Granulomatous slack skin: histopathology diagnosis preceding clinical manifestations by 12 years

Detalhes bibliográficos
Autor(a) principal: Goldsztajn, Karen O.
Data de Publicação: 2012
Outros Autores: Trope, Beatriz Moritz, Lenzi, Maria Elisa Ribeiro, Cuzzi, Tullia, Ramos-e-Silva, Marcia
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/35710
Resumo: Tullia Cuzzi. Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta a informação no documento.
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spelling Goldsztajn, Karen O.Trope, Beatriz MoritzLenzi, Maria Elisa RibeiroCuzzi, TulliaRamos-e-Silva, Marcia2019-09-20T13:06:38Z2019-09-20T13:06:38Z2012GOLDSZTAJN, Karen O. et al. Granulomatous slack skin: histopathology diagnosis preceding clinical manifestations by 12 years. Journal of dermatological case reports, v. 4, p. 108-112, 2012.https://www.arca.fiocruz.br/handle/icict/357101898-7249Tullia Cuzzi. Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta a informação no documento.Federal University of Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Sector of Dermatology. Rio de Janeiro, RJ, Brazil / Federal University of Rio de Janeiro. School of Medicine. Post Graduation Course. Rio de Janeiro, RJ, Brazil.Federal University of Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Sector of Dermatology. Rio de Janeiro, RJ, Brazil / Federal University of Rio de Janeiro. School of Medicine. Post Graduation Course. Rio de Janeiro, RJ, Brazil.Federal University of Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Sector of Dermatology. Rio de Janeiro, RJ, Brazil / Federal University of Rio de Janeiro. School of Medicine. Post Graduation Course. Rio de Janeiro, RJ, Brazil.Federal University of Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Sector of Pathology. Rio de Janeiro, RJ, Brazil / Federal University of Rio de Janeiro. School of Medicine. Rio de Janeiro, RJ, Brazil.Federal University of Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Sector of Dermatology. Rio de Janeiro, RJ, Brazil / Federal University of Rio de Janeiro. School of Medicine. Post Graduation Course. Rio de Janeiro, RJ, Brazil.Background: Granulomatous slack skin is a very rare subtype of T-cell cutaneous lymphoma, characterized by the slow development of cutaneous sagging, especially on flexural areas. Its behavior is indolent and the treatment, in the majority of cases, disappointing. Main observations: We report a 54-year-old black patient with granulomatous slack skin, who at the beginning of the investigation showed intense xeroderma and generalized lymph node enlargement. The diagnosis was established based on histopathologic findings long before the disease’s characteristic clinical presentation appeared. Conclusion: During the twelve years of follow-up, the clinical manifestation evolved to marked skin looseness, most predominant in flexural regions, illustrating the clinical hallmark of granulomatous slack skin, long after first histological abnormalities were observed.engGranulomatous slack skin: histopathology diagnosis preceding clinical manifestations by 12 yearsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleCutaneous T-cell lymphomaDiagnosisGranulomatous cutis laxaGranulomatous slack skinLymphomaMycosis fungoidesOrcein stainingTreatmentinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1748https://www.arca.fiocruz.br/bitstream/icict/35710/1/license.txt8a4605be74aa9ea9d79846c1fba20a33MD51ORIGINALve_Goldsztajn_Karen_etal_INI_2012.pdfve_Goldsztajn_Karen_etal_INI_2012.pdfapplication/pdf2837350https://www.arca.fiocruz.br/bitstream/icict/35710/2/ve_Goldsztajn_Karen_etal_INI_2012.pdf3ed00d2d3a659d91bf8440e15be83edeMD52TEXTve_Goldsztajn_Karen_etal_INI_2012.pdf.txtve_Goldsztajn_Karen_etal_INI_2012.pdf.txtExtracted texttext/plain15560https://www.arca.fiocruz.br/bitstream/icict/35710/3/ve_Goldsztajn_Karen_etal_INI_2012.pdf.txtaa3f77f70eb8db14e0c93aef7939e2c1MD53icict/357102019-10-01 14:19:31.839oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352019-10-01T17:19:31Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Granulomatous slack skin: histopathology diagnosis preceding clinical manifestations by 12 years
title Granulomatous slack skin: histopathology diagnosis preceding clinical manifestations by 12 years
spellingShingle Granulomatous slack skin: histopathology diagnosis preceding clinical manifestations by 12 years
Goldsztajn, Karen O.
Cutaneous T-cell lymphoma
Diagnosis
Granulomatous cutis laxa
Granulomatous slack skin
Lymphoma
Mycosis fungoides
Orcein staining
Treatment
title_short Granulomatous slack skin: histopathology diagnosis preceding clinical manifestations by 12 years
title_full Granulomatous slack skin: histopathology diagnosis preceding clinical manifestations by 12 years
title_fullStr Granulomatous slack skin: histopathology diagnosis preceding clinical manifestations by 12 years
title_full_unstemmed Granulomatous slack skin: histopathology diagnosis preceding clinical manifestations by 12 years
title_sort Granulomatous slack skin: histopathology diagnosis preceding clinical manifestations by 12 years
author Goldsztajn, Karen O.
author_facet Goldsztajn, Karen O.
Trope, Beatriz Moritz
Lenzi, Maria Elisa Ribeiro
Cuzzi, Tullia
Ramos-e-Silva, Marcia
author_role author
author2 Trope, Beatriz Moritz
Lenzi, Maria Elisa Ribeiro
Cuzzi, Tullia
Ramos-e-Silva, Marcia
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Goldsztajn, Karen O.
Trope, Beatriz Moritz
Lenzi, Maria Elisa Ribeiro
Cuzzi, Tullia
Ramos-e-Silva, Marcia
dc.subject.en.pt_BR.fl_str_mv Cutaneous T-cell lymphoma
Diagnosis
Granulomatous cutis laxa
Granulomatous slack skin
Lymphoma
Mycosis fungoides
Orcein staining
Treatment
topic Cutaneous T-cell lymphoma
Diagnosis
Granulomatous cutis laxa
Granulomatous slack skin
Lymphoma
Mycosis fungoides
Orcein staining
Treatment
description Tullia Cuzzi. Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta a informação no documento.
publishDate 2012
dc.date.issued.fl_str_mv 2012
dc.date.accessioned.fl_str_mv 2019-09-20T13:06:38Z
dc.date.available.fl_str_mv 2019-09-20T13:06:38Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv GOLDSZTAJN, Karen O. et al. Granulomatous slack skin: histopathology diagnosis preceding clinical manifestations by 12 years. Journal of dermatological case reports, v. 4, p. 108-112, 2012.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/35710
dc.identifier.eissn.none.fl_str_mv 1898-7249
identifier_str_mv GOLDSZTAJN, Karen O. et al. Granulomatous slack skin: histopathology diagnosis preceding clinical manifestations by 12 years. Journal of dermatological case reports, v. 4, p. 108-112, 2012.
1898-7249
url https://www.arca.fiocruz.br/handle/icict/35710
dc.language.iso.fl_str_mv eng
language eng
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