Overlapping SETBP1 gain-of-function mutations in Schinzel-Giedion syndrome and hematologic malignancies
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| Data de Publicação: | 2017 |
| Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/45518 |
Resumo: | Radboud University Medical Center. Radboud Institute of Molecular Life Sciences. Department of Human Genetics. Nijmegen. The Netherlands. |
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Acuna-Hidalgo, RocioDeriziotis, PelagiaSteehouwer, MarloesGilissen, ChristianGraham, Sarah A.van Dam, SipkoHoover-Fong, JulieTelegrafi, Aida B.Destree, AnneSmigiel, RobertLambie, Lindsday A.Kayserili, HülyaAltunoglu, UmutLapi, ElisabettaUzielli, Maria LuisaAracena, MarianaNur, Banu G.Mihci, ErcanMoreira, Lilia M. A.Borges Ferreira, VivianeHorovitz, Dafne Dain GandelmanRocha, Katia M. daJezela-Stanek, AleksandraBrooks, Alice S.Reutter, HeikoCohen, Julie S.Fatemi, AliSmitka, MartinGrebe, Theresa A.Di Donato, NataliyaDeshpande, CharuVandersteen, AnthonyMarques Lourenço, CharlesDufke, AndreasRossier, EvaAndre, GwenaelleBaumer, AlessandraSpencer, CareniMcGaughran, JulieFranke, LudeVeltman, Joris A.De Vries, Bert B. A.Schinzel, AlbertFisher, Simon E.Hoischen, Alexandervan Bon, Bregje W.2021-01-06T19:42:43Z2021-01-06T19:42:43Z2017Acuna-Hidalgo R, Deriziotis P, Steehouwer M, Gilissen C, Graham SA, van Dam S, Hoover-Fong J, Telegrafi AB, Destree A, Smigiel R, Lambie LA, Kayserili H, Altunoglu U, Lapi E, Uzielli ML, Aracena M, Nur BG, Mihci E, Moreira LM, Borges Ferreira V, Horovitz DD, da Rocha KM, Jezela-Stanek A, Brooks AS, Reutter H, Cohen JS, Fatemi A, Smitka M, Grebe TA, Di Donato N, Deshpande C, Vandersteen A, Marques Lourenço C, Dufke A, Rossier E, Andre G, Baumer A, Spencer C, McGaughran J, Franke L, Veltman JA, De Vries BB, Schinzel A, Fisher SE, Hoischen A, van Bon BW. Overlapping SETBP1 gain-of-function mutations in Schinzel-Giedion syndrome and hematologic malignancies. PLoS Genet. 2017 Mar 27;13(3):e1006683. doi: 10.1371/journal.pgen.1006683. PMID: 28346496; PMCID: PMC5386295.1553-7390https://www.arca.fiocruz.br/handle/icict/4551810.1371/journal.pgen.1006683engPublic Library of Science [Commercial Publisher]Abnormalities, Multiple / geneticsAbnormalities, Multiple / metabolismAbnormalities, Multiple / pathologyBlotting, WesternCarrier Proteins / geneticsCarrier Proteins / metabolismCell LineCell Proliferation / geneticsCell Transformation, Neoplastic / geneticsChildChild, PreschoolCraniofacial Abnormalities / geneticsCraniofacial Abnormalities / metabolismCraniofacial Abnormalities / pathologyFemaleGene Expression ProfilingGenetic Association StudiesGenetic Predisposition to Disease / geneticsGerm-Line MutationHEK293 CellsHand Deformities, Congenital / geneticsHand Deformities, Congenital / metabolismHand Deformities, Congenital / pathologyHematologic Neoplasms / geneticsPhenotypeNuclear Proteins / metabolismHematologic Neoplasms / metabolismHematologic Neoplasms / pathologyNuclear Proteins / geneticsNails, Malformed / pathologyNails, Malformed / metabolismNails, Malformed / geneticsMutationMaleHumansInfantIntellectual Disability / pathologyIntellectual Disability / geneticsInfant, NewbornOverlapping SETBP1 gain-of-function mutations in Schinzel-Giedion syndrome and hematologic malignanciesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleRadboud University Medical Center. Radboud Institute of Molecular Life Sciences. Department of Human Genetics. Nijmegen. The Netherlands.Max Planck Institute for Psycholinguistics. Language and Genetics Department. Nijmegen. The Netherlands.Radboud University Medical Center. Radboud Institute of Molecular Life Sciences. Department of Human Genetics. Nijmegen. The Netherlands.Radboud University Medical Center. Radboud Institute of Molecular Life Sciences. Department of Human Genetics. Nijmegen. The Netherlands. / Radboud University Medical Center. Donders Centre for Neuroscience. Department of Human Genetics. Nijmegen. The Netherlands.Max Planck Institute for Psycholinguistics. Language and Genetics Department. Nijmegen. The Netherlands.University of Groningen. University Medical Center Groningen. Department of Genetics. Groningen. the Netherlands.Johns Hopkins University. McKusick-Nathans Institute of Genetic Medicine. Baltimore, Maryland. USAGeneDx. Gaithersburg. Baltimore, Maryland. USAInstitute of Pathology and Genetics. Gosselies. Belgium.Medical University. Department of Pediatrics and Rare Disorders. Wroclaw. Poland.University of the Witwatersrand. Faculty of Health Sciences. National Health Laboratory Service and School of Pathology. Division of Human Genetics. Johannesburg. South Africa.Koç University School of Medicine. Medical Genetics Department. İstanbul. Turkey.İstanbul University. İstanbul Medical Faculty. Medical Genetics Department. İstanbul, Turkey.Anna Meyer Children's University Hospital. Medical Genetics Unit. Florence. Italy.University of Florence. Genetic Science. Firenze. ItalyPontificia Universidad Católica de Chile. División de Pediatría. / Hospital Dr. Luis Calvo Mackenna. Unidad de Genética. Santiago. Chile.Akdeniz University Medical School. Department of Pediatric Genetics. Antalya. Turkey.Universidade Federal da Bahia. Instituto de Biologia. Laboratório de Genética Humana. Bahia. Brasil.Hospital Santa Izabel. Salvador, BA. Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira. Centro de Genética Médica. Rio de Janeiro, RJ, BrasilUniversidade de São Paulo. Instituto de Biociência. Centro de Estudos de Genoma Humano, São Paulo, SP. Brasil.Children's Memorial Health Institute. Department of Medical Genetics. Warsaw. Poland.Sophia Children's Hospital. Department of Clinical Genetics. Erasmus MC, Rotterdam. The Netherlands.University of Bonn. Institute of Human Genetics. Bonn. Germany / University of Bonn. Children's Hospital. Department of Neonatology and Pediatric Intensive Care. Bonn. Germany.The Johns Hopkins Hospital. Kennedy Krieger Institute. Departments of Neurology and Pediatrics. Division of Neurogenetics. Baltimore, Maryland. USATechnische Universität Dresden. Medizinische Fakultät Carl Gustav Carus. Abteilung Neuropädiatrie. Germany.Phoenix Children's Hospital. Division of Genetics & Metabolism. Phoenix, Arizona. USA.Institute for Clinical Genetics. TU Dresden. Dresden. Germany.Guy's and St. Thomas' NHS Foundation Trust. Department of Genetics. London. United Kingdom.Kennedy Galton Centre. North West Thames Regional Genetics Unit. North West, London. UK / Hospitals NHS Trust. Northwick Park & St Marks Hospital. Harrow, Middlesex. UK.Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Departamento de Genética Médica. Unidade de Neurogenética. São Paulo, SP. Brasil.University of Tübingen. Institute of Medical Genetics and Applied Genomics. Tübingen. Germany.University of Tübingen. Institute of Medical Genetics and Applied Genomics. Tübingen. Germany.Hôpital Pellegrin. Unité de foetopathologie. Bordeaux. FranceUniversity of Zurich. Institute of Medical Genetics. Schlieren. Switzerland.University of the Witwatersrand. Faculty of Health Sciences. National Health Laboratory Service and School of Pathology. Division of Human Genetics. Johannesburg. South Africa.The University of Queensland.Queensland and School of Medicine. Genetic Health Queensland. Royal Brisbane and Women's Hospital. Brisbane, Queensland. Australia.University of Groningen. University Medical Center Groningen. Department of Genetics. Groningen. the Netherlands.Radboud University Medical Center. Radboud Institute of Molecular Life Sciences. Department of Human Genetics. Nijmegen. The Netherlands. / Newcastle University. Institute of Genetic Medicine, International Centre for Life. Newcastle upon Tyne. United Kingdom.Radboud University Medical Center. Radboud Institute of Molecular Life Sciences. Department of Human Genetics. Nijmegen. The Netherlands./ Radboud University Medical Center. Donders Centre for Neuroscience. Department of Human Genetics. Nijmegen. The Netherlands.Radboud University Medical Center. Radboud Institute of Molecular Life Sciences. Department of Human Genetics. Nijmegen. The Netherlands. / Radboud University Medical Center. Donders Centre for Neuroscience. Department of Human Genetics. Nijmegen. The Netherlands.Radboud University Medical Center. Radboud Institute of Molecular Life Sciences. Department of Human Genetics. Nijmegen. The Netherlands. / Radboud University Medical Center.Donders Centre for Neuroscience. Department of Human Genetics. Nijmegen. The Netherlands.University of Zurich. Institute of Medical Genetics. Schlieren. Switzerland.Max Planck Institute for Psycholinguistics. Language and Genetics Department. Nijmegen. The Netherlands. / Radboud University. Donders Institute for Brain, Cognition and Behaviour. Nijmegen. The Netherlands.Radboud University Medical Center. Radboud Institute of Molecular Life Sciences. Department of Human Genetics. Nijmegen. The Netherlands. / Radboud University Medical Center. Donders Centre for Neuroscience. Department of Human Genetics. Nijmegen. The Netherlands. /Radboud University Medical Center. Department of Internal Medicine and Radboud Center for Infectious Diseases. Nijmegen. The Netherland.s.Radboud University Medical Center. Radboud Institute of Molecular Life Sciences. Department of Human Genetics. Nijmegen. The Netherlands.Schinzel-Giedion syndrome (SGS) is a rare developmental disorder characterized by multiple malformations, severe neurological alterations and increased risk of malignancy. SGS is caused by de novo germline mutations clustering to a 12bp hotspot in exon 4 of SETBP1. Mutations in this hotspot disrupt a degron, a signal for the regulation of protein degradation, and lead to the accumulation of SETBP1 protein. Overlapping SETBP1 hotspot mutations have been observed recurrently as somatic events in leukemia. We collected clinical information of 47 SGS patients (including 26 novel cases) with germline SETBP1 mutations and of four individuals with a milder phenotype caused by de novo germline mutations adjacent to the SETBP1 hotspot. Different mutations within and around the SETBP1 hotspot have varying effects on SETBP1 stability and protein levels in vitro and in in silico modeling. Substitutions in SETBP1 residue I871 result in a weak increase in protein levels and mutations affecting this residue are significantly more frequent in SGS than in leukemia. On the other hand, substitutions in residue D868 lead to the largest increase in protein levels. Individuals with germline mutations affecting D868 have enhanced cell proliferation in vitro and higher incidence of cancer compared to patients with other germline SETBP1 mutations. Our findings substantiate that, despite their overlap, somatic SETBP1 mutations driving malignancy are more disruptive to the degron than germline SETBP1 mutations causing SGS. Additionally, this suggests that the functional threshold for the development of cancer driven by the disruption of the SETBP1 degron is higher than for the alteration in prenatal development in SGS. Drawing on previous studies of somatic SETBP1 mutations in leukemia, our results reveal a genotype-phenotype correlation in germline SETBP1 mutations spanning a molecular, cellular and clinical phenotype.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/45518/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALpgen.1006683(3).pdfpgen.1006683(3).pdfapplication/pdf2369443https://www.arca.fiocruz.br/bitstream/icict/45518/2/pgen.1006683%283%29.pdf453f687f6dc08e19ec19de5900a5782dMD52TEXTpgen.1006683(3).pdf.txtpgen.1006683(3).pdf.txtExtracted texttext/plain89627https://www.arca.fiocruz.br/bitstream/icict/45518/3/pgen.1006683%283%29.pdf.txtd06039140d40e344681a002e45046f67MD53icict/455182021-01-07 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| dc.title.pt_BR.fl_str_mv |
Overlapping SETBP1 gain-of-function mutations in Schinzel-Giedion syndrome and hematologic malignancies |
| title |
Overlapping SETBP1 gain-of-function mutations in Schinzel-Giedion syndrome and hematologic malignancies |
| spellingShingle |
Overlapping SETBP1 gain-of-function mutations in Schinzel-Giedion syndrome and hematologic malignancies Acuna-Hidalgo, Rocio Abnormalities, Multiple / genetics Abnormalities, Multiple / metabolism Abnormalities, Multiple / pathology Blotting, Western Carrier Proteins / genetics Carrier Proteins / metabolism Cell Line Cell Proliferation / genetics Cell Transformation, Neoplastic / genetics Child Child, Preschool Craniofacial Abnormalities / genetics Craniofacial Abnormalities / metabolism Craniofacial Abnormalities / pathology Female Gene Expression Profiling Genetic Association Studies Genetic Predisposition to Disease / genetics Germ-Line Mutation HEK293 Cells Hand Deformities, Congenital / genetics Hand Deformities, Congenital / metabolism Hand Deformities, Congenital / pathology Hematologic Neoplasms / genetics Phenotype Nuclear Proteins / metabolism Hematologic Neoplasms / metabolism Hematologic Neoplasms / pathology Nuclear Proteins / genetics Nails, Malformed / pathology Nails, Malformed / metabolism Nails, Malformed / genetics Mutation Male Humans Infant Intellectual Disability / pathology Intellectual Disability / genetics Infant, Newborn |
| title_short |
Overlapping SETBP1 gain-of-function mutations in Schinzel-Giedion syndrome and hematologic malignancies |
| title_full |
Overlapping SETBP1 gain-of-function mutations in Schinzel-Giedion syndrome and hematologic malignancies |
| title_fullStr |
Overlapping SETBP1 gain-of-function mutations in Schinzel-Giedion syndrome and hematologic malignancies |
| title_full_unstemmed |
Overlapping SETBP1 gain-of-function mutations in Schinzel-Giedion syndrome and hematologic malignancies |
| title_sort |
Overlapping SETBP1 gain-of-function mutations in Schinzel-Giedion syndrome and hematologic malignancies |
| author |
Acuna-Hidalgo, Rocio |
| author_facet |
Acuna-Hidalgo, Rocio Deriziotis, Pelagia Steehouwer, Marloes Gilissen, Christian Graham, Sarah A. van Dam, Sipko Hoover-Fong, Julie Telegrafi, Aida B. Destree, Anne Smigiel, Robert Lambie, Lindsday A. Kayserili, Hülya Altunoglu, Umut Lapi, Elisabetta Uzielli, Maria Luisa Aracena, Mariana Nur, Banu G. Mihci, Ercan Moreira, Lilia M. A. Borges Ferreira, Viviane Horovitz, Dafne Dain Gandelman Rocha, Katia M. da Jezela-Stanek, Aleksandra Brooks, Alice S. Reutter, Heiko Cohen, Julie S. Fatemi, Ali Smitka, Martin Grebe, Theresa A. Di Donato, Nataliya Deshpande, Charu Vandersteen, Anthony Marques Lourenço, Charles Dufke, Andreas Rossier, Eva Andre, Gwenaelle Baumer, Alessandra Spencer, Careni McGaughran, Julie Franke, Lude Veltman, Joris A. De Vries, Bert B. A. Schinzel, Albert Fisher, Simon E. Hoischen, Alexander van Bon, Bregje W. |
| author_role |
author |
| author2 |
Deriziotis, Pelagia Steehouwer, Marloes Gilissen, Christian Graham, Sarah A. van Dam, Sipko Hoover-Fong, Julie Telegrafi, Aida B. Destree, Anne Smigiel, Robert Lambie, Lindsday A. Kayserili, Hülya Altunoglu, Umut Lapi, Elisabetta Uzielli, Maria Luisa Aracena, Mariana Nur, Banu G. Mihci, Ercan Moreira, Lilia M. A. Borges Ferreira, Viviane Horovitz, Dafne Dain Gandelman Rocha, Katia M. da Jezela-Stanek, Aleksandra Brooks, Alice S. Reutter, Heiko Cohen, Julie S. Fatemi, Ali Smitka, Martin Grebe, Theresa A. Di Donato, Nataliya Deshpande, Charu Vandersteen, Anthony Marques Lourenço, Charles Dufke, Andreas Rossier, Eva Andre, Gwenaelle Baumer, Alessandra Spencer, Careni McGaughran, Julie Franke, Lude Veltman, Joris A. De Vries, Bert B. A. Schinzel, Albert Fisher, Simon E. Hoischen, Alexander van Bon, Bregje W. |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Acuna-Hidalgo, Rocio Deriziotis, Pelagia Steehouwer, Marloes Gilissen, Christian Graham, Sarah A. van Dam, Sipko Hoover-Fong, Julie Telegrafi, Aida B. Destree, Anne Smigiel, Robert Lambie, Lindsday A. Kayserili, Hülya Altunoglu, Umut Lapi, Elisabetta Uzielli, Maria Luisa Aracena, Mariana Nur, Banu G. Mihci, Ercan Moreira, Lilia M. A. Borges Ferreira, Viviane Horovitz, Dafne Dain Gandelman Rocha, Katia M. da Jezela-Stanek, Aleksandra Brooks, Alice S. Reutter, Heiko Cohen, Julie S. Fatemi, Ali Smitka, Martin Grebe, Theresa A. Di Donato, Nataliya Deshpande, Charu Vandersteen, Anthony Marques Lourenço, Charles Dufke, Andreas Rossier, Eva Andre, Gwenaelle Baumer, Alessandra Spencer, Careni McGaughran, Julie Franke, Lude Veltman, Joris A. De Vries, Bert B. A. Schinzel, Albert Fisher, Simon E. Hoischen, Alexander van Bon, Bregje W. |
| dc.subject.mesh.pt_BR.fl_str_mv |
Abnormalities, Multiple / genetics Abnormalities, Multiple / metabolism Abnormalities, Multiple / pathology Blotting, Western Carrier Proteins / genetics Carrier Proteins / metabolism Cell Line Cell Proliferation / genetics Cell Transformation, Neoplastic / genetics Child Child, Preschool Craniofacial Abnormalities / genetics Craniofacial Abnormalities / metabolism Craniofacial Abnormalities / pathology Female Gene Expression Profiling Genetic Association Studies Genetic Predisposition to Disease / genetics Germ-Line Mutation HEK293 Cells Hand Deformities, Congenital / genetics Hand Deformities, Congenital / metabolism Hand Deformities, Congenital / pathology Hematologic Neoplasms / genetics Phenotype Nuclear Proteins / metabolism Hematologic Neoplasms / metabolism Hematologic Neoplasms / pathology Nuclear Proteins / genetics Nails, Malformed / pathology Nails, Malformed / metabolism Nails, Malformed / genetics Mutation Male Humans Infant Intellectual Disability / pathology Intellectual Disability / genetics Infant, Newborn |
| topic |
Abnormalities, Multiple / genetics Abnormalities, Multiple / metabolism Abnormalities, Multiple / pathology Blotting, Western Carrier Proteins / genetics Carrier Proteins / metabolism Cell Line Cell Proliferation / genetics Cell Transformation, Neoplastic / genetics Child Child, Preschool Craniofacial Abnormalities / genetics Craniofacial Abnormalities / metabolism Craniofacial Abnormalities / pathology Female Gene Expression Profiling Genetic Association Studies Genetic Predisposition to Disease / genetics Germ-Line Mutation HEK293 Cells Hand Deformities, Congenital / genetics Hand Deformities, Congenital / metabolism Hand Deformities, Congenital / pathology Hematologic Neoplasms / genetics Phenotype Nuclear Proteins / metabolism Hematologic Neoplasms / metabolism Hematologic Neoplasms / pathology Nuclear Proteins / genetics Nails, Malformed / pathology Nails, Malformed / metabolism Nails, Malformed / genetics Mutation Male Humans Infant Intellectual Disability / pathology Intellectual Disability / genetics Infant, Newborn |
| description |
Radboud University Medical Center. Radboud Institute of Molecular Life Sciences. Department of Human Genetics. Nijmegen. The Netherlands. |
| publishDate |
2017 |
| dc.date.issued.fl_str_mv |
2017 |
| dc.date.accessioned.fl_str_mv |
2021-01-06T19:42:43Z |
| dc.date.available.fl_str_mv |
2021-01-06T19:42:43Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
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article |
| status_str |
publishedVersion |
| dc.identifier.citation.fl_str_mv |
Acuna-Hidalgo R, Deriziotis P, Steehouwer M, Gilissen C, Graham SA, van Dam S, Hoover-Fong J, Telegrafi AB, Destree A, Smigiel R, Lambie LA, Kayserili H, Altunoglu U, Lapi E, Uzielli ML, Aracena M, Nur BG, Mihci E, Moreira LM, Borges Ferreira V, Horovitz DD, da Rocha KM, Jezela-Stanek A, Brooks AS, Reutter H, Cohen JS, Fatemi A, Smitka M, Grebe TA, Di Donato N, Deshpande C, Vandersteen A, Marques Lourenço C, Dufke A, Rossier E, Andre G, Baumer A, Spencer C, McGaughran J, Franke L, Veltman JA, De Vries BB, Schinzel A, Fisher SE, Hoischen A, van Bon BW. Overlapping SETBP1 gain-of-function mutations in Schinzel-Giedion syndrome and hematologic malignancies. PLoS Genet. 2017 Mar 27;13(3):e1006683. doi: 10.1371/journal.pgen.1006683. PMID: 28346496; PMCID: PMC5386295. |
| dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/45518 |
| dc.identifier.issn.pt_BR.fl_str_mv |
1553-7390 |
| dc.identifier.doi.none.fl_str_mv |
10.1371/journal.pgen.1006683 |
| identifier_str_mv |
Acuna-Hidalgo R, Deriziotis P, Steehouwer M, Gilissen C, Graham SA, van Dam S, Hoover-Fong J, Telegrafi AB, Destree A, Smigiel R, Lambie LA, Kayserili H, Altunoglu U, Lapi E, Uzielli ML, Aracena M, Nur BG, Mihci E, Moreira LM, Borges Ferreira V, Horovitz DD, da Rocha KM, Jezela-Stanek A, Brooks AS, Reutter H, Cohen JS, Fatemi A, Smitka M, Grebe TA, Di Donato N, Deshpande C, Vandersteen A, Marques Lourenço C, Dufke A, Rossier E, Andre G, Baumer A, Spencer C, McGaughran J, Franke L, Veltman JA, De Vries BB, Schinzel A, Fisher SE, Hoischen A, van Bon BW. Overlapping SETBP1 gain-of-function mutations in Schinzel-Giedion syndrome and hematologic malignancies. PLoS Genet. 2017 Mar 27;13(3):e1006683. doi: 10.1371/journal.pgen.1006683. PMID: 28346496; PMCID: PMC5386295. 1553-7390 10.1371/journal.pgen.1006683 |
| url |
https://www.arca.fiocruz.br/handle/icict/45518 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.publisher.none.fl_str_mv |
Public Library of Science [Commercial Publisher] |
| publisher.none.fl_str_mv |
Public Library of Science [Commercial Publisher] |
| dc.source.none.fl_str_mv |
reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
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Fundação Oswaldo Cruz (FIOCRUZ) |
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FIOCRUZ |
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FIOCRUZ |
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Repositório Institucional da FIOCRUZ (ARCA) |
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Repositório Institucional da FIOCRUZ (ARCA) |
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repositorio.arca@fiocruz.br |
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