Dengue fatal cases present virus-specific HMGB1 response in peripheral organs
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/26700 |
Resumo: | Universidade Federal do Rio de Janeiro. Instituto de Química Orgânica. Laboratório de Modelagem Molecular. Rio de Janeiro, RJ, Brasil. |
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Oliveira, Edson R. A.Póvoa, Tiago F.Nuovo, Gerard J.Allonso, DiegoSalomão, Natália G.Oliveira, Carlos A. Basílio deGeraldo, Luiz H. M.Fonseca, Celina G.Lima, Flávia R. S.Borges, Ronaldo MohanaPaes, Marciano V.2018-06-01T20:18:20Z2018-06-01T20:18:20Z2017OLIVEIRA, Edson R. A. et al. Dengue fatal cases present virusspecific HMGB1 response in peripheral organs. Scientifc Reports, v.7:16011, 14p, Nov. 2017.2045-2322https://www.arca.fiocruz.br/handle/icict/2670010.1038/s41598-017-16197-52045-2322engNature Publishing GroupDengueCasos fatáisvírus HMGB1órgãos periféricosDenguefatal casesvirus specific HMGB1peripheral organsDengue fatal cases present virus-specific HMGB1 response in peripheral organsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal do Rio de Janeiro. Instituto de Química Orgânica. Laboratório de Modelagem Molecular. Rio de Janeiro, RJ, Brasil.Instituto de Criminalística. Tocantins, Brasil.Ohio State University Comprehensive Cancer Center. Columbus, Ohio, USA / Phylogeny Inc. Powell, Ohio, USA.Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Laboratório de Genômica Estrutural. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ, Brasil.Universidade Federal do Estado do Rio de Janeiro. Hospital Gaffrée Guinle. Anatomia Patológica. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Ciências Biomédicas. Laboratório de Biologia das Células Gliais. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Ciências Biomédicas. Laboratório de Biologia das Células Gliais. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Ciências Biomédicas. Laboratório de Biologia das Células Gliais. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Laboratório de Genômica Estrutural. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ, Brasil.Dengue is an important infectious disease that presents high incidence and yields a relevant number of fatal cases (about 20,000) every year worldwide. Despite its epidemiological relevance, there are many knowledge gaps concerning dengue pathogenesis, especially with regards to the circumstances that drive a mild clinical course to a severe disease. In this work, we investigated the participation of high mobility group box 1 (HMGB1), an important modulator of inflammation, in dengue fatal cases. Histopathological and ultrastructural analyses revealed that liver, lung and heart post-mortem samples were marked by tissue abnormalities, such as necrosis and apoptotic cell death. These observations go in line with an HMGB1-mediated response and raised concerns regarding the participation of this cytokine in promoting/perpetuating inflammation in severe dengue. Further experiments of immunohistochemistry (IHC) showed increased expression of cytoplasmic HMGB1 in dengue-extracted tissues when compared to non-dengue controls. Co-staining of DENV RNA and HMGB1 in the host cell cytoplasm, as found by in situ hybridization and IHC, confirmed the virus specific induction of the HMGB1-mediated response in these peripheral tissues. This report brings the first in-situ evidence of the participation of HMGB1 in severe dengue and highlights novel considerations in the development of dengue immunopathogenesis.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/26700/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALnataliag_salomao_etal_IOC_2017.pdfnataliag_salomao_etal_IOC_2017.pdfapplication/pdf3614916https://www.arca.fiocruz.br/bitstream/icict/26700/2/nataliag_salomao_etal_IOC_2017.pdf4fec3609e05033581ccc2e77d7948eebMD52TEXTnataliag_salomao_etal_IOC_2017.pdf.txtnataliag_salomao_etal_IOC_2017.pdf.txtExtracted texttext/plain59898https://www.arca.fiocruz.br/bitstream/icict/26700/3/nataliag_salomao_etal_IOC_2017.pdf.txt97ed507927eb281c9e9ecb0d7b747da8MD53icict/267002018-08-15 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dc.title.pt_BR.fl_str_mv |
Dengue fatal cases present virus-specific HMGB1 response in peripheral organs |
title |
Dengue fatal cases present virus-specific HMGB1 response in peripheral organs |
spellingShingle |
Dengue fatal cases present virus-specific HMGB1 response in peripheral organs Oliveira, Edson R. A. Dengue Casos fatáis vírus HMGB1 órgãos periféricos Dengue fatal cases virus specific HMGB1 peripheral organs |
title_short |
Dengue fatal cases present virus-specific HMGB1 response in peripheral organs |
title_full |
Dengue fatal cases present virus-specific HMGB1 response in peripheral organs |
title_fullStr |
Dengue fatal cases present virus-specific HMGB1 response in peripheral organs |
title_full_unstemmed |
Dengue fatal cases present virus-specific HMGB1 response in peripheral organs |
title_sort |
Dengue fatal cases present virus-specific HMGB1 response in peripheral organs |
author |
Oliveira, Edson R. A. |
author_facet |
Oliveira, Edson R. A. Póvoa, Tiago F. Nuovo, Gerard J. Allonso, Diego Salomão, Natália G. Oliveira, Carlos A. Basílio de Geraldo, Luiz H. M. Fonseca, Celina G. Lima, Flávia R. S. Borges, Ronaldo Mohana Paes, Marciano V. |
author_role |
author |
author2 |
Póvoa, Tiago F. Nuovo, Gerard J. Allonso, Diego Salomão, Natália G. Oliveira, Carlos A. Basílio de Geraldo, Luiz H. M. Fonseca, Celina G. Lima, Flávia R. S. Borges, Ronaldo Mohana Paes, Marciano V. |
author2_role |
author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Oliveira, Edson R. A. Póvoa, Tiago F. Nuovo, Gerard J. Allonso, Diego Salomão, Natália G. Oliveira, Carlos A. Basílio de Geraldo, Luiz H. M. Fonseca, Celina G. Lima, Flávia R. S. Borges, Ronaldo Mohana Paes, Marciano V. |
dc.subject.other.pt_BR.fl_str_mv |
Dengue Casos fatáis vírus HMGB1 órgãos periféricos |
topic |
Dengue Casos fatáis vírus HMGB1 órgãos periféricos Dengue fatal cases virus specific HMGB1 peripheral organs |
dc.subject.en.pt_BR.fl_str_mv |
Dengue fatal cases virus specific HMGB1 peripheral organs |
description |
Universidade Federal do Rio de Janeiro. Instituto de Química Orgânica. Laboratório de Modelagem Molecular. Rio de Janeiro, RJ, Brasil. |
publishDate |
2017 |
dc.date.issued.fl_str_mv |
2017 |
dc.date.accessioned.fl_str_mv |
2018-06-01T20:18:20Z |
dc.date.available.fl_str_mv |
2018-06-01T20:18:20Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
OLIVEIRA, Edson R. A. et al. Dengue fatal cases present virusspecific HMGB1 response in peripheral organs. Scientifc Reports, v.7:16011, 14p, Nov. 2017. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/26700 |
dc.identifier.issn.pt_BR.fl_str_mv |
2045-2322 |
dc.identifier.doi.none.fl_str_mv |
10.1038/s41598-017-16197-5 |
dc.identifier.eissn.none.fl_str_mv |
2045-2322 |
identifier_str_mv |
OLIVEIRA, Edson R. A. et al. Dengue fatal cases present virusspecific HMGB1 response in peripheral organs. Scientifc Reports, v.7:16011, 14p, Nov. 2017. 2045-2322 10.1038/s41598-017-16197-5 |
url |
https://www.arca.fiocruz.br/handle/icict/26700 |
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eng |
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eng |
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info:eu-repo/semantics/openAccess |
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openAccess |
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Nature Publishing Group |
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Nature Publishing Group |
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