Population genomics reveals the expansion of highly inbred Plasmodium vivax lineages in the main malaria hotspot of Brazil
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2020 |
| Outros Autores: | , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/44862 |
Resumo: | Universidade de São Paulo. Instituto de Ciências Biomédicas. Departamento de Parasitologia. São Paulo, SP, Brasil. |
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Oliveira, Thais Crippa deíCorder, Rodrigo M.Early, AngelaRodrigues, Priscila T.Andrade, Simone LadeiaAlves, João Marcelo P.Neafsey, Daniel E.Ferreira, Marcelo U.2020-12-14T13:59:09Z2020-12-14T13:59:09Z2020OLIVEIRA, Thaís Crippa de et al. Population genomics reveals the expansion of highly inbred Plasmodium vivaxlineages in the main malaria hotspot of Brazil. Plos Neglected Tropical Diseases, v. 14, n. 10, p. 1-16, Oct. 2020.1935-2727https://www.arca.fiocruz.br/handle/icict/4486210.1371/journal.pntd.00088081935-2735engPublic Lybrary of SciencePlasmodium vivaxLinhagensMaláriaBrasilGenômica populacionalPlasmodium vivaxLineagesPopulation genomicsMalariaBrazilPopulation genomics reveals the expansion of highly inbred Plasmodium vivax lineages in the main malaria hotspot of Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade de São Paulo. Instituto de Ciências Biomédicas. Departamento de Parasitologia. São Paulo, SP, Brasil.Universidade de São Paulo. Instituto de Ciências Biomédicas. Departamento de Parasitologia. São Paulo, SP, Brasil.Broad Institute of Meat and Harvard. Infectious Disease and Microbiome Program. Cambridge, Massachussets, USA / Harvard T. H. Chan School of Public Health. Boston, Massachussets, USA.Universidade de São Paulo. Instituto de Ciências Biomédicas. Departamento de Parasitologia. São Paulo, SP, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Doenças Parasitárias. Rio de Janeiro, RJ, Brasil.Universidade de São Paulo. Instituto de Ciências Biomédicas. Departamento de Parasitologia. São Paulo, SP, Brasil.Broad Institute of Meat and Harvard. Infectious Disease and Microbiome Program. Cambridge, Massachussets, USA / Harvard T. H. Chan School of Public Health. Boston, Massachussets, USA.Universidade de São Paulo. Instituto de Ciências Biomédicas. Departamento de Parasitologia. São Paulo, SP, Brasil.Background: Plasmodium vivax is a neglected human malaria parasite that causes significant morbidity in the Americas, the Middle East, Asia, and the Western Pacific. Population genomic approaches remain little explored to map local and regional transmission pathways of P. vivax across the main endemic sites in the Americas, where great progress has been made towards malaria elimination over the past decades. Methodology/Principal findings: We analyze 38 patient-derived P. vivax genome sequences from Maˆncio Lima (ML)–the Amazonian malaria hotspot next to the Brazil-Peru border—and 24 sequences from two other sites in Acre State, Brazil, a country that contributes 23% of malaria cases in the Americas. We show that the P. vivax population of ML is genetically diverse (π = 4.7 × 10−4), with a high polymorphism particularly in genes encoding proteins putatively involved in red blood cell invasion. Paradoxically, however, parasites display strong genome-wide linkage disequilibrium, being fragmented into discrete lineages that are remarkably stable across time and space, with only occasional recombination between them. Using identity-by-descent approaches, we identified a large cluster of closely related sequences that comprises 16 of 38 genomes sampled in ML over 26 months. Importantly, we found significant ancestry sharing between parasites at a large geographic distance, consistent with substantial gene flow between regional P. vivax populations. Conclusions/Significance: We have characterized the sustained expansion of highly inbred P. vivax lineages in a malaria hotspot that can seed regional transmission. Potential source populations in hotspots represent a priority target for malaria elimination in the Amazon.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/44862/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALSimoneLAndrade_ThaisOliveira_etal_IOC_2020.pdfSimoneLAndrade_ThaisOliveira_etal_IOC_2020.pdfapplication/pdf1655510https://www.arca.fiocruz.br/bitstream/icict/44862/2/SimoneLAndrade_ThaisOliveira_etal_IOC_2020.pdfc9c3a57738d04b85a64d3778d0c586f3MD52TEXTSimoneLAndrade_ThaisOliveira_etal_IOC_2020.pdf.txtSimoneLAndrade_ThaisOliveira_etal_IOC_2020.pdf.txtExtracted texttext/plain55466https://www.arca.fiocruz.br/bitstream/icict/44862/3/SimoneLAndrade_ThaisOliveira_etal_IOC_2020.pdf.txt11d5874495a033b31b08c9108467204dMD53icict/448622021-03-03 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| dc.title.pt_BR.fl_str_mv |
Population genomics reveals the expansion of highly inbred Plasmodium vivax lineages in the main malaria hotspot of Brazil |
| title |
Population genomics reveals the expansion of highly inbred Plasmodium vivax lineages in the main malaria hotspot of Brazil |
| spellingShingle |
Population genomics reveals the expansion of highly inbred Plasmodium vivax lineages in the main malaria hotspot of Brazil Oliveira, Thais Crippa deí Plasmodium vivax Linhagens Malária Brasil Genômica populacional Plasmodium vivax Lineages Population genomics Malaria Brazil |
| title_short |
Population genomics reveals the expansion of highly inbred Plasmodium vivax lineages in the main malaria hotspot of Brazil |
| title_full |
Population genomics reveals the expansion of highly inbred Plasmodium vivax lineages in the main malaria hotspot of Brazil |
| title_fullStr |
Population genomics reveals the expansion of highly inbred Plasmodium vivax lineages in the main malaria hotspot of Brazil |
| title_full_unstemmed |
Population genomics reveals the expansion of highly inbred Plasmodium vivax lineages in the main malaria hotspot of Brazil |
| title_sort |
Population genomics reveals the expansion of highly inbred Plasmodium vivax lineages in the main malaria hotspot of Brazil |
| author |
Oliveira, Thais Crippa deí |
| author_facet |
Oliveira, Thais Crippa deí Corder, Rodrigo M. Early, Angela Rodrigues, Priscila T. Andrade, Simone Ladeia Alves, João Marcelo P. Neafsey, Daniel E. Ferreira, Marcelo U. |
| author_role |
author |
| author2 |
Corder, Rodrigo M. Early, Angela Rodrigues, Priscila T. Andrade, Simone Ladeia Alves, João Marcelo P. Neafsey, Daniel E. Ferreira, Marcelo U. |
| author2_role |
author author author author author author author |
| dc.contributor.author.fl_str_mv |
Oliveira, Thais Crippa deí Corder, Rodrigo M. Early, Angela Rodrigues, Priscila T. Andrade, Simone Ladeia Alves, João Marcelo P. Neafsey, Daniel E. Ferreira, Marcelo U. |
| dc.subject.other.pt_BR.fl_str_mv |
Plasmodium vivax Linhagens Malária Brasil Genômica populacional |
| topic |
Plasmodium vivax Linhagens Malária Brasil Genômica populacional Plasmodium vivax Lineages Population genomics Malaria Brazil |
| dc.subject.en.pt_BR.fl_str_mv |
Plasmodium vivax Lineages Population genomics Malaria Brazil |
| description |
Universidade de São Paulo. Instituto de Ciências Biomédicas. Departamento de Parasitologia. São Paulo, SP, Brasil. |
| publishDate |
2020 |
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2020-12-14T13:59:09Z |
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2020-12-14T13:59:09Z |
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2020 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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OLIVEIRA, Thaís Crippa de et al. Population genomics reveals the expansion of highly inbred Plasmodium vivaxlineages in the main malaria hotspot of Brazil. Plos Neglected Tropical Diseases, v. 14, n. 10, p. 1-16, Oct. 2020. |
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https://www.arca.fiocruz.br/handle/icict/44862 |
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1935-2727 |
| dc.identifier.doi.none.fl_str_mv |
10.1371/journal.pntd.0008808 |
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1935-2735 |
| identifier_str_mv |
OLIVEIRA, Thaís Crippa de et al. Population genomics reveals the expansion of highly inbred Plasmodium vivaxlineages in the main malaria hotspot of Brazil. Plos Neglected Tropical Diseases, v. 14, n. 10, p. 1-16, Oct. 2020. 1935-2727 10.1371/journal.pntd.0008808 1935-2735 |
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