Granulomatous slack skin: histopathology diagnosis preceding clinical manifestations by 12 years
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/35710 |
Resumo: | Tullia Cuzzi. Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta a informação no documento. |
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Goldsztajn, Karen O.Trope, Beatriz MoritzLenzi, Maria Elisa RibeiroCuzzi, TulliaRamos-e-Silva, Marcia2019-09-20T13:06:38Z2019-09-20T13:06:38Z2012GOLDSZTAJN, Karen O. et al. Granulomatous slack skin: histopathology diagnosis preceding clinical manifestations by 12 years. Journal of dermatological case reports, v. 4, p. 108-112, 2012.https://www.arca.fiocruz.br/handle/icict/357101898-7249Tullia Cuzzi. Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta a informação no documento.Federal University of Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Sector of Dermatology. Rio de Janeiro, RJ, Brazil / Federal University of Rio de Janeiro. School of Medicine. Post Graduation Course. Rio de Janeiro, RJ, Brazil.Federal University of Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Sector of Dermatology. Rio de Janeiro, RJ, Brazil / Federal University of Rio de Janeiro. School of Medicine. Post Graduation Course. Rio de Janeiro, RJ, Brazil.Federal University of Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Sector of Dermatology. Rio de Janeiro, RJ, Brazil / Federal University of Rio de Janeiro. School of Medicine. Post Graduation Course. Rio de Janeiro, RJ, Brazil.Federal University of Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Sector of Pathology. Rio de Janeiro, RJ, Brazil / Federal University of Rio de Janeiro. School of Medicine. Rio de Janeiro, RJ, Brazil.Federal University of Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Sector of Dermatology. Rio de Janeiro, RJ, Brazil / Federal University of Rio de Janeiro. School of Medicine. Post Graduation Course. Rio de Janeiro, RJ, Brazil.Background: Granulomatous slack skin is a very rare subtype of T-cell cutaneous lymphoma, characterized by the slow development of cutaneous sagging, especially on flexural areas. Its behavior is indolent and the treatment, in the majority of cases, disappointing. Main observations: We report a 54-year-old black patient with granulomatous slack skin, who at the beginning of the investigation showed intense xeroderma and generalized lymph node enlargement. The diagnosis was established based on histopathologic findings long before the disease’s characteristic clinical presentation appeared. Conclusion: During the twelve years of follow-up, the clinical manifestation evolved to marked skin looseness, most predominant in flexural regions, illustrating the clinical hallmark of granulomatous slack skin, long after first histological abnormalities were observed.engGranulomatous slack skin: histopathology diagnosis preceding clinical manifestations by 12 yearsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleCutaneous T-cell lymphomaDiagnosisGranulomatous cutis laxaGranulomatous slack skinLymphomaMycosis fungoidesOrcein stainingTreatmentinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1748https://www.arca.fiocruz.br/bitstream/icict/35710/1/license.txt8a4605be74aa9ea9d79846c1fba20a33MD51ORIGINALve_Goldsztajn_Karen_etal_INI_2012.pdfve_Goldsztajn_Karen_etal_INI_2012.pdfapplication/pdf2837350https://www.arca.fiocruz.br/bitstream/icict/35710/2/ve_Goldsztajn_Karen_etal_INI_2012.pdf3ed00d2d3a659d91bf8440e15be83edeMD52TEXTve_Goldsztajn_Karen_etal_INI_2012.pdf.txtve_Goldsztajn_Karen_etal_INI_2012.pdf.txtExtracted texttext/plain15560https://www.arca.fiocruz.br/bitstream/icict/35710/3/ve_Goldsztajn_Karen_etal_INI_2012.pdf.txtaa3f77f70eb8db14e0c93aef7939e2c1MD53icict/357102019-10-01 14:19:31.839oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352019-10-01T17:19:31Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
dc.title.pt_BR.fl_str_mv |
Granulomatous slack skin: histopathology diagnosis preceding clinical manifestations by 12 years |
title |
Granulomatous slack skin: histopathology diagnosis preceding clinical manifestations by 12 years |
spellingShingle |
Granulomatous slack skin: histopathology diagnosis preceding clinical manifestations by 12 years Goldsztajn, Karen O. Cutaneous T-cell lymphoma Diagnosis Granulomatous cutis laxa Granulomatous slack skin Lymphoma Mycosis fungoides Orcein staining Treatment |
title_short |
Granulomatous slack skin: histopathology diagnosis preceding clinical manifestations by 12 years |
title_full |
Granulomatous slack skin: histopathology diagnosis preceding clinical manifestations by 12 years |
title_fullStr |
Granulomatous slack skin: histopathology diagnosis preceding clinical manifestations by 12 years |
title_full_unstemmed |
Granulomatous slack skin: histopathology diagnosis preceding clinical manifestations by 12 years |
title_sort |
Granulomatous slack skin: histopathology diagnosis preceding clinical manifestations by 12 years |
author |
Goldsztajn, Karen O. |
author_facet |
Goldsztajn, Karen O. Trope, Beatriz Moritz Lenzi, Maria Elisa Ribeiro Cuzzi, Tullia Ramos-e-Silva, Marcia |
author_role |
author |
author2 |
Trope, Beatriz Moritz Lenzi, Maria Elisa Ribeiro Cuzzi, Tullia Ramos-e-Silva, Marcia |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Goldsztajn, Karen O. Trope, Beatriz Moritz Lenzi, Maria Elisa Ribeiro Cuzzi, Tullia Ramos-e-Silva, Marcia |
dc.subject.en.pt_BR.fl_str_mv |
Cutaneous T-cell lymphoma Diagnosis Granulomatous cutis laxa Granulomatous slack skin Lymphoma Mycosis fungoides Orcein staining Treatment |
topic |
Cutaneous T-cell lymphoma Diagnosis Granulomatous cutis laxa Granulomatous slack skin Lymphoma Mycosis fungoides Orcein staining Treatment |
description |
Tullia Cuzzi. Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta a informação no documento. |
publishDate |
2012 |
dc.date.issued.fl_str_mv |
2012 |
dc.date.accessioned.fl_str_mv |
2019-09-20T13:06:38Z |
dc.date.available.fl_str_mv |
2019-09-20T13:06:38Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
dc.identifier.citation.fl_str_mv |
GOLDSZTAJN, Karen O. et al. Granulomatous slack skin: histopathology diagnosis preceding clinical manifestations by 12 years. Journal of dermatological case reports, v. 4, p. 108-112, 2012. |
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https://www.arca.fiocruz.br/handle/icict/35710 |
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1898-7249 |
identifier_str_mv |
GOLDSZTAJN, Karen O. et al. Granulomatous slack skin: histopathology diagnosis preceding clinical manifestations by 12 years. Journal of dermatological case reports, v. 4, p. 108-112, 2012. 1898-7249 |
url |
https://www.arca.fiocruz.br/handle/icict/35710 |
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eng |
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