Adiponectin, Retinoic Acid Receptor Responder 2, and Peroxisome Proliferator-Activated Receptor-γ Coativator-1 Genes and the Risk for Obesity
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2017 |
| Outros Autores: | , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/24794 |
Resumo: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Humana. Rio de Janeiro, RJ, Brasil. |
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Fonseca, Ana Carolina Proença daOchioni, Alan ClevelandMartins, Raisa da SilvaZembrzuski, Verônica MarquesCampos Junior, MarioRamos, Vivianne GalanteCarneiro, João Regis IvarNogueira Neto, José FirminoCabello, Pedro HernanCabello, Giselda Maria Kalil2018-02-09T16:58:17Z2018-02-09T16:58:17Z2017FONSECA, Ana Carolina Proença da; et al. Adiponectin, Retinoic Acid Receptor Responder 2, and Peroxisome Proliferator-Activated Receptor-γ Coativator-1 Genes and the risk for obesity. Disease Markers, Volume 2017, Article ID 5289120, 8p, 2017.0278-0240https://www.arca.fiocruz.br/handle/icict/2479410.1155/2017/52891201875-8630engHindawi Publishing CorporationObesidadeAdiponectina Fatores de riscoreceptor de ácido retinoicoObesityadiponectinRetinoic Acid Receptor Responder 2proliferator-activated receptor-γ coativator-1Adiponectin, Retinoic Acid Receptor Responder 2, and Peroxisome Proliferator-Activated Receptor-γ Coativator-1 Genes and the Risk for Obesityinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Humana. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Humana. Rio de Janeiro, RJ, Brasil.Universidade Grande Rio. Laboratório de Gnética Humana. Rio de Janeiro, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Humana. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Humana. Rio de Janeiro, RJ, Brasil.Universidade Grande Rio. Laboratório de Gnética Humana. Rio de Janeiro, Brasil.Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Rio de Janeiro, RJ, BrasilUniversidade do Estado do Rio de Janeiro. Departamento e Laboratório de Patologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Humana. Rio de Janeiro, RJ, Brasil / Universidade Grande Rio. Laboratório de Gen[etica Humana. Rio de Janeiro, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Humana. Rio de Janeiro, RJ, Brasil.Obesity is the most common nutritional disorder. This disease is a multifactorial disease influenced by environmental and genetic factors. This study investigated the relationship between common variants of adiponectin (ADIPOQ), retinoic acid receptor responder 2 (RARRES2), and peroxisome proliferator-activated receptor-γ coativator-1 (PPARGC1) and obesity-related traits and susceptibility. A total of 167 individuals with obesity and 165 normal-weight subjects were recruited. Genotype frequencies of rs182052 in ADIPOQ differed significantly between the groups. Genotype AA was observed at a higher frequency in case than in control subjects. Association analysis showed that the A allele was a risk factor for obesity. This polymorphism was associated with body weight, body mass index (BMI), and waist circumference. After stratification by BMI, eutrophic individuals with AA or AG genotypes had higher body weights and waist circumferences than those with GG genotypes. In the case group, no associations were observed, except for stratified subjects with morbid obesity that exhibited a progressive increase of body weight, BMI, and waist circumference when rs182052 A was present. No associations were observed between SNPs in RARRES2 and PPARGC1 and obesity or any other studied variables. The rs182052 polymorphism in ADIPOQ is associated with a higher risk for obesity and obesity-related parameters.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/24794/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALanacarolina_fonseca_etal_IOC_2017.pdfanacarolina_fonseca_etal_IOC_2017.pdfapplication/pdf1750294https://www.arca.fiocruz.br/bitstream/icict/24794/2/anacarolina_fonseca_etal_IOC_2017.pdf85f47db225128bc33f797383b19a1b87MD52TEXTanacarolina_fonseca_etal_IOC_2017.pdf.txtanacarolina_fonseca_etal_IOC_2017.pdf.txtExtracted texttext/plain33336https://www.arca.fiocruz.br/bitstream/icict/24794/3/anacarolina_fonseca_etal_IOC_2017.pdf.txte2cff31999d102b25511989985b47809MD53icict/247942018-08-15 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| dc.title.pt_BR.fl_str_mv |
Adiponectin, Retinoic Acid Receptor Responder 2, and Peroxisome Proliferator-Activated Receptor-γ Coativator-1 Genes and the Risk for Obesity |
| title |
Adiponectin, Retinoic Acid Receptor Responder 2, and Peroxisome Proliferator-Activated Receptor-γ Coativator-1 Genes and the Risk for Obesity |
| spellingShingle |
Adiponectin, Retinoic Acid Receptor Responder 2, and Peroxisome Proliferator-Activated Receptor-γ Coativator-1 Genes and the Risk for Obesity Fonseca, Ana Carolina Proença da Obesidade Adiponectina Fatores de risco receptor de ácido retinoico Obesity adiponectin Retinoic Acid Receptor Responder 2 proliferator-activated receptor-γ coativator-1 |
| title_short |
Adiponectin, Retinoic Acid Receptor Responder 2, and Peroxisome Proliferator-Activated Receptor-γ Coativator-1 Genes and the Risk for Obesity |
| title_full |
Adiponectin, Retinoic Acid Receptor Responder 2, and Peroxisome Proliferator-Activated Receptor-γ Coativator-1 Genes and the Risk for Obesity |
| title_fullStr |
Adiponectin, Retinoic Acid Receptor Responder 2, and Peroxisome Proliferator-Activated Receptor-γ Coativator-1 Genes and the Risk for Obesity |
| title_full_unstemmed |
Adiponectin, Retinoic Acid Receptor Responder 2, and Peroxisome Proliferator-Activated Receptor-γ Coativator-1 Genes and the Risk for Obesity |
| title_sort |
Adiponectin, Retinoic Acid Receptor Responder 2, and Peroxisome Proliferator-Activated Receptor-γ Coativator-1 Genes and the Risk for Obesity |
| author |
Fonseca, Ana Carolina Proença da |
| author_facet |
Fonseca, Ana Carolina Proença da Ochioni, Alan Cleveland Martins, Raisa da Silva Zembrzuski, Verônica Marques Campos Junior, Mario Ramos, Vivianne Galante Carneiro, João Regis Ivar Nogueira Neto, José Firmino Cabello, Pedro Hernan Cabello, Giselda Maria Kalil |
| author_role |
author |
| author2 |
Ochioni, Alan Cleveland Martins, Raisa da Silva Zembrzuski, Verônica Marques Campos Junior, Mario Ramos, Vivianne Galante Carneiro, João Regis Ivar Nogueira Neto, José Firmino Cabello, Pedro Hernan Cabello, Giselda Maria Kalil |
| author2_role |
author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Fonseca, Ana Carolina Proença da Ochioni, Alan Cleveland Martins, Raisa da Silva Zembrzuski, Verônica Marques Campos Junior, Mario Ramos, Vivianne Galante Carneiro, João Regis Ivar Nogueira Neto, José Firmino Cabello, Pedro Hernan Cabello, Giselda Maria Kalil |
| dc.subject.other.pt_BR.fl_str_mv |
Obesidade Adiponectina Fatores de risco receptor de ácido retinoico |
| topic |
Obesidade Adiponectina Fatores de risco receptor de ácido retinoico Obesity adiponectin Retinoic Acid Receptor Responder 2 proliferator-activated receptor-γ coativator-1 |
| dc.subject.en.pt_BR.fl_str_mv |
Obesity adiponectin Retinoic Acid Receptor Responder 2 proliferator-activated receptor-γ coativator-1 |
| description |
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Humana. Rio de Janeiro, RJ, Brasil. |
| publishDate |
2017 |
| dc.date.issued.fl_str_mv |
2017 |
| dc.date.accessioned.fl_str_mv |
2018-02-09T16:58:17Z |
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2018-02-09T16:58:17Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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FONSECA, Ana Carolina Proença da; et al. Adiponectin, Retinoic Acid Receptor Responder 2, and Peroxisome Proliferator-Activated Receptor-γ Coativator-1 Genes and the risk for obesity. Disease Markers, Volume 2017, Article ID 5289120, 8p, 2017. |
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https://www.arca.fiocruz.br/handle/icict/24794 |
| dc.identifier.issn.pt_BR.fl_str_mv |
0278-0240 |
| dc.identifier.doi.none.fl_str_mv |
10.1155/2017/5289120 |
| dc.identifier.eissn.none.fl_str_mv |
1875-8630 |
| identifier_str_mv |
FONSECA, Ana Carolina Proença da; et al. Adiponectin, Retinoic Acid Receptor Responder 2, and Peroxisome Proliferator-Activated Receptor-γ Coativator-1 Genes and the risk for obesity. Disease Markers, Volume 2017, Article ID 5289120, 8p, 2017. 0278-0240 10.1155/2017/5289120 1875-8630 |
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https://www.arca.fiocruz.br/handle/icict/24794 |
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eng |
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eng |
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info:eu-repo/semantics/openAccess |
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openAccess |
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Hindawi Publishing Corporation |
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Hindawi Publishing Corporation |
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reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
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