Dengue fatal cases present virus-specific HMGB1 response in peripheral organs

Detalhes bibliográficos
Autor(a) principal: Oliveira, Edson R. A.
Data de Publicação: 2017
Outros Autores: Póvoa, Tiago F., Nuovo, Gerard J., Allonso, Diego, Salomão, Natália G., Oliveira, Carlos A. Basílio de, Geraldo, Luiz H. M., Fonseca, Celina G., Lima, Flávia R. S., Borges, Ronaldo Mohana, Paes, Marciano V.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/26700
Resumo: Universidade Federal do Rio de Janeiro. Instituto de Química Orgânica. Laboratório de Modelagem Molecular. Rio de Janeiro, RJ, Brasil.
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spelling Oliveira, Edson R. A.Póvoa, Tiago F.Nuovo, Gerard J.Allonso, DiegoSalomão, Natália G.Oliveira, Carlos A. Basílio deGeraldo, Luiz H. M.Fonseca, Celina G.Lima, Flávia R. S.Borges, Ronaldo MohanaPaes, Marciano V.2018-06-01T20:18:20Z2018-06-01T20:18:20Z2017OLIVEIRA, Edson R. A. et al. Dengue fatal cases present virusspecific HMGB1 response in peripheral organs. Scientifc Reports, v.7:16011, 14p, Nov. 2017.2045-2322https://www.arca.fiocruz.br/handle/icict/2670010.1038/s41598-017-16197-52045-2322engNature Publishing GroupDengueCasos fatáisvírus HMGB1órgãos periféricosDenguefatal casesvirus specific HMGB1peripheral organsDengue fatal cases present virus-specific HMGB1 response in peripheral organsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal do Rio de Janeiro. Instituto de Química Orgânica. Laboratório de Modelagem Molecular. Rio de Janeiro, RJ, Brasil.Instituto de Criminalística. Tocantins, Brasil.Ohio State University Comprehensive Cancer Center. Columbus, Ohio, USA / Phylogeny Inc. Powell, Ohio, USA.Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Laboratório de Genômica Estrutural. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ, Brasil.Universidade Federal do Estado do Rio de Janeiro. Hospital Gaffrée Guinle. Anatomia Patológica. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Ciências Biomédicas. Laboratório de Biologia das Células Gliais. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Ciências Biomédicas. Laboratório de Biologia das Células Gliais. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Ciências Biomédicas. Laboratório de Biologia das Células Gliais. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Laboratório de Genômica Estrutural. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ, Brasil.Dengue is an important infectious disease that presents high incidence and yields a relevant number of fatal cases (about 20,000) every year worldwide. Despite its epidemiological relevance, there are many knowledge gaps concerning dengue pathogenesis, especially with regards to the circumstances that drive a mild clinical course to a severe disease. In this work, we investigated the participation of high mobility group box 1 (HMGB1), an important modulator of inflammation, in dengue fatal cases. Histopathological and ultrastructural analyses revealed that liver, lung and heart post-mortem samples were marked by tissue abnormalities, such as necrosis and apoptotic cell death. These observations go in line with an HMGB1-mediated response and raised concerns regarding the participation of this cytokine in promoting/perpetuating inflammation in severe dengue. Further experiments of immunohistochemistry (IHC) showed increased expression of cytoplasmic HMGB1 in dengue-extracted tissues when compared to non-dengue controls. Co-staining of DENV RNA and HMGB1 in the host cell cytoplasm, as found by in situ hybridization and IHC, confirmed the virus specific induction of the HMGB1-mediated response in these peripheral tissues. This report brings the first in-situ evidence of the participation of HMGB1 in severe dengue and highlights novel considerations in the development of dengue immunopathogenesis.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/26700/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALnataliag_salomao_etal_IOC_2017.pdfnataliag_salomao_etal_IOC_2017.pdfapplication/pdf3614916https://www.arca.fiocruz.br/bitstream/icict/26700/2/nataliag_salomao_etal_IOC_2017.pdf4fec3609e05033581ccc2e77d7948eebMD52TEXTnataliag_salomao_etal_IOC_2017.pdf.txtnataliag_salomao_etal_IOC_2017.pdf.txtExtracted texttext/plain59898https://www.arca.fiocruz.br/bitstream/icict/26700/3/nataliag_salomao_etal_IOC_2017.pdf.txt97ed507927eb281c9e9ecb0d7b747da8MD53icict/267002018-08-15 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dc.title.pt_BR.fl_str_mv Dengue fatal cases present virus-specific HMGB1 response in peripheral organs
title Dengue fatal cases present virus-specific HMGB1 response in peripheral organs
spellingShingle Dengue fatal cases present virus-specific HMGB1 response in peripheral organs
Oliveira, Edson R. A.
Dengue
Casos fatáis
vírus HMGB1
órgãos periféricos
Dengue
fatal cases
virus specific HMGB1
peripheral organs
title_short Dengue fatal cases present virus-specific HMGB1 response in peripheral organs
title_full Dengue fatal cases present virus-specific HMGB1 response in peripheral organs
title_fullStr Dengue fatal cases present virus-specific HMGB1 response in peripheral organs
title_full_unstemmed Dengue fatal cases present virus-specific HMGB1 response in peripheral organs
title_sort Dengue fatal cases present virus-specific HMGB1 response in peripheral organs
author Oliveira, Edson R. A.
author_facet Oliveira, Edson R. A.
Póvoa, Tiago F.
Nuovo, Gerard J.
Allonso, Diego
Salomão, Natália G.
Oliveira, Carlos A. Basílio de
Geraldo, Luiz H. M.
Fonseca, Celina G.
Lima, Flávia R. S.
Borges, Ronaldo Mohana
Paes, Marciano V.
author_role author
author2 Póvoa, Tiago F.
Nuovo, Gerard J.
Allonso, Diego
Salomão, Natália G.
Oliveira, Carlos A. Basílio de
Geraldo, Luiz H. M.
Fonseca, Celina G.
Lima, Flávia R. S.
Borges, Ronaldo Mohana
Paes, Marciano V.
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Oliveira, Edson R. A.
Póvoa, Tiago F.
Nuovo, Gerard J.
Allonso, Diego
Salomão, Natália G.
Oliveira, Carlos A. Basílio de
Geraldo, Luiz H. M.
Fonseca, Celina G.
Lima, Flávia R. S.
Borges, Ronaldo Mohana
Paes, Marciano V.
dc.subject.other.pt_BR.fl_str_mv Dengue
Casos fatáis
vírus HMGB1
órgãos periféricos
topic Dengue
Casos fatáis
vírus HMGB1
órgãos periféricos
Dengue
fatal cases
virus specific HMGB1
peripheral organs
dc.subject.en.pt_BR.fl_str_mv Dengue
fatal cases
virus specific HMGB1
peripheral organs
description Universidade Federal do Rio de Janeiro. Instituto de Química Orgânica. Laboratório de Modelagem Molecular. Rio de Janeiro, RJ, Brasil.
publishDate 2017
dc.date.issued.fl_str_mv 2017
dc.date.accessioned.fl_str_mv 2018-06-01T20:18:20Z
dc.date.available.fl_str_mv 2018-06-01T20:18:20Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv OLIVEIRA, Edson R. A. et al. Dengue fatal cases present virusspecific HMGB1 response in peripheral organs. Scientifc Reports, v.7:16011, 14p, Nov. 2017.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/26700
dc.identifier.issn.pt_BR.fl_str_mv 2045-2322
dc.identifier.doi.none.fl_str_mv 10.1038/s41598-017-16197-5
dc.identifier.eissn.none.fl_str_mv 2045-2322
identifier_str_mv OLIVEIRA, Edson R. A. et al. Dengue fatal cases present virusspecific HMGB1 response in peripheral organs. Scientifc Reports, v.7:16011, 14p, Nov. 2017.
2045-2322
10.1038/s41598-017-16197-5
url https://www.arca.fiocruz.br/handle/icict/26700
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Nature Publishing Group
publisher.none.fl_str_mv Nature Publishing Group
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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