Adiponectin, Retinoic Acid Receptor Responder 2, and Peroxisome Proliferator-Activated Receptor-γ Coativator-1 Genes and the Risk for Obesity

Detalhes bibliográficos
Autor(a) principal: Fonseca, Ana Carolina Proença da
Data de Publicação: 2017
Outros Autores: Ochioni, Alan Cleveland, Martins, Raisa da Silva, Zembrzuski, Verônica Marques, Campos Junior, Mario, Ramos, Vivianne Galante, Carneiro, João Regis Ivar, Nogueira Neto, José Firmino, Cabello, Pedro Hernan, Cabello, Giselda Maria Kalil
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/24794
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Humana. Rio de Janeiro, RJ, Brasil.
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spelling Fonseca, Ana Carolina Proença daOchioni, Alan ClevelandMartins, Raisa da SilvaZembrzuski, Verônica MarquesCampos Junior, MarioRamos, Vivianne GalanteCarneiro, João Regis IvarNogueira Neto, José FirminoCabello, Pedro HernanCabello, Giselda Maria Kalil2018-02-09T16:58:17Z2018-02-09T16:58:17Z2017FONSECA, Ana Carolina Proença da; et al. Adiponectin, Retinoic Acid Receptor Responder 2, and Peroxisome Proliferator-Activated Receptor-γ Coativator-1 Genes and the risk for obesity. Disease Markers, Volume 2017, Article ID 5289120, 8p, 2017.0278-0240https://www.arca.fiocruz.br/handle/icict/2479410.1155/2017/52891201875-8630engHindawi Publishing CorporationObesidadeAdiponectina Fatores de riscoreceptor de ácido retinoicoObesityadiponectinRetinoic Acid Receptor Responder 2proliferator-activated receptor-γ coativator-1Adiponectin, Retinoic Acid Receptor Responder 2, and Peroxisome Proliferator-Activated Receptor-γ Coativator-1 Genes and the Risk for Obesityinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Humana. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Humana. Rio de Janeiro, RJ, Brasil.Universidade Grande Rio. Laboratório de Gnética Humana. Rio de Janeiro, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Humana. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Humana. Rio de Janeiro, RJ, Brasil.Universidade Grande Rio. Laboratório de Gnética Humana. Rio de Janeiro, Brasil.Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Rio de Janeiro, RJ, BrasilUniversidade do Estado do Rio de Janeiro. Departamento e Laboratório de Patologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Humana. Rio de Janeiro, RJ, Brasil / Universidade Grande Rio. Laboratório de Gen[etica Humana. Rio de Janeiro, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Humana. Rio de Janeiro, RJ, Brasil.Obesity is the most common nutritional disorder. This disease is a multifactorial disease influenced by environmental and genetic factors. This study investigated the relationship between common variants of adiponectin (ADIPOQ), retinoic acid receptor responder 2 (RARRES2), and peroxisome proliferator-activated receptor-γ coativator-1 (PPARGC1) and obesity-related traits and susceptibility. A total of 167 individuals with obesity and 165 normal-weight subjects were recruited. Genotype frequencies of rs182052 in ADIPOQ differed significantly between the groups. Genotype AA was observed at a higher frequency in case than in control subjects. Association analysis showed that the A allele was a risk factor for obesity. This polymorphism was associated with body weight, body mass index (BMI), and waist circumference. After stratification by BMI, eutrophic individuals with AA or AG genotypes had higher body weights and waist circumferences than those with GG genotypes. In the case group, no associations were observed, except for stratified subjects with morbid obesity that exhibited a progressive increase of body weight, BMI, and waist circumference when rs182052 A was present. No associations were observed between SNPs in RARRES2 and PPARGC1 and obesity or any other studied variables. The rs182052 polymorphism in ADIPOQ is associated with a higher risk for obesity and obesity-related parameters.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/24794/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALanacarolina_fonseca_etal_IOC_2017.pdfanacarolina_fonseca_etal_IOC_2017.pdfapplication/pdf1750294https://www.arca.fiocruz.br/bitstream/icict/24794/2/anacarolina_fonseca_etal_IOC_2017.pdf85f47db225128bc33f797383b19a1b87MD52TEXTanacarolina_fonseca_etal_IOC_2017.pdf.txtanacarolina_fonseca_etal_IOC_2017.pdf.txtExtracted texttext/plain33336https://www.arca.fiocruz.br/bitstream/icict/24794/3/anacarolina_fonseca_etal_IOC_2017.pdf.txte2cff31999d102b25511989985b47809MD53icict/247942018-08-15 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dc.title.pt_BR.fl_str_mv Adiponectin, Retinoic Acid Receptor Responder 2, and Peroxisome Proliferator-Activated Receptor-γ Coativator-1 Genes and the Risk for Obesity
title Adiponectin, Retinoic Acid Receptor Responder 2, and Peroxisome Proliferator-Activated Receptor-γ Coativator-1 Genes and the Risk for Obesity
spellingShingle Adiponectin, Retinoic Acid Receptor Responder 2, and Peroxisome Proliferator-Activated Receptor-γ Coativator-1 Genes and the Risk for Obesity
Fonseca, Ana Carolina Proença da
Obesidade
Adiponectina 
Fatores de risco
receptor de ácido retinoico
Obesity
adiponectin
Retinoic Acid Receptor Responder 2
proliferator-activated receptor-γ coativator-1
title_short Adiponectin, Retinoic Acid Receptor Responder 2, and Peroxisome Proliferator-Activated Receptor-γ Coativator-1 Genes and the Risk for Obesity
title_full Adiponectin, Retinoic Acid Receptor Responder 2, and Peroxisome Proliferator-Activated Receptor-γ Coativator-1 Genes and the Risk for Obesity
title_fullStr Adiponectin, Retinoic Acid Receptor Responder 2, and Peroxisome Proliferator-Activated Receptor-γ Coativator-1 Genes and the Risk for Obesity
title_full_unstemmed Adiponectin, Retinoic Acid Receptor Responder 2, and Peroxisome Proliferator-Activated Receptor-γ Coativator-1 Genes and the Risk for Obesity
title_sort Adiponectin, Retinoic Acid Receptor Responder 2, and Peroxisome Proliferator-Activated Receptor-γ Coativator-1 Genes and the Risk for Obesity
author Fonseca, Ana Carolina Proença da
author_facet Fonseca, Ana Carolina Proença da
Ochioni, Alan Cleveland
Martins, Raisa da Silva
Zembrzuski, Verônica Marques
Campos Junior, Mario
Ramos, Vivianne Galante
Carneiro, João Regis Ivar
Nogueira Neto, José Firmino
Cabello, Pedro Hernan
Cabello, Giselda Maria Kalil
author_role author
author2 Ochioni, Alan Cleveland
Martins, Raisa da Silva
Zembrzuski, Verônica Marques
Campos Junior, Mario
Ramos, Vivianne Galante
Carneiro, João Regis Ivar
Nogueira Neto, José Firmino
Cabello, Pedro Hernan
Cabello, Giselda Maria Kalil
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Fonseca, Ana Carolina Proença da
Ochioni, Alan Cleveland
Martins, Raisa da Silva
Zembrzuski, Verônica Marques
Campos Junior, Mario
Ramos, Vivianne Galante
Carneiro, João Regis Ivar
Nogueira Neto, José Firmino
Cabello, Pedro Hernan
Cabello, Giselda Maria Kalil
dc.subject.other.pt_BR.fl_str_mv Obesidade
Adiponectina 
Fatores de risco
receptor de ácido retinoico
topic Obesidade
Adiponectina 
Fatores de risco
receptor de ácido retinoico
Obesity
adiponectin
Retinoic Acid Receptor Responder 2
proliferator-activated receptor-γ coativator-1
dc.subject.en.pt_BR.fl_str_mv Obesity
adiponectin
Retinoic Acid Receptor Responder 2
proliferator-activated receptor-γ coativator-1
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Humana. Rio de Janeiro, RJ, Brasil.
publishDate 2017
dc.date.issued.fl_str_mv 2017
dc.date.accessioned.fl_str_mv 2018-02-09T16:58:17Z
dc.date.available.fl_str_mv 2018-02-09T16:58:17Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv FONSECA, Ana Carolina Proença da; et al. Adiponectin, Retinoic Acid Receptor Responder 2, and Peroxisome Proliferator-Activated Receptor-γ Coativator-1 Genes and the risk for obesity. Disease Markers, Volume 2017, Article ID 5289120, 8p, 2017.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/24794
dc.identifier.issn.pt_BR.fl_str_mv 0278-0240
dc.identifier.doi.none.fl_str_mv 10.1155/2017/5289120
dc.identifier.eissn.none.fl_str_mv 1875-8630
identifier_str_mv FONSECA, Ana Carolina Proença da; et al. Adiponectin, Retinoic Acid Receptor Responder 2, and Peroxisome Proliferator-Activated Receptor-γ Coativator-1 Genes and the risk for obesity. Disease Markers, Volume 2017, Article ID 5289120, 8p, 2017.
0278-0240
10.1155/2017/5289120
1875-8630
url https://www.arca.fiocruz.br/handle/icict/24794
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Hindawi Publishing Corporation
publisher.none.fl_str_mv Hindawi Publishing Corporation
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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collection Repositório Institucional da FIOCRUZ (ARCA)
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