Benznidazole treatment following acute Trypanosoma cruzi infection triggers CD8+ T-cell expansion and promotes resistance to reinfection

Detalhes bibliográficos
Autor(a) principal: Olivieri, Bianca Perdigão
Data de Publicação: 2002
Outros Autores: Almeida, Vinícius Cotta de, Araujo-Jorge, Tania C.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/41059
Resumo: Acesso aberto em 01/05/2020 - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC132750/pdf/0284.pdf
id CRUZ_fd171696db952e8923451017f74ef47a
oai_identifier_str oai:www.arca.fiocruz.br:icict/41059
network_acronym_str CRUZ
network_name_str Repositório Institucional da FIOCRUZ (ARCA)
repository_id_str 2135
spelling Olivieri, Bianca PerdigãoAlmeida, Vinícius Cotta deAraujo-Jorge, Tania C.2020-05-01T17:30:30Z2020-05-01T17:30:30Z2002OLIVIERI, Bianca Perdigão; ALMEIDA, Vinícius Cotta de; ARAÚJO-JORGE,Tania C. et al. Benznidazole Treatment following Acute Trypanosoma cruzi Infection Triggers CD8 T-Cell Expansion and Promotes Resistance to Reinfection. Antimicrobial Agents and Chemotherapy, v. 46, n. 12, p. 3790-3796, Dec. 2002.0066-4804https://www.arca.fiocruz.br/handle/icict/4105910.1128/aac.46.12.3790-3796.20021098-6596Acesso aberto em 01/05/2020 - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC132750/pdf/0284.pdfFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Ultraestrutura e Biologia Celular. Rio de Janeiro, RJ, Brasil.Harvard Medical School. Massachusetts General Hospital. Gastrointestinal Unit. Boston, Massachussets, USA.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Ultraestrutura e Biologia Celular. Rio de Janeiro, RJ, Brasil.Many studies have shed light on the mechanisms underlying both immunoprotection and immune dysregulation arising after Trypanosoma cruzi infection. However, little is known about the impact of benznidazole (N-benzyl-2-nitroimidazole acetamide), the drug available for clinical treatment of the infection, on the immune system in the infected host. In the present study we investigated the effect of benznidazole therapy on the lymphoid compartment during the course of experimental T. cruzi infection. Although amelioration of a variety of clinical and parasitological signs was observed in treated mice, amelioration of splenocyte expansion was not detected. Interestingly, this sustained splenomegaly observed in benznidazole-treated mice showed a preferential expansion of CD8(+) T lymphocytes. Moreover, although benznidazole treatment blocked the expansion of recently activated CD4(+) and CD8(+) T cells seen in infected hosts, benznidazole treatment led to a selective expansion of effector and memory CD8(+) T lymphocytes in association with a lower rate of apoptosis. In addition, the surviving treated animals were protected from reinfection. Together, these data suggest that, in addition to its well-known direct role in blocking parasite replication in vivo, benznidazole appears to directly affect immune regulation in T. cruzi-infected hosts.engAmerican Society for MicrobiologyTrypanosoma cruziDoença de ChagasTratamento com BenznidazleInfecção agudaExpansão de Células T CD8Resistência a ReinfecçãoChagas DiseaseTrypanosoma cruziBenznidazole TreatmentAcute infectionResistance to ReinfectionCD8 T-Cell ExpansionBenznidazole treatment following acute Trypanosoma cruzi infection triggers CD8+ T-cell expansion and promotes resistance to reinfectioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/41059/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALTaniaAraujoJOrge_ViniciusCAlmeida_etal_IOC_2002.pdfTaniaAraujoJOrge_ViniciusCAlmeida_etal_IOC_2002.pdfapplication/pdf214854https://www.arca.fiocruz.br/bitstream/icict/41059/2/TaniaAraujoJOrge_ViniciusCAlmeida_etal_IOC_2002.pdfef2e81f1d7263987b153780ad2528182MD52TEXTTaniaAraujoJOrge_ViniciusCAlmeida_etal_IOC_2002.pdf.txtTaniaAraujoJOrge_ViniciusCAlmeida_etal_IOC_2002.pdf.txtExtracted texttext/plain41518https://www.arca.fiocruz.br/bitstream/icict/41059/3/TaniaAraujoJOrge_ViniciusCAlmeida_etal_IOC_2002.pdf.txt254965d6a5f8d4cddf773db7cf9cec8aMD53icict/410592022-06-24 13:08:57.064oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352022-06-24T16:08:57Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Benznidazole treatment following acute Trypanosoma cruzi infection triggers CD8+ T-cell expansion and promotes resistance to reinfection
title Benznidazole treatment following acute Trypanosoma cruzi infection triggers CD8+ T-cell expansion and promotes resistance to reinfection
spellingShingle Benznidazole treatment following acute Trypanosoma cruzi infection triggers CD8+ T-cell expansion and promotes resistance to reinfection
Olivieri, Bianca Perdigão
Trypanosoma cruzi
Doença de Chagas
Tratamento com Benznidazle
Infecção aguda
Expansão de Células T CD8
Resistência a Reinfecção
Chagas Disease
Trypanosoma cruzi
Benznidazole Treatment
Acute infection
Resistance to Reinfection
CD8 T-Cell Expansion
title_short Benznidazole treatment following acute Trypanosoma cruzi infection triggers CD8+ T-cell expansion and promotes resistance to reinfection
title_full Benznidazole treatment following acute Trypanosoma cruzi infection triggers CD8+ T-cell expansion and promotes resistance to reinfection
title_fullStr Benznidazole treatment following acute Trypanosoma cruzi infection triggers CD8+ T-cell expansion and promotes resistance to reinfection
title_full_unstemmed Benznidazole treatment following acute Trypanosoma cruzi infection triggers CD8+ T-cell expansion and promotes resistance to reinfection
title_sort Benznidazole treatment following acute Trypanosoma cruzi infection triggers CD8+ T-cell expansion and promotes resistance to reinfection
author Olivieri, Bianca Perdigão
author_facet Olivieri, Bianca Perdigão
Almeida, Vinícius Cotta de
Araujo-Jorge, Tania C.
author_role author
author2 Almeida, Vinícius Cotta de
Araujo-Jorge, Tania C.
author2_role author
author
dc.contributor.author.fl_str_mv Olivieri, Bianca Perdigão
Almeida, Vinícius Cotta de
Araujo-Jorge, Tania C.
dc.subject.other.pt_BR.fl_str_mv Trypanosoma cruzi
Doença de Chagas
Tratamento com Benznidazle
Infecção aguda
Expansão de Células T CD8
Resistência a Reinfecção
topic Trypanosoma cruzi
Doença de Chagas
Tratamento com Benznidazle
Infecção aguda
Expansão de Células T CD8
Resistência a Reinfecção
Chagas Disease
Trypanosoma cruzi
Benznidazole Treatment
Acute infection
Resistance to Reinfection
CD8 T-Cell Expansion
dc.subject.en.pt_BR.fl_str_mv Chagas Disease
Trypanosoma cruzi
Benznidazole Treatment
Acute infection
Resistance to Reinfection
CD8 T-Cell Expansion
description Acesso aberto em 01/05/2020 - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC132750/pdf/0284.pdf
publishDate 2002
dc.date.issued.fl_str_mv 2002
dc.date.accessioned.fl_str_mv 2020-05-01T17:30:30Z
dc.date.available.fl_str_mv 2020-05-01T17:30:30Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv OLIVIERI, Bianca Perdigão; ALMEIDA, Vinícius Cotta de; ARAÚJO-JORGE,Tania C. et al. Benznidazole Treatment following Acute Trypanosoma cruzi Infection Triggers CD8 T-Cell Expansion and Promotes Resistance to Reinfection. Antimicrobial Agents and Chemotherapy, v. 46, n. 12, p. 3790-3796, Dec. 2002.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/41059
dc.identifier.issn.pt_BR.fl_str_mv 0066-4804
dc.identifier.doi.none.fl_str_mv 10.1128/aac.46.12.3790-3796.2002
dc.identifier.eissn.none.fl_str_mv 1098-6596
identifier_str_mv OLIVIERI, Bianca Perdigão; ALMEIDA, Vinícius Cotta de; ARAÚJO-JORGE,Tania C. et al. Benznidazole Treatment following Acute Trypanosoma cruzi Infection Triggers CD8 T-Cell Expansion and Promotes Resistance to Reinfection. Antimicrobial Agents and Chemotherapy, v. 46, n. 12, p. 3790-3796, Dec. 2002.
0066-4804
10.1128/aac.46.12.3790-3796.2002
1098-6596
url https://www.arca.fiocruz.br/handle/icict/41059
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv American Society for Microbiology
publisher.none.fl_str_mv American Society for Microbiology
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/41059/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/41059/2/TaniaAraujoJOrge_ViniciusCAlmeida_etal_IOC_2002.pdf
https://www.arca.fiocruz.br/bitstream/icict/41059/3/TaniaAraujoJOrge_ViniciusCAlmeida_etal_IOC_2002.pdf.txt
bitstream.checksum.fl_str_mv 5a560609d32a3863062d77ff32785d58
ef2e81f1d7263987b153780ad2528182
254965d6a5f8d4cddf773db7cf9cec8a
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
_version_ 1798324784101064704

Registros relacionados