Melanocytic lesions ≤ 6mm: Prospective series of 481 melanocytic trunk and limb lesions in Brazil

Detalhes bibliográficos
Autor(a) principal: Campos-do-Carmo, Gabriella
Data de Publicação: 2021
Outros Autores: Nobre, Aretha Brito, Cuzzi, Tullia, Argenziano, Giuseppe, Ferreira, Carlos Gil, Thuler, Luiz Claudio Santos
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/48395
Resumo: Gávea Medical Center. Rio de Janeiro, RJ, Brazil.
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spelling Campos-do-Carmo, GabriellaNobre, Aretha BritoCuzzi, TulliaArgenziano, GiuseppeFerreira, Carlos GilThuler, Luiz Claudio Santos2021-07-28T20:01:12Z2021-07-28T20:01:12Z2021CAMPOS-DO-CARMO, Gabriella et al. Melanocytic lesions ≤ 6mm: Prospective series of 481 melanocytic trunk and limb lesions in Brazil. PloS one, v. 16, n. 6, p. 1-13, 20211932-6203https://www.arca.fiocruz.br/handle/icict/4839510.1371/journal.pone.0252162engPublic Library of ScienceMelanocytic lesions ≤ 6mm: Prospective series of 481 melanocytic trunk and limb lesions in Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleGávea Medical Center. Rio de Janeiro, RJ, Brazil.National Cancer Institute. Rio de Janeiro, RJ, Brazil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil / Federal University. Rio de Janeiro, RJ, Brazil.University of Campania. Dermatology Unit. Caserta, Italy.Oncoclinicas Institute for Research and Education. Rio de Janeiro, RJ, Brazil.National Cancer Institute. Rio de Janeiro, RJ, Brazil.Early diagnosis when melanoma is still small and thin is essential for improving mortality and morbidity. However, the diagnosis of small size melanoma might be particularly difficult, not only clinically but also dermoscopically. This study aimed to define clinical and dermatoscopic parameters in the diagnosis of suspicious pigmented cutaneous lesions with a diameter of ≤ 6mm and determine the sensitivity, specificity, positive and negative predictive values as well as the accuracy of each clinical and dermatoscopic criterion. This is a transversal, descriptive and analytical study of dermatoscopic analysis with the gold standard being the pathologic examination obtained from the excisional biopsy of suspicious melanocytic lesions with a diameter of ≤ 6mm. Trunk and limb lesion data from a public health service and a private clinic were prospectively collected from 2011 to 2017 by a unique observer. In total, 481 melanocytic lesions were included, with 73.8% being ≤ 4mm in diameter. Overall, 123 were diagnosed as melanoma, 56.0% in situ and 22.0% as thin melanomas (Breslow index 0.1 to 1.0mm). Melanoma presented symmetry in 53.7% of cases, regular borders in 54.5% and a single color in 60.2%. Regarding evolution, 13.8% of melanomas versus 10.9% of benign lesions (p = 0.116) were new by comparing photos from baseline with photos from the follow-up. The majority of melanomas (65%) were found on the limbs compared to 37.2% of the benign lesions at this location (p<0.001). A multiple logistic regression model adjusted for age, gender and location was created. The independent variables associated with the diagnosis of melanoma ≤ 6mm, adjusted for age, gender and location, were: streaks (adjusted Odds Ratio [aOR] 2.5; 95% CI 1.3-4.7; p = 0.006), and the presence of a structureless area (aOR 2.2, 95% CI 1.2-4.0, p = 0.011). Conversely, a symmetric typical pigment network was a protection variable (aOR 0.4, 95% 0.7-0.9, p = 0.040). In conclusion, dermatoscopic criteria have been identified which help to diagnose cases of small size melanoma. These include streaks and structureless areas that can be taken, particularly in consideration for the diagnosis of this subset of small difficult melanomas.LesionsCutaneous melanomaPigmentsCancer detection and diagnosisPathologistsSkin tumorsinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83099https://www.arca.fiocruz.br/bitstream/icict/48395/1/license.txt586c046dcfeef936e32f0323bb9a47c0MD51ORIGINALMelanocytic_Tullia_Cuzzi_etal_INI_2021.pdfMelanocytic_Tullia_Cuzzi_etal_INI_2021.pdfapplication/pdf1698999https://www.arca.fiocruz.br/bitstream/icict/48395/2/Melanocytic_Tullia_Cuzzi_etal_INI_2021.pdfb829a24a2e7ff63dee37c1b4a3152b1cMD52TEXTMelanocytic_Tullia_Cuzzi_etal_INI_2021.pdf.txtMelanocytic_Tullia_Cuzzi_etal_INI_2021.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv Melanocytic lesions ≤ 6mm: Prospective series of 481 melanocytic trunk and limb lesions in Brazil
title Melanocytic lesions ≤ 6mm: Prospective series of 481 melanocytic trunk and limb lesions in Brazil
spellingShingle Melanocytic lesions ≤ 6mm: Prospective series of 481 melanocytic trunk and limb lesions in Brazil
Campos-do-Carmo, Gabriella
Lesions
Cutaneous melanoma
Pigments
Cancer detection and diagnosis
Pathologists
Skin tumors
title_short Melanocytic lesions ≤ 6mm: Prospective series of 481 melanocytic trunk and limb lesions in Brazil
title_full Melanocytic lesions ≤ 6mm: Prospective series of 481 melanocytic trunk and limb lesions in Brazil
title_fullStr Melanocytic lesions ≤ 6mm: Prospective series of 481 melanocytic trunk and limb lesions in Brazil
title_full_unstemmed Melanocytic lesions ≤ 6mm: Prospective series of 481 melanocytic trunk and limb lesions in Brazil
title_sort Melanocytic lesions ≤ 6mm: Prospective series of 481 melanocytic trunk and limb lesions in Brazil
author Campos-do-Carmo, Gabriella
author_facet Campos-do-Carmo, Gabriella
Nobre, Aretha Brito
Cuzzi, Tullia
Argenziano, Giuseppe
Ferreira, Carlos Gil
Thuler, Luiz Claudio Santos
author_role author
author2 Nobre, Aretha Brito
Cuzzi, Tullia
Argenziano, Giuseppe
Ferreira, Carlos Gil
Thuler, Luiz Claudio Santos
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Campos-do-Carmo, Gabriella
Nobre, Aretha Brito
Cuzzi, Tullia
Argenziano, Giuseppe
Ferreira, Carlos Gil
Thuler, Luiz Claudio Santos
dc.subject.en.pt_BR.fl_str_mv Lesions
Cutaneous melanoma
Pigments
Cancer detection and diagnosis
Pathologists
Skin tumors
topic Lesions
Cutaneous melanoma
Pigments
Cancer detection and diagnosis
Pathologists
Skin tumors
description Gávea Medical Center. Rio de Janeiro, RJ, Brazil.
publishDate 2021
dc.date.accessioned.fl_str_mv 2021-07-28T20:01:12Z
dc.date.available.fl_str_mv 2021-07-28T20:01:12Z
dc.date.issued.fl_str_mv 2021
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv CAMPOS-DO-CARMO, Gabriella et al. Melanocytic lesions ≤ 6mm: Prospective series of 481 melanocytic trunk and limb lesions in Brazil. PloS one, v. 16, n. 6, p. 1-13, 2021
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/48395
dc.identifier.issn.pt_BR.fl_str_mv 1932-6203
dc.identifier.doi.none.fl_str_mv 10.1371/journal.pone.0252162
identifier_str_mv CAMPOS-DO-CARMO, Gabriella et al. Melanocytic lesions ≤ 6mm: Prospective series of 481 melanocytic trunk and limb lesions in Brazil. PloS one, v. 16, n. 6, p. 1-13, 2021
1932-6203
10.1371/journal.pone.0252162
url https://www.arca.fiocruz.br/handle/icict/48395
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/48395/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/48395/2/Melanocytic_Tullia_Cuzzi_etal_INI_2021.pdf
https://www.arca.fiocruz.br/bitstream/icict/48395/3/Melanocytic_Tullia_Cuzzi_etal_INI_2021.pdf.txt
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bitstream.checksumAlgorithm.fl_str_mv MD5
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repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
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