Oseltamivir-resistant influenza A(H1N1)pdm2009 strains found in Brazil are endowed with permissive mutations, which compensate the loss of fitness imposed by antiviral resistance

Detalhes bibliográficos
Autor(a) principal: Souza, Thiago Moreno Lopes e
Data de Publicação: 2015
Outros Autores: Rodrigues, Natalia Fintelman, Resende, Paola Cristina, Mesquita, Milene, Gregianini, Tatiana Schaffer, Bozza, Fernando A., Pecego, Ana Carla, Fernandes, Sandra Bianchini, Cury, Ana Luisa Furtado, Riediger, Irina Nastassja, Siqueira, Marilda Agudo Mendonça Teixeira de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/12241
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virus Respiratórios e do Sarampo. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto de Pesquisas Clínicas Evandro Chagas. Laboratório de Medicina Intensiva. Rio de Janeiro, RJ, Brasil.
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spelling Souza, Thiago Moreno Lopes eRodrigues, Natalia FintelmanResende, Paola CristinaMesquita, MileneGregianini, Tatiana SchafferBozza, Fernando A.Pecego, Ana CarlaFernandes, Sandra BianchiniCury, Ana Luisa FurtadoRiediger, Irina NastassjaSiqueira, Marilda Agudo Mendonça Teixeira de2015-11-16T15:57:03Z2015-11-16T15:57:03Z2015SOUZA, Thiago Moreno Lopes e et al. Oseltamivir-resistant influenza A(H1N1)pdm2009 strains found in Brazil are endowed with permissive mutations, which compensate the loss of fitness imposed by antiviral resistance. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 110, n. 1, p. 101-105, Feb. 2015.0074-0276https://www.arca.fiocruz.br/handle/icict/1224110.1590/0074-027601403301678-8060engFundação Oswaldo CruzResistênciaInfluenza A(H1N1)pdm09OseltamivirAntiviralResistanceH275YPermissive mutationOseltamivirVírus da Influenza AAntiviraisOseltamivir-resistant influenza A(H1N1)pdm2009 strains found in Brazil are endowed with permissive mutations, which compensate the loss of fitness imposed by antiviral resistanceinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virus Respiratórios e do Sarampo. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto de Pesquisas Clínicas Evandro Chagas. Laboratório de Medicina Intensiva. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virus Respiratórios e do Sarampo. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virus Respiratórios e do Sarampo. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virus Respiratórios e do Sarampo. Rio de Janeiro, RJ, BrasilLaboratório Central de Saúde Pública do Estado do Rio de Grande do Sul. Seção de Virologia. Porto Alegre, RS, Brasil. ,Fundação Estadual de Produção e Pesquisa em Saúde. Porto Alegre, RS, Brasil.The 2009 pandemic influenza A virus outbreak led to the systematic use of the neuraminidase (NA) inhibitor oseltamivir (OST). Consequently, OST-resistant strains, carrying the mutation H275Y, emerged in the years after the pandemics, with a prevalence of 1-2%. Currently, OST-resistant strains have been found in community settings, in untreated individuals. To spread in community settings, H275Y mutants must contain additional mutations, collectively called permissive mutations. We display the permissive mutations in NA of OST-resistant A(H1N1)pdm09 virus found in Brazilian community settings. The NAs from 2013 are phylogenetically distinct from those of 2012, indicating a tendency of positive selection of NAs with better fitness. Some previously predicted permissive mutations, such as V241I and N369K, found in different countries, were also detected in Brazil. Importantly, the change D344N, also predicted to compensate loss of fitness imposed by H275Y mutation, was found in Brazil, but not in other countries in 2013. Our results reinforce the notion that OST-resistant A(H1N1)pdm09 strains with compensatory mutations may arise in an independent fashion, with samples being identified in different states of Brazil and in different countries. Systematic circulation of these viral strains may jeopardise the use of the first line of anti-influenza drugs in the future.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/12241/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALpaola_resende_etal_IOC_2015.pdfpaola_resende_etal_IOC_2015.pdfapplication/pdf1146844https://www.arca.fiocruz.br/bitstream/icict/12241/2/paola_resende_etal_IOC_2015.pdf7920ec697e0b03b42cb30ad41a2714f7MD52TEXTpaola_resende_etal_IOC_2015.pdf.txtpaola_resende_etal_IOC_2015.pdf.txtExtracted texttext/plain21420https://www.arca.fiocruz.br/bitstream/icict/12241/3/paola_resende_etal_IOC_2015.pdf.txt2c16e5269fa9af0d4b4aae5134fe0506MD53icict/122412023-09-05 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dc.title.pt_BR.fl_str_mv Oseltamivir-resistant influenza A(H1N1)pdm2009 strains found in Brazil are endowed with permissive mutations, which compensate the loss of fitness imposed by antiviral resistance
title Oseltamivir-resistant influenza A(H1N1)pdm2009 strains found in Brazil are endowed with permissive mutations, which compensate the loss of fitness imposed by antiviral resistance
spellingShingle Oseltamivir-resistant influenza A(H1N1)pdm2009 strains found in Brazil are endowed with permissive mutations, which compensate the loss of fitness imposed by antiviral resistance
Souza, Thiago Moreno Lopes e
Resistência
Influenza A(H1N1)pdm09
Oseltamivir
Antiviral
Resistance
H275Y
Permissive mutation
Oseltamivir
Vírus da Influenza A
Antivirais
title_short Oseltamivir-resistant influenza A(H1N1)pdm2009 strains found in Brazil are endowed with permissive mutations, which compensate the loss of fitness imposed by antiviral resistance
title_full Oseltamivir-resistant influenza A(H1N1)pdm2009 strains found in Brazil are endowed with permissive mutations, which compensate the loss of fitness imposed by antiviral resistance
title_fullStr Oseltamivir-resistant influenza A(H1N1)pdm2009 strains found in Brazil are endowed with permissive mutations, which compensate the loss of fitness imposed by antiviral resistance
title_full_unstemmed Oseltamivir-resistant influenza A(H1N1)pdm2009 strains found in Brazil are endowed with permissive mutations, which compensate the loss of fitness imposed by antiviral resistance
title_sort Oseltamivir-resistant influenza A(H1N1)pdm2009 strains found in Brazil are endowed with permissive mutations, which compensate the loss of fitness imposed by antiviral resistance
author Souza, Thiago Moreno Lopes e
author_facet Souza, Thiago Moreno Lopes e
Rodrigues, Natalia Fintelman
Resende, Paola Cristina
Mesquita, Milene
Gregianini, Tatiana Schaffer
Bozza, Fernando A.
Pecego, Ana Carla
Fernandes, Sandra Bianchini
Cury, Ana Luisa Furtado
Riediger, Irina Nastassja
Siqueira, Marilda Agudo Mendonça Teixeira de
author_role author
author2 Rodrigues, Natalia Fintelman
Resende, Paola Cristina
Mesquita, Milene
Gregianini, Tatiana Schaffer
Bozza, Fernando A.
Pecego, Ana Carla
Fernandes, Sandra Bianchini
Cury, Ana Luisa Furtado
Riediger, Irina Nastassja
Siqueira, Marilda Agudo Mendonça Teixeira de
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Souza, Thiago Moreno Lopes e
Rodrigues, Natalia Fintelman
Resende, Paola Cristina
Mesquita, Milene
Gregianini, Tatiana Schaffer
Bozza, Fernando A.
Pecego, Ana Carla
Fernandes, Sandra Bianchini
Cury, Ana Luisa Furtado
Riediger, Irina Nastassja
Siqueira, Marilda Agudo Mendonça Teixeira de
dc.subject.other.pt_BR.fl_str_mv Resistência
topic Resistência
Influenza A(H1N1)pdm09
Oseltamivir
Antiviral
Resistance
H275Y
Permissive mutation
Oseltamivir
Vírus da Influenza A
Antivirais
dc.subject.en.pt_BR.fl_str_mv Influenza A(H1N1)pdm09
Oseltamivir
Antiviral
Resistance
H275Y
Permissive mutation
dc.subject.decs.pt_BR.fl_str_mv Oseltamivir
Vírus da Influenza A
Antivirais
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virus Respiratórios e do Sarampo. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto de Pesquisas Clínicas Evandro Chagas. Laboratório de Medicina Intensiva. Rio de Janeiro, RJ, Brasil.
publishDate 2015
dc.date.accessioned.fl_str_mv 2015-11-16T15:57:03Z
dc.date.available.fl_str_mv 2015-11-16T15:57:03Z
dc.date.issued.fl_str_mv 2015
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SOUZA, Thiago Moreno Lopes e et al. Oseltamivir-resistant influenza A(H1N1)pdm2009 strains found in Brazil are endowed with permissive mutations, which compensate the loss of fitness imposed by antiviral resistance. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 110, n. 1, p. 101-105, Feb. 2015.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/12241
dc.identifier.issn.none.fl_str_mv 0074-0276
dc.identifier.doi.none.fl_str_mv 10.1590/0074-02760140330
dc.identifier.eissn.none.fl_str_mv 1678-8060
identifier_str_mv SOUZA, Thiago Moreno Lopes e et al. Oseltamivir-resistant influenza A(H1N1)pdm2009 strains found in Brazil are endowed with permissive mutations, which compensate the loss of fitness imposed by antiviral resistance. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 110, n. 1, p. 101-105, Feb. 2015.
0074-0276
10.1590/0074-02760140330
1678-8060
url https://www.arca.fiocruz.br/handle/icict/12241
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv Fundação Oswaldo Cruz
publisher.none.fl_str_mv Fundação Oswaldo Cruz
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
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