstream/ri/5453/3/Schistosoma%20mansoni%20antigens%20alter%20the%20cytokine%20response%20in%20vitro%20during%20cutaneous%20leishmaniasis.pdf.txtc2c4bc82f5a46360bfcc3ad93761bb8eMD53ri/54532022-09-23 08:37:29.186oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-09-23T11:37:29Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false |
| dc.title.pt_BR.fl_str_mv |
Schistosoma mansoni antigens alter the cytokine response in vitro during cutaneous leishmaniasis |
| dc.title.alternative.pt_BR.fl_str_mv |
Memórias do Instituto Oswaldo Cruz |
| title |
Schistosoma mansoni antigens alter the cytokine response in vitro during cutaneous leishmaniasis |
| spellingShingle |
Schistosoma mansoni antigens alter the cytokine response in vitro during cutaneous leishmaniasis Bafica, Aline Michelle Barbosa cutaneous leishmaniasis S. mansoni antigens Sm29 SmTSP-2 PIII |
| title_short |
Schistosoma mansoni antigens alter the cytokine response in vitro during cutaneous leishmaniasis |
| title_full |
Schistosoma mansoni antigens alter the cytokine response in vitro during cutaneous leishmaniasis |
| title_fullStr |
Schistosoma mansoni antigens alter the cytokine response in vitro during cutaneous leishmaniasis |
| title_full_unstemmed |
Schistosoma mansoni antigens alter the cytokine response in vitro during cutaneous leishmaniasis |
| title_sort |
Schistosoma mansoni antigens alter the cytokine response in vitro during cutaneous leishmaniasis |
| author |
Bafica, Aline Michelle Barbosa |
| author_facet |
Bafica, Aline Michelle Barbosa Cardoso, Luciana Santos Oliveira, Sérgio Costa Loukas, Alex Varela, Giuseppe Tittoni Oliveira, Ricardo Riccio Bacellar, Maria Olívia Amado Ramos Carvalho Filho, Edgar Marcelino de Araujo, Maria Ilma Andrade Santos |
| author_role |
author |
| author2 |
Cardoso, Luciana Santos Oliveira, Sérgio Costa Loukas, Alex Varela, Giuseppe Tittoni Oliveira, Ricardo Riccio Bacellar, Maria Olívia Amado Ramos Carvalho Filho, Edgar Marcelino de Araujo, Maria Ilma Andrade Santos |
| author2_role |
author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Bafica, Aline Michelle Barbosa Cardoso, Luciana Santos Oliveira, Sérgio Costa Loukas, Alex Varela, Giuseppe Tittoni Oliveira, Ricardo Riccio Bacellar, Maria Olívia Amado Ramos Carvalho Filho, Edgar Marcelino de Araujo, Maria Ilma Andrade Santos Bafica, Aline Michelle Barbosa Cardoso, Luciana Santos Oliveira, Sérgio Costa Loukas, Alex Varela, Giuseppe Tittoni Oliveira, Ricardo Riccio Bacellar, Maria Olívia Amado Ramos Carvalho Filho, Edgar Marcelino de Araujo, Maria Ilma Andrade Santos |
| dc.subject.por.fl_str_mv |
cutaneous leishmaniasis S. mansoni antigens Sm29 SmTSP-2 PIII |
| topic |
cutaneous leishmaniasis S. mansoni antigens Sm29 SmTSP-2 PIII |
| description |
p. 856-863. |
| publishDate |
2011 |
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2011 |
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2012-02-25T16:34:45Z |
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2012-02-25T16:34:45Z |
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