Cross-talk between macrophage migration inhibitory factor and eotaxin in allergic eosinophil activation forms leukotriene C₄-synthesizing lipid bodies
Autor(a) principal: | |
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Data de Publicação: | 2011 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/30160 |
Resumo: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ. Brasil. |
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Abreu, Adriana Vieira deCalheiros, Andrea S.Santos, Fabio P. MesquitaMagalhães, Elisabeth S.Sá, Diego MourãoFaria Neto, Hugo C. CastroBozza, Marcelo T.Melo, Christianne BandeiraBozza, Patrícia T.2018-11-22T14:55:41Z2018-11-22T14:55:41Z2011ABREU, Adriana Vieira de; et al. Cross-Talk between Macrophage Migration Inhibitory Factor and Eotaxin in Allergic Eosinophil Activation Forms Leukotriene C4–Synthesizing Lipid Bodies. Am J Respir Cell Mol Biol., v.44. p.509–516, June 2011.1044-1549https://www.arca.fiocruz.br/handle/icict/3016010.1165/rcmb.2010-0004OC1535-4989engAmerican Thoracic SocietyAsmaInflamação alérgicaGotículas lipídicasleucotrieno C4fator inibitório de migração de macrófagosmacrophage migration inhibitory factorlipid dropletsallergic inflammationasthmaCross-talk between macrophage migration inhibitory factor and eotaxin in allergic eosinophil activation forms leukotriene C₄-synthesizing lipid bodiesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ. Brasil / Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Laboratório de Inflamação. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Microbiologia. Departamento de Imunologia. Rio de Janeiro, RJ. Brasil.Universidade Federal do Rio de Janeiro. Instituto de Microbiologia. Departamento de Imunologia. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ. Brasil.Universidade Federal do Rio de Janeiro. Instituto de Microbiologia. Departamento de Imunologia. Rio de Janeiro, RJ. Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Laboratório de Inflamação. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ. Brasil.Recent studies have demonstrated an essential and nonredundant role for macrophage migration inhibitory factor (MIF) in asthma pathogenesis. Here we investigate the mechanisms involved in MIF-induced eosinophil activation. By using a model of allergic pulmonary inflammation, we observed that allergen challenge-elicited eosinophil influx, lipid body (also known as lipid droplets) biogenesis, and leukotriene (LT) C₄ synthesis are markedly reduced in Mif(-/-) compared with wild-type mice. Likewise, in vivo administration of MIF induced formation of new lipid bodies within eosinophils recruited to the inflammatory reaction site that corresponded to the intracellular compartment of increased LTC₄ synthesis. MIF-mediated eosinophil activation was at least in part due to a direct effect on eosinophils, because MIF was able to elicit lipid body assembly within human eosinophils in vitro, a phenomenon that was blocked by neutralization of the MIF receptor, CD74. MIF-induced eosinophil lipid body biogenesis, both in vivo and in vitro, was dependent on the cooperation of MIF and eotaxin acting in a positive-feedback loop, because anti-eotaxin and anti-CCR3 antibodies inhibit MIF-elicited lipid body formation, whereas eotaxin-induced lipid body formation is affected by anti-CD74 and MIF expression deficiency. Therefore, allergy-elicited inflammatory MIF acts in concert with eotaxin as a key activator of eosinophils to form LTC₄-synthesizing lipid bodies via cross-talk between CD74 and CCR3. Due to the effect of MIF on eosinophils, strategies that inhibit MIF activity might be of therapeutic value in controlling allergic inflammation.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/30160/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALhugocastro_farianeto_etal_IOC_2011.pdfhugocastro_farianeto_etal_IOC_2011.pdfapplication/pdf975659https://www.arca.fiocruz.br/bitstream/icict/30160/2/hugocastro_farianeto_etal_IOC_2011.pdf811e84813b7ef6b3fed05c7c068ee19cMD52TEXThugocastro_farianeto_etal_IOC_2011.pdf.txthugocastro_farianeto_etal_IOC_2011.pdf.txtExtracted texttext/plain47892https://www.arca.fiocruz.br/bitstream/icict/30160/3/hugocastro_farianeto_etal_IOC_2011.pdf.txt52109396d016c6081707d8376df40d29MD53icict/301602022-06-24 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dc.title.pt_BR.fl_str_mv |
Cross-talk between macrophage migration inhibitory factor and eotaxin in allergic eosinophil activation forms leukotriene C₄-synthesizing lipid bodies |
title |
Cross-talk between macrophage migration inhibitory factor and eotaxin in allergic eosinophil activation forms leukotriene C₄-synthesizing lipid bodies |
spellingShingle |
Cross-talk between macrophage migration inhibitory factor and eotaxin in allergic eosinophil activation forms leukotriene C₄-synthesizing lipid bodies Abreu, Adriana Vieira de Asma Inflamação alérgica Gotículas lipídicas leucotrieno C4 fator inibitório de migração de macrófagos macrophage migration inhibitory factor lipid droplets allergic inflammation asthma |
title_short |
Cross-talk between macrophage migration inhibitory factor and eotaxin in allergic eosinophil activation forms leukotriene C₄-synthesizing lipid bodies |
title_full |
Cross-talk between macrophage migration inhibitory factor and eotaxin in allergic eosinophil activation forms leukotriene C₄-synthesizing lipid bodies |
title_fullStr |
Cross-talk between macrophage migration inhibitory factor and eotaxin in allergic eosinophil activation forms leukotriene C₄-synthesizing lipid bodies |
title_full_unstemmed |
Cross-talk between macrophage migration inhibitory factor and eotaxin in allergic eosinophil activation forms leukotriene C₄-synthesizing lipid bodies |
title_sort |
Cross-talk between macrophage migration inhibitory factor and eotaxin in allergic eosinophil activation forms leukotriene C₄-synthesizing lipid bodies |
author |
Abreu, Adriana Vieira de |
author_facet |
Abreu, Adriana Vieira de Calheiros, Andrea S. Santos, Fabio P. Mesquita Magalhães, Elisabeth S. Sá, Diego Mourão Faria Neto, Hugo C. Castro Bozza, Marcelo T. Melo, Christianne Bandeira Bozza, Patrícia T. |
author_role |
author |
author2 |
Calheiros, Andrea S. Santos, Fabio P. Mesquita Magalhães, Elisabeth S. Sá, Diego Mourão Faria Neto, Hugo C. Castro Bozza, Marcelo T. Melo, Christianne Bandeira Bozza, Patrícia T. |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Abreu, Adriana Vieira de Calheiros, Andrea S. Santos, Fabio P. Mesquita Magalhães, Elisabeth S. Sá, Diego Mourão Faria Neto, Hugo C. Castro Bozza, Marcelo T. Melo, Christianne Bandeira Bozza, Patrícia T. |
dc.subject.other.pt_BR.fl_str_mv |
Asma Inflamação alérgica Gotículas lipídicas leucotrieno C4 fator inibitório de migração de macrófagos |
topic |
Asma Inflamação alérgica Gotículas lipídicas leucotrieno C4 fator inibitório de migração de macrófagos macrophage migration inhibitory factor lipid droplets allergic inflammation asthma |
dc.subject.en.pt_BR.fl_str_mv |
macrophage migration inhibitory factor lipid droplets allergic inflammation asthma |
description |
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ. Brasil. |
publishDate |
2011 |
dc.date.issued.fl_str_mv |
2011 |
dc.date.accessioned.fl_str_mv |
2018-11-22T14:55:41Z |
dc.date.available.fl_str_mv |
2018-11-22T14:55:41Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
ABREU, Adriana Vieira de; et al. Cross-Talk between Macrophage Migration Inhibitory Factor and Eotaxin in Allergic Eosinophil Activation Forms Leukotriene C4–Synthesizing Lipid Bodies. Am J Respir Cell Mol Biol., v.44. p.509–516, June 2011. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/30160 |
dc.identifier.issn.pt_BR.fl_str_mv |
1044-1549 |
dc.identifier.doi.none.fl_str_mv |
10.1165/rcmb.2010-0004OC |
dc.identifier.eissn.none.fl_str_mv |
1535-4989 |
identifier_str_mv |
ABREU, Adriana Vieira de; et al. Cross-Talk between Macrophage Migration Inhibitory Factor and Eotaxin in Allergic Eosinophil Activation Forms Leukotriene C4–Synthesizing Lipid Bodies. Am J Respir Cell Mol Biol., v.44. p.509–516, June 2011. 1044-1549 10.1165/rcmb.2010-0004OC 1535-4989 |
url |
https://www.arca.fiocruz.br/handle/icict/30160 |
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eng |
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eng |
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info:eu-repo/semantics/openAccess |
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openAccess |
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American Thoracic Society |
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American Thoracic Society |
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