Clinical trial with liposomal amphotericin B (AMBISOME®) for American Visceral Leisshmaniais (AVL)

Detalhes bibliográficos
Autor(a) principal: Viana, Graça Maria de Castro
Data de Publicação: 2009
Outros Autores: Saldanha, Ana Cristina Rodrigues, Pinheiro, Clélia R, Nascimento, Jeanne d’Arc de Lisboa, Burattini, Marcelo Nascimento, Costa, Jackson Mauricio Lopes
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/9764
Resumo: Federal University of Maranhão. Nucleus of Tropical Pathology and Social Medicine. Department of Pathology. São Luis, MA, Brasil
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spelling Viana, Graça Maria de CastroSaldanha, Ana Cristina RodriguesPinheiro, Clélia RNascimento, Jeanne d’Arc de LisboaBurattini, Marcelo NascimentoCosta, Jackson Mauricio Lopes2015-03-20T13:40:45Z2015-03-20T13:40:45Z2009VIANA, G. M. C. et al. Clinical trial with liposomal amphotericin B (AMBISOME®) for American Visceral Leishmaniais (AVL). Gazeta Médica da Bahia, v. 79, Supl 3, p. 156-162, 2009.0016-545Xhttps://www.arca.fiocruz.br/handle/icict/9764engFaculdade de Medicina da Universidade Federal da BahiaClinical trial with liposomal amphotericin B (AMBISOME®) for American Visceral Leisshmaniais (AVL)info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFederal University of Maranhão. Nucleus of Tropical Pathology and Social Medicine. Department of Pathology. São Luis, MA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFederal University of Maranhão. Nucleus of Tropical Pathology and Social Medicine. Department of Pathology. São Luis, MA, BrasilFederal University of Maranhão. Nucleus of Tropical Pathology and Social Medicine. Department of Pathology. São Luis, MA, BrasilFederal University of São Paulo. Department of Infectious Diseases. São Paulo, SP, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilA prospective, non-randomized study was conducted on 30 patients with American Visceral Leishmaniasis (AVL) aged 3 to 10 years from São Luis, Maranhão - Brazil, who were not previously submitted to treatment. After an informed consent form, was signed by the responsible person, all patients were submitted to anamnesis and physical examination and a standard chart was filled out. The patients were randomly divided into three cohorts of 10 patients each and submitted to the following treatment regimen with liposomal amphotericin B: cohort 1) 2 mg/kg/ day applied on days 1, 2, 3, 4, 5, 6 and 10, total dose of 14 mg/kg; cohort 2) 2 mg/kg/day applied on days 1, 2, 3, 4, and 10, total dose of 10 mg/kg; cohort 3) 2 mg/kg/day applied on days 1, 5, and 10, total dose of 6 mg/kg. An intra-hospital treatment regimen was used which consisted of intravenous administration of the drug over a period of 60 min. Efficacy was 70% in cohort 1, 90% cohort 2, and 80% in cohort 3. The patients were followed up for 6 months. No significant difference was observed between the three regimens in terms of toxicity, tolerability and effectiveness when evaluated by generalizations of the Gehan model and Wilcoxon test.Leishmania chagasiVisceral leishmaniasisLiposomal amphotericin BNortheastern of Brazilinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82352https://www.arca.fiocruz.br/bitstream/icict/9764/1/license.txtafbdf7d7a9bcf771a1cc7edf5f618413MD51ORIGINALViana G M C Clinical trial....pdfViana G M C Clinical trial....pdfapplication/pdf56297https://www.arca.fiocruz.br/bitstream/icict/9764/2/Viana%20G%20M%20C%20Clinical%20trial....pdf60a15921274618c5205c1d89629df812MD52TEXTViana G M C Clinical trial....pdf.txtViana G M C Clinical trial....pdf.txtExtracted texttext/plain32654https://www.arca.fiocruz.br/bitstream/icict/9764/3/Viana%20G%20M%20C%20Clinical%20trial....pdf.txt60d9c4054bef09cc424b413e33b6e65fMD53icict/97642023-03-15 14:32:53.651oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:32:53Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Clinical trial with liposomal amphotericin B (AMBISOME®) for American Visceral Leisshmaniais (AVL)
title Clinical trial with liposomal amphotericin B (AMBISOME®) for American Visceral Leisshmaniais (AVL)
spellingShingle Clinical trial with liposomal amphotericin B (AMBISOME®) for American Visceral Leisshmaniais (AVL)
Viana, Graça Maria de Castro
Leishmania chagasi
Visceral leishmaniasis
Liposomal amphotericin B
Northeastern of Brazil
title_short Clinical trial with liposomal amphotericin B (AMBISOME®) for American Visceral Leisshmaniais (AVL)
title_full Clinical trial with liposomal amphotericin B (AMBISOME®) for American Visceral Leisshmaniais (AVL)
title_fullStr Clinical trial with liposomal amphotericin B (AMBISOME®) for American Visceral Leisshmaniais (AVL)
title_full_unstemmed Clinical trial with liposomal amphotericin B (AMBISOME®) for American Visceral Leisshmaniais (AVL)
title_sort Clinical trial with liposomal amphotericin B (AMBISOME®) for American Visceral Leisshmaniais (AVL)
author Viana, Graça Maria de Castro
author_facet Viana, Graça Maria de Castro
Saldanha, Ana Cristina Rodrigues
Pinheiro, Clélia R
Nascimento, Jeanne d’Arc de Lisboa
Burattini, Marcelo Nascimento
Costa, Jackson Mauricio Lopes
author_role author
author2 Saldanha, Ana Cristina Rodrigues
Pinheiro, Clélia R
Nascimento, Jeanne d’Arc de Lisboa
Burattini, Marcelo Nascimento
Costa, Jackson Mauricio Lopes
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Viana, Graça Maria de Castro
Saldanha, Ana Cristina Rodrigues
Pinheiro, Clélia R
Nascimento, Jeanne d’Arc de Lisboa
Burattini, Marcelo Nascimento
Costa, Jackson Mauricio Lopes
dc.subject.en.pt_BR.fl_str_mv Leishmania chagasi
Visceral leishmaniasis
Liposomal amphotericin B
Northeastern of Brazil
topic Leishmania chagasi
Visceral leishmaniasis
Liposomal amphotericin B
Northeastern of Brazil
description Federal University of Maranhão. Nucleus of Tropical Pathology and Social Medicine. Department of Pathology. São Luis, MA, Brasil
publishDate 2009
dc.date.issued.fl_str_mv 2009
dc.date.accessioned.fl_str_mv 2015-03-20T13:40:45Z
dc.date.available.fl_str_mv 2015-03-20T13:40:45Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.citation.fl_str_mv VIANA, G. M. C. et al. Clinical trial with liposomal amphotericin B (AMBISOME®) for American Visceral Leishmaniais (AVL). Gazeta Médica da Bahia, v. 79, Supl 3, p. 156-162, 2009.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/9764
dc.identifier.issn.none.fl_str_mv 0016-545X
identifier_str_mv VIANA, G. M. C. et al. Clinical trial with liposomal amphotericin B (AMBISOME®) for American Visceral Leishmaniais (AVL). Gazeta Médica da Bahia, v. 79, Supl 3, p. 156-162, 2009.
0016-545X
url https://www.arca.fiocruz.br/handle/icict/9764
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dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv Faculdade de Medicina da Universidade Federal da Bahia
publisher.none.fl_str_mv Faculdade de Medicina da Universidade Federal da Bahia
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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